성악골 절제술후 발생한 중앙부및 구개 결손부의 재건

김훈,임재석,최성원,김호겸,권종진,최미숙,김성문 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.1

There are various defects caused by trauma or resection of maignant tumor in the orofacial region, which can be reconstructed with various regional and pararegional flaps. Among these defects, it is very difficult to reconstruct palatal and midfacial defects after maxillectomy and patients have problems in speaking and swallowing of food. Therefore it is very important for surgeons to reconstruct these defects functionally and esthetically and to return the patients to the normal social activity. These defects are usually obturated with prosthodontic appliances to assist the phonation and swallowing. But nowadays surgical reconstruction by various flaps was considered and performed for better rehabilitation. For this purpose the forehead flap, the nasolabial flap, the tongue flap, the sternocleidomastoideous flap, the temporal flap, the latissimus dorsi flap, the scapular flap etc. are used. We reconstructed small-sized plalatal defects with tongue flap, medium-sized palatal and maxillary defects after maxillectomy with temporal myofascial flap and large midfacial defects including eyeball exenteration with latissimus dorsi myocutaneous flaps. Here we are to report 5 cases of these flaps used for the reconstruction of palatal and midfacial defects and consider the versatility, reliability and limitation in use of these flaps.

Infrared multiple photon dissociation spectroscopy and density functional theory (DFT) studies of protonated permethylated β-cyclodextrin–water non-covalent complexes

Lee, Sung-Sik,Park, Soojin,Kim, Ju-Young,Kim, Hye-Rim,Lee, Sungyul,Oh, Han Bin The Royal Society of Chemistry 2014 Physical chemistry chemical physics Vol.16 No.18

<P>We present infrared multiple photon dissociation (IRMPD) spectroscopy and quantum chemical calculation results for the protonated permethylated β-cyclodextrin (CD)–water non-covalent complex, the simplest β-CD non-covalent complex, in the gas-phase. The IRMPD spectrum in the region 2700–3750 cm<SUP>−1</SUP> consisted of three strong peaks at 3096, 3315, and 3490 cm<SUP>−1</SUP>. These spectral features in the experimental IRMPD spectrum were compared with a large set of infrared absorption spectra predicted using density functional theory (DFT) calculations for the protonated β-CD–water complex. Complex III (see Fig. 4c), in which the water molecule (at the primary rim) and the proton (at the secondary rim) were separated, was found to suitably reflect the main spectral characteristics found in the experimental IRMPD spectrum. The absence of the homodromic hydrogen bond ring, due to replacement of hydroxyl groups with methoxy groups in permethylated β-CD, rendered the primary rim open compared with the unmodified β-CD ‘one-gate-closed’ lowest energy conformer. This study demonstrates that IRMPD studies combined with DFT theoretical calculations can be a good method for studying molecular interactions of large host–guest pairs.</P> <P>Graphic Abstract</P><P>Water was found to interact with permethylated β-CD through multiple hydrogen bondings with methoxy groups of the rim. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cp54841d'> </P>

유년기 안구적출술 및 방사선치료로 인하여 발생된 안와 열성장에 대한 재건 치험례

홍관석,김성문,김훈,임재석,최미숙,최성원,권종진 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.1

There are many reports of the surgical management for the craniofacial abnormalities arising from the irradiation of the head and face for treatment of childhood cancers. Since the mordern combined-modality theraphy for childhood cancers began in the late 1960s and the early 1970s, recent reports have described the occular, dental and maxillo-facial abnormalities after irradiation in long-term survivors of cancers of the head and face. The resultant deformities may be known to be difficult to reconstruct with surgical techniques. This paper describes the late reconstructive surgery for the unilateral orbital and malar hypoplasia after eyeball enucleation and irradiation during childhood to correct the facial asymmetry and expand the contracted orbital socket into the functional dimension for the retaining eyeball prosthesis with spherical implant. We reports the satisfactory preliminary results from the midfacial osteotomy through the supero-lateral orbital rim and malar bone and the antero-lateral repositioning with the autogenous bone grafting in 26 year-old female patient who will be planned to make the new eyeball prosthesis by the department of ophthalmology.

크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

제주도 지하수 질산염 농도의 시·공간적 변화 특성: 장기(1993-2015) 모니터링 자료의 평가

김호림(Ho-Rim Kim),오준섭(Junseop Oh),도현권(Hyun-Kwon Do),이경진(Kyung-Jin Lee),현익현(Ik-Hyun Hyun),오상실(Sang-Sil Oh),감상규(Sang-Kyu Kam),윤성택(Seong-Taek Yun) 대한자원환경지질학회 2018 자원환경지질 Vol.51 No.1

1993년부터 2015년까지 관측된 제주도 지하수 장기모니터링 관측정(N = 4,835)에서 수집된 지하수 수질자료(N = 21,568)를 기반으로 질산성질소의 시공간적 변동 특성을 평가하였다. 제주도 지하수의 질산성질소 농도의 중앙값은 2.5 mg/L로서 다른 국가나 대륙의 조사 결과에 비해 다소 높거나 유사한 것으로 나타났다. 또한 지하수 용도, 행정구역 및 고도 별로 유의한 차이를 보였다. 특히, 산간 지역에 비해 저지대 해안가에 위치한 농업 및 주거지역에서 농도가 높음을 확인하였다. Mann-Kendall 및 Sen’s slope 분석을 활용한 질산성질소 농도의 추세 분석 결과, 하류 저지 대에 비해 중산간지역에서의 질산성질소 농도 증가 경향이 뚜렷하였다. 제주도 내 토지 피복의 시계열 변화 특성과 결부 지어 보면, 중산간지역의 오염 증가 추세는 농업지역의 확장 등 인위적 활동 증가에 기인한 결과로 판단된다. 반면,기지정된 지하수자원특별관리구역에서는 전반적으로 질산성질소 농도의 감소 경향이 나타났는데, 이는 지하수 관리 측면에서 수질관리를 위한 적극적인 정책이 유효함을 시사한다. 본 연구에서는 제주도 지하수의 질산성질소 오염관리를 위한 적정 방안을 제안한다. The spatio-temporal variations of nitrate concentrations in groundwater of Jeju Island were evaluated by an analysis of time series groundwater quality data (N = 21,568) that were collected from regional groundwater monitoring (number of wells = 4,835) for up to 20 years between 1993 and 2015. The median concentration of NO 3 -N is 2.5 mg/L, which is slightly higher than those reported from regional surveys in other countries. Nitrate concentrations of groundwater in wells tend to significantly vary according to different water usage (of the well), administrative districts, and topographic elevations: nitrate level is higher in low-lying agricultural and residential areas than those in high mountainous areas. The Mann-Kendall trend test and Sen’s slope analysis show that nitrate concentration in mid-mountainous areas tends to increase, possibly due to the expansion of agricultural areas toward highland. On the other hand, nitrate concentrations in the Specially Designated Groundwater Quality Protection Zones show the temporally decreasing trend, which implies the efficiency of groundwater management actions in Jeju. Proper measures for sustainable groundwater quality management are suggested in this study.

高興郡 浦頭面에 있어서의 肺吸蟲症의 疫學的 推移

林漢鍾,李駿商,金東彦,鄭城守 고려대학교 의과대학 1980 고려대 의대 잡지 Vol.17 No.1

It is recognized that Ko Heung Gun is the most well known endemic foci of paragonimiasis in Korea. Authors carried out the survey for human paragonimiasis in Po Du Myun, Ko Heung Gun (from 1968 to 1979) by the use of intradermal screening test with Veronal buffered saline antigens. In 1968 and 1979, inhabitants, of all age groups in these areas were examined. In 1979, 1,484 middle school students in Po Du Myun and 1,247 high school students in Ko Heung Eup were examined. The infestation rate of crabs with Paragonimus metacercaria was also examined. The following results were obtained in this survey. 1. In 1968, 353 inhabitants were showed 56.9% positive reaction, with sexual difference of 60.2% in male and 50.8% in female. The positive rate was shown over 50% in the age groups of over 10 years old. 2. In 1979, 387 inhabitants were showed 48.8% positive reaction, with sexual difference of 61.0% in male and 38.6% in female. The positive rate was shown over 50% in the age groups over 40 years old. 3. In 1979, middle school students in Po Du Myun were showed 16.4% positive reaction and high school students in Ko Heung Eup were showed 5.7% positive reaction. 4. The positive rate of Paragonimus metacercariae was 25.0% in crabs (Eriocheir japonicus) and the mean number of metacercaria per crab was 0.6.

생식주기 동안 흰쥐 자궁에서 발현되는 c-myc 관련 RCL 유전자의 기능

김도림,강성구 인제대학교 2004 仁濟論叢 Vol.19 No.1

자궁은 착상 임신 유지 및 분만을 위해 증식과 분비의 주기적인 시기를 겪는다. 배아가 착상하지 못한다면 자궁내막 조직은 퇴화되지만 배아 착상 시에는 자궁내막조직은 유지가 되며 임신 유지와 분만을 위한 과정이 진행된다. 이러한 자궁의 변화는 직접적으로 난소호르몬인 프로게스테론 (progesterone)과 에스트로겐(estrogen)의 영향을 받으며 간접적으로는 다양한 성장인자(growth factor), 사이토킨(cytokines)의 영향을 받는다. 발정주기에는 세포의 분화와 증식에 관련된 많은 유전자들이 발현된다. 본 연구는 생리 주기에서 발현되는 유전자를 분석하기 위하여 cDNA microarray를 통하여 실험하였다. 실험동물을 발정전기(proestrus), 발정기(estrus), 발정후기 (metestrus), 발정말기(diestrus)로 분류하였다. 자궁 적출 후 total RNA를 추출하였다. 추출한 RNA로부터 32P로 표지된 cDNA probe를 합성하였고 Atlas Rat Toxicology 1.2 Array (Clontech)에 hybridization을 하였다. 선별된 유전자로는 growth-related c-rnyc responsive protein RCL, heat shock 47-kDa protein (HSP47), cytochrome c oxidase polypeptide VIc2 (COX6C2), calreticulin (CALR)등이 있다. RCL 유전자는 RT-PCR을 이용하여 검증하였다. RCL 유전자 발현은 발정전기에 가장 높았으며 생식주기가 진행됨에 따라 감소 하였다. 본 연구를 통해 RCL유전자는 생식주기의 조절과 임신, 불임에 관한 중요한 정보를 제공할 것이며 이러한 유전자의 기작과 기능에 대한 연구가 더 필요하다. The uterus undergoes dynamic changes during the cycle and displays many features typical of developmental process. In order to be prepared for implantation, endometrium undergoes predictable, sequential phases of proliferlation and secretory changes. In the absence of an embryo the uterus will progress through a predictable series of stages ultimately terminating in tissue regression and apotosis. In the presence of an embryo, the endometrium not only is maintained, but also progress through an additional program of events. The uterus during estrus cycle synthesize a complex of signaling molecules with specific spatial and temporal modes of expression and which are critical for cell proliferlation and differentiation. The purpose of this investigation was to use cDNA microarrays to evaluate the expression of genes in rat uterus during estrus cycle. Animals were sacrificed on pro-estrus, estrus, metestrus, diestrus. Total RNA was isolated from the uterus. 32P-labelled cDNA was generated from total RNA and hybridizied with the Atlas Rat Toxicology 1.2 Array.(Clontech). Differential gene expression profiles were revealed growth-related c-myc responsive protein RCL, heat shock 47-kDa protein, cytochrome c oxidase polypeptide VIc2 and calreticulin. Reverse transcription polymerase chain reaction (RT-PCR) was used to validate the relative expression pattern of RCL gene. Using this approach we found that RCL gene expression in rat uterus was altered with estrus cycle. The identification of differentially expressed genes may provide important information in the regulation of estrus cycle, pregnancy and infertility. Our long-term goal is to determine the role of these differnetially expressed genes during estrus cycle

우심방과 우심실의 거대 심장 혈관종 1예

김제열,조상호,김건일,허경림,김현숙,조구영,최영진,이원용,임종윤 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Cardiac tumors, especially the primary tumors involving any part of the heart are extremely rare and its relative incidence has been reported to be approximately 0.02%. We report a patient with huge cardiac hemangioma who complained of shortness of breath, general weakness, and dizziness, Imaging study by echocardiography and computed tomography of thorax revealed a huge lobulating mass like a bunch of grapes in the right chamber of heart. The surgical exploration of thorax was performed and a histological diagnosis of spindle cell hemangioma was obtained by microscopy. The patient was treated by surgical resection of the tumor and doing well after surgery. Our experience indicated that prompt diagnosis and treatment of cardiac hemangioma is imperative for patients' prognosis.

음파에 의한 게의 추음성에 관한 연구

金尙漢,梁龍林 釜山水産大學校 1970 釜山水産大學 硏究報告 Vol.10 No.2

남해 및 부산 해변에 서식하고 있는 게{사각게:Sesarma(Parasesarma)picta(de Haan), 두이빨 사각게:Sesar-ma(Chromantes) bidens (de Haan), 엽낭게:Scopimera globosa de Haan}의 추음성(趨音性)을 조사하여 본 결과 (1) 700∼900 C.P.S.의 음파를 보냈을 때 추음성의 효과가 가장 좋다. (2) 보호색을 띄고 있으며 항상 은신하는 습성이 있어 추음할 때도 역시 은신의 기회를 노린다. (3) 추음 속도는 추음 효과가 가장 좋을 때 1cm/sec 정도이다. 가을 밤에 해변에 기어 오르는 큰 게에 대한 추음성의 frequency 측정은 앞으로 시도될 것이고, 각종 고기에 대한 추음성과 배음성(背音性)의 주파수에 관한 연구는 앞으로 어업에 큰 역할을 할 것으로 간주된다. The idea of luring numerous crabs by using underwater acoustical equipment was conceived on the theoretical thought that if numerous crabs could be lured to a location and driven into the fishing net, the fishing efficiency could be increased by many folds. It has been found by analysing the data of frequency that an under water acoustical equipment with frequency response of 700-900 cycles per second. It was noted during these experiments that numerous crabs gathered around the under water acoustical equipment.

전신성홍반성루푸스 환자에서 발생한 순수어농

김윤정,김해림,박시내,윤종현,이상헌,박성환,김호연 대한내과학회 2004 대한내과학회지 Vol.66 No.4

순수어농이란 발성언어에 대한 이해와 반복에 장애를 보이지만 읽기, 쓰기, 비발성언어에 대한 이해는 보존되는 경우를 일컫는다. 저자들은 45세 루푸스 환자에서 루푸스 혈관염으로 인해 일차 청각 피질을 포함한 왼쪽 관자이랑에 뇌경색이 발생하여 초래한 순수어농 1예를 경험하였기에 보고하는 바이다. Pure word deafness is characterized by an impairment of auditory comprehension and repetition of speech while a preservation of reading, writing, spontaneous speech and ability to comprehend non-verbal sounds. It is caused by trauma, infection in the temporal lobe of brain. In most cases, the lesions are bilateral, in the middle third of superior temporal gyri, but in a few cases unilateral lesions of dominant temporal lobe are localized. We experienced a case of 45 year-old right handed wonman with systemic lupus erythemato년 (SLE) who presented pure word deafness after left temporal lobe infarction including primary auditory center. Her comprehension was impaired, while reading and visual comprehension were normal. Audiometric tests and auditory evoked potentials disclosed no hearing defect. Brain MRI showed a left temporal lobe infarction without abnormal vascular finding in MRA. She wasdiagnosed as pure word deafness due to SLE vasculitis and managed with high dose steroid and cyclophosphamide therapies.