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Bae, Gi-Sang,Kim, Dong-Goo,Jo, Il-Joo,Choi, Sun-Bok,Kim, Myoung-Jin,Shin, Joon Yeon,Kim, Dong-Uk,Song, Ho-Joon,Joo, Myungsoo,Park, Sung-Joo ELSEVIER 2019 INTERNATIONAL IMMUNOPHARMACOLOGY Vol.69 No.-
<P><B>Abstract</B></P> <P>Heme oxygenase-1 (HO-1) has an anti-inflammatory action in acute pancreatitis (AP). However, its mechanism of action and natural compounds/drugs to induce HO-1 in pancreas are not well understood. In this study, we investigated the regulatory mechanisms of HO-1 during AP using desoxo-narchinol-A (DN), the natural compound inducing HO-1 in the pancreas. Female C57/BL6 Mice were intraperitoneally injected with supramaximal concentrations of cerulein (50 μg/kg) hourly for 6 h to induce AP. DMSO or DN was administered intraperitoneally, then mice were sacrificed 6 h after the final cerulein injection. Administration of DN increased pancreatic HO-1 expression through activation of activating protein-1, mediated by mitogen-activated protein kinases. Furthermore, DN treatment reduced the pancreatic weight-to-body weight ratio as well as production of digestive enzymes and pro-inflammatory cytokines. Inhibition of HO-1 by tin protoporphyrin IX abolished the protective effects of DN on pancreatic damage. Additionally, DN treatment inhibited neutrophil infiltration into the pancreas via regulation of chemokine (C-X-C motif) ligand 2 (CXCL2) by HO-1. Our results suggest that DN is an effective inducer of HO-1 in the pancreas, and that HO-1 regulates neutrophil infiltration in AP via CXCL2 inhibition.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Desoxo-narchinol-A (DN) is a natural compound of HO-1 inducer in pancreas. </LI> <LI> Mechanism of DN-induced HO-1 is mediated by MAPK/Activator Protein-1/HO-1 signaling. </LI> <LI> DN-induced HO-1 blocks neutrophil infiltration into pancreas via inhibition of CXCL2. </LI> <LI> DN inhibits cerulein-induced acute pancreatitis (AP) and AP-associated lung injury. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jin‑Kyung Jeon,Hyunseon Seo,Jimin Park,Soo Ji Son,Yeong Rim Kim,Eun Shil Kim,Jong Woong Park,Woong‑Gyo Jung,Hojeong Jeon,Yu‑Chan Kim,Hyun‑Kwang Seok,Jae Ho Shin,Myoung‑Ryul Ok 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4
The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implantsbecause the device loses its fi xation strength before the fractured bone heals. This study suggests a new approach to overcomethis hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is anessential process in early bone regeneration, a Mg implant coated with electrospun nanofi bers containing nitric oxide (NO),which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to bestored on the NO donor-conjugated nanofi ber coating, stably delivered, and released to the fractured bone tissue near theimplanted sites. An in vitro corrosion test reveals no adverse eff ect of the released NO on the corrosion behavior of the Mgimplant. Simultaneously, the optimal concentration level of NO released from the implant signifi cantly enhances tube networkformation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis canbe accelerated by combining NO-releasing nanofi bers with a Mg implant. With its proven feasibility, the proposed approachcould be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fi xation.
私立大學生의 成長發育 및 營養狀態에 關한 硏究 : 中學校 入試有無過程을 通한 比較
朴淳永,具燾書,朴良元,金振浩,南炳執,朴昌植,朴喆斌 慶熙大學校 1980 論文集 Vol.10 No.-
In order to ascertain any possible changes in the physical and the nutritional status of Korean high school students before and after the abolishment of college entrance examination system, an intensive survey was conducted on the physical conditions of the incoming freshmen students (9532 males and 3428 females) of Kyung Hee University from 1972 to 1980. The finding are as below. 1. Physical growth conditions In each of the average physical dimensions of body height, body weight, chest girth and sitting height, a remarkable improvement was recorded for all age groups after the matriculation was abolished. 2. Physical and nutritional indices Relative body weight showed constant values of 35.0 in male and 32.0 in female. Relative chest girth showed the normal chest girth style in all age groups of both sexes. Relative sitting height showed a constant value of 54 for both sexes. The values of vervaeck index of th nutritional status were shown to be between 86-87 in male and 83-94 in female, Pelidisi index 91 and 92-93, Rohrer index of physical status 121-125 and 130-132, and Kaup index 206-211 and 202-210, respectively.
Protective Effect of Baicalin Against Carbon Tetrachloride–Induced Acute Hepatic Injury in Mice
Park, Sang-Won,Lee, Chan-Ho,Kim, Yeong Shik,Kang, Sam Sik,Jeon, Su Jin,Son, Kun Ho,Lee, Sun-Mee The Japanese Pharmacological Society 2008 JOURNAL OF PHARMACOLOGICAL SCIENCES Vol.106 No.1
<P>This study examined the effects of baicalin, a bioactive flavonoid isolated from <I>Scutellariae Radix</I>, on carbon tetrachloride (CCl<SUB>4</SUB>)-induced liver injury. Mice were treated intraperitoneally with 0.5 ml/kg CCl<SUB>4</SUB> and different groups of animals received 25, 50, 100, and 200 mg/kg baicalin. At 24 h after the CCl<SUB>4</SUB> treatment, the level of serum aminotransferases and lipid peroxidation was significantly elevated, whereas the hepatic glutathione content was decreased. These changes were attenuated by baicalin. The histological studies showed that baicalin inhibited the portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia, which are the three most common characteristics of CCl<SUB>4</SUB>-induced liver damage. The serum level and mRNA expression of tumor necrosis factor-α were markedly increased by the CCl<SUB>4</SUB> treatment but suppressed by baicalin. The mRNA and protein expression levels of inducible nitric oxide synthase and heme oxygenase-1 increased significantly at 24 h after the CCl<SUB>4</SUB> treatment. Baicalin attenuated the increase in the protein and gene expression of inducible nitric oxide synthase but augmented the increase in those of heme oxygenase-1. These findings suggest that baicalin protects hepatocytes from the oxidative damage caused by CCl<SUB>4</SUB>, and this protection is likely due to the induction of HO-1 expression and the inhibition of the proinflammatory mediators.</P>
버스정보시스템(BIS)을 위한 모바일 환경의 시각화 기법 연구
박동규,박진화,이수진,박은호,류동성,어윤 국립7개대학공동논문집간행위원회 2004 공업기술연구 Vol.4 No.-
In this paper we describe a visualization method for Bus Information System(BIS) on Mobile Environment. A BIS is a key service for Intelligent Transport System(ITS) on public transportation area. We present a client-server based visualization technique for bus route information over Internet Protocol and user-oriented regional information service with a voice and animation. We also describe the design and implementation of this kind of schematic map generation system with icon and label.
Park, Jin Woo,Song, Ho-Sueb Korean AcupunctureMoxibustion Medicine Society 2021 대한침구의학회지 Vol.38 No.4
Background: This study sought to determine whether the antioxidant effects of astaxanthin (AST) could have an anti-inflammatory effect to reduce inflammation caused by atopic dermatitis (AD). Methods: Using a mouse model of AD induced by phtalic acid (PA), the levels of inflammation, inflammatory agents, and evidence of antioxidant activity were examined in PA treated mice (n = 3), PA-AST treated mice (n = 3), and a control group of mice (n = 3). This included measurements of ear thickness, levels of mast cells, IgE, inflammatory cytokine, malondialdehyde (MDA), hydrogen peroxide, HO-1, and GPx-1. Results: AST treatment significantly prevented inflammation as measured by ear thickness (p < 0.05), mast cell count (p < 0.001), and IgE concentration in the blood (p < 0.001). Levels of TNF-α (p < 0.001), IL-1β (p < 0.001), IL-6 (p < 0.001), and MDA (p < 0.05) were also significantly lower. In addition, GSH levels increased significantly (p < 0.001), and the level of hydrogen peroxide significantly reduced (p < 0.01). The expression of HO-1, GPx-1 increased. Conclusion: In this small experimental study, AST acted on inflammatory mechanisms that induced AD, through anti-inflammatory and antioxidant mechanisms, and is a candidate of interest in the clinical treatment of AD.
장민호,조가익,하진용,정광석,박성배,주기재 한국어류학회 2002 韓國魚類學會誌 Vol.14 No.4
설악산 국립공원지역 산간계류의 17개 지점에서 2000년 6월부터 2001년 6월까지 어류상 및 이화학적 요인을 계절별로 총 4회에 걸쳐 분석하였다. 모든 조사지점은 1~3차의 하천으로 비교적 물리·화학적 교란이 적었으며 하천폭은 5~30 m 정도였다. 채집된 어류는 총 18과 42종 2,557개체였고, Cyprinidae는 16종으로 84.7%의 상대풍부도를 나타냈으며, Gobiidae 4종, 5.0?의 상대풍부도를 보였다. Cyprinidae는 전체 채입종의 37.2%를 나타냈다. 우점종은 Zacco temminck로 10개 지점에서 738개체가 채집되어 28.9%의 상대풍부도를 나타냈으며, 아우점종은 Rhynchocypris kumkangensis와 Z. platypus로 각각 4개 지점 648개체(25.3%)와 7개 지점 344개체(13.5%)로 나타났다. 한국고유종(Korean endemic species)은 모두 4과 11종 781개체로 30.5%의 상대풍부도를 나타냈으며, 고유화 빈도는 25.6%로 한국의 평균 고유화 빈도와 유사하게 나타났다. 본 조사에서 외래어는 채집되지 않았다. 국립공원 내에 서식하는 어류의 다양성 유지와 회복을 위해서는 공원 내는 물론 경계지역 하천의 체계적인 관리가 요구된다. The fish fauna of mountain streams in the Seorak National Park area was investigated from June 2000 to June 2001 (4 times). All 17 sites were relatively undisturbed 1st to 3rd order streams. A total of 2,557 individuals were collected and classified into 17 families and 43 species. Cyprinidae accounted for 37.2% (16 species) of the total fish species and 84.7% (2,165 ind.) of the total abundance. Subdominant families were Gobiidae (4 species, 5.0%) and Balitoridae (3 species, 3.4%). Zacco temmincki (RA 28.9%, 10 sites) dominated. Subdominant species were Rhynchocypris kumkangensis (25.3%, 4 sites) and Zacco platypus (13.5%, 7 sites). Eleven of the species are endemic to Korea (4 families, 30.5%). Exotic species were not collected in this survey. Fish diversity was higher in streams around the boundary area than in the national park. Therefore, management of streams in the boundary area to protect the fish biodiversity can be efficiently conducted. Habitat degradation should be reduced for the conservation and restoration of fish diversity.