간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현

김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5

Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.

A cephalometric study on the velopharyngeal changes after maxillary protraction

Lee, Nam-Ki,Cha, Bong-Kuen 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.2

이 연구의 목적은 훼이스마스크로 상악 전방견인치료를 받은 성장기 골격성 Ⅲ급 부정교합자 25명(남 10, 여 15, 평균나이 9.9세)에서 단기간의 정적인 구개범인두 변화를 측모두부방사선 계측사진상에서 선 계측, 각도 계측 및 비율 계측을 시행하여 평가하는 것이다. 경구개 평면각의 변화량은 maxillary depth 또는 N perp to A의 변화량과 음의 상관관계를 보였다(p <0.01). 경 연구개 각의 증가는 유의성이 있었으며, 이는 경구개 평면각의 변화보다 연구개 평면각의 변화의 영향을 더 받았다(p <0.001). 연조직 과 경조직 비인두 깊이의 증가는 유의성이 있었으며 (p <0.001), 이들의 변화량과 연구개 평면각의 변화량간에는 양의 상관관계를 보였다(p <0.05). 경구개 길이의 증가는 유의성이 있었으며 (p <0.001), 이는 연조직 비인두 깊이의 증량과 음의 상관관계를 보였다(p <0.05). Need 비율 S (C)의 증가는 유의성이 있었으나 (p <0.001), 이러한 증가는 이전 연구에서 보고된 Need 비율 S (C)의 정상범위 내에 있었다. 이 연구로 상악골의 전방견인 후에 정적인 구개범인두 부위에 변화가 있을지라도 구개범인두의 적격성이 유지됨을 알 수 있었다. The purpose of this study was to investigate cephalometrically the short term static velopharyngeal changes in 25 patients (10 boys and 15 girls, aged from 5 years 9 months to 12 years 10 months in the beginning of treatment) with skeletal Class Ⅲ malocclusions who underwent nonsurgical maxillary protraction therapy with a facemask The linear, angular and ratio measurements were made on lateral cephalograms. Only the change in hard palatal plane angle was negatively correlated with the change in maxillary depth or N-perp to A (p < 0.01). The change in velar angle showed a statistically significant increase (p < 0.001). This change was influenced more by the soft palatal plane angle than by the hard palatal plane angle (p < 0.001). The changes in soft tissue nasopharyngeal depth and hard tissue nasopharyngeal depth showed statistically significant increases (p < 0.001). Correlations between the changes in soft tissue (or hard tissue) nasopharyngeal depth and the change in soft palatal plane angle were significant (p < 0.05). The increase in hard palate length was statistically significant (p < 0.001). The change in hard palate length was negatively correlated with the change in soft tissue nasopharyngeal depth (p < 0.05). The change in need ratio S (C) showed a statistically significant increase (p < 0.001). But this difference was within the normal range reported by previous studies. These findings indicate that the velopharyngeal competence was maintained even if the anatomical condition of the static velopharyngeal area were changed after maxillary protraction.

조혈모세포이식환자에서 조혈기능의 회복과 관련된 인자들에 관한 연구

정기주,강명수,권기두,김경하,이상철,김현정,배상병,김찬규,이남수,이규택,원종호,홍대식,박희숙 순천향대학교 의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.1

..

명리학에서 십성(十星)의 성립과 개념 확장에 관한 연구

이남연 ( Nam-yeon Lee ),김기승 ( Ki-seung Kim ) 산업진흥원 2022 산업진흥연구 Vol.7 No.1

이 논문의 목적은 명리학(命理學)에서 사용되는 육친(六親) 혹은 육신이라 불리는 십성(十星)의 근원과 주요고전에서의 십성의 의미를 확인하고, 현대 명리학에서 사용되는 십성의 개념을 분석하는 한편, 단순한 육친관계에 그치지 않고 보다 발전적인 형태의 십성의 개념을 심도 있게 연구하는 것이었다. 실제로 명리학에서 육친의 관념을 정하고 육친이라는 용어를 처음 사용한 것은『연해자평』이다. 『연해자평』, 『삼명통회』, 『자평진전』등 주요 고전 명리학에서 설명하는 십성의 내용은 대부분 순수 육친이라는 설정에 그쳤다. 이후 1963년에 발간된 『사주정설』에서는 육친의 설정에 그친 그간의 한계를 벗어나 십성의 작용을 설명하기 시작하였는데, 특히 김기승의 『과학명리』는 십성의 개념을 단순히 육친관계와 작용을 설명하는데 그치지 않고 인간의 심리와 선천적성을 확인할 수 있는 새로운 장을 열었다는 것에 주목할 만하다. 이 연구에서는 주요 고전에서의 십성의 개념과 현대 명리학에서 김기승의 『과학명리』에서 설명하는 십성의 개념과 성향을 알아보고 그 개념이 어떻게 변화되었는지를 알아보고자 하였다. 이 연구가 십성에 대한 인식 및 활용면에서 향후 명리학(命理學)의 연구에 발전적인 도움이 될 것으로 사료된다. The purpose of this paper was to confirm the source of Shipsong called Yookchen or Yooksheen used in Myeongleehak and the meaning of Shipsong in major classics. It is to investigate the concept of Shipsong used in modern Myeongri, and to study in-depth the concept of Shipsong in a more advanced form, not just in family relationships. In reality, the concept of Yookchen was defined and the term Yookchen was first used in Yeonhaejapyeong. Most of the contents of the major classics, such as Yeonhaejapyeong, Sammyeontonghwe, and Japyeonjinjeong, were limited to setting only family concepts. Then, in 1963, Sajoojeongsul was published, which explained both family relations and the action of Shipsong. In particular, it is noteworthy that the scientific reputation written by Ki-seung Kim did not only explain the concept of Shipsong but also opened a new chapter to confirm human psychology and aptitude. In this study, I tried to find out the concept and tendency of Shipsong described in Kim Ki-seung's Science Myeongri in the major classics and how the concept changed. I hope this study will be of some help to the study of Myeongleehak in the future in terms of understanding and utilization of Shipsong.

운동선수의 임장불안에 대한 연구

홍관이,이광재,김두경,부기원,노성규,한상준,박기동,오수일,문병용,이철규,박장평,엄기진,박남환 江原大學校附設 體育科學硏究所 1984 江原大學校附設體育科學硏究所論文集 Vol.- No.9

This study is designed to grasp the elements and situations of stage fright in order to propose a part of ways to cope with it. We make 511 top-class high school players, male and female, in the central districts (Seoul, Inchon, Kyungki, Chungbuk, and Kangweon Province) on object of questionnaire, and get the following results. Through players generally have all-round characters they show weakness in the superiority and emotional stability while showing strength in the sonformity. This fact comes to be related to the elements which cause stage fright. Physiological changes also have many effects on the symptom of stage fright. Especially, stage fright increases when players show sensitive reaction to the self-consciousness of final consequence which comes from the tension or uneasiness of sympathetic nerve, Thus, it turns out that players make use of reducing psychological burden by physical exercise or adjusting the level of demanded result in order to release the stage fright.

Pneumatosis intestinalis and portal venous gas secondary to gefitinib therapy for Lung adenocarcinoma

( Joo Young Lee1 ),( Hye-suk Han ),( Sung-nam Lim ),( Young Kwang Shim ),( Yong Hyeok Choi ),( Ok-jun Lee ),( Ki Hyeong Lee1 ),( Seung Taik Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.-

지역사회획득 폐렴의 치료지침 권고안

송재훈,정기석,강문원,김도진,배현주,서지영,심태선,안중현,안철민,우준희,이남용,이동건,이미숙,이상무,이영선,이혁민,정두련,지역사회획득 폐렴 치료지침 제정위원회 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

A successful therapy of community-acquired pneumonia requires appropriate empirical antimicrobial therapy. Etiology and antimicrobial susceptibility of major pathogens of pneumonia can differ by country. Therefore, an ideal treatment guideline of community-acquired pneumonia should be based on the studies performed in each country. We developed a treatment guideline for community-acquired pneumonia in immunocompetent adults in Korea. This guideline was developed by the joint committee of the Korean Society for Chemotherapy, the Korean Society of Infectious Diseases, and the Korean Academy of Tuberculosis and Respiratory diseases.

BMB Reports : Connexin32 inhibits gastric carcinogenesis through cell cycle arrest and altered expression of p21^Cip1 and p27^Kip1

( Hyang Jee ),( Su Hyung Lee ),( Jun Won Park ),( Bo Ram Lee ),( Ki Taek Nam ),( Dae Yong Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2013 BMB Reports Vol.46 No.1

Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition, after Cx32 overexpression in the human gastric cancer cell line AGS, cell proliferation, cell cycle analyses, and p21^Cip1 and p27^Kip1 expression levels were examined by bromodeoxyuridine assay, flow cytometry, real-time RT-PCR, and western blotting. Immunohistochemical study noted a strong inverse correlation between Cx32 and Ki67 expression pattern as well as their location. In vitro, overexpression of Cx32 in AGS cells inhibited cell proliferation significantly. G1 arrest, up-regulation of cell cycle-regulatory proteins p21^Cip1 and p27^Kip1 was also found at both mRNA and protein levels. Taken together, Cx32 plays some roles in gastric cancer development by inhibiting gastric cancer cell proliferation through cell cycle arrest and cell cycle regulatory proteins. [BMB Reports 2013; 46(1): 25-30]

中風病辨證診斷標準에 의한 臨床的 硏究

任長信,文祥官,高昌男,權正男,曺基湖,金永錫,裵亨燮,李京燮 경희대학교 1997 慶熙醫學 Vol.13 No.3

建築工業敎育科 敎育改善에 관한 硏究 : 敎育課程을 中心으로 Focused on the development of curriculum

李昌甲,朴萬植,延吉煥,崔武革,李基男 충남대학교 공업교육연구소 1981 論文集 Vol.4 No.1

Due to the radical change of society and the technological innovation, it is inevitable to rearrange the educational objective of the Department of Architectural Engineering Education and to reorganize the curriculum responding to the objective. In this study, all the current curricula of architectural institutions have been analized to identify problems, and the educational objective of the department of architectural engineering education have been established based on the objective of the College of Industrial Education. As the result of the above studies, the model curriculum for the major subjects have been developed in order to have following characteristics. 1. The required subjects were limited to the basic fields in order to cover the education in the technical high school. 2. The elective subjects were organized into three fields, namely, architecture, structural engineering, and building materials and construction to meet the diversified demands to a possible maximum extent.