비외상성 두개내 출혈 환자에서 심근손상의 발생과 예후에 미치는 영향

강구현,황성호,이강현,조준휘,김성환,문중범,박해상,이서영,이성수,김헌주 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Objective: The aim of this study was to investigate the clinical significance of myocardial injuries in patients with nontraumatic intracranial hemorrhage by identifying the occurrence of myocardial injury and defining its correlation with subsequent cardiovascular events. Subjects and methods: One hundred twenty-four patients with nontraumatic intracraninal hemorrhage presented to the emergency department within six hours from onset of symptoms were enrolled. Brain CT, serial electrocardiography, and echocardiography were done at the emergency center. Blood samples for troponin I and creatine kinase(CK)-MB were drawn immediately and eight hours after admission, Troponin I and CK-MB were measured using a chemiluminescent immunoassay, respectively. Results: Electrocardiographic and echocardiography abnormalities were found in 65 cases(52.4%) and 21 cases(17%), respectively. Serum troponin I and creative kinase-MB were increased in 35 cases (28.2%) and in 58 cases(46.8%), respectively. Abnormal findings of echocardiography and ECG, as well as elevated levels of serum troponin I and creative kinase-MB, were associated with an increased risk of cardiovascular event and survival. Logistic regression analysis revealed that an abnormal echcocardiographic finding and elevation of serum troponin I were factors associated with the occurrence an adverse cardiovascular event and that electrocardiographic abnormalities and initial mental status were factors associated with poor prognosis. Conclusion: This study reveals that actual myocardial injury develops in a significant proportion of patients with nontraumatic intracranial hemorrhage and that the development of the myocardial injury is associated with an adverse cardiovascular event that occurs during admission.

좌전하행지 관동맥 개구부위의 망사형의 관(Slotted Tube)스텐트와 나선형 코일(Coil)스텐트 삽입후 단기 및 장기 암상 경과의 비교

박훈기,박성욱,이일수,이상곤,김진우,이근,정상식,이철환,홍명기,김재중,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

다제내성 그람양성균에 대한 Linezolid(Zyvox^(�))의 시험관내 항균력 비교

박대원,정희진,엄중식,황병연,김성범,이재갑,이연주,정혜원,정성주,박재형,이진수,손장욱,김우주,김민자,박승철 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

배경 : MRSA, VRE, VRSA같은 다제 내성 그람 양성균의 등장에 따라 glycopeptide를 대체할 새로운 항생제의 개발이 필요하게 되었고 결과적으로 새로운 항생제인 linezolid라는 항생제가 개발되었다. Linezolid는 이전의 항생제와는 다른 새로운 계열의 oxazolidinone으로 경구 이용률이 우수하다. 원내 및 원외감염의 중요한 원인균이 되고 있는 MRSA, VRE에 대한 적절한 경구용 항균제가 없는 국내에서 폐렴 및 피부 연조직 감염에서 경구용으로 사용해 볼 수 있는 약제이다. 본 연구에서는 고대 구로 병원에서 분리된 MRSA, VRE 등을 대상으로 다른 여러 항균제와 비교한 linezolid의 시험관내 항균력을 조사하고자 하였다. 재료 및 방법 : 연구대상은 1998년 1월부터 2000년 12월까지 본원에서 입원 및 외래를 통하여 피부 연조직 감염증 및 호흡기 감염증, 요로감염증으로 진단된 환자들의 가검물로부터 분리된 MRSA 60균주, VRE 43균주, PRSP 25균주를 액체배지 또는 한천배지 희석법을 통하여 linezolid 및 기타 항균제에 대한 최소발육억제농도를 구하였다. 결과 : 실험에 사용한 S. aureus는 모두 MRSA였고 이들은 linezolid에 대해 MIC_(90) 2㎍/㎖(MIC 범위 1-2㎍/㎖), Enterococcus spp는 모두 VRE로 linezolid의 MIC_(90)은 2㎍/㎖로 MIC 범위는 1-4㎍/㎖였다. 한 개의 균주에서 MIC 4㎍/㎖로 중등도 감수성을 보였으나 MIC breakpoint가 (8㎍/㎖인 내성균주는 없고 모두 감수성을 보였다. S. pneumoniae의 경우 penicillin 내성이었고, linezolid MIC_(90) 1㎍/㎖ (MIC 범위 0.5-1㎍/㎖)로 전부 감수성을 보였다. 결론 : Linezolid는 MRSA를 위시한 VRE, PRSP 등의 다제 내성 그람 양성균에 대하여 우수한 시험관내 항균력을 보임을 알 수 있었다. Background : The emergence of multi-drug resistant Gram-positive cocci, such as MRSA, VRE, and VRSA, necessitated to develop new antibiotics, which could replace the glycopeptide. As a result, a new antibiotics named linezolid was developed. Linezolid is different line of oxazolidinones with a good oral bioavailability, compared to other antibiotics. Since appropriate oral antibiotics are not presently available for MRSA, which is a major cause of nosocomial and community acquired infections, the introduction of linezolid will have favorable effect on treatment of infections such as pneumonia or skin infections. In this study, we investigated the antibiotic effect of linezolid on MRSA and VRE isolated from patients who were treated in Korea University Guro Hospital. Material and Methods : By using broth microdilution and agar dilution method we measured minimum inhibitory concentration (MIC) with sixty S. aureus, forty three Enterococcus spp., and twenty five S. pneumoniae isolates from patients who were diagnosed as skin, soft tissue, respiratory, and urinary infections in Korea University Guro Hospital from January, 1998 to December, 2002. Results : All of S. aureus used in this study were MRSA, and MIG_(90) of linezolid was below 2 ㎍/㎖ (MIC ranged between 1-2 ㎍/㎖). All of Enterococcus spp. were VRE, and had MIG_(90) of 2 ㎍/㎖ (MIC ranged between 1 to 4 ㎍/㎖). One of the VRE showed intermediate susceptibility with MIC of 4 ㎍/㎖. However, none was resistant with MIC breakpoint above 8 ㎍/㎖. All of S. pneumoniae were resistant to penicillin, but they were susceptible to linezolid with MICao of 1 ㎍/㎖(MIC range 0.5-1㎍/㎖). Conclusion : In conclusions, linezolid has an excellent in vitro antibiotic effect on multi-drug resistant Gram-positive cocci, such as MRSA, PRSP, and VRE.

방사선 조사 후 대뇌결질에 분포한 Neuropeptide-Y 양성신경세포에 관한 면역조직화학적 연구

이상욱,김종중,정윤영,정종달,오윤경 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Background and Objectives : Severe irradiation on the cerebral cortex of the human and animals may result in functional alterations of central nervous system. The purpose of this study, the irradiation effects on the cerebral cortex of the rats after brain irradiation was to investigate the change of distribution and morphology of neuropeptide-Y(NPY) neurons. Materials and Methods : Radiation was produced by the linear accelerator 6MV X-ray, and the animals were categorized into control and experimental groups and we use 45 Sprague-Dawley rats weighing about 200~250gm. The head areas of the animals were positioned within the radiation field of 12㎝ × 20㎝ and with the radiation depth of 1.5㎝. Sodium chloral hydrate-anesthetized rats were exposed to the radiation with the dose rate of 240 cGy/min. The total dose was 1800 cGy. Animals were sacrificed on 2 hours, 5 hours, 1 day, 3 days, 7days after brain irradiation. Under anesthesia, animals were perfused with 4% paraformaldehyde-1% glutaraldehyde solution. On one or two hours after the perfusion, brain were taken out and refixed over night in the same fixative. Using ABC immunohistochemistry, morphology and distribution of neuropeptide-Y immunoractive(NPY-IR) neurons were studied on the cerebral cortex of the control and brain-irradiated rats. We used light, transmission electron and confocal laser scanning microscope. Results : The following results were obtained : 1. On control group, NPY-IR neurons were found in all layers of the primary sensory and motor cerebral cortex, and the NPY-IR neurons were concentrated within the layer II, III, IV, V and VI. The typical NPY-IR perikarya was bipolar and multipolar shape. 2. On 2 hours, 5 hours, 1 day after X-irradiation, decreased number of NPY-IR neurons were detected in the primary sensory and motor cerebral cortex of the rats. Also shrunken and transformed NPY-IR neurons were detected in the primary sensory and motor cerebral cortex of the rats. 3. On 3 days and 7 days after X-irradiation, morphology and distribution of NPY-IR neurons in the primary sensory and motor cerebral cortex was generally restored. 4. In optical serial section analysis of NPY-IR neurons, high fluorescence intensity were observed in a part of the 8~11 sections of the control and all irradiated groups. In optical single section analysis of NPY-IR neurons, red color(high fluorescence intensity) was observed in a part of 6, 7 sections of the control and all irradiated groups. 5. By electron microscopy, NPY-IR neurons on 2 hours, 5 hours, 1 day after X-irradiation rats exhibited severe alterations of their organelles concerning intracellular material transport ; such as disappearance of microvilli and basal infoldings, reduction of invaginating pits on the basal and apical plasma membranes, reduction of transformed vesicles and shrunken Golgi complexes, etc. Conclusion : From the above results, it was concluded that the release of neurotransmitters and transcapillary leakage of blood substance were occurred on 2 hours, 5 hours, 1 day after X-irradiation, but the condition was generally restored on 3 days and 7 days following X-irradiation.

油菜의 雄性不稔系統에 關한 發生學的 硏究

李萬相,李重浩 圓光大學校 1981 論文集 Vol.15 No.1

油菜의 雄性不稔系統인 Mokpo MS, Chisa MS와 正常品種인 龍塘을 比較品種으로 하여 雄性不稔發現에 있어 그 原因올 밝히기 爲하여 發生學的으로 調査하였던 바, Chisya MS는 不完全하고, Mokpo MS는 小胞子母細胞減數分裂異常으로 四分子期 以後 退化되기 시작하여 開花直前에는 小胞子나 花紛粒은 찾아 볼 수 없고, 絨毯組織, 內被, 中層, 表皮가 그대로 殘存하고 있는 點으로 보아 完全한 雄性不稔系統임이 確實하다. 大胞子에서 Chisaya MS는 正常的으로 卵裝置가 形成되나, Mokpo MS는 異常이 있다. Present work was carried out to investigate the cause of male sterile appearance in the rape with Mokpo MS line and Chisaya MS one as the male sterile lines and with cv Yongdang as nomal variety. The results obtained were as follows: The male sterility of Chisaya MS line was imperfect, but that of Mokpo MS line was perfect on account of abnormal meiotic division of microspore mother cells or being lacking pollen grains at just before blooming and judging from intact remain of tapetal tissue, endothicium, middle layer and epidermis of anther at just before blooming. The egg apparatus of Chisaya MS line was normal, but that of Mokpo MS line, abnormal.

두개강내 추골동맥의 박리성 동맥류 : 2부검례 보고

이상용,조갑래,서중석 大韓法醫學會 2000 대한법의학회지 Vol.24 No.1

Two autopsied cases of dissecting aneurysms of intracranial vertebral artery are reported and the appropriate literature is reviewed to investigate the pathological characteristics and pathogenesis. The location and pathological features of the aneurysms are similar in the two cases. The aneurysms in both cases are confined to the intracranial vertebral artery and massive subarachnoid hemorrhage in basal cistern develop caused by the rupture of the arterial wall. And the aneurysms show mainly subadventitial dissection and display intimal thickening, disruption of internal elastic lamina, and degeneration of the media. Based on their pathological investigation of these two cases and a review of reported cases, the authors propose that weakness of internal elastic lamina may be responsible for initiating dissection in susceptible individuals and hypertention is one of contributing factors that result in weakness of internal elastic lamina.

실존주의 사상과 현대 영미문학 : 현대 실존 해석학과 포스트모던 문학까지

이상혁,양병현,최진영,현중식 中央大學校 人文科學硏究所 1998 人文學硏究 Vol.27 No.-

토끼 간조직의 Stimulatory Guanine Nucleotide 결합 단백의 αsubunit 에 대한 cDNA 염기서열에 관한 연구

이상훈,노연희,한중수,고재경 한양대학교 의과대학 1993 한양의대 학술지 Vol.13 No.1

G proteins, a family of guanine nucleotide-binding protein superfamily, are involved in transmembrane signaling systems as transducers. In this study cDNAs encoding αsubunit of the stimulatory G protein (G α ) from rabbit liver were cloned and their nucleotide sequences were determined : a λgt 11 cDNA library from total cellular poly (A)' mRNA in rabbit liber was screened for recombinant λDNA that codes for G α with labeled probe. The probe used was an EcoRI digested 3' end fragment of cDNA for G α from olfactory neuroepithelium of rat. Six of the approximately recombinant clones were screened by in situ hybridization and by autoradiography, detecting sixteen positive clones. These clones were tested using polymerase chain reaction (PCR) technique and thirteen of them were turned out to have two sets of conserved sequence in αcDNA. Four clonse among them were selected form analysis of their cDNA sequences, showing the presence of two types of cDNA, namely and with the total length of nucleotide sequence of1.392bp and 1.613bp, respectively . From nucleotide sequence analysis the amino acid residues of -1 and α-2 were deduced : they contain 335 and 386 amino acid residues (including the initiator methionine), respectively. The calculated molecular weights for and were 38.9kd and 44.6kd, respectively. The significant difference in size between two cDNAs for G αseemed to be due to the assumption that alternative promoter and leading exon might be involved in transcribing the mRNA for . Two types of cDNA from rabbit liver shared over 95% of amino acid homology with that from rat olfactory neuroepichelium if deleted portions are not counted. More information on the cDNAs could be obtained through further studies such as Sl nuclease protection experiment, expression and mutation study.

축구화 스터드의 형태변화에 따른 회전마찰력

이중숙,박상균 한국운동역학회 2004 한국운동역학회지 Vol.14 No.2

J. S. LEE, S. K. Park. Rotational Friction of Different Soccer Stud. Korean journal of Sport Biomechanics, Vol. 14, No. 2, pp. 121-138, 2004. The design of soccer studs is important for providing friction on a variety of surfaces. We hypothesized that a certain type of soccer studs could improve performance due to high rotational friction. Thus, this study was conducted to determine the relationship between the frictional characteristics and different soccer stud design. Twelve recreational soccer players were recruited. Rotational friction data from the force plate was collected for all subjects during normal walking with 180 degree rotation. Walking speed was controlled at 1.2 m/s (±0.1 m/s) with timing lights on infilled artificial turf. Three different types of soccer studs and one running shoe were tested. Repeated measures ANOVA was used to determine significance. Significant differences were found in rotational friction with four different shoes. Trx and World studs tended to have greater maximum rotational friction than the running shoe (Nova) and traditional soccer shoe(Copa Mondial). The results were as follow : world(25.95Nm) ) trx(25.74Nm) ) copa(22.50Nm) ) nova(16.36Nm). The difference may be due to the number, location, size, and shape of studs. We concluded that stud design influences rotational friction between the shoe and surface during movement. Based on studs design and contact area, Trx with blade type studs are recommended since it showed high rotational friction for performance as well as enough contact area for stability. However, differences due to the mechanical properties of soccer studs are still being investigated.

DAC 정책을 이용한 학사 데이타베이스 보안 시스템의 설계 및 구현

이중인,진성일 충남대학교 자연과학연구소 1992 忠南科學硏究誌 Vol.19 No.1

In this thesis, We study the efficient and secure access control mechanism using discretionary access control policies by viewing table in a database system for the academic affairs. We design and implement a database security system for the academic affairs, that is protected from an unauthorized user's access using INFORMIX DBMS. In addition, this system satisfies the C DIVISION(C1, C2 CLASS) security criteria of the DoD.