재발성 비호즈킨림프종에서 말초혈액조혈모세포이식의 결과

한성민,최신,유영진,김성록,한태희 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Objective: This study is aimed to assess the effectiveness and safety of the autologous stem cell transplantation for patients with relapsed aggressive non-Hodgkin's lymphoma(NHL). Methods and Materials: We performed a retrospective analysis of 4 patients with relapsed aggressive NHL who undergone the autologous stem cell transplantation from the Inje University Sanggyepaik hospital. Results: All three patients with diffuse large B cell NHL have been in disease-free status without evidence of relapse for 5∼13 months after transplantation. A patient with extranodal NK/T cell lymphoma expired due to treatment related complications. Conclusion: High dose chemotherapy with autologous peripheral blood stem cell trar splantation(PBSCT) is an effective treatment for relapsed diffuse large B cell lymphoma.

들기 작업시 손잡이의 영향에 관한 연구

장성록,배동철 한국안전학회 2003 한국안전학회지 Vol.18 No.2

Despite rapid technological advance and increased automation facilities, many jobs and activities in our living require manual materials handling(MMH). These include wide variety of activities such as moving things, lifting bags, boxes or cartons, etc. Many studies found that handle could affect on maximum acceptable weight of lifting, but there were few studies for the effects of work posture and coupling in lifting tote box. This study performed that ten male college students were required to lift a tote box with and without handle for three postures (bending, straight, right angle posture). From the experiment, following results were obtained. (1) MVC reduced maximum 23% by type of handle. (2) MVC was highest in straight posture, but was lowest in right angle posture. (3) As a result of ANOVA, MVC paid attention to posture and coupling. (p<0.01) (4) To all handle types. biceps brachii activity was increased in right angle posture, but reduced in straight posture. (5) To all posture, biceps brachii activity was most lively in no handle. The results of MVC measurement, subjective rating. EMG analysis, statistic analysis showed that maximum acceptable weight of lifting was influenced by type of handle and straight posture was more comfortable than other postures. Based on these results. it was concluded that acceptable weight of lifting has to differ for work posture and coupling.

인적오류에 의한 항공사고 분석

장성록,황진태,배동철 釜慶大學校 2001 釜慶大學校 論文集 Vol.6 No.-

This study aimed to investigate the human-related causes of aircraft accidents and present the basic data for developing human-error prevention program. Peterson's model of accident causation and Cooper's model of safety culture were applied to analyze the severe causes of aircraft accidents for last 10 years. For analyzing the causes of aircraft accidents, expert's opinion method was adopted. The analyses showed that the overload and decision error were major causes of aircraft accidents. The causes and backgrounds of human error were found with respect to human, tasks, organization.

두경부 종양세포주에 대한 Mithramycin A의 세포자멸사 유도성 및Cisplatin 항암작용 증가효과

이강대,손성환,박종욱,김영록,이봉주,김주연 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.1

Background and Objectives : Cisplatin (CP) is a major chemotherapeutic agent for head and neck cancer. However, cancer cells can get drug resistance through recovering the DNA damage by CP. Mithramycin A (MA) can inhibit gene expression of multidrug resistance gene 1, c-myc or h-ras. The goal of this study is to evaluate the therapeutic effect of MA alone and combination of MA and CP on head and neck cancer cell lines. Materials and Methods : Two head and neck cancer cell lines (AMC-HN4, AMC-HN7) were treated with MA. The cellular proliferation, apoptosis and protein expression were measured with XTT assay, FACS analysis, and western blotting, respectively after MA treatment in cell lines. In order to know the combination effect of MA with CP, the cancer cell lines were treated with MA, CP, and MA/CP combination, and cellular proliferation, apoptosis and expression of apoptosis-associated proteins were measured. Results : MA inhibited the proliferation of head and neck cancer cells and induce dapoptosis. Increase of caspase activation, PLC-?1 fragmentation and percent apoptosis by MA treatment was blocked by z-VAD-fms, but not blocked by N-Acetyl Cystein. Combination of MA and CP significantly inhibited cancer cell growth and increased apoptosis compared to MA and CP alone, and it also suppressed the expression of anti-apoptotic proteins such as XIAP and Mcl-1. Conclusions : The present study suggests that MA alone andMA/CP combination chemotherapy could be a potential regiment for the control of the head and neck cancer.

건설현장 화재예방에 관한 연구 : 용접작업을 중심으로

목연수,장성록,이영섭,고성석 한국산업안전학회 2002 한국안전학회지 Vol.17 No.2

Current fire safety in the construction sites has developed piecemeal over a considerable period of time. However, the law and regulation of fire safety is insufficient to protect fire in the construction sites. The frequency of fire in the construction sites is very rare but it brings longterm deterioration durability of building structure and large scale industrial calamity. There are many process of works and each work deals with many kind of flammable material, so it is very difficult find a proper safety fire prevention. This study executed the questionnaire and fire experiment of the welding work to provide effective fire prevention counterplan.

Prazosin의 항고혈압 효과에 대한 임상적 관찰

서세웅,이균태,김연호,조성락,신영우,신영기 최신의학사 1984 最新醫學 Vol.27 No.8

A Case Study of Ergonomic Evaluation for the Control Rooms of a Petroleum Complex

Seong Rok Chang,Hoon-Yong Yoon,Hong-In Cheng 대한인간공학회 2017 大韓人間工學會誌 Vol.36 No.1

Objective: Two control rooms of a petroleum complex were ergonomically evaluated for this study using diverse drawings of the rooms. The objective of the study is to show the evaluation process and its results, assessment method and essential elements for drawing-based ergonomic evaluation. Background: Ergonomics can enhance the working environment and safety for a control room when implemented effectively. A control room design was examined by ergonomists based on ergonomic principles and well-practiced standards. This study was conducted because a construction consortium wanted to perform an ergonomic evaluation of the control rooms before the construction. Method: A simple evaluation process, composed with a pre-evaluation, an evaluation and a post-evaluation, was employed to carry out the study. ISO 11064, NUREG- 700, NUREG/CR-6150, and CRIOP were reviewed to evaluate the control rooms. The assessment ranges over the control room layout, workstations, display and control, environmental requirements and safety. Three ergonomists participated in the study and performed the evaluation for two months. Results: An experienced consortium of construction companies designed the petroleum complex and control rooms. No significant ergonomic design problems were detected. Quantitative recommendations were provided for the layout and workstation dimensions. Specific design directions were also proposed for environmental requirements and safety. Conclusion and Application: Design advice and minor potential problems were reported as results of the drawing-based ergonomic evaluation. More practical suggestions could be additionally provided if an on-site assessment was conducted. However, the ergonomic evaluation used in this study could be helpful and applied to designing and evaluating other various control rooms prior to their construction.

A Review on the Application of Nanotechnology in Food Processing and Packaging

Seong-In Cho,Yong-Rok Kim,Joon Woo Lee,Dae-Sup So,Yong-Jin Cho,Hyun Kwon Suh,Tu San Park,Seoung-Im Oh,Ji-Eun Im 한국산업식품공학회 2010 산업 식품공학 Vol.14 No.4

Currently, nanotechnology is widely applied in various industrial fields and is rapidly emerging as a promising future technology. In food industries, nanotechnology is used to enhance food quality and safety. Numerous cutting-edge studies on the advantages of nanotechnology have been conducted in the fields of food processing, food ingredients and additives, food packaging, and food engineering for optimal health. The market for these areas of research has grown steadily, and is expected to continue to do so. Because of this, R&D for nanotechnology that can be used effectively in food industries is being performed by several companies, as well as in academic research institutions around the world. This review describes the recent global R&D trends that have been in progress for two key areas: food processing and food packaging.

Inhibitory Effects of Lactic Acid Bacteria with High Alcohol Dehydrogenase and Acetaldehyde Dehydrogenase Activity on Triglyceride Accumulation in HepG2 Cell

Seong Rok Sim,Hyun Joon Park,Won Jun Kim,Chul Sung Huh 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Alcoholic liver disease (ALD) is one of the most prevalent liver diseases globally. The disease can be caused by alcohol abuse and the chronic consumption of alcohol. ALD begins with alcoholic fatty liver (AFL), which is characterized by progressive hepatic steatosis. Alcohol is metabolized mainly in the liver to acetaldehyde by alcohol dehydrogenase (ADH) and then decomposed to acetic acid, a non-toxic substance by acetaldehyde dehydrogenase (ALDH). Therefore, lactic acid bacteria (LAB) with high ADH and ALDH activity can advance alcohol metabolism in the body and help improve various diseases associated with liver damage. This study isolated LAB strains with ADH and ALDH activity from Korean fermented foods and baby feces using NAD<SUP>+</SUP> and BCA protein assay. Two strains were selected by alcohol and acetaldehyde decomposition ability that showed a reduction of more than 90%. Additionally, it was confirmed that fat accumulation in the HepG2 cells was suppressed according to the order of treatment with alcohol and LAB. Those results suggest that selected probiotic strains are effective in decomposing alcohol by improving alcohol metabolism.

Effect of Trunk and Upper Arm Angle on Lifting Capacity

Chang, Seong Rok The Korean Society of Safety 2011 International Journal of Safety Vol.10 No.1

Lifting capacity and difficulty of task are influenced by body posture. In RULA and REBA, the body was divided into segments which formed two groups, A and B. Group A includes the upper and lower arm and wrist while group B includes the neck, trunk and legs. This ensures that whole body posture is recorded so that any awkward or constrained posture of the legs, trunk or neck which might influence the posture of the upper limb. This study aimed to measure MVC (maximum voluntary contraction) and subjective judgment in psychophysical method (Borg's scale) according to trunk and upper arm angle and to analyze results statistically. The results of this study were that lifting capacity was more influenced by interaction of body posture rather than angles of each part, and MVC variation according to trunk and upper arms angles should different patterns. This means that we consider the interaction of trunk angles and upper arm angles when we access risk factors of the postures. This survey would be also the basic data to evaluate difficulty of lifting tasks according to body postures ergonomically.