비혈연간 조혈모세포이식 후 재발한 만성골수성백혈병에서 Gleevec에 의한 완전관해 및 공여자 조혈 재건 1예

박사라,김우건,이제환,최성준,형철호,손희정,강혜진,지형석,이정신,이규형 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2

저자들은 만성골수성백혈병으로 동종 골수이식 후 림프구성급성전환으로 재발한 환자에서, Gleevec 투약 후 DLI (donor lymphocyte infusion) 없이 공여자 조혈(donor hematopoiesis)의 재건이 이루어지고, 세포유전학적, 분자생물학적 기준에서 모두 완전관해에 이르고, 12개월째 관해를 유지하고 있는 환자를 경험하였기에 이를 보고하는 바이다. 본례의 환자에서 Gleevec은 동종 골수이식 후 급성전환기로 재발한 환자에서도 매우 효과적인 것으로 나타났다. Gleevec은 동종 골수이식 후 재발한 만성골수성백혈병에서 Interferon-α, DLI, 2차골수이식 등 기존의 치료의 문제점을 보완할 수 있는 유용한 치료방법으로 사용될 수 있을 것으로 생각되며, 이의 장기적 치료효과의 평가와 기존치료와의 병합요법의 유용성 등에 대한 향후 연구가 필요할 것으로 생각된다. We report a 32-year old woman with chronic myelongenous leukemia (CML) in lymphoid blast crisis, who underwent allogenic bone marrow transplantation (BMT) from HLA phenotype full mached unrelated donor. Her disease relapsed into full-blown blast crisis. Upon treatment with gleevec, she achieved immediate remission of leukemia as well as the donor type hematopoiesis without donor lymphocyte infusion (DLI). Our case suggests the high effectiveness of gleevec in CML relapsed after allogeneic BMT. Further studies are needed to define the role of gleevec (with or without DLI) in the management of CML relapsed after allogeneic BMT.

洛東江 河口海城의 식물플랑크톤 極大城 變動에 관한 數値시뮬레이션 : Ⅱ. 식물플랑크톤 극대역 변동의 수치시뮬레이션 Ⅱ. The numerical simulation on variation of phytoplankton maximum region

이대인,김동명,김형철,이석모,박청길 한국환경과학회 2000 한국환경과학회지 Vol.9 No.5

It is very important to interprete and simulate the variation of phytoplankton maximum region for the prediction and control of red tide. This study was composed of two parts, first, the hydrodynamic simulation such as residual current and salinity diffusion, and second, the ecological simulation such as phytoplankton distribution according to freshwater discharge and pollutant loads. Without the Nakdong river discharge, residual current was stagnated in inner side of this estuary, and surface distribution of salinity was over 25psu. On the contrary, with summer mean discharge, freshwater stretched very far outward and some waters flowed into Chinhae Bay through the Kadok channel, and low salinity extended over coastal sea and salinity front occurred. From the result of contributed physical process to phytoplankton biomass, the accumulation was occurred at the west part of this estuary and the Kadok channel with the Nakdong river discharge. When more increased input discharge, the accumulation band was transported to outer side of this estuary. The frequently outbreak of red tide in this area is caused by accumulation of physical processes. The phytoplankton maximum region located inner side of this estuary without the Nakdong river discharge and with mean discharge of winter, but it was moved to outer side when mean discharge of the Nakdong river was increased. The variation of input concentration from the land loads was not largely influenced on phytoplankton biomass and location of maximum region. When discharge was increased, phytoplankton maximum region was transferred to inner side of the Kadok channel. On the other hand, when discharge was decreased, phytoplankton maximum region was transferred to inner side of this estuary and chlorophyll a contents increased to over 20㎍/L. Therefore, if any other conditions are favorable for growth of phytoplankton, decrease of discharge causes to increase of possibility of red tide outbreak.

개인방사선피폭선량평가

이형섭,김장렬,윤석철,이상윤 대한방사선 방어학회 1994 방사선방어학회지 Vol.19 No.2

최근, 개인방사선피폭선량평가에 관한 기술기준이 과학기술처에 의해 고시됨에 따라 국내에서도 개인선량계를 이용한 체외피폭선량평가결과의 신뢰성 문제가 크게 대두되고 있다. 한국원자력연구소에서는 이러한 구내의 상황을 인식하고 자체적인 신뢰성 확보를 위해 미국의 Oak Ridge국립연구소의 주관하에 개인피폭선량의 평가에 관한 국제상호비교검증시험(Personnel Dosimetry Intercomparison Study ; PDIS) 을 수행하였다. 비교 검증시험에는 한국원자력연구소에서 사용하고 있는 Teledyne PB-3 열형광선량계가 사용되였으며 선량게산 알고리즘은 Teledyne PB-3 version1.5-1989를 사용하였다. 본 연구에서는 지금까지 실시된 PDIS의 결과를 요약하고 현재 PB-3 시스템의 개인선량평가성능에 대해 고찰하였으며, 선량평가절차에 대한 문제점 도출을 통하여 직업적 방사선피폭선량 평가능력의 향상을 위한 방안을 제시하였다. Recently, the Ministry of Science and Technology issued a Ministerial Ordinance (N0 1992-15) about the technical criteria on personnel radiation dosimetry. In today's climate, it is important to demonstrate and document that the processor's systems and services to others meet national standards of quality. The purpose of this study is to verify the performance of the Teledyne PB-3 personnel dosimetry system that is generally used in Korea Atomic Energy Research Institute (KAERI) by intercomparison with Oak Ridge National Laboratory. The KAERI has been participated in this personnel dosimetry intercomparison study(PDIS) program since 1991 and it could be possible to test and calibrate personnel monitoring system. This report presents a summary and analysis of by about 50 does equivalent measurements reported for PDIS-16 through 18 (1991-1993) with emphasis on neutron does equivalent sensitivity, accuracy and methods to improve personnel dosimetry performance are also discussed.

敎科課程을 中心으로 한 韓日農學系(園藝·食品·獸醫)大學의 敎育現況 調査

李愚升,孫泰華,尹衡植,毛麒喆 경북대학교 1982 새마을 硏究論叢 Vol.2 No.-

The authors studied on the curicullum between Korea and Japan in the deaprtments of horiculture, food technology and veterinary. The results are as follows. 1. In the department of horticulture, professional education period was 3 years in Korea while 2 or 2.5 years in Japan. These results were compared among 3 colleges of Korea and Japan. Credits for graduation was 48-52% for propessional education with submajoring subjects and 45% when majoring subject in Korea, but 54-61% in Japan. Credits for required subjects were 17-29% among credits for graduation in Korea while 28-29% in Japan. 2. Cultural education period is almost 1 year in Korea, but different in Japan. Credits for graduation are as follows; Cultural education is 36-37%, majoring fields 15% and the others 12-13% in Korea while 43-46% for cultural education, 54-57% for majoring field in Japan. Differences were shown among 3 colleges dealt with the department of food technology by locational characteristics in Japan. 3. In the department of Veterinary, collage curicullums were not fixed for the students because of transitional period. Required subjects among 4 colleges were shown as the same tendency in Korea.

專門大學 體育舞踊科 敎育課程의 開發硏究

李鐵煥,金泰亨,李任仙,姜信和 진주여자전문대학 1986 論文集 Vol.8 No.-

인체의 수동적 전기특성 계측법 개발

이현철,윤재현,박형준 원광대학교 공업기술개발연구소 2003 工業技術開發硏究誌 Vol.23 No.-

In this study, a system for the method measuring of passive electrical properties in the human body was developed. The system was composed of the stimulating part for input with voltage(about 2[㎷]) and of the measuring part for measurement of electrical properties in human body. As a result of this experiment, the frequency characteristic of each subject represent that the electrical properties goes up in spite of a constant stimulate-voltage according to frequency (l[㎐]-50[㎑]) increment. Namely, the amplitude of stimulate-signal was not reflected but frequency was reflected on the measured results. This result be estimated that the proposed system is able to measure the passive electrical properties of human body. Also, it would be estimated neural signal propagation directions by using the method developed in this study was measured passive electrical properties in each part of body.

음압에 의한 인체 표피의 팽창 정도 및 형태학적 변화에 관한 연구

이민재,강형철 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.3

이화 여자 대학교 의과대학 부속 동대문 병원 백반증 크리닉을 방문한 백반증 환자중 표피이식술을 시행한 11명의 전흉부와 복부 18부위에서 일정한 시간동안 일정한 음압으로 흡입수포를 만들었을 때 표피 면적의 팽창 정도를 측정하고, 흡입으로 팽창된 표피의 형태학적 변화를 주사전자현미경과 투사전자현미경으로 관찰하여 다음과 같은 결과를 얻었다. 표피직경은 흡입 전 평군 7.6mm에서 흡입후 평군 11.0mm로 평균 46.4%, 표피면적은 평균 45.0㎟에서 95.9㎟으로 115.0% 증가하여, 팽창도 증가는 통계학적으로 유의하였다(p<0.05). 형태학적 변화로는 표피두께가 현저히 감소되고 표면과 평행한 방향으로 표피의 기저세포, 핵 및 세포간교가 신장된 소견을 보였으며, 각화세포 및 멜라닌세포의 핵 주변에 공포화 현상을 나타내었다. 결론적으로 표피의 팽창 정도 및 형태학적 변화 측정이 피부 표피의 물리학적 성질과 구조를 이해하는데 도움이 되며, 표피 이식수술시 필요한 정확한 공여부 피부면적을 예측하는데 이용될 수 있으리라 생각된다. Recently, autologous epidermal graft using suction-blister has been used in the treatment of depigmented diseases. The suction-blister is produced by separation of epidermis from dermis by negative pressure, and the separated epidermis is a good source for studying the properties of the epidermis itself. In this day, we measured the pre-expanded control diameter and post-expanded diameter induced by negative pressure in the anterior chest and abdomen of patients and calculated the expansibility of epidermis from the measurements, and studied the morphological changes of the expanded epidermis using scanning electron microscope and transmission electron microscope. As a result, the diameter of epidermis was elongated 46.4%, from a mean of 7.6mm to 11. 0mm and the calculated area was expanded 115.0%, from a mean of 45.0㎟ to 95.9㎟ by suction. Both were statistically significant(p<0.05). And morphologically, the thickness of epidermis was markedly decreased and the basal keratinocytes, their nuclei and intercellular bridges were elongated parallel to the skin surface, and paranuclear vacuolization was observed in keratinocytes andmelanocytes. In conclusion, above results are helpful in understanding the physical property and structure of epidermis and can be used for estimating the exact size of the donor skin needed for epidermal graft.

부산지역 모 공단 및 인근지역 사업체의 산업보건 실태에 관한 조사연구

이동영,손혜숙,이채언,박형종,김대환,엄상화,최성용,유병철 인제대학교 1993 仁濟醫學 Vol.14 No.4

부산지역 공단 및 인근지역 사업체의 산업보건실태를 파악하기 위하여 205개 사업체의 보건담당자를 대상으로 1990년도의 보건실태에 관한 설문조사를 하였다. 조사내용을 일반사항, 보건관리실태에 관한 사항, 작업장 유해환경 및 보호구 지급사항, 건강관련 사항 및 근무조건에 관한 사항 등으로 대별하여 분석ㆍ관찰하였다. In order to obtain the fundamental data for developing more effective and acceptable programs of public health manegement in an industrial complex, 205 health manager in the plants answered the questionaire of the status of industrial health during 1990. The questionaire consisted of general charateristics, health care status, environmental problems, health problems, and others. 72.4% of 205 plants had less than 100 workers. Fabricated metal manufacture was 32.4%. Although Footwear manufacture was 6.4%, the percentage of workers was 33.1% of total workers. The percentage(56.2) of retired women was higher than that(38.2) of men. 51.9% of total plants has recieving group health care services. 85.4% of plants was exposed to noise, 66.5% was exposed to dust. Ear plug and mask were given to prevent noise and dust in 69.2% and 68.6%, respectively. Among 22,299 workers, 618(2.8%) were diagnosed as suspected non-occupatinal disease. 85.9% of them worked on continuously and had their disease treated. The cases suspected for occupational disease was 100 workers. 82.5% of them changed their post. 45% had the compensation for their occuaptional disease. The rate of working: accidents was 2.3%.

상용 실시간 운영체제에서 EDF스케줄링 알고리즘 및 스택자원정책의 구현

이형철,김용석 강원대학교 정보통신연구소 2001 정보통신논문지 Vol.5 No.-

We implemented the EDF scheduling algorithm and the Stack Resource Policy to overcome the upper bound of processor utilization and to solve the priority inversion problem, respectively. The target for the implementation is a VME board based on MPC 860 which is family of PowerPC processor. RTEMS(Real-Time Executive for Multiprocessor Systems) which is a real-time OS developed OAR, is the basis of the implementation of EDF algorithm. The original RTEMS is based on fixed priority scheduling. Implementation shows better processor utilization than the rate monotonic scheduling algorithm. The implementation of stack resource policy is shown to solve the priority inversion problem by applying the well known PathFinder example.

Bacillus thuringiensis var. darmstadiensis 와 var. sotto의 내독소와 Bacillus thuringiensis var. kurstaki가 생산하는 아밀라제의 연구

이형환,김삼찬,황광현,임창로,조용칠,정인명 건국대학교 교육대학원 1991 敎育論叢 Vol.15 No.-

Endotoxin crystals produced by B.thuringiensis var. darmstadiensis cultured in modified GYS medium over 72 h were ovoidal in shape and separated using Renografin gradient centrifugation. The crystal protein bands were observed. When B.thuringiensis var sotto was grown in the modified GYS broth, it entered stationary phase at 8-9 h after inoculation. Proteinaceous crystals were banded at the position in 40% of Renografin gradient. The solubilized crystal proteins were formed by two bands, 130 Kd and 68 Kd in the SDS-PAGE. One plasmid was observed in B.thuringiensis var darmstadiensis and no plasmid in var. sotto in this study. Enzyme activity of amylase produced B.thuringiensis var kurstaki strain in the basal medium was 0.4 units per ml, and was enhanced to 0.6 units per ml in the basal medium contained soluble starch, Ca^++, Mg^++ and Mn^++ ions. Amylase production medium containing soluble starch was suitable for the amylase production and the highest activity appeared at 4-6 h after cultivation at 32℃. The amylase activity obtained by ethanol precipitation was 0.20 units per ml in 0.1 M phosphate buffer. The band of the molecular weight of 50 Kd was observed by SDS-PAGE analysis. Km value of the amylase for the soluble starch was 6.80 mg per ml.