太谿穴의 臨床 活用에 대한 文獻考察

구성태,송문영,강정묵,김용명,박보라,이은석,홍정아,김경식,손인철 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1

Literally, the mean of Tae-gye is highest brook. And on the basis of the acupuncture theory, Tae-gye point is the Soo earth point and source point of the Kidney Channel as well. In addition, Tae-gye point is one of the Yang-Returning Nine points. We were trying to study bibliographically on the Tae-gye point because Tae-gye point can be used very broadly across the symptoms in the theoretical aspect described above. As a results, we found out that according to the classical books of acupuncture, Tae-gye point is entering point of the Meridian Water as a source point and can be used at both Kidney-Sufficient Syndrom and Kidney-Deficient Syndrom. And Tae-gye can be applied to the disease of kidney or bladder that is urogenital symtoms, Also, Tae-gye is an useful option of tooth-ache, asthma, indigestion, constipation, edema etc whose cause is related with decrease of Kidney ki.

신세포암과 방광 이행상피세포암에서 Prostate Specific Membrane Antigen의 발현

조성태,김성용,이영구 大韓泌尿器科學會 2001 Korean Journal of Urology Vol.42 No.7

N₂O 가스로 열산화된 게이트 산화막의 전기적 특성

김태형,김창일,최현식,장의구,서용진,이철인 중앙대학교 생산공학연구소 1992 생산공학연구소 논문집 Vol.1 No.2

미래의 ULSI 소자의 게이트 산화막으로 이용하기 위하여 N₂O 가스 분위기에서 기존의 전기로를 이용한 실리콘의 열산화에 의해 N₂O 산화막을 형성하였고, MOS 소자를 제작하여 전기적 특성을 고찰하였다. 900℃에서 90분간 산화한 N₂O 산화막의 경우, 플랫밴드 전압(??), 고정전하밀도(??)와 플랫밴드 전압의 변화량(??)은 각각 0.81 [V], ?? [??]와 80∼95[mV]를 나타내었다. N₂O 산화막의 전기전도기구는 저전계 영역에서는 Fowler-Nordheim 터널링, 고전계영역에서는 Poole-Frenkel 방출이 지배적으로 나타났고, 절연파괴전계는 16 [MV/㎝]로 높게 나타났다. 따라서 N₂O 산화로 형성된 게이트 산화막이 ULSI 소자의 게이트 유전체로 응용이 가능하리라 생각된다. In order to applicate gate insulators in future ULSI devices, electrical properties was investigated in MOS device with N₂O oxide grown by thermal oxidation using conventional furnace in N₂O ambient. For the sample oxidized at 900℃ for 90 min, Flatband voltage(??), fixed charge density(??) and shifts of flatband voltage(??) after BTS was obtained 0.81 [V], ?? [??] and 80∼95[mV], respectively. The dominant conduction mechanism of N₂O oxide appeared to be Fowler-Nordheim tunneling in the low electrical field region(4-6 [MV/㎝]) and to be Poole-Frenkel emission in the high electrical field region( 9 [MV/㎝] or above). Dielectrics breakdown fields of N₂O oxide appeared about 16 [MV/㎝]. These results suggest that the N₂O oxides is a promising candidate for ultrathin gate dielectric for MOS ULSI applications.

일부 인쇄회로기판 납땜근로자들의 눈, 호흡기, 피부의 증상에 대한 조사연구

유재영,우극현,김진석,함정오,최태성,하봉구,정상재,박신구,김일룡 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.4

목적 : 이 연구는 납점작업자를 대상으로 납점작업으로 유발될 가능성이 높은 눈, 호흡기, 피부 등의 증상호소율 및 노출강도에 따른 관련성을 파악하기위해 수행되었다. 방법 : 연구참가자 146명중 연구목적에 적합한 20명을 제외한 126명을 대상으로 '눈이 가렵고 충혈됨', '코가 가렵거나 파가움', '재채기', '콧물'. '코막힘' , '목이 따끔거림' , '목에 무언가가 걸려있는것 같음' , '갑자기 연속적인 기침을 함' , '운동 시에 다른 사람에 비해 숨이 가쁨', '숨을 쉴 때 쌕쌕하는 소리가 남', '가래가 끓음', '손이나 안면에 가려움을 느낌' , '안면에 여드름이 날' '손이나 안면에 붉은 반점이 남' 등 14가지 증상에 대한 경험유무와 혈중연농도, 납점작업의 건강위험요인에 대한 지식상태 등을 조사하였다. 결과 : 조사된 14가지의 증상 중, '갑자기 연속적인 기침을 함'이 하루 납점시간 4시간 이상인 군아서 4시간 미만인 군보다 유의하게 증상호소율이 높았으며, 다른 증상의 경우 하루 납땜시간에 따라 유의한 결과를 보이지 않았다. 납땜작업의 건강위험요인에 대한 질문에 12.8 %가 플럭스에 의한 건강위험을 지적하였다. 전체 대상자의 평균 혈중연농도는6.05 rg/dL였으며, 히고치는 15.50 rg/dL이었다.결론 : 납땜작업자에게 호흡기 증상의 위험이 높을 가능성이 있으며, 납땜작업의 건강위험에 대한추가적인 연구와 납점작업자들을 대상으로 납점작업에 의해 유발될 수 있는 건강장해에 대한 적극적인교육 및 홍보활동을 필요로 한다. Objectives : This study was conducted to evaluate the prevalence of ocular, respiratory and skin symptoms among solderers and to investigate the relationship between symptom prevalence and exposure intensity. Methods : We analyzed 126 eligible participants out of a population of 146 male solder-ers who completed the symptom questionnaires. Fourteen symptoms including 'itchy and red eyes', 'itchy or prickly nose', 'sneezing', 'rhinorrhea', 'blocked nose', 'prickly throat', 'foreign body sensation in throat', 'sudden bouts of coughing', 'exertional breathlessness', 'wheezing', 'sputum production', 'itchy face or hands', 'acneiform erup-tions on the face' and 'red spots on the face or hands' were contained. Blood lead levels of all the 126 participants were tested and the participants' own assessments of the health risk of soldering were collected. Results : Of the 14 investigated symptoms, 'sudden bouts of coughing' was significantly more prevalent in solderers who worked 4 hours or more a day than those who worked less than 4 hours a day, as for the other symptoms, there were no significant differences in the prevalences related to daily soldering hours. 2.8% of the solderers considered the risk of flux exposure to be serious. The mean blood lead bevel was 6.05 μg/dL (maximum 15.50 μg/dL). Conclusions : Soldering may increase the risk of respiratory symptoms. Further invert tigations on the hazards of soldering processes are warranted and solderers should be educarted on these hazards.

일개 지역 전공의들의 주사침 상해

박신구,이종영,송정흡,유재영,최태성 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.1

목 적 : 병원 종사자들 중에서 전공의들의 주사침 상해의 실태를 파악하고, 주사침 상해 발생의 관련 요인을 알아보고자 하였다. 방 법 : 2000년 7얼에 대구지역에 소재한 전공의 수련병원 중 대학병원 2개소와 종합병원 1개소의 전공의 695명 전원을 대상으로 실시한 자가 기입식 설문지를 통하여 자료를 얻었단. 정확하게 응답한 443명(63.7 %)을 최종분석대상으로 하였다. 결 과 : 새로운 연차가 시작된 4개월 동안 경험한 주사침 상해는 응답자 443명중 200명으로 45.1 %이었고, 평균상해횟수 1.8회, 1000명당 1년 상해율은 5,377건 이었다. 업무특성에 따라 인턴이 96.5 %, 외과계 레지던트가 40.6 %, 내과계 레지던트가 34.4 %의 주사침 상해를 경험하였다. 주사침상해 발생의 관련요인을 분석하기 위해 다중 로지스틱 회귀분석(multiple logistic regression analysis)을 시행하였고, 분석결과는 내과계 레지던트에 비해 인턴이, 12시간이하 근무시간에 비해 16시간이상의 근무시간이 유의한 관련요인으로 나타났다. 결 론 : 병원종사자들 중에서 전공의들은 높은 주사침 상해율을 나타내고 있다. Objectives : This study was conducted in order to assess the experience of needle stick injury among interns and residents working in hospitals during the previous 4 nonths. Methods : We conducted a questionnaire survey of 695 interns and residents working in two university hospitals and one general hospital in Tague city. Four hundred and forty three of those questioned(63.7 %) fully responded. Results : Two hundred of the respondents(45.1 %) suffered at least one injury. Respondents suffered an average of 1.8 injuries. 96.5 % of interns, 40.6 % of surgical residents and 34.4 % of non-surgical residents suffered at leat one injury. According to multiple logistic regression, Intern status and an increased amount of working time is associated with high risk of needle stick injury. Conclusions : This study demonstrates that interns and residents suffer a high rate of needle stick injury.

무시멘트성 비구컵 사용시 Polyethylene 마모율 : AML Prosthesis 중심으로

박태수,안기찬,서승석,김영창,최장석,이영구 인제대학교 1997 仁濟醫學 Vol.18 No.2

비구를 metal-back이 있는 polyethylene 컵으로 시멘트를 사용치 않고 치환한 경우에서 비구컵 외전 각도와 인공 골두의 크기가 비구 polyethylene 마모에 미치는 효과를 문헌 고찰과 함께 보고하면서, polyethylene 마모가 고관절 치환술후의 장기적 추적과 연관성이 있는 바 추척 관찰에 유용성을 파악하기 위해 연구를 시행하였다. The amount of linear wear of the polyethlene of eighty four AML acetabular components, implanted without cement during a primary total hip replacement in seventy- two patients, were determined by a comparison of the thickness of the cup as measured on the initial and most recent follow-up radiographs. The measurements were corrected for magnification error by direct measurement of the diamenter of the femoral head on each radiographs. The mean duration of follow-up was seventy-eight months(range, 65 to 125 months). Linear wear averaged 1.94±0.74 millimeter(range, Zero to 9.61 millimeter) over-all, with a mean rate of 0.26±0.15 millimeter(range, zero to 1.10 millimeter) per year. An increase rate of per year correlated with a 32mm femoral head than 28mm femoral head, but there was no relationship with the weight or sex of the patients, the initial thickness of the polyethylene, or the angle of the abduction of the cup.

제조합 대장균에서 과발현된 Citrobacter freundii KCTC2006 유래의 β-Tyrosinase를 이용한 3,4-Dihydroxyphenyl-L-alanine의 생산

이승구,노현수,홍승표,이규종,왕지원,태동년,엄기남,방상구,김영준,성문희 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1

재조합 대장균에서 대량발현 시킨 Citrobacter freundii KCTC 2006 유래이 효소 β-tyrosinase를 이용하여 pyrocatechol, sodium pyruvate, ammonium acetate로부터 3,4-dihydroxy phenyl-L-alanine을 생산하기 위한 연구를 수행하였다. 이 효소반응에 적합한 온도 및 pH 조건은 각각 18℃와 8.5로 결정되었고, 반응액 중의 ammonium acetate와 sodium pyruvate의 농도는 각각 300 mM, 50 mM 이상으로 조절하는 것이 적합하였다. Pyrocatechol의 경우는 20 mM에서 가장 높은 반응성을 나타냈으나, 기질을 반복적으로 첨가하며 장시간 동안 효소반응을 수행하는 경우에는 pyrocatechol의 고갈을 피하기 위하여, 20 mM에서 50 mM 사이로 조절하였다. 한편, 반응액 중에 ethanol을 10% 첨가한 경우에는 반응속도가약 20% 증가하였다. 이상과 같은 효소반응특성에 기초하여 조제한 기질용액에 β-tyrosinase를 1 unit/㎖ 농도로 가하고, pyrocatechol과 pyruvate가 고갈되지 않도록 간헐적으로 첨가하면서 효소반응을 수행한 결과, 24시간 만에 85.2%의 수율로 31.6g/ℓ의 3,4-dihydroxyphenyl-L-alanine를 생산할 수 있었다. By using the β-tyrosinase of Citrobacter freundii KCTC2006, which was cloned and overexpressed in Escherichia coli, 3,4-dihydroxy phenyl-L-alanine (L-DOPA) was synthesized efficiently from pyrocatechol, sodium pyruvate, and ammonium acetate. Optimal temperature and pH for the reaction were determined to be about 18℃ and 8.5, respectively. The effects of substrate concentrations were also examined at different concentrations of ammonium acetate, sodium pyruvate, and pyrocatechol. Ammonium acetate and sodium pyruvate increased the reaction rate until the concentrations reached to 300 mM and 50 mM, respectively. Although pyrocatechol showed the optimal concentration at 20 mM, it was controlled between 20 mM and 50 mM to avoid the depletion of substrate during the enzymatic synthesis. Based on above results, a reaction medium for the production of L-DOPA was prepared and incubated with 1 unit/㎖ of β-tyrosinase. Pyrocatechol and sodium pyruvate was added to the reaction solution intermittently to avoid the substrate depletion during the enzymatic reaction. After 24 hour of reaction, 31.6 g/ℓ L-DOPA was accumulated in the reaction solution as soluble and precipitated ones and the conversion yield was about 85.2%.

콩에서 발생하는 강낭콩일반모자이크바이러스(BCMV)와 땅콩위축바이러스(PSV)의 저항성 평가

이영훈, 윤영남, 강범규, 김현영, 최만수, 구성철, 김현태, 윤홍태, 이수헌, 백인열 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

It has been reported several viral diseases in soybean. The occurrence of Bean common mosaic virus and Peanut stunt virus are able to induce severe problem because the main breeding target for viral disease was focused on Soybean mosaic virus. BCMV is a spcies of the genus Potyvirus of the family Potyviridae. BCMV reduces yield by as much as 80% and also adversely affects seed quality in common bean. BCMV has a worldwide distribution because of its high rates 35% of transmission via seeds produced by plants systemically infected prior to bloom. PSV is a species of the genus Cucumovirus of the family Bromoviridae. PSV has been reported to be economically damaging on beans worldwide. Although the virus is reportedly seed transmissible at very low rates, infected plants rarely produce pods with normal viable seeds. The most satisfactory management method of viral diseases such as BCMV and PSV is the use of resistant cultivars and healthy seed. For the overcome of genetic resistance by new virus such as BCMV and PSV, virus diseases monitoring and researches need to study deeply and continually. In this study, we conducted the resistance screen on BCMV and PSV for selection of resistance cultivars. We inoculated on 128 cultivars with PSV and BCMV respectively. These cultivars were classified through pathogenic response such as resistance, necrosis and susceptibility. In addition, 99 and 66 resistant cultivars were confirmed against PSV and BCMV respectively.

이공산(異功散)의 in vitro에서 Cisplatin 유도 신장독성의 감소 효과

정지창,장성구,이경태,노영수,안규석,오수명 慶熙大學校 1997 論文集 Vol.26 No.-

In vitro model systems are increasingly used to investigate the mechanism of chemical-induced toxicity and for toxicological screening of new drug families. The effect of Ekongsan on the cytotoxicity induced by cisplatin on human and rabbit kidney cells was evaluated by tetrazolium-dye(MTT) assay. On the basis of Cl_50 value, cisplatin-induced cytotoxicity on human renal cortical cells was increased depend on concentration, whereas Ekongsan alone did not influence Simultaneous administration of cisplatin and Ekongsan, cytotoxicity of cisplain was reduced depend on the concentration of Ekongsan. With primary cultured proximal tubule cells results to reduce the cisplatin induced-cytotoxicity by Ekongsan was comparable to those with renal cortical cells. Based on these results, Ekongsan may has the potency to protect the nephrotoxicity induced by cisplatin.

좌심실 이완기 장애 평가에서 Atrioventricular Plane Displacement의 임상적 중요성

정연손,조구영,이태유,김근숙,최창순,류제헌,최민호,박우정,임종윤,이영 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.12