셀레나이트로 유도되는 백내장에서 선삼 성분에 따른 백내장 억제효과의 비교 분석

이상목,정문선,정진호,김미금,위원량,박정일,이진학,Sang Mok Lee,MD,Jung Moon Sun,MD,Jin Ho Jeong,MD,Mee Kum Kim,MD,Won Ryang Wee,MD,Jeong Hill Park,PhD,Jin Hak Lee,MD 대한안과학회 2010 대한안과학회지 Vol.51 No.5

Purpose: To compare the protective effects of saponin and non-saponin Sun-ginseng extract fractions in a selenite-induced rat cataract model. Methods: A total of 101 Sprague-Dawley rat pups were divided into four groups by treatment: Sun-ginseng, saponin fraction, non-saponin fraction, and control. For induction of cataracts, sodium selenite 15 nmol/g was injected subcutaneously in 13 day-old rat pups. Sun-ginseng extract 100 μg/g (Group I, Ginseng Science, Seoul, Korea), saponin fraction 100 μg/g (Group II), non-saponin fraction 100 μg/g (Group III), and phosphate buffered saline (Control group) were injected intraperitoneally every two days for a total of seven injections. The rats were sacrified and their lenses were dissected and photographed at day 7 and 14, and the cataracts were graded according to the ratio of the cataract area to the total lens area. The blind method was used for the evaluation of the cataract area. Results: At day 14, cataract formation rates (CFR) were 33.3% in group I, 76.4% in group II, 41.2% in group III, and 77.7% in the control group. The mean cataract area (MCA) was 13.4±20.8% in group I, 14.4±11.7% in group II, 5.7±7.7% in group III, and 15.8±12.1% in the control group. Group III showed statistically significant results compared with those of control group (CFR p=0.001, MCA p=0.001). We observed significantly lower incidence and smaller mean cataract area in Group I and Group III at day 7 compared with the control group (Group I, CFR p=0.018; Group III, CFR p=0.032, MCA p=0.005). Conclusions: The protective effects of Sun-ginseng extract are caused by the components in the non-saponin fraction, not by those in the saponin fraction, in a selenite-induced cataract rat model. J Korean Ophthalmol Soc 2010;51(5):733-739

특정 염색체 부위에 위치하는 유전자 발굴 - 신경계 발달에 관련된 유전자

박선화,김창미,정혜선,전용혁,김현 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.2

현행 고등학교 중국어 교과서에 게재된 사진의 문화적 고찰

朴現圭,陳秀美,柳知惠,金善兒 한국중국문화학회 2001 中國學論叢 Vol.12 No.-

自從1992年8月, 韓中兩國建交以后, 在外交·商務·文化交流1留學·旅游等各個方面都得到了蓬勃的發展. 爲了順應這一國際潮流, 最重要駒就是語言能力. 因此, 敎育部的敎育課程也增大了對中國語敎育的關心, 事實上在高中敎育中, 將中國語選爲第二外國語的比率呈逐漸增加的縕勢. 在外國語敎育中, 作爲基本的敎材的作用不僅在外國語敎育方面, 而且還注重于對使用相應語言的國家和民族的文化進行理解. 因此, 最近爲了在中國語敎育課程中也强化有關中國文化敎育的重要性, 在敎材課文中直接載入中國文化以及韓中兩國文化之뇌較等內容, 而且在敎材中還附加照片和揷鬪資料, 幷行視覺敎育 通過這-方法, 學生在首次接觸中國語敎材時, 通過封面和封面內的照片, 以及本文中的據獨照片, 可以更加准確地把握何霜中國的形象和文化.本論文正是着眼于這-點, 選擇第雌騙驗育課程中被選定的一般高中現行中國語敎材共5冊, 以其中所登載的照片爲對象進行分析. 同時分析內容還包括, 讀些照片對于學生來說, 在了解中國文化方面如何有效地傳達知識, 在增進理解方面會起到多大作用, 幷旦對這里所存在的間題進行討論, 探求合理的改善方案. 書本是內容的充實也固然重要, 但外部的設計以及附加照片 1 揷圖等視覺效果也不容忽視, 具有同等的重要性. 一般的書籍如此, 而作爲敎材來講, 在增進學習效果方面, 這種視覺效果更重要. 本論文雖然以對現行中國語敎材中所收錄駒部分照片爲進行了分析, 但在誤計彧圖片部分也可作與沈相同約結論. 2002年敎育課程的轉換時機卽將來臨, 中國語敎材也重新進拒了改編. 希望今盾被改編的中國語敎材將對本論文中所提及的問題進行改善, 對書中的每一張照片都進行愼重的選擇, 從而可使學習中國語的學生更加准確多方面地了解中國文化. 爲了對這些間題進行改善, 筆者認爲敎育當局應該投入更多的關心, 幷在制度上予以充分的協助.

구속스트레스를 가한 흰쥐에서 Cholate류의 항스트레스작용에 관한 연구

박인,김양일,이선미,조태순 성균관대학교 약학연구소 1996 成均藥硏論文集 Vol.8 No.1

This study was done to investigate whether cholic acid derivatives have anti-stress activity and what is a cause of this anti-stress effect. Seven cholic acid derivatives (cholic acid, taurocholic acid, ursodeoxycholic acid, tauroursodeoxychoic acid, chenodeoxy cholic acid, dehydrocholic acid, hyodeoxycholic acid) were used, silymarin and valproic acid were used as positive controls. Stress was induced by restraint immobilization technique plus water immersion (24hrs) and adrenal weight, spleen weight, adrenal ascorbic acid, serum cholesterol, lactate dehydrogenase (LDH), alkaline phosphatase (ALP), adrenal cholesterol, glucose and corticosterone levels were measured as stress indicators. Most cholic acid derivatives markedly decreased the adrenal weight, and TUDCA and DHCA increased the spleen weight. The restraint stress induced increments in serum LDH, ALP and cholesterol were attenuated by most cholic acid derivatives. Cholic acid, taurocholic acid and tauroursodeoxycholic acid only increased the content of adrenal ascorbate. While valproic acid showed an inhibitory effect against stress, silymarin did not. Our findings suggest that most cholic acid derivatives have anti-stress effect and that their anti-stress effect is, in part, related to choleretic activity.

말초성 신경아세포종 : 두개골 발생 증례 보고 Involving Skull

박양화,권익승,류연석,신미경,최문배,홍승관,문명선 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.4

The peripheral neuroblastomas are malignant neoplasms that originate from the adrenal gland and sympathetic nervous tissues. They usually occur in childhood. They exhibit such malignant features that they metastasize early to lung, liver, bone, rarely skull and other structures. The patients with peripheral neuroblastoma have short duration of symptom and short survival period. They reveal the characteristic light microscopic features that resemble other small cell carcinomas. The establishment of final diagnosis of peripheral neuroblastoma needs various special stainings for small cell carcinomas, and the electron microscopic findings are the most reliable. The authers recently experienced a case of peripheral neuroblastoma in a 26-year old man which involved right frontoparietal skull vault. The only chief complaint was a local non-tender mass at right frontoparietal scalp. Neither headache nor any neurological deficits was detected. Simple skull X-ary revealed a punched out rediolucency at right frontoparietal bone and brain CT showed a superficial elliptical high density mass that enhanced strongly. The mass was totally removed by wide craniectomy. The tumor invaded and penetrated the dura but the arachnoid membrane. at the tumor bed was not invaded by the tumor. The tumor was confirmed as peripheral neuroblastoma by various special stainings for small cell carcinomas. Following surgical resection of the mass, post-operative radiotherpy was offered(4800 rads for about 5 weeks). The patient aggrevated progressively and showed numerous metastases to such bones as lumbar vertebrae, pelvis and humerus to became paraplegic. 8 months after the operation, the patient died.

카드뮴폭로후 혈액과 요중 카드뮴의 변화양상

박정덕,김미정,최병선,홍연표,장임원 大韓産業醫學會 1994 대한직업환경의학회지 Vol.6 No.2

The changes of cadmium(Cd) in plasma, whole blood, erythrocyte and urine in Sprangue-Dawley male rats exposed to intravenous singleinjection of 0.8 ㎎ CdCl₂/kg of body weight were investigated. Blood was taken at 0.5 to 672 hours, and 24 hour-urine was collected by using metabolic cage for the same period. The plasma level of Cd was reached to peak at 0.5 hour after injection and reduced rapidly in 1 hour. The Cd level in blood was the highest in plasma and the lowest in erythrocyte at 0.5 hour after injection. However, in one hour postinjection, the levels of Cd were higher in order of erythrocyte, whole blood and plasma, up to 4 weeks. The changes of urinary volume and creatinine were not significant between Cd-treated and saline-treated groups. However, urinary protein was slightly increased with time in Cd-treated group. Urinary Cd level was higher in Cd treated group than control. These results suggest that the measurement of Cd in erythrocyte and urine is valuable for the biological index to estimate recent Cd exposure.

Head-Space SPME에 의한 생체시료 중 메스암페타민류 분석(Ⅲ)

박미정,최상길,손행자,최화경,최영남,허상철,박종서,정희선 內務部 國立科學搜査硏究所 2002 國立 科學 搜査 硏究所 年報 Vol.34 No.-

高脂肪食餌에 添加한 靈芝버섯이 成年쥐의 體成分 含量에 미치는 影響

朴善子,金聖美 啓明大學校 生活科學硏究所 1990 科學論集 Vol.16 No.-

This study was designed to investigate the influence of the Ganoderma Lucidum(G.L.)on high lipid diet in adult rats. Male Sprague-Dawley rats were divided into 3 groups and fed diets containing 0.0%(control),0.5%G.L. and 2.0%G.L.powder for 33 days. The results were as follows : 1. The body weight gain and the weight of final organs were no significant difference among three groups. 2. The total cholesterol content in the liver was the highest in control group and the lowest in the G.L.2.0% group. 3. The liver total lipid content the G.L. groups was lower than that of the control group, and G.L. groups showed a significant difference.(p<0.001) 4. The total cholesterol content in the serum was the lowest in G.L.2.0% group, and highest in the control group. 5. The HDL-cholesterol content in the G.L groups was higher than that of the control group, but each group showed no difference at significance. 6. Levels of HDL-cholesterol/Total cholesterol were higher in G.L.fed groups than in the control group. 7. G.L. 2.0% group,G.L.0.5% group, and control group were the order in the serum triglyceride levels. 8. The phospholipid content in the serum was the highest in G.L. 0.5 group and each group showed a great significant difference.(p<0.01) 9. The ratio serum Total cholesterol/ phospholipid was the highest in control group and each group showed a great significant difference.(p<0.01) 10. In conclusion, the reduction of liver total lipid is affected by Hyperlipemia,when G.L.was added to high lipid diet on Adult Rats.

청소년을 위한 교육 프로그램 개발·실시 및 평가에 관한 연구

계선자,이정우,김명자,박미석,송말희,유을용,김경아,정진희 대한가정학회 2003 Human Ecology Research(HER) Vol.41 No.8

The main goal of this program is to build a healthy adolescent culture by broadening the understanding of adolescents and recognition of the environment as well through the development of educational programs centering on the domains of peer relationships, intimacy in dating relationships and sex, leisure activities, and consumption life of adolescents. The program was carried out to 10 young boys and girls for two days/one night and the major findings of the effects of the program through a qualitative evaluation were as follows: First, the program provided adolescents with a proper opportunity to promote a sense of self-confidence through the self-reevaluation process. Secondly, the program provided adolescents with a chance to firmly recognize to become good friends with others though the enhancement of self-esteem, which helped them to build a healthy peer relationship. Thirdly, adolescents were able to promote their views on sex and sexual decision-making by acquiring a proper knowledge of intimacy in dating relationships and of sex, and by candidly expressing their own opinions on sex with instructors. Fourthly, the program provided adolescents with an opportunity to look back on their leisure life with family members which had been neglected thus far and to renew their recognition of active leisure activities. Fifthly, the program provided adolescents with a chance to reflect on their unplanned consumption life and to be firmly determined to refrain from impulsive purchasing and extravagance.

OECD 주요국의 약제비 증가 억제방안 고찰

장선미,박정영,김성옥 서울대학교 보건대학원 2001 서울大學校 保健環境硏究所論叢 Vol.11 No.1

During last 30 years, most developed countries have been experienced rapid increase of pharmaceutical expenditures. In 1996, pharmaceutical expenditures represent 0.7-2.2% (Mean 1.2%) of GDP and 8-29% (Mean 15.4%) of National Health Expenditures in OECD countries. Thus most developed countries have developed and implemented various type of drug policies to contain expansion of pharmaceutical expenditures, because the pharmaceutical expenditures may be increased with growth of old population and become budgetary burden of NHS of NHI States. In this study, we introduced and reviewed various type of pharmaceutical policy of OECD countries to contain the pharmaceutical expenditure as follows. They are grouped as three different strategies by targets; physician, patient and health industry. First, we reviewed strategy to control physicians' prescribing behavior. These are 1. Budgeting constraints of prescribing (DRG, Pharmaceutical fixed budget), 2. Direct limitations of volume and expenditure, and 3. Guidelines for physicians, Benchmarking and feedback. Second, we reviewed strategy to control patient. These are 1. Co-payments and 2. Reference pricing. Third, we reviewed strategy to control Health Industry, These are 1. Price control (pricing), Reference pricing system, 2. Profit control, 3. Listing and delisting from reimbursement and 4. Fostering the use of generic drugs. The strategies to control physicians' prescribing may be effective if economic incentive or disincentive as well as information (lists or guidelines) is given to physicians. The strategies to control patients' should be accompanied with advance preparations such as considerations including health effect, equity, and quality (bio-equivalence). The impacts and considerations of these strategies which are implemented in OECD countries give us valuable lessons in developing policies to reduce pharmaceutical expenditure of Korea.