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Jianyin Xie,Fengmei Li,Najeeb Ullah Khan,Xiaoyang Zhu,Xueqiang Wang,Zhifang Zhang,Xiaoqian Ma,Yan Zhao,Quan Zhang,Shuyang Zhang,Zhanying Zhang,Jinjie Li,Zichao Li,Hongliang Zhang 한국유전학회 2019 Genes & Genomics Vol.41 No.3
Introduction As one of the main yield components, grain number per panicle (GNP) played critical role in the rice yield improvement. The identification of natural advantageous variations under different situations will promote the sustainable genetic improvement in rice yield. Objectives This study was designed to identify natural genotypes in a rice mini-core collection, to examine the genotypic effects across the indica and japonica genetic background in different environments, and excavating the superior genotypes that had drove the modern genetic improvement. Methods The association mapping of GNP was carried out using a mini-core collection including 154 indica and 119 japonica accessions in seven different environments. Genotypic effects of each genotype for each QTL were calculated and genotype frequency distortion between the commercial rice cultivars and landraces was screened by χ2-test. Results In total, 74 QTLs containing stable and sensitive QTLs in various environments were detected. Within them, 20 positive and 24 negative genotypes in indica, and 24 positive and 16 negative genotypes in japonica were identified. When checking the accumulation of positive genotypes identified in indica across cultivars in each of the two subspecies, it indicated that increased number of positive genotypes identified in indica results in the substantially increased GNP in both indica and japonica across all of the environments, while this trend was not obvious for the positive genotypes identified in japonica especially in short day environments. Moreover, the positive and negative genotype frequency distortion between the landraces and commercial rice cultivars indicated that both positive selection of positive genotypes and negative selection of negative genotypes had driven the genetic improvement on GNP. Conclusion Our findings suggested that the accumulation of positive genotypes and purifying negative genotypes played equivalently important roles in the improvement of rice yield, but the efficient use for some QTLs or genotypes depends on the comprehensive evaluation of their effect under diverse genetic backgrounds and environments.
Numerical study of wind profiles over simplified water waves
Shuyang Cao,Enzhen Zhang,Liming Sun,Jinxin Cao 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.21 No.3
Vertical profiles of mean and fluctuating wind velocities over water waves were studied, by performing Large-Eddy Simulations (LES) on a fully developed turbulent boundary layer over simplified water waves. The water waves were simplified to two-dimensional, periodic and non-evolving. Different wave steepness defined by a /λ ( a : wave amplitude; λ : wavelength) and wave age defined by c/Ub (c: phase velocity of the wave; Ub : bulk velocity of the air) were considered, in order to elaborate the characteristics of mean and fluctuating wind profiles. Results shows that, compared to a static wave, a moving wave plays a lesser aerodynamic role as roughness as it moves downstream slower or a little faster than air, and plays more aerodynamic roles when it moves downstream much faster than air or moves in the opposite direction to air. The changes of gradient height, power law index, roughness length and friction velocity with wave age and wave amplitude are presented, which shed light on the wind characteristics over real sea surfaces for wind engineering applications.
Numerical study of wind profiles over simplified water waves
Cao, Shuyang,Zhang, Enzhen,Sun, Liming,Cao, Jinxin Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.21 No.3
Vertical profiles of mean and fluctuating wind velocities over water waves were studied, by performing Large-Eddy Simulations (LES) on a fully developed turbulent boundary layer over simplified water waves. The water waves were simplified to two-dimensional, periodic and non-evolving. Different wave steepness defined by $a/{\lambda}$ (a : wave amplitude; ${\lambda}$ : wavelength) and wave age defined by $c/U_b$ (c: phase velocity of the wave; $U_b$ : bulk velocity of the air) were considered, in order to elaborate the characteristics of mean and fluctuating wind profiles. Results shows that, compared to a static wave, a moving wave plays a lesser aerodynamic role as roughness as it moves downstream slower or a little faster than air, and plays more aerodynamic roles when it moves downstream much faster than air or moves in the opposite direction to air. The changes of gradient height, power law index, roughness length and friction velocity with wave age and wave amplitude are presented, which shed light on the wind characteristics over real sea surfaces for wind engineering applications.
Panpan Duan,Qingbo Xu,Shuyang Shen,Yanyan Zhang,Lei Zhang,Feiya Fu,Xiangdong Liu 한국섬유공학회 2019 Fibers and polymers Vol.20 No.9
We presented a one-pot approach for fabrication of antibacterial cotton fabric using an emulsion of silvernanoparticles (Ag NPs) protected by mercaptosuccinic acid (MSA). The emulsion was used to finish cotton fabrics via a paddry-cure process, making the MSA molecules covalently linked to the cotton fibers by ester linkages with the hydroxylgroups of cellulose. The coordination bonds between the MSA molecules and the Ag NPs provide stable and durable effecton the immobilization of the Ag NPs on the cotton fabric, endowing its antibacterial function with an outstanding launderingdurability. Even experienced 50 consecutive laundering tests, the modified cotton fabric exhibits satisfactory bacterialreduction rates against both Staphylococcus aureus and Escherichia coli. This paper provides a simple fabricationmethodology to mitigate the safety risk and environmental impact that are typically found in the antimicrobial cotton textilesbased on Ag NPs.
Ting Liu,Qing Li,Zhen Lin,Chunhua Liu,Wei Pu,Shasha Zeng,Jun Lai,Xuebin Cai,Lisha Zhang,Shuyang Wang,Miao Chen,Wei Cao,Hongfeng Gou,Qing Zhu 대한암학회 2024 Cancer Research and Treatment Vol.56 No.2
Purpose Patients with advanced biliary tract cancer (BTC) have a poor survival. We aim to evaluate the efficacy and safety of nab-paclitaxel plus gemcitabine and cisplatin regimen in Chinese advanced BTC patients.Materials and Methods Eligible patients with locally advanced or metastatic BTC administrated intravenous 100 mg/m<sup>2</sup> nab-paclitaxel, 800 mg/m<sup>2</sup> gemcitabine, and 25 mg/m<sup>2</sup> cisplatin every 3 weeks. The primary endpoint was progression-free survival (PFS). The secondary endpoints included overall survival (OS) and adverse events, while exploratory endpoint was the association of biomarkers with efficacy.Results After the median follow-up of 25.0 months, the median PFS and OS of 34 enrolled patients were 7.1 months (95% confidence interval [CI], 5.4 to 13.7) and 16.4 months (95% CI, 10.9 to 23.6), respectively. The most common treatment-related adverse events at ≥ 3 grade were neutropenia (26.5%) and leukopenia (26.5%). Survival analyses demonstrated that carcinoembryonic antigen (CEA) levels could monitor patients’ survival outcomes. A significant increase in the number of infiltrating CD4+ cells (p=0.008) and a decrease in programmed death-1–positive (PD-1+) cells (p=0.032) were observed in the response patients.Conclusion In advanced BTC patients, nab-paclitaxel plus gemcitabine and cisplatin regimen showed therapeutic potential. Potential prognostic factors of CEA levels, number of CD4+ cells and PD-1+ cells may help us maximize the efficacy benefit.