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Qun Wang,Xueli Gao,Zhun Ma,Jian Wang,Xiaojuan Wang,Yang Yang,Congjie Gao 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.64 No.-
For PES-based TFC FO membranes, a significant water flux surge occurred after a moderate ultrasonic irradiation. The Change in membrane transport parameters illustrated that internal concentration polarization (ICP) was weakened due to decreased structural parameter. Combined water flux enhancement via real-time ultrasonic irradiation was obtained and related to the CP effect and membrane orientation. Increasing irradiation intensity was more suitable in PRO mode than in FO mode. Low FS concentration in concentration combinations represented high ratio of ultrasonic-induced flux increment to energy input. Multiplying concentration difference was beneficial to obtain high conversion ratio of ultrasonic power to water flux.
ZNF424, a novel human KRAB/C2H2 zinc finger protein, suppresses NFAT and p21 pathway
( Yue Qun Wang ),( Jun Mei Zhou ),( Xiang Li Ye ),( Yong Qi Wan ),( Yong Qing Li ),( Xiao Yan Mo ),( Wu Zhou Yuan ),( Yan Yan ),( Na Luo ),( Ze Qun Wang ),( Xiong Wei Fan ),( Yun Deng ),( Xiu Shan Wu 한국생화학분자생물학회 (구 한국생화학회) 2010 BMB Reports Vol.43 No.3
Zinc finger-containing transcription factors are the largest single family of transcriptional regulators in mammals, which play an essential role in cell differentiation, cell proliferation, apoptosis, and neoplastic transformation. Here we have cloned a novel KRAB-related zinc finger gene, ZNF424, encoding a protein of 555aa. ZNF424 gene consisted of 4 exons and 3 introns, and mapped to chromosome 19p13.3. ZNF424 gene was ubiquitously expressed in human embryo tissues by Northern blot analysis. ZNF424 is conserved across species in evolution. Using a GFP-labeled ZNF424 protein, we demonstrate that ZNF424 localizes mostly in the nucleus. Transcriptional activity assays shows ZNF424 suppresses transcriptional activity of L8G5-luciferase. Overexpression of ZNF424 in HEK- 293 cells inhibited the transcriptional activity of NFAT and p21, which may be silenced by siRNA. The results suggest that ZNF424 protein may act as a transcriptional repressor that suppresses NFAT and p21 pathway to mediate cellular functions. [BMB reports 2010; 43(3): 212-218]
Wang, Xia,Liu, Hao,Wang, Xin,Zeng, Zhi,Xie, Li-Qun,Sun, Zhi-Guang,Wei, Mu-Xin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Purpose: This study was conducted to assess the preventive effect of Actinidia valvata Dunn (AVD) extract on an animal model of gastrointestinal carcinogenesis on the basis of changes in tumor incidence, cell proliferation, and apoptosis. Materials and Methods: Seventy-five male Wistar rats were divided into five different treatment groups with 15 rats in each group. Group I was given normal feed, whereas Groups II to IV were treated with 10% sodium chloride in the first six weeks and 100ug/mL of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in drinking water for 24 weeks. Group II was then given normal feed, whereas Group III was given AVD extract (0.24g/kg/day) for 12 weeks. Group IV was given AVD extract from the first week to the 36th week, whereas Group V was treated with AVD extract alone for 36 weeks. All rats were sacrificed at the end of the 36-week experiment and assessed for the presence of gastrointestinal tumors. The occurrence of cancer was evaluated by histology. Bax, Bcl-2, Caspase-3, and cyclinD1 were determined by immunohistochemical staining and Western blotting. Results: The incidences of gastric cancer were 0% in Group I, 73.3% in Group II, 33.3% in Group III, 26.7% in Group IV, and 0% in Group V. Bcl-2 and cyclinD1 expression was decreased in AVD extract treated groups, whereas Bax and Caspase-3 expression was increased. Comparison with group II revealed significant differences (p<0.01). Conclusions: AVD extract exhibits an obvious preventive effect on gastrointestinal carcinogenesis induced by MNNG in rats through the regulation of cell proliferation and apoptosis.
Wang, Ya-Dong,Zhai, Wen-Long,Wang, Hai-Yu,Xia, Xiang-Qun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Background: A number of studies have reported the association of X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism with susceptibility to hepatocellular carcinoma (HCC). However, the results were inconsistent and inconclusive. The aim of this study was to comprehensively explore the association of XRCC1 Arg399Gln variant with HCC risk. Materials and Methods: Systematic searches of PubMed, Elsevier, Science Direct, CNKI and Chinese Biomedical Literature Database were performed. Pooled odds ratio (OR) with 95% confidence intervals (CI) was calculated to estimate the strength of association. Results: Overall, we observed an increased HCC risk among subjects carrying XRCC1 codon 399 Gln/Gln, Arg/Gln and Gln/Gln+Arg/Gln genotypes (OR=1.20, 95%CI: 1.05-1.38, OR=1.16, 95%CI: 1.05-1.28, and OR=1.14, 95%CI: 1.04-1.24, respectively) based on 20 studies including 3374 cases and 4633 controls. In subgroup analysis, we observed an increased risk of XRCC1 codon 399 Gln/Gln, Arg/Gln and Gln/Gln+Arg/Gln polymorphisms for HCC in hospital-based study (OR=1.25, 95%CI: 1.03-1.51, OR=1.21, 95%CI: 1.07-1.36 and OR=1.18, 95%CI: 1.06-1.31, respectively) and in Asian population (OR=1.19, 95%CI: 1.03-1.38, OR=1.17, 95%CI: 1.04-1.30 and OR=1.14, 95%CI: 1.04-1.25, respectively). Limiting the analysis to the studies with controls in agreement with Hardy-Weinberg equilibrium (HWE), we observed an increased HCC risk among Gln/Gln, Arg/Gln and Gln/ Gln+Arg/Gln genotype carriers (OR=1.17, 95%CI: 1.05-1.29, OR=1.12, 95%CI: 1.00-1.25 and OR=1.11, 95%CI: 1.02-1.21, respectively). Conclusions: This updated meta-analysis results suggest that XRCC1 Arg399Gln variants may contribute to HCC risk. Well-designed studies with larger sample size were required to further verify our findings.
Qun Wang,김형국,Li Dong Chen,Xiao Min Li,황윤회 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.51 No.2I
Two kinds of colossal electroresistance (CER) cells, Ag/Pr$_{0.7}$Ca$_{0.3}$MnO$_{3}$/Pt and In/Pr$_{0.7}$ Ca$_{0.3}$MnO$_{3}$/Pt, were prepared to study the memory function. Different reversible-resistance-switching phenomena were observed, depending on the applied electrodes. The I-V characteristics of the two cells have opposite hysteresis properties. The power consumptions and the threshold voltages were also investigated. In particular, the Ag/Pr$_{0.7}$Ca$_{0.3}$MnO$_{3}$/Pt cell with an Ohmic contact interface exhibited better resistance switching retention and small power consumption. In contrast, the In/Pr$_{0.7}$Ca$_{0.3}$MnO$_{3}$/Pt cell with a Schottky contact interface exhibited poor resistance switching retention and large power consumption. The results suggest that the CER cell with an Ohmic contact is better for the resistance memory function.
Effects of N- and N-In Doping on ZnO Films Prepared by Using Ultrasonic Spray Pyrolysis
Qun Wang,박세정,신동명,김형국,황윤회,Yiwen Zhang,Xiaomin Li 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.11
The effects of N-doping, and N-In co-doping on ZnO films were studied by analyzing the structural,electrical, and optical properties of the films prepared by using an ultrasonic spray pyrolysis(USP) method. According to scanning electron microscopy (SEM) data, all films had very complexsurface structures. Their polycrystallinity were also proven by using an X-ray diffraction method. The Hall-effect measurement showed that both the undoped and the N-doped ZnO films exhibitedn-type conductivity and that the N-In co-doped ZnO film showed p-type conductivity. In the extendedX-ray absorption fine structure (EXAFS) analysis, the number of oxygen atoms in the N-Incodoped ZnO films was found to be larger than that in the N-doped and the undoped ZnO films. The photoluminescence spectra also showed that the N-In co-doping suppressed the concentrationof oxygen vacancies in the ZnO films. Through an effective incorporation of indium atoms, moreoxygen atoms seem to have been introduced into the lattice of the N-In co-doped ZnO films.
Column Generation Algorithm-Based DTN Routing Strategy in Complex Data Transmission Scenario
Qun Wang,Huanyan Qian,Chenchen Ni,Qianmu Li 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.6
An ideal routing strategy shall be able to help the delay tolerant network (DTN) achieve an optimal transmission performance under the premise of lower energy consumption. However, due to the diverse of the application scenarios, it is hard to use one or more types of routing strategies as a universal optimum solution. There is a need to establish a routing strategy model of the corresponding DTN network for different application scenarios, analyze and evaluate the strategy model in combination of the knowledge of the operational research and statistics. For a complex data transmission DTN network scenario, with the introducing of a line programming method, the big-data and multi-node network transmission problem can be abstracted to a large-scale line programming problem. In this paper, the feasibility of solving the large-scale line programming problem by the column generation algorithm has been analyzed, and a column generation algorithm-based DTN routing strategy under the complex data transmission scenario has been designed. This routing strategy can realize the quantization of the routing strategy performance by the column generation algorithm. Also, by the simulation experiments, the performance of complex data transmission DTN routing strategy under different factors has been analyzed, and the performance of the column generation algorithm-based DTN routing strategy has been compared with the performance of the traditional jet waiting routing strategy
Wang, Bo,Su, Yun,Yang, Qun,Lv, Decheng,Zhang, Weiguo,Tang, Kai,Wang, Hong,Zhang, Rui,Liu, Yang Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.5
Human osteosarcoma usually presented a high tendency to metastatic spread and caused poor outcomes, however, the underlying mechanism was still largely unknown. In the present study, using a series of in vitro experiments and an animal model, we investigated the roles of HOX antisense intergenic RNA (HOTAIR) during the proliferation and invasion of osteosarcoma. According with our results, HOTAIR was commonly overexpressed in osteosarcoma, which significantly correlated with advanced tumor stage, highly histological grade and poor prognosis. In vitro and in vivo experiments demonstrated that knockdown of HOTAIR could notably suppress cellular proliferation, inhibit invasion and decrease the secretion of MMP2 and MMP9 in osteosarcoma. Collectively, our results suggested that HOTAIR might be a potent therapeutic target for osteosarcoma.