Targeting Multiple Myeloma Cell Death with Polyphenol EGCG

Tae‐Hoon Lee,Hee‐Young Yang,Hoon‐In Choi,Ung Yang,Kyoung‐Jin Chung,Lina Ren 한국동물생명공학회(구 한국동물번식학회) 2011 발생공학 국제심포지엄 및 학술대회 Vol.2011 No.1

(‐)‐Epigallocatechin 3‐gallate (EGCG) is a potent antioxidant polyphenol in green tea that acts as an anticancer agent via both direct and indirect pathways. Although the relationship between EGCG’s anticancer effects and its antioxidant activity is not fully understood, it is known that EGCG stimulates production of reactive oxygen species (ROS), which induce oxidative stress leading to cell death. In IM9 multiple myeloma cells, EGCG acted in a dose‐ and time‐dependent manner to induce apoptotic cell death. Among the antioxidant enzymes expressed in IM9 cells, levels of peroxiredoxin (Prdx) V were selectively and significantly reduced by EGCG. Moreover, the ROS scavenger NAC completely inhibited EGCG‐induced apoptosis and PrdxV reduction, while overexpression of PrdxV, but not a PrdxVC48S mutant, protected IM9 cells from EGCG‐induced apoptosis. EGCG‐induced reductions in cell viability and PrdxV levels were also observed in primary CD138+ multiple myeloma cells from patients. These results suggest that PrdxV is a key target via which EGCG mediates its anticancer effects.

강력범죄 피해자의 외상 후 스트레스 증상 및예측요인에 대한 탐색적 연구

김태경(Kim, Tae­Kyoung),윤성우(Yun, Sung­Woo),이영은(Lee, Young­Eun),이새롬(Lee, Saerom) 한국피해자학회 2018 被害者學硏究 Vol.26 No.1

The aim of this study was to investigate the posttraumatic stress symptoms of violent crime and predictors to the symptoms. For this, we analyzed data of 473 victims registered to the integrated supporting center for violent crime victims who agreed to participate in the study. The results showed that more than 90% of victims experience significant PTSD symptoms, 30% of them were in extreme mental confusion that required medication or hospitalization. There was a significant difference in the severity of sequela according to gender, time since visiting to the center, pre-event adaptation level, and event type. Although the victim experienced more avoidance and hypervigilance symptoms than the family, the psychological distress experienced by the family was not less than that of the victim. Psychological sequela of the events were found to be more severe with more experiences of childhood trauma, lack of ego resilience, low level of perceived social support, strong dissociation tendency, and avoiding coping styles. A result of the stepwise regression analysis, avoidant coping style explained 10.6% of the total variance. Limitations and implications of this study were discussed.

21가지 장미꽃 품종의 페놀성 화합물 함량 및 항산화 활성

조연재(Yeon Jae Jo),서정현(Jeong Hyun Seo),홍채영(Chae Young Hong),김성태(Seung Tae Kim),최은경(Ehn-Kyoung Choi),김윤배(Yun-Bae Kim),이준수(Junsoo Lee),정헌상(Heon Sang Jeong) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.4

본 연구는 21품종의 장미꽃에 대한 식품 및 화장품 원료로 사용 가능성을 살펴보기 위해 페놀성 화합물과 항산화 활성을 평가하였다. 총 폴리페놀, 총 플라보노이드 및 타닌 함량은 러버샤이 품종에서 각각 379.70 mg GAE/extract g, 50.10 mg CE/extract g 및 339.44 mg TAE/extract g으로 높게 나타났으며, 칠백리 품종에서 각각 107.25 mg GAE/extract g, 9.46 mg CE/extract g 및 36.31 mg TAE/extract g으로 낮았다. 페놀산 함량은 총 폴리페놀 함량과 유사한 결과를 보였으며, 러버샤이 품종에서 27.40 mg/extract g으로 높았다. 안토시아닌은 대부분 cyanidin-3,5-diglucoside로 확인되었으며 총 안토시아닌 함량은 유니나 품종에서 8.80 mg/extract g으로 가장 높았다. ABTS 및 DPPH 라디칼 소거 활성은 각각 428.10 및 419.59 mg AAE/extract g로 러버샤이 품종에서 가장 높았으며, 항산화 활성과 페놀 화합물의 함량과 높은 양의 상관관계를 보였다. 이러한 결과는 러버샤이와 같은 항산화 활성이 뛰어난 품종들이 관상 목적뿐만 아니라 높은 기능성을 가진 식품 및 화장품의 원료로 사용 가능성이 있다고 판단된다. This study evaluated the functional components and antioxidant activities of 21 different rose flower extracts, to confirm their value as a food and cosmetics ingredient. The highest values of total polyphenol, flavonoid and tannin contents (379.70±1.64 mg GAE/extract g, 50.10±0.76 mg CE/extract g, and 339.44±1.20 mg TAE/extract g, respectively) were obtained in Lover Shy. The proanthocyanidin content ranged from 61.88 mg CE/extract g in the Unina cultivar to 5.34±0.13 mg CE/extract g in the Aileen cultivar. The phenolic acid content obtained was highest in the Lover Shy cultivar (27.40±0.26 mg/extract g), whereas highest levels of anthocyanin (8.83±0.03 mg/extract g) were obtained in the Unina cultivar. High ABTS and DPPH radical scavenging activities were determined in the Lover Shy cultivar (428.10±0.29 and 419.59±3.12 mg AAE/extract g, respectively). Taken together, these results indicate that the antioxidant activity and functional components of Lover Shy cultivar are superior, and this extract can potentially be applied as a food and cosmetic ingredient.

사업장(事業場) 근로자(勤勞者)의 사상체질(四象體質)에 따른 생활습관(生活習慣), 자각증상(自覺症狀), 건강인식(健康認識)에 관(關)한 연구(硏究)

서명효,강홍구,장두섭,왕명자,차남현,김삼태,권소희,정해경,송용선,이기남,Seo Muoung-Hoy,Kang Hong-Goo,Jahng Doo-Sub,Wang Myoung-Ja,Cha Nam-Hyun,Kim Sam-Tae,Kwon So-Hee,Jung Hae-Kyoung,Song Yung-Sun,Lee Ki-Nam 대한예방한의학회 2003 대한예방한의학회지 Vol.7 No.2

The study was conducted to evaluate the difference of life style, subjective symptoms and health cognition depending on the Sasang Constitution in the industrial workers. The results were as follows ; Constitutional distribution among exposed group were Tae-eum In(38.4%), So-eum In(35.2%), and So-yang In(26.4%) and it was turned out that Tae-eum In took a higher portion of Sasang constitution than other constitutions in technician workers. 'Exercise' and 'Obesity' were found most in Tae-eum In, In So-eum In there were many 'Normal' weight and 'Having digestive disorders' were found most in So-eum In. There were no significant difference in the health cognition among the constitutions. The closer to 'normal' weight, the higher prevalence in 'having' concern about health condition and the more 'normal' condition in sleeping, the higher prevalence of 'having' self-confident in present health.

Compocasting 법에 의한 AZ91D/SiC_pMMCs(metal matrix composites)제조

이경태,김세광,구형찬,김달식,김영직 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.2

Metal matrix composites have toughness, machinability and heat conductivity, which can be obtained in metals, as well as hardness, high temperature stability, which can be obtained in ceramics. The purpose of this study is to find the optimum production condition of a compocasting method which is composed of stirring SiC particles inside a matrix which is presented as a solid or liquid state. During the compocasting method. SiC particles are mechanically incorporated into the matrix. From this study, sound AZ91D/SiC_p composites were obtained when stirring the matrix for 60minutes between 583-588℃.

Carbosulfan의 피부자극성, 안점막 자극성 및 피부감작성등의 알러지성 효과에 관한 연구

이상훈,이동연,백경진,김태원,정두순,임종환,김명석,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Many studies have been published on the human health effects of carbosulfan toxicity. Carbosulfan used as an insecticide can produce an irritating and allergenic effect when acting on the skin. In this study, a sensitization test on albino guinea pigs and intradermal reactivity and occular irritation test on albino rabbits were carried out with carbosulfan. Signs of acute skin inflammation appeared along with the clinical symptom of chronic dermatosis caused by the solution irritating characteristics. Moreover, carbosulfan showed severe eye irritation with conjuctival redness and severe opacity on cornea. Preventive measures should involve workers' obligatory instructions on the noxious impact on human skin and strict observance of industrial safety rules.

통합 통신망 관리 시스템 구축 방안 연구

이종근,임미경,이광휘,김한경,김태수 國立 昌原大學校 精報通信硏究所 1998 精報通信論文集 Vol.2 No.-

This paper presents a system for internetworking between different network management protocols. The internetworking system between SNMP(Simple Network Management Protocol) and CMIP(Common Management Information Protocol) has been designed. SNMP has been used as a standard protocol in Internet while CMIP has been selected as management protocol in OSI network. This approach is different from previous researches which convert protocols between management protocols. We have newly defined manage objects structure. Thus, even if a new management protocol would be introduce in addition, the new gateway system needs not be designed. We can achieve it through minimum modification in the interface of the managed objects. So, we can support managed objects defined previously using MOVI(Manage Object View Interface) concept presented in our previous research. Through this research, we have some additional benefits: it is able to internetwork between more complicated network management protocols, to increase usefulness of SNMP and CMIP, also it will use in internetworking between new network management protocols.

素問·刺法論에 對한 硏究

李載胎,鄭憲瑩,琴坰樹,朴炅 한국전통의학연구소 1999 한국전통의학지 Vol.9 No.1

This fasciale, a remainder of So Moon(素問) with Bon Byung Ron(本病論), is a part of the theory of the Five Circuit Phases and the Six Atmospheric Influences(五運六氣學) that studied and discussed the rules of the weather change in ancient oriental medicine. The change in weather is one of the most important factors which influence man's health therefore the theory is worth while to study further. This fascicle explains the cause of diseases occured by irregular and exceptional change of weather and acupunctural treatment methods to prevent and cure those kinds of disease as its title -Ja Bup Ron(刺法論)-suggests. During Tang Dynasty(唐) when Wang Ping(王氷) commentated the So Moon(素問) only the title of this fascicle was kept but the contents of it was lost differing from Seven volumes of the Five Circuit Phases and the Six Atmospheric Influences(運氣七篇). However in the times of the North Song Dynasty(北宋) when Kao Pao-Heng(高保衡), Lin I(林億) and the other scholars studied and compared medical books this fasciale and another lost fasciale-Bon Byung Ron(本病論) appeared with theirs notes. So these two fascicles called Lost Volumes of So Moon(素問遺篇). But we can infer these two fascicles were written by a certain Taoist during the ninth and tenth century A.D. - the former times of Kao Pao-Heng(高保衡), Lin I(林億) and the other scholars studied and compared medical books during the North Song Dynasty(北宋) since Wang Ping(王氷) because this fascicle connots the Taoism training methods such as Pe Gi(閉氣), Jon Sang Bup(存想法) and Oi Dan Bup(外丹法) and so on. This thesis runs as follows; Chapter 1 deals with acupuncture treatment to prevent and cure UI(鬱) disease occuerd by Sung Gi Bu Jun(升之不前) of the Six Atmospheric Influence(六氣). Chapter 2 deals with acupuncture treatment to prevent and cure diseases due to Bul Chun Jung(不遷正) and Bul Toi Wui(不退位) of the Six Atmospheric Influence(六氣). Chapter 3 deals with acupuncture treatment of an epidermic(疫癘) due to the deviation of the Five Ciecuit Phases from the regularity(五運失守). Chapter 4 deals with the symptomes of an epidemi and the preventive treatments such as Jon Sang Bup(存想法), Vomitory treatment(吐法), respiratory treatment(汗法) and So Kum Dan Bang(小金丹方). Chapter 5 deals with the interaction among the five viscera and the six bowels as well as the principle of the acupuncture.

S-상 심실중격의 임상적 고찰

이동민,장경식,양종태,장대용,김종오,서영욱,고영엽,홍순표 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

Background: The sigmoid septum described an anatomical variation in the contour of the left ventricular outlet. It is related to degenerative change with aging. We observed clinical significance of sigmoid septum in Korean. Methods: Echocardiographic examination was performed in 434 patients. Sigmoid septum is defined as discrete bulging of the proximal interventricular septum with that thickness is greater than 1.3cm or the thickness is grater 1.5 times than adjacent mid interventricular septum in apical 3 chamber view. Result: The incidence of patient with sigmoid septum(septum patient) is 24.8% (male 8.4%, female 16.3%) . The incidence increases with age and is more common in women. The patients with sigmoid septum were compared with targeted groups, there was no significant difference in blood pressure between them, but in height and weight, the former were lower. (p<001, p<03). In the patients with sigmoid septum, weight and the surface area of a body have an opposite correlation with increase of age (p<03, r=-0.34) (p<04, r=-0.31) , but no decrease of height was found according to age increase (p=0.47, r=-0.11) The main reason patients with sigmoid septum ask echocardiolography and its clinical symptoms were abnormal results of previous electrocardiography and/or usual chest pain. Compared with control group, interventricular septal thickness is larger in septum patients (p<001). The thickness of interventricular septum located in subaortic left ventricular outflow tract is 1.6±0.3cm. There is another web like structure that continued from interventricualr septum to anterior free wall of left ventricle and the width is 1.6±0.4cm. A sign of insignificant obstruction due to left ventricular outflow was observed from three sigmoid septum patients. Conculusion: Septum patient is largely found in older age group and the body weight and body surface area are lower than control group. The body weight and body surface area are opposite correlation with age. So sigmoid septum is considered as structural change by weight reduction with aging. It is assumed that septum patients are related with asymptomatic ischemia because they have more abnormal ECG finding such as T wave inversion on precordial leads or standard leads, nonspecific ST-T change, LBBB etc. Sigmoid septum is not only proximal interventricular septal bludging but also another web like structure continuing to anterior wall of left ventricle.

금속이 이온 교환된 제올라이트 촉매를 이용한 부타디엔의 딜즈-알더 반응

이은경,박상언,이태진 영남대학교 공업기술연구소 1999 工業技術硏究所論文集 Vol.27 No.2

1,3-Butadiene can usually produce 4-vinylcyclohexene via the well-known Diels-Alder reaction using homogeneous catalyst. This reaction was carried out over metal-zeolite catalysts prepared by ion exchange method. Ammonia was a very effective reducing agent for the preparation of monovalent copper from Cu2+-zeolites. Cu+-zeolite catalyst showed high conversion. To correlate the reaction activity with catalyst acidity, the conversion was investigated for various supports. Among the catalysts tested, NaY showed the highest activity. Characterization of metal included within zeolite has been carried out with a combination of in-situ photoluminescence and ESR in order to obtain a detailed description of Cu ion under vacuum. In-situ IR measurement was also conducted to study converting 4-vinylcyclohexene for cyclodimerization of 1,3-butadiene with conjugated double bond.