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Shu-Tsen Liu(Shu-Tsen Liu),Sheng-Che Lin(Sheng-Che Lin),Jane Pei-Chen Chang(Jane Pei-Chen Chang),Kai-Jie Yang(Kai-Jie Yang),Che-Sheng Chu(Che-Sheng Chu),Chia-Chun Yang(Chia-Chun Yang),Chih-Sung Liang( 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.
( Kai Yang ),( Yulong Tang ),( Yanyun Ma ),( Qingmei Liu ),( Yan Huang ),( Yuting Zhang ),( Xiangguang Shi ),( Li Zhang ),( Yue Zhang ),( Ji’an Wang ),( Yifei Zhu ),( Wei Liu ),( Yimei Tan ),( Jinran 대한피부과학회 2021 Annals of Dermatology Vol.33 No.6
Background: Androgenetic alopecia (AGA) leads to thinning of scalp hair and affects 60%~70% of the adult population worldwide. Developing more effective treatments and studying its mechanism are of great significance. Previous clinical studies have revealed that hair growth is stimulated by 650-nm red light. Objective: This study aimed to explore the effect and mechanism of 650-nm red light on the treatment of AGA by using ex vivo hair follicle culture. Methods: Human hair follicles were obtained from hair transplant patients with AGA. Hair follicles were cultured in Williams E medium and treated with or without 650-nm red light. Real-time RT-PCR and immunofluorescence staining were used to detect the expression level of genes and proteins in hair follicles, respectively. RNA-sequencing analysis was carried out to reveal the distinct gene signatures upon 650 nm treatment. Results: Low-level 650 nm red light promoted the proliferation of human hair follicles in the experimental cultured-tissue model. Consistently, 650 nm red light significantly delayed the transition of hair cycle from anagen to catagen in vitro. RNA-seq analysis and gene clustering for the differentially expressed genes suggests that leukocyte transendothelial migration, metabolism, adherens junction and other biological process maybe involved in stimulation of hair follicles by 650-nm red light treatment. Conclusion: The effect of 650-nm red light on ex vivo hair follicles and the transcriptome set which implicates the role of red light in promoting hair growth and reversing of miniaturization process of AGA were identified.
CK2 phosphorylates AP-2α and increases its transcriptional activity
( Kai Qun Ren ),( Shuang Lin Xiang ),( Fang Li He ),( Wen Feng Zhang ),( Xiao Feng Ding ),( Yan Yang Wu ),( Li Ping Yang ),( Jian Lin Zhou ),( Xiang Gao ),( Jian Zhang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.7
Transcription factor AP-2α involves in the process of mammalian embryonic development and tumorigenesis. Many studies have shown that AP-2α functions in association with other interacting proteins. In a two-hybrid screening, the regulatory subunit β of protein casein kinase 2 (CK2β) was identified as an interacting protein of AP-2α; we confirmed this interaction using in-vitro GST pull-down and in-vivo co-immunoprecipitation assays; in an endogenous co-immunoprecipitation experiment, we further found the catalytic subunit α of protein casein kinase 2 (CK2α) also exists in the complex. Phosphorylation analysis revealed that AP-2α was phosphorylated by CK2 kinase majorly at the site of Ser429, and such phosphorylation could be blocked by CK2 specific inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) in a dose-dependent manner. Luciferase assays demonstrated that both CK2α and CK2β enhanced the transcription activity of AP-2α; moreover, CK2β increased the stability of AP-2α. Our data suggest a novel cellular function of CK-2 as a transcriptional co-activator of AP-2α.
Kai Yang,Gang Wang,Fulong Liu,Yanxia Zhao 한국고분자학회 2019 Macromolecular Research Vol.27 No.10
The removal of Cd(II) ions from wastewater via the compound flocculation of O-xanthogenated chitosan Schiff base (XCTS) and Fe(III) ions was studied. The compound flocculant Fe(III)/XCTS was effective in an acid range of pH 3.0-5.0. When the pH was 3.0 and the compound ratio of [Fe(III)]/[XCTS] was 1:12, the compounded system Fe(III)/XCTS had the best effect on the removal of Cd(II) ions; the removal rate of Cd(II) ions was greater than 99.5%, and the Cd(II) ion concentration of the treated wastewater met the 0.1 mg L-1 limit set by the National Integrated Wastewater Discharge Standard of China. Furthermore, while studying the compound flocculation of Fe(III) ions and XCTS, we found that the approach enhanced the growth and structure of the flocs in the progress of removing Cd(II) ions.
Exponential Stability Analysis of Planar Piecewise-Linear Systems: An Integral Function Approach
Kai Liu,Yu Yao,Baoqing Yang,Venkataramanan Balakrishnan,Yang Guo 제어·로봇·시스템학회 2012 International Journal of Control, Automation, and Vol.10 No.2
This paper studies the exponential stability of continuous-time planar piecewise-linear systems (PPLS). By introducing a novel conception of integral function of PPLS and showing its properties, a sufficient and necessary condition for the exponential stability is derived. Furthermore, the exponential growth rate of system trajectories can be obtained accurately by computing the convergence radius of integral function. The algorithm for computing the integral function is developed and two examples are given to demonstrate the proposed approach.
Kai Yang,Jun Wang,Wei Yu 한국유변학회 2016 Korea-Australia rheology journal Vol.28 No.3
Large amplitude oscillation shear (LAOS) is used to investigate the yielding and flow behavior of yield stress materials. Considering the problems in determination of the yield stress from the apparent dynamic moduli and relative harmonic intensity using Fourier Transform Rheology, we proposed a new approach based on 2D mechanical correlation spectra (2D-MCS) to quantify the yield stress. We have proved that the nonlinear synchronous self-correlation intensity as functions of stress/strain amplitude can be used to determine the yield stress unambiguously from the change of scaling exponent. The yield stresses from 2D-MCS analysis are well consistent with those from the stress ramp experiments.
Design, Drive and Control of a Novel SMA-actuated Humanoid Flexible Gripper
Yang Kai,Wang Yanjue 대한기계학회 2008 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.22 No.5
recovering wire w1, with remembered ‘U’ shape, is located along the rod’s axis. The restoring wire w2, with memorized straight shape, is located in parallel with the rod’ axis with an offset distance d1. Two strain gauges, arranged in complemental configuration and sticking to the rod, are used to implement accurate displacement control. Upon the elicitation of the structure of a human being’s hands, a finger with multi-units is proposed. The finger has two flexible rods with embedded SMA wires and one shorter rod as a connecting part. The number and position of fingers are investigated by making use of a nonlinear plan process with an index W, a function of grasp matrix G. The hardware of the drive and control system of the gripper has been completed on the base of a DSP chip. After the track plan is realized in the joint space through B spline interpolation method, the software of the position control system is fulfilled through two-staged slide control strategy. The simulations and experiments of step response of the SMA actuator are carried out. It is shown in the experiments that the maximum angle between ends’ tangents of each finger is 68.5, 79 and 79 degrees, respectively, and the tip of each finger could reach its final position by using approximately the same time period.
Sequence of Tense in English and Chinese
Kai Yang,Seung-Man Kang 한국중원언어학회 2020 언어학연구 Vol.0 No.55
This paper delves into the so-called sequence of tense (SOT) phenomena in English and Chinese, in which the reading of the past tense of the embedded clause matches with that of the matrix clause to be simultaneous or past-shifted with the time referred to by the tense in the matrix clause. Our research leads us to conclude this paper as follows. First, Chinese is also an SOT language in that the embedded clause has either a simultaneous or a past-shifted reading if the matrix predicate is an intensional verb in the past tense and the embedded predicate is a stative verb in the past tense as well. Second, both simultaneous and past-shifted readings in Chinese, unlike in English, can be conveyed even when the matrix and the embedded clause are morphologically in the present tense due to the existence of a sentential aspectual marker le. Finally, some ‘episodic verbs’ such as huaiyun ‘pregnant’ and shengbing ‘sick’ in the embedded clause in Chinese, construed as ‘stative predicates’ in English, should be classified as ‘eventive verbs’ in Chinese to yield a past-shifted interpretation.
Kai Yang,Cheng FangWang,Chun Xue You,Zhu Feng Geng,Rui Qi Sun,Shan Shan Guo,Shu Shan Du,Zhi Long Liu,Zhi Wei Deng 한국응용곤충학회 2014 Journal of Asia-Pacific Entomology Vol.17 No.3
During our screening program for agrochemicals from Chinese medicinal herbs and wild plants, the essential oilof Litsea cubeba fruits was found to possess strong contact toxicity against the cigarette beetle Lasiodermaserricorne adults and the booklouse Liposcelis bostrychophila, with LD50 values of 27.33 μg/adult and71.56 μg/cm2, respectively, and also showed strong fumigant toxicity against the two stored product insectswith LC50 values of 22.97 and 0.73 mg/L, respectively. The essential oil obtained by hydrodistillation wasinvestigated by GC MS. The main components of the essential oil were identified to be E-citral (geranial)(27.49%), Z-citral (neral) (23.57%) and D-limonene (18.82%) followed by β-thujene (3.34%), β-pinene (2.85%), α-pinene (2.57%), 6-methyl-5-hepten-2-one (2.40%) and linalool (2.36%). Citral (Z/E-citral), D-limonene, β-pinene,α-pinene and linalool were separated and purified by silica gel column chromatography and preparative thinlayer chromatography, and further identified by means of physicochemical and spectrometric analysis. Citral andlinalool showed strong contact toxicity against L. serricorne and L. bostrychophila (LD50 = 11.76, 12.74 μg/adultand 20.15, 99.97 μg/cm2, respectively) and fumigant toxicity against L. serricorne and L. bostrychophila (16.54,18.04 mg/L air and 0.14, 0.71 mg/L air, respectively). Otherwise, citral, D-limonene and linalool were strongly repellentagainst the cigarette beetle L. serricorne as the essential oil whereas β-pinene and α-pinene exhibited weakerrepellency against the cigarette beetle compared with the positive control, DEET. Moreover, except α-pinene andlinalool, the other three compounds as well as the essential oil exhibited comparable repellency against thebooklouse relative to DEET.