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      • KCI등재

        Creutzfeldt-Jacob병 1례

        홍승철,한진희,정종현,김소양,허균,이성필 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

        저자들은 Creutzfeldt-Jacob병 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 환자는 약 4개월에 걸친 비교적 짧은 기간 동안 중증의 인지 기능 장애와 시각 장애, 보행장애와 하지의 약화, 불수의적 운동 등과 함께 섬망상태에까지 이르게 되어 본원 정신과에 입원하게 되었다. 정신상태 검사상, 반응시간의 지체, 언어장애와 보속증, 시간에 대한 지남력 장애, 주의 집중력 장애, 단기 및 장기 기억 장애, 추상적 사고능력 장애 등의 소견을 보였고, 이러한 증상들은 입원후 치료에도 불구하고 빠르게 악화되었다. 뇌파검사상 지속적인 다발초점성 서파가 모든 전극에서, 특히 우측 전두부에서 현저하게 나타나는 소견을 보였고, 병리조직학적 검사상 대뇌 피질에 신경손실을 동반한 해면화와 신경교 증식증을 나타냈다. 이상의 소견들은 모두 CJD의 진단에 합당하였다. We report a case of Creutzfeldt-Jacob disease and review the relevant literatures. This 56-year-old male patient was admitted to our hospital with a history of rapidly progressing cognitive dysfunction, visual disturbance, gait disturbance, weakness, involuntary movement of lower extremities, and the symptoms of delirium. On mental status examination, he showed psychomotor retardation, speech disturbance, perseveration, disorientation, impairment of short-term and long-term memory, and inability of abstract thinking. He had a rapid downhill course, along with shakiness of trunk, rigidity of the limbs, myoclonus, confusion, and finally, inability to speak or move on the bedside. On electroencephalogram(EEG), continuous multifocal show delta activities were found in all leads, especially in the right frontal areas. Brain biopsy showed, spongiosis with neuronal loss and gliosis noted at the cerebral cortex. These findings were compatible with Creutzfeldt-Jacob disease.

      • KCI등재

        수술실 손 소독제의 종류에 따른 균주 수의 변화

        홍성윤,김정민,김소영,이수정,오은실,양서인,김화실,김남초 병원간호사회 2006 임상간호연구 Vol.11 No.2

        Purpose: The present study purposed to compare the hand washing effect of 7.5% powidone-iodine, which is used in the operation room of C university hospital in Seoul, with that of Ethyl alcohol-CHG mixture recommended by the US Association of Operating Room Nurses (2002) and to adopt a more effective hand disinfectant. Method: In a quasi-experimental design, 48 medical staff who participated in operations during the period from November 2004 to February 2005 had hand washing using the two kinds of hand disinfectants: 7.5% povidone-iodine and the ethyl alcohol-CHG mixture. Their palms were swabbed and cultured just after hand washing and again after taking dff sterile gloves after the operation. The number of colonies from the two occasions were counted and compared. Result: The number of general bacillus increased significantly in the group using 7.5% povidone-iodine compared to that in the group using the ethyl alcohol-CHG mixture. The number of general bacillus increased signficantly in doctors compared to that in nurses. The factors affecting the increase of the number of general bacillus were disinfectants and medical personnel. The number of general bacillus was expected to increase 9.41 times with 7.5% povidone-iodine than with the ethyl alcohol-CHG mixture and 14.87 times in doctors than in nurses. Conclusion: This study shows that the ethyl alcogol-CHG mixture has a stronger hand disinfection effect than 7.5% povidone iodine. Thus we need to change the hand disinfectant used in operating rooms as soon as possible in order to minimize the infection of wounds resulting from operations.

      • KCI등재

        경도인지장애 환자에서 복합-일상활동의 제한

        홍지혜,정한용,김양래,이소영,김진만 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.4

        Objectives : Mild cognitive impairment (MCI) is distinguished from mild dementia by an absence of global intellectual deterioration and the preservation of activities of daily living (ADL). Recently, however, it became apparent that impairment of instrumental activities of daily living (IADL) is present before the threshold of dementia is reached. Thus, we want to examine whether IADL are impaired in patients with MCI, and which items of IADL are particularly involved. We divided the MCI group into amnestic (aMCI) and non-amnestic MCI (naMCI), and compared to the cognitively nonnal controls. In this study, we focused on the instrumental activities of daily living (IADL). Methods : The sample consisted of 69 community-dwelling older adults from a welfare center for the aged in Korea. The subjects were divided into three diagnostic groups; aMCI [N=19, memory domains below -1.5 standard deviation (SD)], naMCI (N= 19, other cognitive domains below -1.5 SD, except memory domains) and cognitive normal controls (N=31). Subjects were assessed both on IADL and the cognitive function. In order to assess the IADL, we used the Seoul -Instrumental Activities of Daily Living (S-IADL). Included measures of cognitive tests are as follows ; Seoul Verbal Learning Test (SVLT), Rey Complex Figure Test (RCFT), Korean-Boston Naming Test (K-BNT), Stroop test, and Korean-Mini Mental Status Examination (K-MMSE). Groups were compared on the S-IADL and the cognitive tests. Results : The three groups did not differ in the mean age, gender distribution and years of education. S-IADL were shown to be different between the groups in this study. Suects with aMCI were significantly more impaired in S-IADL in comparison to the controls [F (2,50) = 4.251, P=0.020]. And on four items ofS-IADL (shopping, transportation, medication and talking about recent events), subjects with aMCI showed higher impairment compared to the controls. However, the S-IADL did not differ between the subjects with naMCI and controls. Conclusion : In this study, impairment of S-IADL was shown in subjects with aMCI. And S-IADL ofnaMCI was not Significantly differed from aMCI and controls. The results suggest that naMCI would be distinguished from aMCI in characteristics and prognosis.

      • 인상채득방법이 임플란트 주모형의 정확성에 미치는 영향

        김영오,양홍서 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.1

        The purpose of this study was to compare the accuracy of master cast fabricated by using different impression methods at the different impression levels. The master model used in this study was resin block having four implant analogs. Impression method studied were 1) direct method on fixture level (Group FIX-D), 2) Indirect method on fixture level(Group FIX-I), 3) Modified indirect method on fixture level(Group FIX-M) 4) Direct method on abutment level(Group AB-D) and 5) Indirect method on abutment level(Group AB-I). Each of the five groups took 10 impressions. Fifty impressions were made for master cast by using Impregum FIX impression material loaded on individual tray. Three dimensional measuring microscope was used to measure the inter-implant distance. Error rate of each inter-implant distance were calculated and evaluated. The results were as follows. 1. Group FIX exhibited higher accuracy than group AB. 2. In group FIX, modified indirect method showed the highest accuracy, while indirect method showed the lowest accuracy. In group Ab, indirect method showed the higher accuracy than direct method. 3. Group FIX showed larger horizontal error than group AB. But, group AB showed the larger vertical error than group FIX. 4. Group Fix-M showed smallest vertical and horizontal error.

      • 접착용 시멘트의 결합강도에 임시 접착제와 탈감작제가 미치는 영향

        신세나,양홍서 전남대학교 치의학연구소 2002 구강과학 Vol.14 No.3

        This study investigated the effect of temporary cement and desensitizer on the bond strength of luting cements. Total 96 dentin specimens were divided Into two groups with and without temporary cementation. For temporary cement-treated group. specimens were cemented with Temp-bond® and all specimens were stored in dlstilled water at 37℃ for 7days. Each group was further divided into 3 subgroups with Gluma®, One-step® application and without desensitizer. After desensitizer application, Ni-Cr specimens were luted to dentin surface with Panavia-F® and Vitremer® Specimens were placed in distilled water at 37℃ for 24 hours and shear bond strength between metal and dentin was measured by a universal testing machine The results were as follows : 1. In Panavia-F® cemented groups. the combination of One-step® without temporary cement showed the greatest strength. Among the desensitizer types, One-step® showed the highest bond strength. followed by No-desensitizer, Gluma®. 2. In Vitremerff cemented groups, the combination of no temporary cement and witllout desensitizer showed the greatest bond strength. Among the desensitizer types, No-desensitizer group showed the highest bond strength. 3. The use of Gluma® significantly reduced the shear bond strength in Panavia-F® and Vitremer® groups. 4. All temporary cement-treated groups showed a significant lower shear bond strength than without temporary cement groups. 5. Desensitizer application significantly influenced the bond strellgth of the resin cement and resin modified glass ionomer cement.

      • 임플랜트 고정체의 형태와 연결방식에 따른 임플랜트 및 지지조직의 응력분포

        한상운,양홍서 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.2

        In this study, four finite element models were constructed in the mandible having a single implant fixture connected to the first premolar-shaped superstructure, in order to evaluate how the shape of the fixture and the implant-abutment connection would influence the stress level of the supporting tissues, fixtures, and prosthethic components. In each model, the superstructures were constructed using UCLA type abutment, ADA type Ⅲ gold alloy was used to fabricate a crown andthen connected to the fixture with an abutment screw. The models BRA, END, FRI, ITI were constructed from the mandible implanted with Branemark, Endopore, Frialit-2, I.T.I systems respectively. In each model, 150 N of vertical load was placed on the central pit of an occlusal plane and 150 N of 40˚ oblique load was placed on the buccal cusp. The displacement and stress distribution in the supporting tissues and the other components were analysed using a 2-dimensional finite element analysis. The maximum stress in each reference area was compared. The results obtained were as follows : 1. Under 40˚ oblique loading, the maximum stress was larger in the implant. superstructure and supporting tissue, compared to the stress pattern under vertical loading. 2. In the implant, prosthesis and supporting tissue, the maximum stress was smaller with the internal connection type (FRI) and the morse taper type (ITI) when compared to that of the external connection type (BRA & END), 3. In the superstructure and jmplant/abutment interface. the maximum stress was smaller with the internal connection type (FRI) and the morse taper type (ITI) when compared to that of the external connection type (BRA & END). 4. In the implant fixture, the maximum stress was smaller with the internal connection type (FRI) and the morse taper type (ITI) when compared to that of the external connection type (BRA & END). 5. The stress was more evenly distributed in the bone/implant interface through the FRI of trapezoidal step design. Especially Under 40˚ oblique loading, The maximum stress was smallest in the bone/implant interface. 6. In the implant and superstructure and supporting tissue, the maximum stress occured at the crown loading point through the ITI. In short, the stress distribution of the supporting tissue was affected by shape of a fixture and implant-abutment connection. The magnitude of maximum stress was reduced with the internal connection type (FRI) and the morse taper type (ITI) in the implant, prosthesis and supporting tissue. Trapezoidal step design of FRI showed evenly distributed the stress at the bone/implant interface.

      • 전치부 치간이개의 수복종류에 따른 유한요소법적 응력분석

        박상현,양홍서 전남대학교 치과대학 1989 전남치대논문집 Vol.1 No.2

        The purpose of this study was to analyze the stress of restoration, tooth and adjacent supporting structures according to the width of anterior diastema and the type of restorations. The finite element models of right and left central incisors were divided into four groups according to the type of restorations of each model were inputed to the two dimensional finite element program and stresses were analyzed. Results were as follows: 1. In case of non-splint group, high tensile stress in distocervical area and slight compressive stress in contact point were observed, and compressive and tensile stress were distributed widely in dentin and supporting tissues. 2. In case of splint group, high compressive and tensile stresses were concentrated to splinting area and the stress concentrations of dentin and supporting tissues were less distribution than those of non-splint group, since almost all the stresses were received in metal framework. 3. In the single unit PFM group, as the width of the diastema was increased, the tensil stress was increased in the distocerivical area of porcelain. 4. In the PFM group, the concentration of tensile stresses were seen in the porcelain layer below the metal framework in splint group, whereas stresses were concentrated to distocervical area in non-splint group. 5. The highest compressive and tensile stresses were concentrated to splint area in resin splint group of all groups. 6. The stresses concentration of compact bone were seen mainly in the distal surface in splint group, whereas stresses were distributed widely in non-splint group.

      • 수복재료와 임플랜트 종류에 따른 임플랜트및 지지조직의 응력분포

        최창환,양홍서,오종석 전남대학교 치의학연구소 2001 구강과학 Vol.13 No.4

        This study was aimed to analyze the stress distribution of implant and supporting tissue in single tooth implant restoration using Bra˚emark system®(Nobel Biocare, Gothenberg, Sweden) and Bicon system(Bicon Dental Implants, Boston, MA). Two dimensional finite element analysis model was made at mandibular first premolar area. As a crown materials porcelain, ceromer, ADA type Ⅲ gold alloy were used. Tests have been performed at 25Kgf vertical load on central fossa of crown portion and at 10㎏ load with 45° lateral direction on cusp inclination. The displacement and stresses of implant and supporting structures were analyzed to investigate the influence of the crown material and the type of implant systems by finite element analysis. The results were obtained as follows: 1. The type of crown material influenced the stress distribution of superstructure, but did not influence that of the supporting alveolar bone. 2. The stress distribution of ceromer and type Ⅲ gold alloy and porcelain is similar. 3. Stress under lateral load was about twice higher than that of vertical load in all occlusal restorative materials. 4. In Bicon system, stress concentration is similar in supporting bone area but CerOne system generated about 1.5times greater stress more in superstructure material. 5. In Bra˚emark models, if severe occlusal overload is loaded in superstructure, gold screw or abutment will be fractured or loosened to buffer the occlusal overload but in Bicon models such buffering effect is not expected, so in Bicon model, load can be concentrated in alveolar bone area.

      • Ceromer crown의 교합면 두께에 따른 압축 파절 강도의 비교

        김지연,양홍서 전남대학교 치과대학 2001 구강과학 Vol.13 No.2

        This study investigated the compressive fracture strength of Targis ceromer crown by the difference of occlusal thickness on a maxillary first premolar. Control group was a castable IPS­Empress all­ceramic crown with occlusal thickness of 1.5mm constructed by layered technique. Experimental groups were Targis crowns having different occlusal thicknesses of 1.0 mm, 1.5 mm, 2.0mm, 2.5mm, respectively. The classification of Targis group is T10, T15, T20, T25 AND T15N (for no­thermocycling and occlusal thickness of 1.5mm). Ten samples were tested per each group. Except occlusal thickness, all dimension of metal die is same with axial inclination of 10˚and marginal width 0.5mm chamfer. All crowns were cemented with Panavia F and thermocycled 1,000 times between 5℃ and 55℃ water bath with 10 sec dwelling time and 10 sec resting time. The compressive fracture strength was measured by universal testing machine. The results were as follows: 1. Fracture strength was increased as the occlusal thickness increased : compressive fracture strength of Group T10, T15, T20, T25 was 66.65±4.88 kgf, 75.04±3.01 kgf. 87.07±7.06 kgf and 105.03±10.56 kgf, respectively. 2.When comparing material, Targis crown had higher fracture strength than IPS ­ Empress crown : the mean compressive strength of group T15 was 75.04±3.01 kgf and the value of group Control was 37.66±4.28 kgf. 3. Fracture strength was decreased by thermocycling : the compressive fracture strength of T15 was 75.04±3.01 kgf, which is lower than 90.69±6.88 kgf of group T15N. 4. The fracture line of crowns began at the loading point and extended along long axis of tooth. IPS-Empress showed adhesive failure pattern whereas Targis had adhesive and cohesive failure. In the SEM view, stress was distributed radially from loading point and the crack line was more prominent on Targis crown.

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