한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

Stretch-Shorening Cycle이 ArmCurl 동작에 미치는 영향

우병훈,김석희,임용규 漢陽大學校 體育科學硏究所 2003 體育科學 Vol.23 No.23

In this research, We were selected 10 students from Physical Education at the H University in Seoul through random sampling and by group they had no physical defects. We were compared them mutually through mechanical analysis according to muscular contraction type in the stretch-shortening cycle and shortening-stretch cycle in concentric and eccentric contractions. To investigate their differences, We were performed armcurl motion analysis. As a result, We were derived conclusions as follows. As for the maximum momentum of total segments that is a kinetic variable, that of SSC was higher by DM 0.06kg · m/sec. and by DM 0.97J in the mechanical energy of the total segments; and by DM 22.20N at the maximum power than that of CC. In the analysis of integral electromyography that is avariable of analysis of electromyography, the integral electromyography of biceps brachii muscle increased by DM 0.0240mv · s in the case of the SSC motion than when in the CC motion. There was no difference in the triceps brachii muscle. On the basis of this conclusion, We consider that the stretch-shortening cycle can affect many parts in the movement of the body. Through the results of the analysis of the armcurl motion, we can see that the stretch-shortening cycle is able to put out its strength by using elastic energy accumulated at the time of concentric contractions after accumulating elastic energy through pre-stretching before concentric contractions. Furthermore, since it puts out much more power 'in utilizing muscles compared to simple concentric contractions, We think the training method such as plyometric training can develop more power than previous training methods.

The Effect of Service Quality on Satisfaction, Image and Word-of-Mouth Intention of the Seoul Square Skating Rink Users

윤태훈,손석정,백우열 남서울대학교 2010 남서울대학교 논문집 Vol.16 No.2

본 연구는 서울광장 스케이트장의 서비스품질이 이용객들의 만족, 이미지 그리고 구전의도에 미치는 영향을 규명하는데 그 목적이 있다. 이를 위해 서울시청 앞 서울광장 스케이트장을 이용하는 시민들을 모집단으로 선정하여 편의추출법을 통해 450명을 선택한 다음 자기평가기입법으로 설문에 응답하게 하였다. 450부의 설문지 가운데 409부가 회수되었고 이 가운데 신뢰성이 떨어진다고 판단되는 30부의 설문지를 제외하고 379부가 통계분석에 이용되었다. 수집된 자료는 SPSS Ver. 10.0프로그램을 이용하여 빈도분석, 요인분석, 신뢰도분석을 실시하였으며 연구가설의 검증을 위해 t검정과 일원변량분석, 회귀분석을 실시하였다. 이상의 연구방법을 통해 도출된 결과는 다음과 같다. 첫째, 이용시민들의 성별에서는 식음서비스에서 유의한 차이가 나타났으며, 연령별에서 운영서비스와 이벤트 및 프로그램 서비스가 유의한 차이가 나타났다. 학력별로 이벤트 및 프로그램 서비스에서 유의적인 차이가 나타났으며, 연령별로 운영서비스와 이벤트 및 프로그램 서비스가 유의적인 차이가 나타났다. 직업별로는 운영서비스와 식음서비스, 안전서비스, 이용서비스에 유의한 차이가 나타났으며, 총수입별로는 이용서비스에 있어 통계적으로 유의한 차이가 있는 것으로 나타났다. 둘째, 스케이트장 서비스품질이 이용 시민행동에 미치는 영향은 먼저 서비스품질 속성인 운영서비스, 이벤트 및 프로그램 서비스, 안전서비스가 이용객들의 만족도에 유의한 영향을 미치는 것으로 나타났으며 운영, 이벤트 및 프로그램 서비스도 이용객들의 이미지에 유의한 영향을 미치는 것으로 나타났다. 결과적으로 서울광장 스케이트장이 이용객들에게 사랑 받는 명소로 자리 잡기 위해서는 우선적으로 운영과 안전에 관련된 서비스를 개선하고 강화할 필요성이 요구되고 있다. 주요어: 스케이트장, 서비스품질, 만족도, 이미지, 구전의도

경사도 변화에 따른 트레드밀 역보행의 운동학적 분석

김석희,우병훈,임용규 漢陽大學校 體育科學硏究所 2003 體育科學 Vol.23 No.23

The purpose of this study is to understand special features of back ward walking through 3-dimensional kinematic analysis of backward walking inconsideration of treadmill gradient in 10 male university students in the in twenties and to provide the information required for deciding workload or for preventing injuries. In this stuidy, the walking speed of the treadmill was set at 3.Okm/h and the gradient of the treadmill was set at 0°, 5° and 10°. the APAS were used for the collection of image data and analysis. and one-way ANOVA was used to analyze the differences according to gradients. As there analysis and result show, The first, cadence at 0° was higher than at 5° and 10° The second, support time at 5° was longer than that of 0° and 10°The third, ankle joint displacement became generally low as gradient increased. The fourth, in the knee joint, displacement became higher as gradient increased in the early stage of backward walking. ; however, there was no difference at the later stage. Lastly, no angle displacement of hip joints showed in back ward walking. The study suggests that it will be more desirable to analyze kinetic variables on the backward walking. Therefore it needs the following study for the factor like that continuously.

Prevotella nigrescens의 용혈특성에 관한 연구

곽주석,장훈상,장석우,이수종,유용욱,민경산 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.4

세균의 용혈활성은 세균이 숙주 내에서 생존하기 위해 필요한 철을 획득하기위한 특성이며 기능면에서 볼 때 숙주에 대한 중요한 독력인자로 간주될 수 있다. 본 연구에서는 괴사치수 및 치근단 치주염으로 진단된 환자의 근관에서 분리한 Prevotella nigrescens의 용혈활성을 다양한 조건 하에서 측정하여 그 특성을 규명하는 것을 목적으로 한다. 1. 임상에서 분리한 P. nigrescers와 표준균주인 P. nigrescers ATCC 33563에서 모두 용혈활성이 나타났다. 2. 사람, 면양 및 말 세 가지 종에 대해 용혈활성을 비교한 결과 사람의 적혈구에서 가장 강한 용혈활성을 나타내었다. 3. 용혈소 억제제인 NaN₃와 dithiothreitol (DTT)는 농도의존적으로 P.nigrescers의 용혈활성을 감소시켰다 (p<0.05). 4. P. nigrescers가 최대 용혈활성을 나타내는 최적의 pH는 4이었으며, 50℃이하의 온도에서는 용혈활성을 보였으나 95℃에서 급격히 감소하였다. 5.배양조건에 따른 P. nigrescens의 용혈활성을비교한 결과 10% CO₂배양기에 배양한 경우혐기성 조건에서 배양한 것보다 더 높은 용혈활성을 보였다. Hemolytic property is a specific feature of bacteria to obtain iron which is essential for its survival in host tissues. Therefore, it is thought to be one of several factors of virulence. The purpose of this study was to investigate the hemolytic properties of Prevotella nigrescens isolated from the teeth diagnosed as pulp necrosis and apical periodontitis under the presence of hemolysin inhibitors such as NaN3 and dithiothreitol, heat, various pH and cultural conditions. The results were as follows; 1. Clinically isolated P. nigrescens strains and standard P. nigrscens ATCC 33563 showed hemolytic activity. 2. P. nigrescens showed higher hemolytic activity against human erythrocytes than sheep or horse erythrocytes. 3. NaN₃ and dithiothreitol (DTT) reduced the hemolytic activity of P. nigrescens in a dose dependent manner (p<0.05). 4. Optimal pH for the maximum hemolytic activity of P. nigrescens was 4.0 and the hemolysin was stable under the 50℃, but the hemolytic activity was significantly decreased at 95℃. 5. P. nigrescens cultured in 10% CO₂ condition showed higher hemolytic activity than the bacteria cultured in the anaerobic condition.[J Kor Acad Cons Dent 30(4):335-343,2005]

抗癌白朮散의 抗癌 및 抗轉移 效果에 關한 硏究

李錫雨,金聖勳 대한동의병리학회 1996 동의생리병리학회지 Vol.10 No.2

現在 大田大韓方病院에서 癌治療에 이용되고 있는 消積白朮散보다 有效한 抗癌 및 抗轉移 效果를 나타내며, 抗癌劑의 副作用을 抑制할 수 있는 새로운 韓方處方 開發을 위한 努力으로 抗暗性이 認定된는 4가지 藥物을 消積白朮散에 加味하여 抗癌 및 抗轉移 實驗을 施行하였다. in vitro에서 B16-Fo, A549 및 SUN-1등의 癌細胞에 대한 細胞毒性, A549 癌細胞에 대한 附着沮止效果, protein kinase C 沮害作用을 살펴보았고, in vivo에서는 S-180을 腹部로 移植한 후 生存比, 血液學的 變化를, B16-Fo 癌株를 尾靜脈에 移植하고 pulmonary colonization assay, 臟器의 病理組織變化 및 血液學的 變化 등을 檢討하였다. A549, B16-Fo, SNU-1, S-180 細胞에 대한 in vitro, in vivo 實驗에서 抗癌效果가 認定되었고, 癌株에 대하여서는 SNU-1, A549, B16-Fo 등의 順序로 特異한 抗腫瘍 效果를 보였으며, 抗轉利實驗으로 實施한 Protein Kinase C 活性沮害作用 및 動物組織檢事에서도 有效한 抗轉移 效果를 나타냈다. For the development of more effective new anti-cancer perscription, antitumor and antimetastatic effect of hangambaekchulsan(HBS) was evaluated experi-mentally and results were obtained as follows: 1. The concentration inhibiting cell growth below 55% was 10-3g/㎖ of HBSB against B16-Fo, 10-3g/㎖ of HBS and HBSB against A549 and 10-3g/㎖ of HBS, 10-³g/㎖∼10-⁴g/㎖ of HBSB against SNU-1. 2. HBS and HBSB acted specifically on the cancer cells of SNU-1, A549 and B16-Fo in order. 3. Medicinal herbs inhibiting cell growth such as B16-Fo, A549 and SNU-1 up over 30% were Orostachys Herba, Lonicerae Flos, Taraxaci Radix, Pinelliae Rhizoma, Scutellariae Radix, Curcumae Radix, Lithospermi Radix, Oldenlandiae diffusae Herba. 4. Over 50% inhibition of protein kinase C was shown in 125㎍/㎖ HBS and HBSB, Orostachys Herba, Lonicerae Flos, Lithospermi Radix, Coicis Semen, Aurantil nobilis Pericarpium. 5. Weight of B16-Fo tumor was significantly inhibited in HBS and HBSB treated groups as compared with control data and T/C % to S-180 was 136% and 147% respectively. 6. Number of platelet was significantly in HBS and HBSB treated groups, but platelet aggregation was significantly inhibited only in HBS treated group. 7. Over 50% inhibition of cell adhesion of A549 was 10-³g/㎖ of HBS and HBSB, Lonicerae Flos, Taraxaci Radix, Oldenlandiae diffusae Herba. 8. HBS and HBSB significantly inhibited pulmonary colonization as compared with control data. 9. In pathohistological changes HBS and HBSB inhibited the metastasis of B16-Fo as compared with control but HSBS was more effective. From the above results HBS had antitumor and antimetastatic effects in dose-dependent manner, which suggests that HBS can be clinically applied to cancer patients.

국내에서 분리된 Esherichia Coli 와 Klebsiella pneumoniae의 CTX-M형 Extended-Spectrum β-Lactamase 생성 현황

배일권,우건조,정석훈,박광옥,조병규,김둘만,권수봉,김현주,강현경 대한임상미샐물학회 2004 Annals of clinical microbiology Vol.7 No.1

Low doses of ionizing radiation suppress doxorubicin-induced senescence-like phenotypes by activation of ERK1/2 and suppression of p38 kinase in MCF7 human breast cancer cells

신재식,우상혁,이형찬,홍승우,유두현,홍석일,이왕재,이명석,진영우,안성관,진동훈,박인철 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

Low doses of ionizing radiation suppress doxorubicin-induced senescence-like phenotypes by activation of ERK1/2 and suppression of p38 kinase in MCF7 human breast cancer cells

신재식,우상혁,이형찬,홍승우,유두현,홍석일,이왕재,이명석,진영우,안성관,진동훈,박인철 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1

노인 인구에서 신경인지기능저하와 혈청 지질농도와의 상관성

유영선,최석주,정성수,김지은,윤성욱,전동욱,백준형,박성우,이정구,추일한,김영훈 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.6

Objectives : In this study, the authors evaluated the correlation between eurocognitive impairments and serum lipids levels among Korean elderly over the age of 65. Methods : A total of 609 elderly individuals participated in this study. Screening for cognitive impairments were carried out using the Mini-Mental Status Examination-Korean version (MMSE-KC). There were 197 subjects above 1.5SD Of MMSE- KC and they were evaluated using the Korean versions of the Consortium to Establish a Registry for Alzheimer's Disease (AD) (CERAD-KC) and Geriatric Depression Scale (GDS-K). Results : There was a correlation between old age/low levels of education and AD (p<0.05, P<0.01). There was an inverse correlation between the serum level of total cholesterol and the word list recognition test scores. The serum levels of LDL cholesterol were inversely correlated with the scores on the constructional praxis test, word list recall test and word list recognition test. Inverse correlations between the serum level of triglyceride and scores on the word list recall test and word list recognition test were also observed. Conclusion : There were inverse correlations between the serum levels of lipids and language/memory function in subjects with AD.