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- 저자 : Xiaojuan Wang (검색결과 32 건)
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Wang, Lan,Wang, Li,Li, Xiaojuan,Wang, Linsong,Roh, Kwang-Soo,Wang, Myeong-Hyeon The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.2
Light and temperature variations are important during the vegetative stage of the Chinese red radish. We found that peroxidase (POD) and catalase activities and the content of pelargonidin were decreased by treatments of short of light perioid and low temperatures, while the content of hydrogen peroxide was increased. The POD isoenzymes of the radish organs were detected diversely depending on the developmental stages by polyacrylamide gel electrophoresis analysis; semi-quantitative RT-PCR revealed that expression was significantly induced during the flourishing anthesis stage in the bud. These results suggest that POD expression is both time-dependent and tissue-specific and that light and temperature conditions can influence the growth and antioxidant activity of the radish.
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Wang Boyu,Guo Xiaolin,Yuan Lin,Fang Qinglong,Wang Xiaojuan,Qiu Tianyi,Lai Caifeng,Wang Qi,Liu Yang 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.5
In this study, a series of flexible neutron/gamma shielding composites are fabricated through the doping of Gd2O3 into the matrix of SEBS with (MGd2O3: MSEBS) % from 5% to 100%. Neutron transmittance test shows an exponential attenuation with the increase of areal density of Gd, in which the transmittance T ranges from 59.1440% to 35.3026%, with standard deviation less than 2.2743%, mass attenuation coefficient mm from 0.3194 cm2 /g to 0.4999 cm2 /g, and half value layer-HVL value from 2.4530 mm to 1.1313 mm. Shielding efficiency of the Gd2O3/SEBS composites is basically improved in comparison with that of B4C/SEBS. The transmittance T, mass/linear attenuation coefficient mm and m, HVL and effective atomic number Zeff for the shielding of g rays (39 keV, 59 keV and 122 keV) are measured and calculated with XCOM as well as MCX programs. Finally, plots of the three dimensional relationships between transmittance, doping amount and thickness are provided to the guidance for engineering shielding design. In summary, the Gd2O3/SEBS composite is proved to be an effective flexible neutron/low energy g rays shielding material, which could be of potential applications in the field of nuclear technology and nuclear engineering.
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Pretreatment of Switchgrass with Electrolyzed Water and a Two-stage Method for Bioethanol Production
Xiaojuan Wang,Hao Feng,Zhiyi Li 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.3
In this study, switchgrass, which is a promising energy crop, was treated with two new pretreatment methods for the production of bioethanol. Acidic electrolyzed water (AEW) and alkaline electrolyzed water (ALEW) were first used as pretreatment catalysts at three temperatures (170,185, and 200oC) and 3 treatment times (5, 15, and 25 min). In the two-stage pretreatment, 1.0, 2.0 and 3.0% H2O2solutions were used to partially remove hemicellulose and lignin during the 1st stage at 50oC for 16, 24, or 32 h at a solid concentration of 5%. The supernatant of the 1st stage was used for hemicellulose precipitation. The remaining solids were subjected to a 2nd stage treatment with hot water at 121oC for 30 min in an autoclave at a solid concentration of 12.5%. In the electrolyzed water pretreatment,the highest glucose yield was achieved by pretreatment with ALEW at 200oC and 25 min, which resulted in the release of 23.8 g glucose from 100 g dry switchgrass. The hydrolyzate obtained from switchgrass pretreated with 3% H2O2 for 16 h followed by enzymatic hydrolysis was fermented using S. cerevisiae at 30oC for 96h without any concentration or detoxification steps. The final ethanol concentration was 11.8 g/L and the productive yield was 74% of the theoretical yield. A mass balance for the two-stage process showed that 12 g of ethanol was produced from 100 g dry switchgrass. In this study, switchgrass, which is a promising energy crop, was treated with two new pretreatment methods for the production of bioethanol. Acidic electrolyzed water (AEW) and alkaline electrolyzed water (ALEW) were first used as pretreatment catalysts at three temperatures (170,185, and 200oC) and 3 treatment times (5, 15, and 25 min). In the two-stage pretreatment, 1.0, 2.0 and 3.0% H2O2solutions were used to partially remove hemicellulose and lignin during the 1st stage at 50oC for 16, 24, or 32 h at a solid concentration of 5%. The supernatant of the 1st stage was used for hemicellulose precipitation. The remaining solids were subjected to a 2nd stage treatment with hot water at 121oC for 30 min in an autoclave at a solid concentration of 12.5%. In the electrolyzed water pretreatment,the highest glucose yield was achieved by pretreatment with ALEW at 200oC and 25 min, which resulted in the release of 23.8 g glucose from 100 g dry switchgrass. The hydrolyzate obtained from switchgrass pretreated with 3% H2O2 for 16 h followed by enzymatic hydrolysis was fermented using S. cerevisiae at 30oC for 96h without any concentration or detoxification steps. The final ethanol concentration was 11.8 g/L and the productive yield was 74% of the theoretical yield. A mass balance for the two-stage process showed that 12 g of ethanol was produced from 100 g dry switchgrass.
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Lan Wang,노광수,Li Wang,Xiaojuan Li,Linsong Wang,왕명현 한국응용생명화학회 2009 Journal of Applied Biological Chemistry (J. Appl. Vol.52 No.2
Light and temperature variations are important during the vegetative stage of the Chinese red radish. We found that peroxidase (POD) and catalase activities and the content of pelargonidin were decreased by treatments of short of light perioid and low temperatures, while the content of hydrogen peroxide was increased. The POD isoenzymes of the radish organs were detected diversely depending on the developmental stages by polyacrylamide gel electrophoresis analysis; semi-quantitative RT-PCR revealed that expression was significantly induced during the flourishing anthesis stage in the bud. These results suggest that POD expression is both timedependent and tissue-specific and that light and temperature conditions can influence the growth and antioxidant activity of the radish.
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Junyan Wang,Xiaojuan Wang,Keqin Hua,Yisong Chen 대한배뇨장애요실금학회 2019 International Neurourology Journal Vol.23 No.2
Purpose: Transvaginal mesh (TVM) results in a greater anatomic cure but more complications. We aimed to compare laparoscopic sacrocolpopexy (LSC) plus colporrhaphy with the small intestine submucosa (SIS) graft versus TVM for advanced pelvic organ prolapse (POP). Methods: Patients with advanced POP who underwent LSC plus colporrhaphy with the SIS graft or TVM at a center between September 2015 and November 2016 were studied. Anatomical outcomes were evaluated using POP quantification. Functional outcomes related to POP and sexual life were evaluated using the Pelvic Floor Distress Inventory (PFDI-20) and the Pelvic Organ Prolapse/Urinary Incontinence Sexual Function Questionnaire (PISQ-12). Data regarding surgical procedures and patient demographic variables were recorded. Chi-square and Student t -tests were used for 2 independent samples. Results: A total of 76 patients were enrolled in this study with 26 patients in the LSC plus colporrhaphy with the SIS graft group (group A) and 50 patients with TVM group (group B). All patients in both groups demonstrated significant improvement in anatomical outcomes (P<0.05) after surgery. PFDI-20 scores were significantly improved 12 months after operation in both groups (P<0.001). PISQ-12 scores were significantly improved in patients after surgery, especially patients in group A (P<0.001). Mesh exposure occurred in both groups as follows: 8 patients (30.7%) in group A and 5 patients (10%) in group B. Conclusions: Even though both surgeries showed excellent results for subjective and objective outcomes, the use of an SIS graft might increase the exposure of polypropylene mesh. We do not recommend LSC plus colporrhaphy with the SIS graft for advanced multiple-compartments prolapse.
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Qun Wang,Xueli Gao,Zhun Ma,Jian Wang,Xiaojuan Wang,Yang Yang,Congjie Gao 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.64 No.-
For PES-based TFC FO membranes, a significant water flux surge occurred after a moderate ultrasonic irradiation. The Change in membrane transport parameters illustrated that internal concentration polarization (ICP) was weakened due to decreased structural parameter. Combined water flux enhancement via real-time ultrasonic irradiation was obtained and related to the CP effect and membrane orientation. Increasing irradiation intensity was more suitable in PRO mode than in FO mode. Low FS concentration in concentration combinations represented high ratio of ultrasonic-induced flux increment to energy input. Multiplying concentration difference was beneficial to obtain high conversion ratio of ultrasonic power to water flux.
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Ren Xiaojuan,Feng Chao,Wang Yubo,Chen Pu,Wang Simeng,Wang Jianling,Cao Hongxin,Li Yujun,Ji Meiju,Hou Peng 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Solute carrier family 39 member 10 (SLC39A10) belongs to a subfamily of zinc transporters and plays a key role in B-cell development. Previous studies have reported that its upregulation promotes breast cancer metastasis by enhancing the influx of zinc ions (Zn2+); however, its role in gastric cancer remains totally unclear. Here, we found that SLC39A10 expression was frequently increased in gastric adenocarcinomas and that SLC39A10 upregulation was strongly associated with poor patient outcomes; in addition, we identified SLC39A10 as a direct target of c-Myc. Functional studies showed that ectopic expression of SLC39A10 in gastric cancer cells dramatically enhanced the proliferation, colony formation, invasiveness abilities of these gastric cancer cells and tumorigenic potential in nude mice. Conversely, SLC39A10 knockdown inhibited gastric cancer cell proliferation and colony formation. Mechanistically, SLC39A10 exerted its carcinogenic effects by increasing Zn2+ availability and subsequently enhancing the enzyme activity of CK2 (casein kinase 2). As a result, the MAPK/ERK and PI3K/AKT pathways, two major downstream effectors of CK2, were activated, while c-Myc, a downstream target of these two pathways, formed a vicious feedback loop with SLC39A10 to drive the malignant progression of gastric cancer. Taken together, our data demonstrate that SLC39A10 is a functional oncogene in gastric cancer and suggest that targeting CK2 is an alternative therapeutic strategy for gastric cancer patients with high SLC39A10 expression.
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Porous membranes in pressure-assisted forward osmosis: Flux behavior and potential applications
Yang Yang,Xueli Gao,Zhaokui Li,Qun Wang,Senjie Dong,Xiaojuan Wang,Zhun Ma,Leyi Wang,Xinyan Wang,Congjie Gao 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.60 No.-
In this work, pressured-assisted forward osmosis (PAFO) was performed using porous membranes to achieve higher fluxes. The effects of additional pressure and membrane orientation on membrane performance were investigated. When ultralow additional pressure (0.04 bar) was applied, the water flux at AL-FS orientation (i.e. active layer facing the feed solution) was observed to double. Reverse solute diffusion was also inhibited dramatically at both membrane orientations in PAFO. Filtration tests revealed that porous membranes with ultralow pressure in FO were more applicable than ultrafiltration (UF) because mild condition (i.e., 0.12 bar versus 1.25 bar) is conducive to preserving microalgae cell integrity.
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Xiaojuan Chao,Hui Qian,Shaogui Wang,Sam Fulte,Wen-Xing Ding 대한간학회 2020 Clinical and Molecular Hepatology(대한간학회지) Vol.26 No.4
Autophagy is a highly conserved catabolic process that degrades cytosolic proteins and organelles via formation of autophagosomes that fuse with lysosomes to form autolysosomes, whereby autophagic cargos are degraded. Numerous studies have demonstrated that autophagy plays a critical role in the regulation of liver physiology and homeostasis, and impaired autophagy leads to the pathogenesis of various liver diseases such as viral hepatitis, alcohol associated liver diseases (AALD), non-alcoholic fatty liver diseases (NAFLD), and liver cancer. Recent evidence indicates that autophagy may play a dual role in liver cancer: inhibiting early tumor initiation while promoting progression and malignancy of already formed liver tumors. In this review, we summarized the progress of current understanding of how hepatic viral infection, alcohol consumption and diet-induced fatty liver diseases impair hepatic autophagy. We also discussed how impaired autophagy promotes liver tumorigenesis, and paradoxically how autophagy is required to promote the malignancy and progression of liver cancer. Understanding the molecular mechanisms underlying how autophagy differentially affects liver cancer development and progression may help to design better therapeutic strategies for prevention and treatment of liver cancer.
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( Zhiguo Wang ),( Hong Luo ),( Zehui Fang ),( Yanling Fan ),( Xiaojuan Liu ),( Yujing Zhang ),( Shuping Rui ),( Yafeng Chen ),( Luojia Hong ),( Jincheng Gao ),( Mei Zhang ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.9
Acute myeloid leukemia (AML) is one of the most common hematological malignancies all around the world. MicroRNAs have been determined to contribute various cancers initiation and progression, including AML. Although microRNA-204 (miR-204) exerts anti-tumor effects in several kinds of cancers, its function in AML remains unknown. In the present study, we assessed miR-204 expression in AML blood samples and cell lines. We also investigated the effects of miR-204 on cellular function of AML cells and the underlying mechanisms of the action of miR-204. Our results showed that miR-204 expression was significantly downregulated in AML tissues and cell lines. In addition, overexpression of miR-204 induced growth inhibition and apoptosis in AML cells, including AML5, HL-60, Kasumi-1 and U937 cells. Cell cycle analysis further confirmed an augmentation in theapoptotic subG1 population by miR-204 overexpression. Mechanistically, baculoviral inhibition of apoptosis protein repeat containing 6 (BIRC6) was identified as a direct target of miR-204. Enforcing miR-204 expression increased the luciferase activity and expression of BIRC6, as well as p53 and Bax expression. Moreover, restoration of BIRC6 reversed the pro-apoptotic effects of miR-204 overexpression in AML cells. Taken together, this study demonstrates that miR-204 causes AML cell apoptosis by targeting BIRC6, suggesting miR-204 may play an anti-carcinogenic role in AML and function as a novel biomarker and therapeutic target for the treatment of this disease. [BMB Reports 2018; 51(9): 444-449]
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