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최승윤,배상희,송유한,Choi Seung Yoon,Bae Sang Hee,Song Yoo Han 한국응용곤충학회 1970 한국식물보호학회지 Vol.9 No.1
본 시험은 유기인계 살충제인 Terracur P입제 및 Lebaycid 입제와 유기염소계 살충제인 상감마입제$(\gamma-BHC 입제)$를 수면시용 하였을때 수도요해충인 이화명충, 끝 동매미충, 애멸구 및 흰둥멸구에 대한 동시방제가능성과 방제적기를 구명하고 약제간의 방제효과를 비교코저 실시하였다. 얻어진 시험결과는 다음과 같다. 1) 약제처리후 부화직후 이화명충 접종 시험에 있어서 상감마와 Terracur P는 높은 살충율을 보였으나 Lebaycid의 살충율은 낮았다. 約 $50\%$ 살충력 잔효일수에 있어서 상감마는 8-14日이었고 Terracur P는 6일간이었다. 2) 당초 계획된 방제적기에 관한 정보는 얻을 수 없었다. 즉 주어진 일간격이 좁아 유의한 차를 얻을 수 없었다. 3) 1,2화기 이화명충에 대한 방제효과는 Terracur P=상감마>Lebaycid의 순이었다. 4) Terracur P와 Lebaycid 입제의 처리는 끝동매미충의 방제효과가 좋았으나 상감마$(\gamma-BHC 입제)$의 방제효과는 기대할 수 없었다. 끝동매미충에 대한 Terracur P와 Lebaycid입제의 잔효력은 30일 이상이었다. 5) 애멸구와 흰등별구에 대한 시험은 충의 서식밀도가 낮기 때문에 약제간 방제효과를 얻을 수 없었다. 6) 공시약제중 Terracur P와 Lebaycidd입제는 이화명충과 끌동매미충의 동시방제제로서 사용할 수 있을 것 같다. This experiment was conducted to find out the simultaneous control effect of granulated insecticides on the several major rice insect pests in Korea. The granulated insecticides used were Terracur P$5\%$ (one of the phosphoric insecticides), Lebaycid $5\%$, and Sang-gamma (gamma-BHC) $6\%$. Those insecticides were broadcasted by hand on the paddy field at the ratio of 3kg. in June and 4kg. in August per 10 a, and the date of insecticidal application was based on the maximum moth occurrence of the rice stem borer in 1969. The rice insect pests tested in this study were rice stem borer (Chilo suppressalis W.), green rice leafhopper (Nephotettix bipunctatus cincticeps U.), smiller brown planthopper (Laodelphax striatellus F.), and white back planthopper (Sogotella furcifera H.). For the study of residual effectiveness of the insecticides, the rice stem borer larvae just hatched from the eggs were installed on the sheath of rice plants collected from the paddy field after insecticidal treatment, and the mortality was made at 48 hours after installation. High mortality was observed in Terracur P and Sang-gamma treatments and low mortality in Lebaycid treatment. The duration of residual effects giving about 50% mortality was about 14 days in Sang-gamma and about 6 days in Terracur P treatments. The study on the effectiveness of the insecticides to the rice stem borer in the paddy field was made by the number of dead blades and white heads of the rice plants injured by the larvae, and the number of survival larvae in the straws after crop harvest. The order of insecticidal effectiveness to the rice stem borer was Terracur P=Sang-gamm>Lebaycid. The study on the effectiveness of the insecticides to the leafhoppers and planthoppers in the paddy field was made by the population density by sweeping (5 times) at the given day intervals after treatments. Terracur P was highly effective for the control of the green rice leafhoppers and Lebaycid was moderately effective, but Sang-gamma seemed not to be effective. The effectiveness of the insecticides tested to the planthoppers was not clear, and it seemed to related with the low insect population density. Study on the determination of proper timing of insecticidal application was not also made clear, and it seemed to be short in the range of day intervals in the insecticidal application. For the study on the control effects of the rice insect pests, rice yield per 100 hills per plot was observed. There was no statistically significant difference among the treatments in rice yields, but the order of yield (Terracur P>Sang-gamma>Lebaycid>Control) was paralleled with the tends of control effects above mentioned. In a view point of simultaneous control of the rice stem borers and green rice leafhoppers by the application of granulated insecticides, Terracur P and Lebaycid were more effective than Sang-gamma which have been used.
Clinical characteristics and prognostic factors of invasive intracranial aspergillosis (초)
( Sung Joon Jin ),( Se Na Hwang ),( Su Jin Jeong ),( Hee Kyung Choi ),( Han Sung Lee ),( Bum Sik Chin ),( Sang Hoon Han ),( Chang Oh Kim ),( Hyo Youl Kim ),( Young Goo Song ),( Jun Yong Choi ),( June 대한내과학회 2008 대한내과학회 추계학술대회 Vol.2008 No.-
( Sang Hyun Yoon ),( Hee Seung Lee ),( Moon Jae Chung ),( Jeong Youp Park ),( Seung Woo Park ),( Si Young Song ),( Jae Bock Chung ),( Seung Min Bang ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: In recent studies, metformin has shown potential anti-cancer effects by lowering serum insulin and insulin-like growth factor 1 levels, and direct inhibition of cancer cell growth by activating 5` adenosine monophosphate-activated protein kinase protein, which inactivates proteins in the mammalian target of rapamycin pathway. The aim of this study was to evaluate potential anti-tumor effect of metformin on the treatment outcomes of patients with pancreatic adenocarcinoma (PAC).Methods: From May 2005 to December 2013, patients who were confi rmed as PAC and diabetes mellitus (DM) were analyzed retrospectively. For this study, medical records including DM history, medication, clinical outcomes of PAC and radiologic images were reviewed. Exclusion criteria were insuffi cient medical records, no history of DM before diagnosis of PAC, no treatment of PAC or other than adenocarcinoma in histology. Results: During the study period, 270 patients were included for the analysis. There were 175 patients (64.8%) with metformin exposure for DM management. The median overall survival time was 12.4 months for metformin-exposed group, and 8.8 months for metformin-unexposed group (P = 0.004, Log-rank test). In univariate analysis, metformin exposure, low serum CA19-9 level (<1000 U/mL), small primary cancer size (=20mm), no tail involvement, good performance status and resectable cancer stage were associated with favorable outcome of survival. In multivariate analysis, metformin exposure, low serum CA19-9 level (<1000 U/mL) and resectable cancer stage were associated with favorable outcome. The treatment modality of DM other thanmetformin (insulin, sulfonylurea, thiazolidinedione, dipeptidyl peptidase IV inhibitor) did not show the signifi cant effect on survival. Conclusions: Metformin exposure showed favorable treatment outcomes in PAC patients. Future prospective studies are required.
The Serine Proteinase Inhibitor OsSerpin Is a Potent Tillering Regulator in Rice
( Song Yion Yeu ),( Bong Soo Park ),( Wan Gyu Sang ),( Yang Do Choi ),( Min Chul Kim ),( Jong Tae Song ),( Nam Chon Paek ),( Hee Jong Koh ),( Hak Soo Seo ) 한국식물학회 2007 Journal of Plant Biology Vol.50 No.5
Tillering in rice (Oryza sativa L.) is an important agronomic trait that enhances grain production. A tiller is a specialized grainbearing branch that is formed on a non-elongated basal internode that grows independently of the mother stem. Transgenic rice over-expressing the transcription factor OsTB1, a homologue of maize TB1 (Teosinte Branched 1), exhibits markedly reduced lateral branching without the propagation of axillary buds being affected. However, the tillering mechanism remains unknown. Therefore, to further understand that mechanism, we applied proteomics methodology to isolate the proteins involved. Using two-dimensional gel electrophoresis and mass spectrometry, our analysis of the basal nodes from two rice cultivars that differ in their numbers of tillers showed that a rice serine proteinase inhibitor, OsSerpin, accumulates in great amounts in high-tillering ``Hwachung`` rice. Northern blot analysis revealed that much more OsSerpin transcript is found in ``Hwachung`` than in relatively low-tillering ``Hanmaeum``, likely because of high levels of transcription. Therefore, our data suggest that OsSerpin content determines the extent of lateral branching.
Sang Jun Song,Cheol Hee Park 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.4
The introduction of robot-assisted (RA) systems in knee arthroplasty has challenged surgeons to adopt the new technologyin their customized surgical techniques, learn system controls, and adjust to automated processes. Despite the potentialadvantages of RA knee arthroplasty, some surgeons remain hesitant to adopt this novel technology owing to concerns regardingthe cumbersome adaptation process. This narrative review addresses the learning-curve issues in RA knee arthroplastybased on the existing literature. Learning curves exist in terms of the operative time and stress level of the surgical team butnot in the final implant positions. The factors that reduce the learning curve are previous experience with computer-assistedsurgery (including robot or navigation systems), specialization in knee surgery, high volume of knee arthroplasty, optimizationof the RA workflow, sequential implementation of RA surgery, and consistency of the surgical team. Worse clinicaloutcomes may occur in the early postoperative period, but not in the later period, in RA knee arthroplasty performed duringthe learning phase. No significant differences were observed in implant survival or complication rates between the RA kneearthroplasties performed during the learning and proficiency phases.
Sang Jun Kim,Ji Eun Kim,최고은,Da Hyun Song,김선정,Tae Hee Kim,류진,Soo Hyun Kim,정영미 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Self-assembled peptide (SAP)-substance P (SP) hydrogels can be retained in the joint cavity longer than SP alone, and they can alleviate inflammation and ameliorate cartilage regeneration in knee osteoarthritis (OA). We conducted a preclinical study using diverse animal models of OA and an in vitro study using human synoviocytes and patient-derived synovial fluids to demonstrate the effect of SAP-SP complex on the inflammation and cartilage regeneration. Methods Surgical induction OA model was prepared with New Zealand white female rabbits and chemical induction, and naturally occurring OA models were prepared using Dunkin Hartely female guinea pigs. The SAP-SP complex or control (SAP, SP, or saline) was injected into the joint cavities in each model. We performed microcomputed tomography (Micro-CT) analysis, histological evaluation, immunofluorescent analysis, and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling (TUNEL) assay and analyzed the recruitment of intrinsic mesenchymal stem cells (MSCs), macrophage activity, and inflammatory cytokine in each OA model. Human synoviocytes were cultured in synovial fluid extracted from human OA knee joints injected with SAP-SP complexes or other controls. Proliferative capacity and inflammatory cytokine levels were analyzed. Results Alleviation of inflammation, inhibition of apoptosis, and enhancement of intrinsic MSCs have been established in the SAP-SP group in diverse animal models. Furthermore, the inflammatory effects on human samples were examined in synoviocytes and synovial fluid from patients with OA. In this study, we observed that SAP-SP showed anti-inflammatory action in OA conditions and increased cartilage regeneration by recruiting intrinsic MSCs, inhibiting progression of OA. Conclusions These therapeutic effects have been validated in diverse OA models, including rabbits, Dunkin Hartley guinea pigs, and human synoviocytes. Therefore, we propose that SAP-SP may be an effective injectable therapeutic agent for treating OA. Graphical Abstract In this manuscript, we report a preclinical study of novel self-assembled peptide (SAP)-substance P (SP) hydrogels with diverse animal models and human synoviocytes and it displays anti-inflammatory effects, apoptosis inhibition, intrinsic mesenchymal stem cells recruitments and cartilage regeneration