Effect of Ligustilide Supplement on Physical Fitness of Athletes

Xiaojuan Gao,Shuai Yang,Meng Liu,Yawen Jiang,Li Wenyan,Rui Ma,Zijian Zhao,Xuelin Zhang 아시아건강운동학회 2020 Journal of Asian Society for Health & Exercise Vol.2 No.2

PURPOSE: In this study, high content ligustilide plant extract was supplemented to monitor the changes of physical fitness and physiological function of athletes, and to explore the effect of ligustilide plant extract on physical function and physical fitness of athletes. METHODS: Thirty five high-level basketball players from Zhengzhou University were selected and divided into two groups randomly: nutritional supplement group (S, n = 18) and control group (C, n=17). This study was approved by the Ethics Committee of Zhengzhou University. Informed consent was obtained from each subject. The intervention period was 8 weeks, six days per week. The training method adopted the small cycle plate training scheme. We measured changes of the scores of rating of perceived exertion (RPE), physical fitness test (15m running, 30m running, 400m running) and routine blood test (mainly including red blood cell count, hemoglobin concentration and average erythrocyte hemoglobin concentration, etc.) before and after training. RESULTS: In group S, the percentage of RPE (grade 6-11) and RPE (grade 12-18) before experiment was 37.5% and 62.5%. After 8 weeks of experiment, 62.5% of RPE (grade 6-11) and 37.5% of RPE (grade 12-18). In group C, 14% of RPE (grade 6-11), 86% of slight RPE (grade 12-18), and 100% of RPE (grade 12-18) after 8 weeks of experiment. It was found that after 8 weeks of training, the number of red blood cells, the concentration of hemoglobin and the average concentration of red blood cell hemoglobin in group S were significantly higher than those before the experiment (p <0.05). According to the comparison of the physical fitness test results of the athletes in group S, it was found that the performance of 400m after 4 weeks and 8 weeks was significantly higher compared with pre-experiment (p<0.05). The changes of 30m and 15m were not significant different (p>0.05). The 400-meter test performance of athletes in group C was significantly higher than that before the experiment only after 8 weeks of training (p<0.05). CONCLUSIONS: Ligustilide supplementation can increase the number of red blood cell and hemoglobin concentration of athletes and has a positive impact on the physical fitness of athletes and the recovery of fatigue.

Clinical Application Value of Lactobacillus Plantarum PS128 in Patients with Anxiety Disorders

Xiaojuan Meng,Yajie Gao,Hang Qi,Yongyan Ding,Yaqing Sun 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.3

Objective: PS128 is a novel psycho biotic strain, it has been reported to play an important role in neuropsychiatric disorders. This study investigated the clinical effect of PS128 supplementation on patients with anxiety. Methods: A total of 200 patients with anxiety were recruited, and divided into two groups (n = 100/group). The control group received oral treatment with citalopram, and the PS128 group received PS128 capsules based on citalopram treatment. Hamilton Anxiety Scale (HAMA) and Self-Rating Anxiety Scale (SAS) were used to evaluate the anxiety levels. After 2 months of continuous administration, clinical efficacy was evaluated according to HAMA score. Results: There was no significant difference in HAMA and SAS scores between the two groups before treatment. With the treatment prolonged, the HAMA and SAS score decreased gradually in both control and PS128 groups, and the decrease rate of PS128 group was significantly greater than that of the control group. The clinical effective rates of PS128 group were higher than those in the control group, high levels of clinical cure rate were also detected in the PS128 group. Compared with the control group (22%), the incidence of adverse reactions was significantly reduced for patients in the PS128 group (4%). Conclusion: The treatment effect of citalopram combined with PS128 against anxiety is satisfactory clinically. It can greatly improve the anxiety symptoms of patients, increase the cure rate, reduce adverse reactions.

Porous membranes in pressure-assisted forward osmosis: Flux behavior and potential applications

Yang Yang,Xueli Gao,Zhaokui Li,Qun Wang,Senjie Dong,Xiaojuan Wang,Zhun Ma,Leyi Wang,Xinyan Wang,Congjie Gao 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.60 No.-

In this work, pressured-assisted forward osmosis (PAFO) was performed using porous membranes to achieve higher fluxes. The effects of additional pressure and membrane orientation on membrane performance were investigated. When ultralow additional pressure (0.04 bar) was applied, the water flux at AL-FS orientation (i.e. active layer facing the feed solution) was observed to double. Reverse solute diffusion was also inhibited dramatically at both membrane orientations in PAFO. Filtration tests revealed that porous membranes with ultralow pressure in FO were more applicable than ultrafiltration (UF) because mild condition (i.e., 0.12 bar versus 1.25 bar) is conducive to preserving microalgae cell integrity.

Combined water flux enhancement of PES-based TFC membranes in ultrasonic-assisted forward osmosis processes

Qun Wang,Xueli Gao,Zhun Ma,Jian Wang,Xiaojuan Wang,Yang Yang,Congjie Gao 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.64 No.-

For PES-based TFC FO membranes, a significant water flux surge occurred after a moderate ultrasonic irradiation. The Change in membrane transport parameters illustrated that internal concentration polarization (ICP) was weakened due to decreased structural parameter. Combined water flux enhancement via real-time ultrasonic irradiation was obtained and related to the CP effect and membrane orientation. Increasing irradiation intensity was more suitable in PRO mode than in FO mode. Low FS concentration in concentration combinations represented high ratio of ultrasonic-induced flux increment to energy input. Multiplying concentration difference was beneficial to obtain high conversion ratio of ultrasonic power to water flux.

A New Method for Piping Risk Evaluation on Unconfined Aquifers under Dewatering of Deep Foundation Pits

Da Li,Jianjun Ma,Chaosheng Wang,Xiaojuan Gao,Mingjing Fang 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.8

This paper presents a new method to evaluate the piping risk of unconfined sandy cobble aquifers during the dewatering of deep foundation pits. Firstly, the possibility of piping is judged according to the particle size distribution and pore diameter of the sandy cobble stratum. Secondly, the critical hydraulic gradients of particles with different sizes are calculated according to the pipe flow model. Thirdly, the hydraulic gradient around the foundation pit during the dewatering process is calculated by numerical method. Then, combined with the distribution of hydraulic gradient around the foundation pit and the critical hydraulic gradients of particles with different sizes, the range of moveable particles with different sizes in the surrounding stratum is evaluated. Finally, according to the sandy cobble aquifers conditions and the influence of particle movement on the stratum, the level of piping risk is determined. This method was successfully applied to evaluate the piping risk of Tawan Station in Luoyang Metro Line No.1, and according to the risk evaluation the pensile curtain was recommended for the retaining structure in this case. From the satisfied applications, this method is a reference for the evaluation of piping risk and selection of retaining structure when considering the impact of the dewatering in deep foundation pit with unconfined aquifers on the surrounding stratum.

MiR-204 acts as a potential therapeutic target in acute myeloid leukemia by increasing BIRC6-mediated apoptosis

( Zhiguo Wang ),( Hong Luo ),( Zehui Fang ),( Yanling Fan ),( Xiaojuan Liu ),( Yujing Zhang ),( Shuping Rui ),( Yafeng Chen ),( Luojia Hong ),( Jincheng Gao ),( Mei Zhang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.9

Acute myeloid leukemia (AML) is one of the most common hematological malignancies all around the world. MicroRNAs have been determined to contribute various cancers initiation and progression, including AML. Although microRNA-204 (miR-204) exerts anti-tumor effects in several kinds of cancers, its function in AML remains unknown. In the present study, we assessed miR-204 expression in AML blood samples and cell lines. We also investigated the effects of miR-204 on cellular function of AML cells and the underlying mechanisms of the action of miR-204. Our results showed that miR-204 expression was significantly downregulated in AML tissues and cell lines. In addition, overexpression of miR-204 induced growth inhibition and apoptosis in AML cells, including AML5, HL-60, Kasumi-1 and U937 cells. Cell cycle analysis further confirmed an augmentation in theapoptotic subG1 population by miR-204 overexpression. Mechanistically, baculoviral inhibition of apoptosis protein repeat containing 6 (BIRC6) was identified as a direct target of miR-204. Enforcing miR-204 expression increased the luciferase activity and expression of BIRC6, as well as p53 and Bax expression. Moreover, restoration of BIRC6 reversed the pro-apoptotic effects of miR-204 overexpression in AML cells. Taken together, this study demonstrates that miR-204 causes AML cell apoptosis by targeting BIRC6, suggesting miR-204 may play an anti-carcinogenic role in AML and function as a novel biomarker and therapeutic target for the treatment of this disease. [BMB Reports 2018; 51(9): 444-449]