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송윤섭,김민의,이남규,박영호,전윤수,김응구 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2
Micropenis is defined as a normally formed penis with a size greater than 2 standard deviations below the mean. Twenty three patients with micropenis were managed at Soonchunhyang University Hospital from January 1988 to December 1995 We interviewed and examined them with micropenis to investigate the cause of micropenis, concomitant diseases, the efficacy of treatment and their sexual activity in postpubertal men. The patients were divided into 2 groups: 16 prepubertal and 7 postpubertal men. 9 patients had cryptorchidism, 3 of them were bilateral and 5 patients had hypospadias. Etiology was determined by hormonal assay including HCG stimulation test ; 8 as hypogonadotrophic hypogonadism, 4 as primary testicular dysfunction and 5 as idiopathic. However etiology was undetermined in 6 patients. All patients had endocrine therapy using HCG or depot testosterone. All except 4 cases responded satisfactorily. All postpubertal patients(group 2) were below the 10th percentile. Puberty was delayed in 3 patients in the older group. All patients were heterosexual and they have had erections and orgasms. Five patients have had ejaculations, 3 of them were sexually active and they have experienced vaginal penetration, Nevertheless, their sexual partners have had complaints and the patients themselves have felt ashamed and dissatisfied. Fortunately, they were mentally healthy. None of these patients were married or had a child.
건설현장 근로자들의 안저예방실태와 사고예방과의 개선요인 조사연구
심규범,남철현,최상복,이송권,이정희,이순자,문기내,김문환 慶山大學校 保健福祉硏究所 2003 保健福祉硏究 Vol.8 No.-
This study was conducted to examine aspects of health and safety education and demand level of safety education in construction job sites in order to provide direction of safety education development. The subjects of this study were 566 workers who were working in construction job sites located in Daegu City and Kyungbuk Province. Data were collected from June 1, 2002 to August 30, 2002. The results of this study can be summarized as follows. 1. According to safety education by experience methods, the proportion of education by lecture was highest (90.6%). The proportion of education by field practice was 13.1%. 2. Among the education methods which they thought as the most desirable method, the proportion of audio-visual education was 39.4% and the proportion of education by experience was 37.5%. Those who had more monthly income and higher education level preferred audio-visual education, while those who were younger and less educated preferred education by experience. 3. In the case of the contents of the safety education which they thought as the most important one, the proportion of enhancement of safety awareness and education of risk factors was highest (24.7%). The groups of older workers, having longer working period, and belonging to higher education level preferred these contents. 4. According to the factors which were most important to increase effectiveness of the safety education were workers' voluntary participation (27.7%), 40 to 49 years old (27.7%), and monthly income of one million, five hundred thousand won to one million, nine hundred ninety thousand won (32.0%). The proportions of lower educated workers and working as daily workers were also high. 5. The variable which most influenced the safety education was age. The safety awareness of construction job sites was the second highest influential variable. From above results, it is clear that the workers' participation in the safety education was low since most of the safety educations were formal education by lecture. Although they participated in the education, the education was also not effective because they compulsorily participated in it. Therefore, it can be concluded that effective alternative policies must be formulated.
송관규(Gwan Gyu Song),정문기(Moon Gi Chung),권오상(Oh Sang Kwon),박창규(Chang Gyu Park),백세현(Sei Hyun Baik),서홍석(Hong Seog Seo),오동주(Dong Joo Oh),이창홍(Chang Hong Lee),원남희(Nam Hee Won) 대한내과학회 1995 대한내과학회지 Vol.48 No.5
N/A Temporal arteritis is an inflammatory disease of the elastic artery with unknown etiology. It usually affects patients over the age of 50, and is often associated with polymyalgia rheumatica. We have experienced a 66-year-old female patient with temporal arteritis who presented as a new onset headache and temporal artery abnormalities. Temporal artery biopsy was performed, which showed typical findings of temporal arteritis. To our knowledge, this is the first case of temporal arteritis in Korea. We hereby report a case of temporal arteritis with a brief review of literature.
소화기 ; 경기서부 단일기관에서 최근 11년간의 헬리코박터 파일로리 제균율 변화
송종규 ( Jong Gyu Song ),이상우 ( Sang Woo Lee ),박진용 ( Jin Yong Park ),남승주 ( Seung Joo Nam ),김승영 ( Seung Young Kim ),안재홍 ( Jae Hong Ahn ),김진남 ( Jin Nam Kim ),박선민 ( Seon Min Park ),김정한 ( Jeong Han Kim ),김동일 대한내과학회 2009 대한내과학회지 Vol.76 No.3
목적: 우리 나라 H. pylori 제균 요법의 1차 제균 치료제인 proton pump inhibitor와 amoxicillin, clarithromycin을 병합 하는 삼제 요법은 초창기에는 90% 이상의 제균율을 보이는 유용한 치료법이었으나, 이후 연구 결과들은 제균율이 이에 미치지 못하는 결과를 보였다. 이에 대해 최근 11년간의 H. pylori가 증명된 환자들을 대상으로 1차 및 2차 치료의 제균율 변화 추이 그리고 제균 치료에 영향을 주는 요인들을 분석하고자 하였다. 방법: 고려대학교 안산병원에서 1997년 1월부터 2007년 12월까지 상부위장관 내시경검사를 통해 H. pylori 감염이 확인된 후 1차 삼제 요법으로 제균 치료를 시행받은 환자를 대상으로 후향 연구를 하였다. 추적이 가능하였던 환자들은 치료 종료 2주 이내에 치료 순응도와 부작용 발생 여부에 대한 질문에 답하였고, 치료 종료 후 최소 4주 이상 경과한 후 상부위장관 내시경검사를 통한 조직검사 및 신속요소분해효소검사 또는 13C-요소호기검사를 시행하여 제균 여부를 평가하였다. 결과: 1997년부터 2007년까지 1차 삼제요법의 제균율은 유의한 감소추세를 보였다. 2차 치료로 사용된 4제 요법(PPI 포함 bismuth, metronidazole, tetracycline)은 유의한 감소를 보이지 않았다. 1주 치료와 2주 치료간의 제균 성공률이나 재활성화율은 차이가 없었고, 내시경으로 진단된 병변의 종류에 따른 제균율의 차이 또한 관찰되지 않았다. 결론: H. pylori의 1차 치료 권고안인 삼제요법은 장기간 관찰한 결과 점차 제균율이 감소하는 추세를 보였다. 이러한 추세로 볼 때, 결국에는 삼제요법을 근간으로 하는 1차 치료 권고안의 변화가 필요한 시점이 발생할 것이다. 이를 위하여, 전국 규모의 제균율 데이터 확보 및 향후 제균율의 변화를 지속적으로 추적관찰할 필요가 있을 것이다. Background/Aims: The standard triple therapy used as the first-line treatment for Helicobacter pylori that combines a proton pump inhibitor (PPI), amoxicillin, and clarithromycin had an initial eradication rate of 90%. However, many recent studies have not found this level of effectiveness. This study evaluated the trend in the eradication rates of H. pylori infection over the last 11 years. Methods: This was a retrospective study of patients diagnosed with H. pylori infection between 1997 and 2007 and treated with triple therapy (PPI, amoxicillin, and clarithromycin). The patients answered questions about compliance and side effects within 2 weeks of completing their treatment. In addition, we assessed whether the H. pylori had been eradicated at least 4 weeks after the treatment using a 13C-urea breath test, rapid urease test, or histopathological examination. Results: The eradication rate with first-line triple therapy decreased over the study period. There was no change in the eradication rate with second-line quadruple therapy (PPI, bismuth, metronidazole, and tetracycline). There were no differences in the eradication rate and recrudescence between 1- and 2-week regimens. Conclusions: The effectiveness of the recommended first-line triple therapy for H. pylori eradication has decreased significantly in the last decade. Therefore, the first-line therapy based on the combination of PPI, amoxicillin and clarithromycin may need to be changed in the near future. (Korean J Med 76:303-310, 2009)
규칙적인 유산소성 운동이 여성 고령자의 혈압, 혈중지질 및 혈중철분지표에 미치는 영향
김용규 ( Kim Yong Gyu ),김남수 ( Kim Nam Su ),송종국 ( Song Jong Gug ) 한국운동영양학회 2003 Physical Activity and Nutrition (Phys Act Nutr) Vol.7 No.3
The purpose of the study was to evaluate the effect of long term aerobic exercise on blood pressure, blood lipids and hematological parameters in elderly women. Subjects included twenty elderly women over 65 years old. They were selected from the elderly welfare house located at Sung-nam City. The subjects were subdivided into two groups including exercise group (n=10), and control group (m=10). They were all living in Sung-nam City and regularly go to the elderly welfare house. Anthropometric measurements included body weigh, and height. Blood pressure was measured at the onset and phase Ⅳ of the Korotkoff sounds. After an overnight fast of at least 12 hours blood samples of 10㎖ were drawn from antecubital veins. Serum was then separated for detenmination of total cholesterol, triglycerides, high density lipoprotein cholesterol and low density lipoprotein cholesterol. Hemoglobin, hematocrit, red blood cell, Hemoglobin, hematocrit, red blood cell, mean corpuscular volume, mean corpuscular hemoglobin concentration, and mean corpuscuar hemoglobin were analyzed by automated instrumentation (ADVIA 120. Bayer. USA). Serum iron and total iron binding capacity were datermined by auto-analyzer (HITACHI 7150, Tokyo, Japan) and transfemin saturation was calculated by dividing serum iron concentration by TIBC. The supervised exercise training program was conducted for 16 weeks with 3 days per week, 60 min for each session throughout the entire period of study. The exercise training program included 5-min warm-up for calisthenics and stretching, 50 min for aerobic dancing or ground walking and 5-min for cool-down. The results of the study showed that body weight were significantly increased in control group during the period of study. Systolic and diastolic blood pressure were significantly decreased (p<0.05) for exercise group after 16 weeks of aerobic exercise. Although no difference were found for total cholesterol and triglyceride in exercise group, there were significant increase (p<0.05) for those variables in control group. Significant increase could be observed for RBC in exercising group. Howeverm significant decrease (p<0.01) was found for MCV and MCH in exercise group after 16 weeks of aerobic exercise. This study indicates that long term aerobic exercise has a positive effect on blood pressure and blood lipids.
The Serine Proteinase Inhibitor OsSerpin Is a Potent Tillering Regulator in Rice
( Song Yion Yeu ),( Bong Soo Park ),( Wan Gyu Sang ),( Yang Do Choi ),( Min Chul Kim ),( Jong Tae Song ),( Nam Chon Paek ),( Hee Jong Koh ),( Hak Soo Seo ) 한국식물학회 2007 Journal of Plant Biology Vol.50 No.5
Tillering in rice (Oryza sativa L.) is an important agronomic trait that enhances grain production. A tiller is a specialized grainbearing branch that is formed on a non-elongated basal internode that grows independently of the mother stem. Transgenic rice over-expressing the transcription factor OsTB1, a homologue of maize TB1 (Teosinte Branched 1), exhibits markedly reduced lateral branching without the propagation of axillary buds being affected. However, the tillering mechanism remains unknown. Therefore, to further understand that mechanism, we applied proteomics methodology to isolate the proteins involved. Using two-dimensional gel electrophoresis and mass spectrometry, our analysis of the basal nodes from two rice cultivars that differ in their numbers of tillers showed that a rice serine proteinase inhibitor, OsSerpin, accumulates in great amounts in high-tillering ``Hwachung`` rice. Northern blot analysis revealed that much more OsSerpin transcript is found in ``Hwachung`` than in relatively low-tillering ``Hanmaeum``, likely because of high levels of transcription. Therefore, our data suggest that OsSerpin content determines the extent of lateral branching.