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대사체들의 거울상체비를 이용한 불법 약물남용과 치료용 약 사용의 구별
신호상,박종세,Shin, Ho-Sang,Park, Jong-Sei 생화학분자생물학회 1993 한국생화학회지 Vol.26 No.8
Amphetamine과 methamphetamine의 거울상이성질체들을 N-MTPA [${\alpha}$-methoxy-${\alpha}$-(trifluoromethyl)phenylacetyl] 유도체들로 바꾸어 capillary gas-chromatography를 이용하여 분리하였고 levorphanol과 dextrophan은 chiral phase column을 이용하여 분리하였다. 이들 이성질체들은 비대칭 삼차원의 단백질 구조를 가진 효소들의 영향을 받게 되어 서로 다른 대사속도를 갖었다. 이들 대사체들의 거울상체간의 조성비는 대사체가 불법약물의 직접 사용에서 나왔는지 아니면 다른 치료약의 사용에서 나왔는지를 구별할 때 이용되어졌다. 또한 치료약의 독특한 대사체의 검출도 추가적인 증거가 될수 있었다. The enantiomers of amphetamine and methamphetamine were separated through conversion to the N-MTPA derivatives. Also levorphanol and dextrophan were separated by chiral phase column. The enantiomers of amphetamine and methamphetamine after oral administration of famprofazone were excreted at different rates under the influence of enzymes that were chiral three dimensional protein structures. In differentiating the use of medicines from direct use of illicit drugs, the evaluation of the enantiomeric composition of the compound was very valuable. This determination was assisted by determination of a unique metabolic product.
연속 철근콘크리트 슬래브 교량의 윤하중 분포폭에 관한 연구
신호상,오병환 한국콘크리트학회 1998 콘크리트학회지 Vol.10 No.4
The wheel load distribution width for lane load is not specified in current Korea bridge design code(KD code), not like in current AASHTO and AASHTO LRFD specifications which specity it as twice of wheel load distribution width for wheel load. In this study, the wheel load distribution width in continuous reinforced concrete slab bridge is investigated. The major variables affecting the wheel load distribution of a reinforced concrete continuous slab bridge are the span length, bridge width, existence edge beam and boundary condition. From a series of comprehensive parametric study on each variable, the formula for wheel load distribution in continuous reinforced concrete slab bridge is proposed from the nonlinear regression analysis of finite element analysis results. The proposed formulas can be used efficiently in the accurate design of continuous reinforced concrete slab bridges. 현행 AASHTO 및 AASHTO LRFD 설계기준에는 차선하중에 대한 윤하중분포폭을 차륜하중에 적용되는 윤하중분포폭의 2배를 적용하도록 규정하고 있다. 이에 반해 국내 도로교 표준시방서에는 차선하중에 대한 윤하중분포폭의 규정은 없는 실정이다. 본 연구에서는 연속 철근콘크리트 슬래브 교량에 대한 윤하중분포폭에 관한 연구를 수행하였다. 연속슬래브 교량의 윤하중분포폭에 영향을 미치는 인자들로는 지간길이, 교량폭, 단부보 및 지점조건이 있다. 이들 각 인자들에 대한 유한 요소 모델의 구성 및 해석을 통하여 연속 철근콘크리트 슬래브 교량의 합리적인 윤하중분포폭의 식을 제안하였다. 본 연구에서 제안된 윤하중분포폭의 식은 현행 도로교 표준시방서에 제시되어 있지 않은 철근콘크리트 연속 슬래브 교량의 보다 정확한 설계 및 합리적인 내하력 산정시 매우 효율적으로 사용될 것으로 사료된다.
신호상,권오승,Sin, Ho Sang,Gwon, O Seung Korean Chemical Society 2000 Bulletin of the Korean Chemical Society Vol.21 No.11
A simultaneous determination method of BTEX (benzene, toluene, ethylbenzene, o,m.p-xylene) and TPH (kerosene, diesel, jet fuel and bunker C) in soil with gas chromatography/flame ionization detection (GC-FID) was described. The effects of extracti on method, extraction solvent, solvent volume and extraction time on the extraction performance were studied. A sonication method was simpler and more efficient than Soxhlet or shaking methods. Sonication with 10 mL of acetone/methylene chloride (1 : 1, v/v) for 10 min was found to be optimal extraction conditions for 20 g of soil. Peak shapes and quantification of BTEX and TPH were excellent, with linear calibration curves over a wide range of 1-500 mg/L for BTEX and 10-5000 mg/L for TPH. Good reproducibilities by sonication were obtained, with the RSD values below 10%. By using about 20 g of soil, detection limits were 0.8 mg/L for BTEX and 10 mg/L for TPH. The advantages of this procedure are the use of simple and common equipment, reduced volumes of organic solvents, rapid extraction periods of less than 20 min, and simultaneous analysis of volatile and semivolatile compounds.
Simultaneous Determination of Benzidine, Acetylbenzidine and di-Acetylbenzidine in Rat Urine
신호상,이진현,안혜실,홍춘표,최석남,Sin, Ho Sang,Lee, Jin Hyeon,An, Hye Sil,Hong, Chun Pyo,Choe, Seok Nam Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.7
A gas chromatography/mass spectrometric assay method has been developed for the simultaneous determination of benzidine (BZ), N-acetyl benzidine (ABZ) and N,N-diacetyl benzidine (DABZ) in rat urine. BZ, ABZ and DABZ were extracted from urine at pH 8 with ethyl ether. Conjugated urinary metabolites were extracted at pH 8 after hydrolysis with 1 M HCl for 30 min at 100 $^{\circ}C.$ The dried extract was dissolved in 100 ${\mu}{\ell}$ of ethylacetate and then injected in gas chromatography-mass spectrometric (GC-MS) system without further purification or modification. BZ, ABZ and DABZ have good chromatographic properties and offer very sensitive response for the EI-MS (SIM) without any derivatization. The recoveries for BZ, ABZ and DABZ were about 98.0, 81.8 and 71.4%, respectively, at pH 8.0 and the concentration of 5.0 ng/mL. The coefficients of variation of BZ and ABZ were less than 9.5% from 0.1 to 100 ng/mL and that of DABZ was less than 13% in the same concentration range. The detection limits of the assay were 0.01 ng/mL for both BZ and ABZ, and 0.05 ng/mL for DABZ in urine or plasma 1.0 mL.
유비쿼터스 건설에의 RFID 활용에 대한 고찰;창업관점에서
신호상,황찬규,Shin, Ho-Sang,Hwang, Chan-Kou 한국벤처창업학회 2006 벤처창업연구 Vol.1 No.1
Telematics is spotlighted as the future industry and anticipated the rapid growth. But it is not showing the expected development because of technical and economical blocks. So that there would happen a setback in setting the u-Transportation strategy which is the advanced national transportation system by the year 2020. In this paper, the stat of arts about related technology are introduced, which could give a solution in the technical and economical demerits and design the revitalization in ITS based on Telematics. And also the present application condition in RFID (Radio Frequency Identification) which would be the Blue Ocean in the Ubiquitous construction industry is researched and the commercialization scheme is studied.