비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351)

體液을 利用한 惡性腫瘍診斷法

全弼鉉,朴吉秀,康柄鎬 醫藥係社 1958 綜合 醫學 Vol.3 No.3

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351) 배경 : Gemcitabine, paditaxel, docetaxel, vinorelbine, ir-rinotecan 새로운 항종양제의 출현으로 일차 치료의효과가 증대 되고 있고 재발시에도 좋은 신체 활동도를 보이고 있어서 이차 치료의 대상군도 늘어나는 효과를 보이고 있다. 치료의 필요성은 증대 되고 있지만 현재까지 표준 치료가 확립되지 않은 상황에서 Gem-citabine과Vinorelbine모두 독성이 강하지 않아서 혼합 요법이 가능한 장점이 있고 비소세포 폐암에 대한효과도 입증이 되어있어서 본 연구는 반응이 없거나 반응을 보인후에 재발된 진행된 비소세포 폐암에 ge-mdtabine과 vinorelbine 흔합 요법을 시행하여서 치료 반응률과 생존율 그리고 부작용을 평가하였다. 대상 및 방법 :2000년 6월부터 2004년 3월까지 충남대학교병원에내원하여 진행성 비소세포 폐암 IIIA/IIIB, IV로 진단을 받고 일차 항암화학요법치료를 받은 환자중에 초기 치료에 반응이 없거나, 치료에 반응이 있었으나 병이 진행된 환자로 추적 관찰 기간이 6개월 이상인 환자를 대상으로 생존율과 반응률 그리고 독성을 분석하였다. 결과 : 총 치료 반응률은 17%. 반응 유지기간의 중앙값은 3.1개월(1-10개월)이었고 생존기간의 중앙값은 8.2개월 (1-23개월) 그리고 1년 생존율은 35%였다. 항암화학요법에 의한 독성은 3도 이상의 중성구 감소가 12%, 오심과 구토가 12.5% 였다. 결론 : 일차 치료에 반응이 없거나 재발한 비소세포 폐암환자의 이차 치료로 gemcitabine과 vinorelbine 혼합요법은 효과적이라고 생각되며 향후 3상 연구를 통한다른 약제와의 비교 연구가 필요하다고 생각된다.

류마티스 관절염과 동반된 궤양성 대장염 1예

정종필,김윤아,서강석,김태현,김춘호,박정복,이광욱 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

The gastrointestinal involvement in rheumatoid arthritis may be broad and includes many causes: drug induced colitis, colitis associated with infectious agents, vasculitis in gut, autoimmune disease located in gut. Rheumatoid arthritis is a chronic multisystemic disease of unknown cause. Although a number of mixed autoimmue disease exist, there were rare reports about Ulcerative colitis with Rheumatoid arthritis associated. We report one case of Rheumatoid arthritis patient who diagnosed as Ucerative colitis by colonoscopic and histologic finding with review of literature.

운전자의 교통정보활용과 시스템화에 관한 연구

신성필,오윤표 동아대학교 건설기술연구소 2000 硏究報告 Vol.24 No.2

This study aimed to develop systems and devices for solution of diverse traffic problems by effective collection, adjustment and systemization of kinds of information of drivers. It has been indicated that the traffic problems can not be easily solved without considering and attitude and perception of drivers. It's been known that systems or devices which are capable of gathering traffic information created from drivers including road users can reduce traffic congestion and accidents in advance. In Korea, it is desirable to use regional drivers experience, knowledge, and ideas in by communicating among citizens and administrators new traffic safety alternative. This study suggested a new traffic Information system that can collect, change, and maintain the credible real time traffic data, which also can automatically manage a process of controlling traffic flow based on the administrators decision.

형광백혈구 안저촬영술에서 플로레신 염색의 안정성과 형광림프구의 분리

김윤희,강필성,김강주,양연식,김재덕 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.1

Recently, retinal blood flow has been studied with several methods, targeted dye delivery method, fluorescent vesicle system, laser Doppler velocimetry, acridine orange staining method. Authors presented a new method, fluorescein leukocyte angiography using a scanning laser ophthalmoscope which include external staining of leukocyte with fluorescein dye and reintroduce the fluorescent leukocyte into the blood flow. Authors tried to check security of external fluorescein staining of leukocytes and separation of fluorescent lymphocytes from whole blood and supernatant fluid using Ficoll-Paque, with cell viability, leukocyte recovery rate and erythrocyte contamination rate. There was no significant difference in cell viability, leukocyte recovery rate and erythrocyte contamination rate between fluorescein staining group and non-staining group. Fluorescent lymphocytes could be separated from whole blood and supernatant solution after gravity sedimentation with 6% hetastarch and the gravity sedimented group had low erythrocyte contamination rate than whole blood group(p≤0.05). In conclusion, external fluorescein staining procedure of leukocyte during fluorescein leukocyte angiography could be performed without cell injury compared to non-fluorescein staining group and fluorescent lymphocyte could be separated from whole blood and supernatant fluid after gravity sedimentation.

순환기 반응기에서 ceramic bead에 코팅된 TiO₂ 광촉매를 이용한 MTBE의 광분해

류성필,오윤근 濟州大學校 海洋硏究所 2004 해양과환경연구소 연구논문집 Vol.28 No.2

The objective of this study is to delineate removal efficiency of the MTBE in solution by TiO₂ photocatalytic degradation as a function of the following different experimental conditions : Initial concentration of MTBE, air flow rate in solution, H₂O₂ dosage and pH of the solution. Photodegradation rate was increased with decreasing initial concentration of MTBE. The removal efficiency was 82% after 180 min in the case of MTBE concentration of 100 mg/L but 100% after 180 min in the case of 20 mg/L. Removal efficiency was increased with increasing pH. H₂O₂ dosage and air flow rate in solution.

RF DIN Connector의 Passive IMD 개선에 관한 연구

고윤선,정재필,오창헌,신동욱 한국항행학회 2002 韓國航行學會論文誌 Vol.6 No.3

최근 이동통신 서비스가 확대됨에 따라 인접 기지국간의 간섭문제가 증가하게 되었으며, 그에 따라 CDMA시스템의 active IMD 뿐만 아니라 PIMD (Passive Inter Modulation Distortion)에 대한 문제도 시스템 설계 시 고려되어야 한다. 본 논문에서는 RF connector 중 대표적 connector인 7/16“ DIN connector를 통하여 동촉선에서의 PIMD발생 정도를 분석하였고, PIME 개선 방안을 제안하였다. 첫째, 대부분의 전류가 통과하는 경로에는 표면조도가 좋은 금속이 전도율이 좋아 유리하며, 둘째 RF에너지가 충분ㅎ히 한 매질에서 통과할 수 있도록 최소 5m 이상으로 도금을 해야 함을 알수 있었다. 셋째, 도금 재료의 노화현상 방지를 위해 비열이 높고 전도율이 높은 금속 선택이 필수적이며, 비용절감 면에서는 삼원합금 등 대체 도금 재질 개발이 요구됨을 알 수 있었다. 현재 국내 PIMD 규격인 KTF-150dBc를 만족시키기 위해서는 7/16“ DIN connector 의 경우 도금재질에 관계없이 표면조도 6s, 도금두께 5m일때 KTF의 PIMD 규정을 만족시킬 수 있음을 알 수 있었다. Recently, as the range of mobile communication services is extended, the interference between adjacent base-stations is increased. Nowdays, on of the important factors causing interference is IMD(Inter-Modulation Distortion) problems. Not only active IMD but also passive IMD effects must be considered to design a CDMA system. In this study, we design and implement 7/16'' DIN connectors which have a various intensity of surface illumination, thickness and quality of plating material to analyze the effects of PIMD. And propose the methods for improving the PIMD characteristics: First, it is more profitable to use the metal which has good intensity of surface illumination where most of all electric currents passes through it. Secondly, we should plate metals more than 5 μm for RF energy enough to propagate in a medium. Thirdly, it is necessary to select a metal having high conductivity and specific heat to protect the aging phenomenon of plate material. And it is required to develop a new plating material to replace the current materials, such as the alloy of three components for cost reduction. We have to know that the plate which has intensity of surface illumination 6 S and the thickness of plating material 5 μm satisfy domestic PIMD specification (KTF) - 150 dBc, regardless of the plate material in case of 7/16'' DIN connector.

TNF-α 유전자형과 방광암과의 관계

정필두,김은정,엄민식,서정원,윤석중,김종석,이상철,김원재 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: TNF-α는 일부 종양의 종양화 과정과 관련이 있는 것으로 알려져 있다. 본 연구는 TNF-α 발현에 영향을 미치는 TNF-α 촉진자 -308 부위의 유전적 다형성이 방광암과 관련이 있는지 유무를 알고자 시행하였다. 대상 및 방법: 유전자 분석을 위하여 환자 113명 및 대조군 109명으로부터 혈액을 채취하여 genomic DNA를 분리한 후 PCR-RFLP 및 direct DNA sequencing을 통하여 TNF-α유전자의 다형성을 조사하여 방광암의 발생, 병기 및 분화도와 비교 검토하였다. 결과: TNF-α 촉진자 -308 부위의 유전형은 대조군에서는 GG형이 83.5%(90례 및 GA형이 16.5%(19례)로 관찰되었으며 AA형은 없었다. 환자군에서는 GG 형이 85.4%(97례), GA형 및 AA형은 각각 13.1%(15례)및 0.8%(1례)에서 관찰되었다. 두 군 모두에서 GG형이 가장 많이 나타났으며 다음으로 GA형을 보이고 AA형은 1례의 방광암 환자에서만 관찰되었다. -308부위의 경우도 두 군 사이에 유전자형의 차이는 없었다(p=0.259) 분화도별 분포를 보면 grade I이 20례, grade II가 49례, grade Ⅲ은 34례였고 병기별로 표재성인 경우가 90례였으며 침윤성은 14례였다. 분화도가 나빠질수록 GA형이 증가하였다(p=0.04). 그러나 병기와 TNF-α promoter -308부위의 유전자형 사이에는 유의한 상관 관계가 없었다(p=0.123). 결론: 방광암 환자의 혈액에서 GA genotype이 관찰되는 경우, 분화도가 나쁠 가능성이 매우 높기 때문에 좀 더 적극적인 치료와 세밀한 추적관찰을 함으로써 방광암으로 인한 사망과 암의 진행을 예방할 수 있을 것으로 기대한다. Purpose : Tumor necrosis factor-alpha (TNF-α) is involved in tumorigenesis of several cancers as an endogenous tumor promoter. The purpose of this study was to investigate whether genetic polymorphism of TNF-α promoter region (-308) was associated with human bladder tumor. Materials and Methods: The DNA from 113 and 109 respective blood samples of bladder tumor Patients and control group was analyzed by PCR-based restriction fragment length polymorphism (RFLP) and direct DNA sequencing methods to characterize the genetic polymorphism of -308 promoter region of the TNF-α gene in bladder tumor patients. We compared the association of bladder tumor with genetic Polymorphism of TNF-α promoter region(-308) in relation to the stage, grade, recurrence and progressio. Results : Eighty-six percents(97/113) of bladder tumor patients and 83.5% (90/109) of control group showed genotype GG at -308 region of TNF-α. Difference in genetic variations of TNF-α promoter (-308) did not exist between bladder tumor patients and control group(p=0.259). Tumor grade was significantly related to the GA genotype (p=0.04). The higher is the grade in bladder tumor, the more frequent was the GA genotype. Tumor stage, recurrence and progression were not significantly associated with genetic polymorphism of TNF-α promoter region (-308). Conclusion: The GA genotype of TNF-a promoter region (-308) had a significant impact on TNF-α production and was related to higher grade tumor compared to GG genotype. TNF-α serum levels in bladder tumor patients were significantly higher than controls. These data suggested that TNF-α might involve the tumorigenesis of the bladder rather than treatment or prevention of bladder tumor.

백색광 간섭형 센서의 신호처리

오승필,김도익,예윤해,-- 경희대학교 레이저공학연구소 2001 레이저공학 Vol.12 No.-

We propose a signal processing method for white light interferometry which requires a series of analog signal processing circuitry to locate the central interference fringe with high speed. The method is applied to a fiber optic sensor consisted of an ELED, a sensing Fabry-Perot interferometer, and a Michelson interferometer for phase-matching and phase modulation. The temporal shift of sensor response is measured by the shift of the central fringe position. The test results show that the WLI sensor system is able to differentiate the change of 0.02℃ when it is implemented as a temperature sensor.