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MicroRNA-497 Suppresses Proliferation and Induces Apoptosis in Prostate Cancer Cells
Wang, Li,Li, Bo,Li, Lei,Wang, Te Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
MicroRNAs (miRNAs) are a class of endogenously expressed small, non-coding, single-stranded RNAs that negatively regulate gene expression, mainly by binding to 3'- untranslated regions (3'UTR) of their target messenger RNAs (mRNAs), which cause blocks of translation and/or mRNA cleavage. Recently, miRNAprofiling studies demonstrated the microRNA-497 (miR-497) level to be down-regulated in all prostate carcinomas compared with BPH samples. The purpose of this study was to investigate the potential role of miR-497 in human prostate cancer. Proliferation, cell cycle and apoptosis assays were conducted to explore the potential function of miR-497 in human prostate cancer cells. Results showed that miR-497 suppressed cellular growth and initiated G0/G1 phase arrest of LNCaP and PC-3 cells. We also observed that miR-497 increased the percentage of apoptotic cells by increasing caspase-3/7 activity. Taken together, our results demonstrated that miR-497 can inhibit growth and induce apoptosis by caspase-3 activation in prostate cancer cells, which suggest its use as a potential therapeutic target in the future.
Fast 3D reconstruction method based on UAV photography
Jiang-An Wang,Huang‐Te Ma,Chun-Mei Wang,Yong-Jie He 한국전자통신연구원 2018 ETRI Journal Vol.40 No.6
3D reconstruction of urban architecture, land, and roads is an important part of building a “digital city.” Unmanned aerial vehicles (UAVs) are gradually replacing other platforms, such as satellites and aircraft, in geographical image collection; the reason for this is not only lower cost and higher efficiency, but also higher data accuracy and a larger amount of obtained information. Recent 3D reconstruction algorithms have a high degree of automation, but their computation time is long and the reconstruction models may have many voids. This paper decomposes the object into multiple regional parallel reconstructions using the clustering principle, to reduce the computation time and improve the model quality. It is proposed to detect the planar area under low resolution, and then reduce the number of point clouds in the complex area.
Yi-Ting Wang,Chun-Kai Yang,Sheng-Di Lin,Chi-Te Liang 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.64 No.10
We have performed magneto-transport measurements on a two-dimensional electron system(2DES) which is in close proximity to nanoscaled scatterers. Weak localization, as evidenced bynegative magnetoresistance, is observed. In this work, we use the extracted phase coherence rateas a thermometer to measure the electron’s effective temperature Te in our 2DES when a highdriving current I flows through the device. We find that Te / I0.52, consistent with 1/ep T2in two dimensions, where 1/ep is the electron-phonon scattering rate. However, the phase coherencerate 1/ T, with a very small offset, is consistent with zero-temperature dephasing. Mostimportantly, our experimental results are in agreement with the fact that at low temperatures, thedominant phase-breaking mechanism is electron-electron scattering, not electron-phonon scattering. Therefore we are able to investigate both electron-electron scattering and electron-phonon scatteringwhich are, in most cases, difficult to study independently in the linear region. Our data showthat the electron heating effect is a very powerful tool for studying semiconductor devices.
The Correlation between Thyrotropin and Dyslipidemia in a Population-based Study
Li Lu,Beibei Wang,Zhongyan Shan,Fengwei Jiang,Xiaochun Teng,Yanyan Chen,Yaxin Lai,Jiani Wang,Haibo Xue,Sen Wang,Chenyan Li,He Liu,Ningna Li,Jiashu Yu,Liangfeng Shi,Xin Hou,Qian Xing,Xue Bai,Weiping Te 대한의학회 2011 Journal of Korean medical science Vol.26 No.2
This study investigated the relationship between serum thyrotrophin levels and dyslipidemia in subclinical hypothyroid and euthyroid subjects. A total of 110 subjects with subclinical hypothyroidism and 1,240 euthyroid subjects enrolled in this study. Patients with subclinical hypothyroidism had significantly lower high density lipoprotein cholesterol (HDL-C) levels than those who were euthyroid. The lipid profiles were each categorized and mean thyrotrophin levels were higher in subjects in the dyslipidemia subclasses than subjects in the normal subclasses. Thyrotrophin was positively associated with serum triglyceride and negatively associated with serum HDL-C in women. Thyrotrophin was also positively associated with total cholesterol (TC) in the overweight population along with TC and LDL-C in overweight women. In the euthyroid population, thyrotrophin was positively associated with TC in the overweight population. In conclusion, serum thyrotrophin was correlated with dyslipidemia in subclinical hypothyroid and euthyroid subjects; the correlation was independent of insulin sensitivity.
Indentation deformation of mesoporous anodic aluminum oxide
Te-Hua Fang,Tong Hong Wang,Shao-Hui Kang,Cheng-Hsin Chuang 한국물리학회 2009 Current Applied Physics Vol.9 No.4
Mechanical properties of anodic aluminum oxides (AAO) were achieved by means of a scanning electron microscope (SEM), an atomic force microscope (AFM), and indentation measurements. A two-step anodized mesoporous anodic aluminum oxide was successfully fabricated vertically and hollowly. Both microindentation and nanoindentation were carried out. Localized pop-in can be found during nanoindentation due to the collapse of the beneath cylindrical structures. Over a certain load, microindentation may induce radial cracks from the indented edge to outward of the AAO. The underside of the indented AAO sample was milled to figure out the structural changes. Mechanical properties of anodic aluminum oxides (AAO) were achieved by means of a scanning electron microscope (SEM), an atomic force microscope (AFM), and indentation measurements. A two-step anodized mesoporous anodic aluminum oxide was successfully fabricated vertically and hollowly. Both microindentation and nanoindentation were carried out. Localized pop-in can be found during nanoindentation due to the collapse of the beneath cylindrical structures. Over a certain load, microindentation may induce radial cracks from the indented edge to outward of the AAO. The underside of the indented AAO sample was milled to figure out the structural changes.
Wang, Yi-Ting,Woo, Tak-Pong,Lo, S.-T.,Kim, Gil-Ho,Liang, Chi-Te Korean Physical Society 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.64 No.10
In this report, we will discuss the nonmonotonic magnetoresistance (MR) in an AlGaN/GaN high-electron-mobility transistor (HEMT) in a perpendicular magnetic field B in the ballistic region (kBT tau/A < 1) and in the weakly-disordered limit (kFl = 159 a parts per thousand << 1), where kB, T, tau, A , k F, and l represent the Boltzmann constant, temperature, elastic scattering time, reduced Planck constant, Fermi wave vector and mean free path, respectively. The MR shows a local maximum between the weak localization (WL) and the Shubnikov-de Haas regions. In the low magnetic field regime, the quantum correction to the conductivity is proportional to T (-3/2), which is consistent with a recent theory [T. A. Sedrakyan, and M. E. Raikh, Phys. Rev. Lett. 100, 106806 (2008)]. According to our results, as the temperature is increased, the position of the MR maximum in B increases. These results cannot be explained by present theories. Moreover, in the high-magnetic-field regime, neither the magnetic and nor the temperature dependences of the observed MR is consistent with present theories. We, therefore, suggest that while some features of the observed nonmonotonic MR can be successfully explained, further experimental and theoretical studies are necessary to obtain a thorough understanding of the MR effects.
The Performance Study of a Virtualized Multicore Web System
( Chien-te Lu ),( C. -s. Eugene Yeh ),( Yung-chung Wang ),( Chu-sing Yang ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.11
Enhancing the performance of computing systems has been an important topic since the invention of computers. The leading-edge technologies of multicore and virtualization dramatically influence the development of current IT systems. We study performance attributes of response time (RT), throughput, efficiency, and scalability of a virtualized Web system running on a multicore server. We build virtual machines (VMs) for a Web application, and use distributed stress tests to measure RTs and throughputs under varied combinations of virtual cores (VCs) and VM instances. Their gains, efficiencies and scalabilities are also computed and compared. Our experimental and analytic results indicate: 1) A system can perform and scale much better by adopting multiple single-VC VMs than by single multiple-VC VM. 2) The system capacity gain is proportional to the number of VM instances run, but not proportional to the number of VCs allocated in a VM. 3) A system with more VMs or VCs has higher physical CPU utilization, but lower vCPU utilization. 4) The maximum throughput gain is less than VM or VC gain. 5) Per-core computing efficiency does not correlate to the quality of VCs or VMs employed. The outcomes can provide valuable guidelines for selecting instance types provided by public Cloud providers and load balancing planning for Web systems.
( Tzi Yuan Wang ),( Yi Hsuan Tsai ),( I Zen Yu ),( Te Sheng Chang ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.3
3`-Hydroxygenistein can be obtained from the biotransformation of genistein by the engineered Pichia pastoris X-33 strain, which harbors a fusion gene composed of CYP57B3 from Aspergillus oryzae and a cytochrome P450 oxidoreductase gene (sCPR) from Saccharomyces cerevisiae. P. pastoris X-33 mutants with higher 3`-hydroxygenistein production were selected using a periodic hydrogen peroxide-shocking strategy. One mutant (P2-D14-5) produced 23.0 mg/l of 3`-hydroxygenistein, representing 1.87-fold more than that produced by the recombinant X-33. When using a 5 L fermenter, the P2-D14-5 mutant produced 20.3 mg/l of 3`-hydroxygenistein, indicating a high potential for industrial-scale 3`-hydroxygenistein production.