Vasodilation Effect of 2-benzyl-5-hydroxy-6-methoxy-3, 4-dihydroisoquinolin- 1-one

Wei-Qi,Yong-Xiao Cao,Zhi-Zheng Xiong,Ting-Ting Chen,Xiao-Yan Gao,Hang Yu,San-Qi Zhang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.8

A 2-Benzyl-5-hydroxy-6-methoxy-3, 4-dihydroisoquinolin-1-one (ZC2) is a newly synthesized isoquinolinone compound. Its effect on vasodilation was evaluated in the present study. Isometric tension of rat artery rings was recorded by a sensitive myography system in vitro. The results showed that ZC2 relaxed rat mesenteric arteries pre-contracted by KCl, phenylephrine and 9, 11- dideoxy- 11α, 9α-epoxymethano-prostaglandin F2α (U46619), and abdominal aorta pre-contracted by KCl in a concentration-dependent manner. The ZC2-induced vasodilation was not affected by an endothelium denudation. ZC2 rightwards shifted the concentration-contraction curves, induced by KCl, phenylephrine, and 5-hydroxytryptamine (5-HT) in a non-parallel manner, which suggests that the vasodilation effects are most likely via voltage-dependent calcium channel (VDCC) and receptor-operated calcium channel (ROCC). Moreover, in Ca2+-free medium, ZC2 concentration-dependently depressed the vasoconstrictions induced by phenylephrine and CaCl2, and decreased a contractile response induced by caffeine, which indicates a role of extracellular Ca2+ influx inhibition through VDCC and ROCC, and intracellular Ca2+ release from Ca2+ store via the ryanodine receptors. Glibenclamide did not affect the vasodilation induced by ZC2, suggesting that ATP sensitive potassium channel is not involved in the vasodilation. The results indicate that ZC2 induces vasodilation by inhibiting the VDCC and ROCC, and receptormediated Ca2+ influx and release. The inhibition of intracellular Ca2+ release may be mediated via the ryanodine receptors.

매체 유저 인터페이스에서 플랫화 도형의 응용 연구

이기항(Li qi-hang),이동훈(Lee dong-hun) 한국콘텐츠학회 2016 한국콘텐츠학회 종합학술대회 논문집 Vol.2016 No.5

로고 디자인에서 티베트 문화적 기호의 응용에 관한 연구

이기항 ( Li Qi Hang ),안병진 ( Ahn Byoung Jin ) 한국기초조형학회 2020 기초조형학연구 Vol.21 No.1

본 논문은 우선 문헌 정리를 통해 티베트 역사의 변천과 문화의 발전 맥락을 서술하고, 티베트의 문화적 특징을 찾아내려 한다. 방대하고 복잡한 티베트 문화체계 속에서 문화 기호를 찾아 분류하여 체계적인 티베트 문화 기호체계를 형성하고, 이를 통해 티베트 지역 기호 시스템의 특수성을 관찰하고자 한다. 티베트 지역의 기호는 풍부하고 복잡한 특징이 있다. 평면디자인의 필요에 따라 수집, 정리하는 과정에서 이미지, 의미, 은유를 분석 맥락으로 하여, 그 시각적 특징, 기능적 특징과 사회적 특징을 관찰하고자 한다. 따라서 기호 시스템 정리 과정에서 퍼스의 기호학 이론을 기본적인 분석방법으로 하여, 퍼스의 3차성 기호 이론으로 티베트 문화의 시각적 기호를 추출한다. 분석을 통해 티베트 지역의 로고 디자인은 설산, 건축물, 제사, 색채 등 현지 특색이 드러나는 문화적 기호를 주로 사용하고 있었다. 이러한 기호들은 로고 디자인에서 충분히 활용되었는데, 이는 티베트 문화가 독특한 심미적 가치와 자아 동일성을 가지고 있다는 것을 의미한다. 하지만 분석을 통해 티베트 지역 로고디자인의 수준이 평균적으로 낮으며, 대다수가 직접적으로 현실의 사물 형상을 사용한 것을 알 수 있었다. 다시 말해 도상 기호에 대한 응용은 보편적이었지만 더 많은 문화적 내용을 담은 지표 기호와 상징 기호의 응용에서는 노골적이고 빈약한 느낌으로, 로고 디자인에 필수적이라고 할 수 있는 추상성과 재미가 부족했으며 로고의 심미적 측면과 재사용성도 부족한 면이 있었다. 티베트 지역의 경제 발전 수준이 로고 디자인의 수준을 결정하는데 큰 영향을 끼친 것으로 보인다. 특히 현대 디자인 시장에서 현존하는 티베트의 로고들은 대부분 경쟁력이 부족하다. 본 논문은 티베트 지역의 전형적인 문화적 기호를 추출하여 티베트 지역의 로고 디자이너들에게 참고할 수 있는 내용을 제공하고자 했다. In this paper, first of all, through literature review, the historical changes and cultural development of Tibet are elaborated, and the cultural characteristics of Tibet are extracted. In the complicated Tibetan cultural system, the author classifies the cultural symbols to form a systematic Tibetan cultural symbol system, and observes the particularity of the Tibetan symbol system. Tibetan symbols are rich and chaotic. According to the needs of graphic design, the author uses image, meaning and metaphor as the main analysis line when collecting and sorting, and observes their visual, functional and social characteristics. Therefore, in the collation of the symbol system, the author uses Pierce's Semiotics Theory as the basic analysis method, and uses Pierce's three-level symbol theory to extract the visual symbols of Tibetan culture. In addition, the author observes the application of these cultural symbols in the design through cases, analyzes the successful cases and shortcomings in the existing application, and provides the early theoretical and case support for the follow-up research of Tibetan cultural symbols, as well as the reference coordinates on the cultural symbols for the logo design in Tibet. Through analysis, it is found that the local characteristic cultural symbols, such as snow mountain, architecture, sacrifice, color and other different types of cultural symbols, are widely used in the logo design of Tibet area. These symbols are fully used in logo design, indicating that Tibetan culture has its unique aesthetic value and self-identity. However, through analysis, it is also found that the level of logo design in Tibet is generally low, most of which directly use the real image of things, and the application of iconicity symbols are more common. But in the use of indicator symbols and convention symbols which contain more cultural content, it is straightforward and simple, lacking the necessary abstraction and interest of logo design. Esthetic and reuse of logo is also inadequate. The level of economic development in Tibet largely determines the level of logo design, especially in the modern design market, the existing marks often appear to be competitive. In this paper, the author extracts the typical cultural symbols of Tibet, trying to provide some reference for the designers of Tibetan regional symbols.

Impact and close-in blast response of auxetic honeycomb-cored sandwich panels: Experimental tests and numerical simulations

Qi, Chang,Remennikov, Alex,Pei, Lian-Zheng,Yang, Shu,Yu, Zhi-Hang,Ngo, Tuan D. Elsevier 2017 COMPOSITE STRUCTURES -BARKING THEN OXFORD- Vol.180 No.-

<P><B>Abstract</B></P> <P>Protecting building, critical infrastructure and military vehicles from Improvised Explosive Devices (IEDs) has become a critical task. This study aims to examine the performance of a new protective system utilizing auxetic honeycomb-cored sandwich panels for mitigation of shock loads from close-in and contact detonations of high explosives. Both field blast tests and drop weight tests were performed using the proposed sandwiches asa shield for concrete panels in combination with conventional steel protective plates. The combined shield was found to be effective in protecting reinforced concrete structures against severe impact and close-in blast loadings. The honeycomb core with re-entrant hexagonal cells shows evident auxetic characteristics which contribute substantially to outstanding force mitigation and blast-resistance performances of such sandwich panels. Numerical simulations showed good agreement with the experimental results. The proposed auxetic panels were found to perform better than conventional honeycomb panels of the same size, areal density and material. Both were found to boost the energy absorption of the monolithic steel plate by a factor of 2.5 by changing its deformation pattern under close-in blast loading. In addition, a combination of the steel plate and an auxetic sandwich panel has aerial specific energy absorption (<I>ASEA</I>) higher than either of them, showing great potential for the development of lightweight blast protection of civil, mining, military, nuclear infrastructure and vehicles.</P>

Metabolism of dl-Praeruptorin A in Rat Liver Microsomes using HPLC-Electrospray Ionization Tandem Mass Spectrometry

Hang Ruan,Xuan Zhu,Zhen Zhang,Xin-fang Liang,Yan Fu,Mei-qin Su,Qi-lin Liu,Xiu-min Wang 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.8

dl-Praeruptorin A (Pd-Ia) is the major active constituent of the traditional Chinese medicine Peucedanum praeruptorum Dunn. Recently it has been identified as a novel agent in the treatment and prevention of cardiovascular diseases. Accordingly, we investigated the metabolism of Pd-Ia in rat liver microsomes. The involvement of cytochrome P450 (CYP) and CYP isoforms were identified using a CYP-specific inhibitor (SKF-525A), CYP-selective inhibitors (α-naphthoflavone, metyrapone, fluvastatin, quinidine, disulfiram, ketoconazole and ticlopidine) and CYP-selective inducers (phenobarbital, dexamethasone and β-naphthoflavone). Residual concentrations of the substrate and metabolites were determined by HPLC, and further identified by their mass spectra and chromatographic behavior. These experiments showed that CYP450 is involved in Pd-Ia metabolism, and that the major CYP isoform responsible is CYP3A1/2, which acts in a concentration-dependent manner. Four Pd-Ia metabolites (M1, M2, M3, and M4) were detected after incubation with rat liver microsomes. Hydroxylation was the primary metabolic pathway of Pd-Ia, and possible chemical structures of the metabolites were identified. Further research is now needed to link the metabolism of Pd-Ia to its drug-drug interactions.

Strong adsorption of arsenic species by amorphous zirconium oxide nanoparticles

Hang Cui,Shian Gao,Jian Ku Shang,Qi Li 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.4

A novel oxide adsorbent of amorphous zirconium oxide (am-ZrO2) nanoparticles was synthesized by a simple hydrothermal process for effective arsenic removal from aqueous environment. Due to their high specific surface area (327.1 m2/g), large mesopore volume (0.68 cm3/g), and the presence of high affinity surface hydroxyl groups, am-ZrO2 nanoparticles demonstrated exceptional adsorption performance on both As(III) (arsenite) and As(V) (arsenate) without pre-treatment at near neutral condition. At pH ~ 7,the adsorption kinetic is fast and the adsorption capacity is high (over 83 mg/g for As(III) and over 32.4 mg/g for As(V), respectively). Under low equilibrium arsenic concentrations (Ce at 0.01 mg/L, the maximum contaminant level (MCL) for arsenic in drinking water), the amount of arsenic adsorbed by am-ZrO2 nanoparticles is over 0.92 mg/g for As(III) and over 5.2 mg/g for As(V), respectively. The adsorption mechanism of arsenic species onto am-ZrO2 nanoparticles was found to follow the inner-sphere complex mechanism. Testing with arsenic contaminated natural lake water confirmed the effectiveness of these am-ZrO2 nanoparticles in removing arsenic from natural water. The immobilized am-ZrO2 nanoparticles on glass fiber cloth demonstrated an even better arsenic removal performance than dispersed am-ZrO2nanoparticles in water, paving the way for their potential applications in water treatment facility to treat arsenic contaminated water body without pre-treatment. 2012 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

Experimental and numerical investigation on post-earthquake fire behaviour of the circular concrete-filled steel tube columns

Yu-Hang Wang,Qi Tang,Mei-Ni Su,Ji-Ke Tan,Wei-Yong Wang,Yong-Sen Lan,Xiao-Wei Deng,Yong-Tao Bai,Wei Luo,Xiao-Hua Li,Jiu-Lin Bai 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.38 No.1

Post-earthquake fire is a common disaster which causes serious safety issues to infrastructures. This study aims to investigate the residual loading capacities of circular concrete-filled steel tube (CFST) columns under post-earthquake fire experimentally and numerically. The experimental programme contains two loading steps - pre-damage cyclic loading at room temperature and transient state tests with constant compression loads. Three finite element models are developed and validated against the test results. Upon validation, a total of 48 numerical results were generated in the parametric study to investigate the effects of thickness and strengths of steel tube, axial compression ratio and damage degree on the fire resistance of circular CFST columns. Based on the analysis on experimental and numerical results, the loading mechanism of circular CFST columns is discussed. A design method is proposed for the prediction of fire resistance time under different seismic pre-damage and compression loads. The predictions by the new method is compared with the newly generated experimental and numerical results and is found to be accurate and consistent with the mean value close to the unity and a coefficient of variation around 1%.

Photo-Electrical Properties of Trilayer MoSe2 Nanoflakes

Yang Hang,Qi Li,Wei Luo,Yanlan He,Xueao Zhang,GANG PENG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.7

The photo-electrical properties of trilayer MoSe2 nanoflakes, fabricated by mechanical exfoliation, were systematically studied in this paper. The trilayer MoSe2 nanoflakes are n-type and possess a high gate modulation (On/Off ratio is larger than 10 5) and a relatively high carrier mobility (1.79 cm2 V-1 s-1). The field effect transistor (FET) device of MoSe2 shows sensitive photo response, high photoresponsivity (Rλ = 26.2 mA/W), quick response time (t < 20 ms), high external quantum efficiency (η = 5.1%) and high detection rate (D = 2.7 x 10 9 W-1) for red and near-infrared wavelength. These results showed that the device based on few-layer MoSe2 nanoflakes exhibited good photo-electrical properties, which might open a new way to develop few-layer MoSe2-based material in the application of FETs and optoelectronics.

Research in Equalizing Charging Control Strategy in Li-ion Power Battery

Bo Wu,Hang Liu,Haiying Wang,Zongru Zhou,Qi Fan 보안공학연구지원센터 2013 International Journal of Control and Automation Vol.6 No.2

An Efficient Dynamic Graph Partitioning Management Method

He Li,Qi Sun,Hang Yuan,Jongtae Lim,Kyoungsoo Bok,Jaesoo Yoo 한국콘텐츠학회 2017 한국콘텐츠학회 ICCC 논문집 Vol.2017 No.12