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( Sang Cheol Bae ),( Jinseok Kim ),( Jung Yoon Choe ),( Won Park ),( So Ra Lee ),( Yong Ho Ahn ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Etanercept is a recombinant fusion protein that blocks TNF. HD203 is a biosimilar of etanercept with demonstrated comparability across pharmacokinetics, safety and tolerability. The objectives of this study were to evaluate equivalence in effi cacy and compare safety of HD203 with reference etanercept, in combination with MTX in patients with RA. (ClinicalTrials. gov NCT01270997). Methods: Korean patients (male or female aged =20 years) with active RA were randomized (1:1) to 25 mg HD203 or reference etanercept, administered subcutaneously twice weekly with MTX for 48 weeks. The primary endpoint was the proportion of patients achieving ACR20 at week 24. Secondary endpoints included ACRn, DAS28, andEULAR response at week 24 and 48, safety and immunogenicity. Results: In total, 294 patients were randomized: HD203, n=147; reference etanercept, n=147. The proportion of patients achieving ACR20 at week 24 was not signifi cantly different between HD203 and reference etanercept. Equivalent effi cacy was demonstrated within predefined margins. There were no significant differences between proportions achieving ACR20 at week 12 and 48. ACR50 and ACR70 displayed similar trends. There were no signifi cant differences between groups for ACRn, DAS28, and EULAR response. Safety set analysis (HD203, n=147; reference etanercept, n=146) revealed no signifi cant difference for treatment-emergent (all-causality) adverse events (AEs): HD203 76. 87% vs. reference etanercept 78. 08% (p=0. 8040). No significant differences between HD203 and reference etanercept were observed for adverse drug reactions, serious AEs, or discontinuations due to AEs. Few patients tested positive for anti-drug antibodies. Conclusions: The study met the primary endpoint of demonstrating equivalent effi cacy of HD203 compared to reference etanercept. HD203 was well tolerated, with a safety profi le comparable to reference etanercept in this population of patients with RA.
So‑Ra Han,Sung‑Min Jang,Young Min Chi,Byeollee Kim,정상희,Yung Mi Lee,Jun Uetake,Jun Hyuck Lee,Hyun Park,오태진 한국유전학회 2020 Genes & Genomics Vol.42 No.9
Background Spingobium sp. PAMC 28499 is isolated from the glaciers of Uganda. Uganda is a unique region where hot areas and glaciers coexist, with a variety of living creatures surviving, but the survey on them is very poor. The genetic character and complete genome information of Sphingobium strains help with environmental studies and the development of better to enzyme industry. Objective In this study, complete genome sequence of Spingobium sp. PAMC 28499 and comparative analysis of Spingobium species strains isolated from variety of the region. Methods Genome sequencingwas performed using PacBio sequel single-molecule real-time (SMRT) sequencing technology. The predicted gene sequences were functionally annotated and gene prediction was carried out using the program NCBI nonredundant database. And using dbCAN2 and KEGG data base were degradation pathway predicted and protein prediction about carbohydrate active enzymes (CAZymes). Results The genome sequence has 64.5% GC content, 4432 coding protein coding genes, 61 tRNAs, and 12 rRNA operons. Its genome encodes a simple set of metabolic pathways relevant to pectin and its predicted degradation protein an unusual distribution of CAZymes with extracellular esterases and pectate lyases. CAZyme annotation analyses revealed 165 genes related to carbohydrate active, and especially we have found GH1, GH2, GH3, GH38, GH35, GH51, GH51, GH53, GH106, GH146, CE12, PL1 and PL11 such as known pectin degradation genes from Sphingobium yanoikuiae. These results confrmed that this Sphingobium sp. strain PAMC 28499 have similar patterns to RG I pectin-degrading pathway. Conclusion In this study, isolated and sequenced the complete genome of Spingobium sp. PAMC 28499. Also, this strain has comparative genome analysis. Through the complete genome we can predict how this strain can store and produce energy in extreme environment. It can also provide bioengineered data by fnding new genes that degradation the pectin
Bae, Sang-Cheol,Kim, Jinseok,Choe, Jung-Yoon,Park, Won,Lee, Sang-Heon,Park, Yong-Beom,Shim, Seung-Cheol,Lee, Shin-Seok,Sung, Yoon-Kyoung,Choi, Chan-Bum,Lee, So-Ra,Park, HanYu,Ahn, Yongho H. K. Lewis 2017 Annals of the rheumatic diseases Vol.76 No.1
<P>Conclusion The study met the primary objective of demonstrating equivalent efficacy of HD203 and ETN. HD203 was well tolerated, with safety comparable with ETN in this population of patients with RA.</P>
Reciprocal Lattice Explorer의 原理와 使用法
徐日煥,李珍昊,秋錦洪,林星秀,柳保盈,朴晶蘭,金文執,趙素羅,金憲俊,李正秀,成百石 충남대학교 자연과학연구소 1993 忠南科學硏究誌 Vol.20 No.2
Reciprocal lattice explorer는 de Jong-Bouman camera와 Buerger precession camera를 合친것이다. 이 explorer를 使用하면 goniometer에 한번 固定한 試料를 使用하여 그 試料의 空間群을 決定하는데 必要한 모든 寫眞을 撮影할 수 있으며 그들은 찌그러지지 않은 逆格子面의 寫眞들이다. 本 論文에서는 de Jong-Bouman 과 Buerger precession 寫眞術의 原理와 使用法을 記述 하였고 또한 de Jong-Bouman의 振動寫眞과 zeroth layer 寫眞으로부터 11個 Laue群의 識別方法도 提示하였다. The reciprocal lattice explorer is an instrument which incorporates the principles of both the Buerger precession and the de Jong-Bouman methods. On the explorer all photographs which are necessary for a space group determination can be taken with a single setting of a crystal and the photographs show undistorted pictures of the reciprocal lattice planes. In this paper, the principles and the usages of the de Jong-Bouman and the Buerger precession photography are described, and a method of 11 Laue group identification using the de Jong-Bouman oscillation and zeroth layer photographs is shown.
點郡 3㎖(H) 의 振動寫眞 및 Weissenberg寫眞에서의 特性
이진호,류보영,조소라,김문집,추금홍,서일환,임성수 순천향대학교 1993 논문집 Vol.16 No.3
Crtstallographic cell constants of point group ?? are a =b≠c, α=β=90。, and γ=120。. There are mirror plane symmetries in oscillation photography taken at a-axis and b-axis, but no plane symmetry at c-axis. Since Weissenberg zeroth layer taken at a- and b-axis obeys Friend's law, half of the photography shows non-symmetric unit of diffraction intensity. There are 6 mirror planes in the Weissenberg zeroth layer when the photography was taken at c-axis, therefore 1/12 of the unit cell is non-symmetric unit.
Weissenberg 寫眞 技法에 의한 酸化마그네슘(MgO)의 結晶構造
이진호,류보영,조소라,김문집,추금홍,서일환,임성수 순천향대학교 1993 논문집 Vol.16 No.3
The structure of MgO crystal is faced centered cubic(FCC) with cell parameters of a=b=c=4.21Å, α=β=γ=90。. The ionic bond length between Mg and O atoms is 2.1Å. This crystal belongs to m3m point group and to Fm3m space group.
김민경,이인환,신애숙,김나희,김혜미,심소라,나병조,조승연,박성욱,정우상,문상관,박정미,고창남,조기호,김영석,배형섭,Kim, Min-kyung,Lee, ln-whan,Shin, Ae-sook,Kim, Na-hee,Kim, Hye-mi,Shim, So-ra,Na, Byung-Jo,Cho, Seung-yeon,Park, Seong-uk,Jung, Woo Sang 대한중풍순환신경학회 2010 대한중풍.순환신경학회지 Vol.11 No.1
Object : This study was conducted as part of the national project to standardize stroke diagnosis in Korean medicine. In this study, we aimed to evaluate the characteristics of acute stroke between heat pattern group and cold pattern group. Methods : We recruited stroke patients from 5 universities(Kyung-Hee University oriental medical center, Kyung-Hee University East-West Neo medical center, Kyungwon university lncheon oriental medical center, Kyungwon university Songpa oriental medical center and DongGuk university llsan oriental medical center) from April, 2007 until February, 2010. We diagnosed them and selected 463 heat pattern patients and 182 cold pattern patients. Results : We find that the risk factor of smoking, alcohol, diet(prefer to meat) are more associated with the heat pattern group. On the other hand, inflammation history in recent 3 months and diet(prefer to sea food) are more associated with the cold pattern group. RBC, Hg, Hct, TG, CK and Cl are more related to the heat pattern group. CPT, total cholesterol and HDL are more related to the cold pattern group. Tae-eum type takes high distribution of the heat pattern group, and So-eum type takes high distribution of the cold pattern group. Conclusions : This study provides evidence that the heat pattern group have more risk factor than the cold pattern group.
( Sang-hyeok Cho ),( Yujin Jeong ),( Eunju Lee ),( So-ra Ko ),( Chi-yong Ahn ),( Hee-mock Oh ),( Byung-kwan Cho ),( Suhyung Cho ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.4
Erythrobacter species are extensively studied marine bacteria that produce various carotenoids. Due to their photoheterotrophic ability, it has been suggested that they play a crucial role in marine ecosystems. It is essential to identify the genome sequence and the genes of the species to predict their role in the marine ecosystem. In this study, we report the complete genome sequence of the marine bacterium Erythrobacter sp. 3-20A1M. The genome size was 3.1 Mbp and its GC content was 64.8%. In total, 2998 genetic features were annotated, of which 2882 were annotated as functional coding genes. Using the genetic information of Erythrobacter sp. 3-20A1M, we performed pangenome analysis with other Erythrobacter species. This revealed highly conserved secondary metabolite biosynthesis-related COG functions across Erythrobacter species. Through subsequent secondary metabolite biosynthetic gene cluster prediction and KEGG analysis, the carotenoid biosynthetic pathway was proven conserved in all Erythrobacter species, except for the spheroidene and spirilloxanthin pathways, which are only found in photosynthetic Erythrobacter species. The presence of virulence genes, especially the plant-algae cell wall degrading genes, revealed that Erythrobacter sp. 3-20A1M is a potential marine plant-algae scavenger.
( Sang-hyeok Cho ),( Eunju Lee ),( So-ra Ko ),( Sangrak Jin ),( Yoseb Song ),( Chi-yong Ahn ),( Hee-mock Oh ),( Byung-kwan Cho ),( Suhyung Cho ) 한국미생물 · 생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.4
The symbiotic nature of the relationship between algae and marine bacteria is well-studied among the complex microbial interactions. The mutual profit between algae and bacteria occurs via nutrient and vitamin exchange. It is necessary to analyze the genome sequence of a bacterium to predict its symbiotic relationships. In this study, the genome of a marine bacterium, Pseudoruegeria sp. M32A2M, isolated from the south-eastern isles (GeoJe-Do) of South Korea, was sequenced and analyzed. A draft genome (91 scaffolds) of 5.5 Mb with a DNA G+C content of 62.4% was obtained. In total, 5,101 features were identified from gene annotation, and 4,927 genes were assigned to functional proteins. We also identified transcription core proteins, RNA polymerase subunits, and sigma factors. In addition, full flagella-related gene clusters involving the flagellar body, motor, regulator, and other accessory compartments were detected even though the genus Pseudoruegeria is known to comprise non-motile bacteria. Examination of annotated KEGG pathways revealed that Pseudoruegeria sp. M32A2M has the metabolic pathways for all seven vitamin Bs, including thiamin (vitamin B1), biotin (vitamin B7), and cobalamin (vitamin B12), which are necessary for symbiosis with vitamin B auxotroph algae. We also identified gene clusters for seven secondary metabolites including ectoine, homoserine lactone, beta-lactone, terpene, lasso peptide, bacteriocin, and nonribosomal proteins.
Experience with TVT-O for the Surgical Treatment of Female Stress Urinary Incontinence
( So Ra Kim ),( Gun Ho Jeon ),( Dae Yeon Kim ),( Sung Hoon Kim ),( Hee Dong Chae ),( Jong Hyeok Kim ),( Chung Hoon Kim ),( Yong Man Kim ),( Young Tak Kim ),( Byung Moon Kang ),( Joo Hyun Nam ) 대한산부인과학회 2009 Journal of Womens Medicine Vol.2 No.1
Objective: We evaluated the clinical efficacy and safety of inside-out transobturator vaginal tape (TVT-O) for the surgical treatment of female stress urinary incontinence. Methods: We analyzed the medical records of 239 women with stress urinary incontinence and who were treated with TVT-O between March 2004 and July 2007. We retrospectively investigated the patient characteristics, the operative time, the number of hospital days, the efficacy, and the complication rate by conducting a 1 year follow-up survey. Results: One hundred eighty-three patients were included in the study. The mean age was 55.7 years (range, 31~74 years) and the mean operative time was 20.1 minutes (range, 12~40 minutes). Of the 76 patients who underwent TVT-O only, 94 patients were discharged the same day of surgery and the mean hospital stay was 0.4 days (range, 0~4.0 days). Of the 183 patients who were followed for 1 year, 162 (88.7%) were assessed as completely dry, 15 (8.2%) showed improvement, and 4 (2.2%) were deemed to have failed. There were no intra-operative bladder, urethral, or bowel injuries; 32 cases (17.5%) showed complications of surgery during the 1 year follow-up period. Thirteen (7.1%) cases were shown to have de novo urgency, 5 (2.7%) cases had urinary retention, 6 (3.3%) cases had vaginal erosions, and 8 (4.4%) cases had wound hematomas and lower extremity discomfort. Conclusion: Our experience showed that TVT-O is an effective and safe procedure for the surgical treatment of female stress urinary incontinence.