의약품의 효능별 안전성·유효성 평가에 관한 조사연구(Ⅰ) : 항균제 Antiboiotics

박윤주,최기환,김동섭,박인숙,정면우,임화경,오우용,강주희,박찬웅,김주일 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

새로운 물질이 개발되어 신약으로 탄생하기까지 많은 시간과 노력, 예산이 필요하다. 최근, 우리 나라에서도, 신약캐발이 어릴고 힘든 분야이지만 새로운 신약개발을 총해 얻어지는 분가가치가 막대함을 인식, 연구에 박차를 가하 있는 실정이다. 본 연구는, 의약품 개발 선진국인 미국 FDA에서 발행하는 참고자료 중 항균제 임상편가에 대한 가이드라인 및 주요 임상적응증별 항균제 기발(지역사획회득성 폐렴, 원내감염성 계렴, 급성기관지염의 2차세균감염, 만성기지염의 급성세균성 악화, 연쇄구균에 의한 인두영 및 편도염 , 단순성 요로감염증, 복합성 요로감염증 및 신우신영, 급성 세균성 부비동옆, 항 바이러스제 개발시 전임상단계에서 고려사항, 항 바이러스제 허가와 된련 잉상적 고려사항, 카레타 괸련 혈류감염)에 있어서의 파이드라인 등의 자료를 소개함으로져, 향후 제약사의 항균제 신약개발 및 허가 신청된 의악품의 전임상차료 및 잉상시험자료의 검토 평가업무에 참고자료로 활용될 수 있을 것이다. Changing or unclear interpretations of clinical trial data needed to demonstrate the effectiveness and safety of antimicrobial drug products have a times led to confusion and frustration on the part of both applicants and division of these drug products reviewers. The FDA published guidance on desing clinical protocols, implementing, and analyzing data from clinical trials for antimicrobial drug products has been presented and additional companion guidances introduced specific issues to individual infections. This document provides applicants and reviewers with minimal information appropriate for the clinical development of routine antimicrobial drug products and identifies issues common to many antimicrobial drug applications. The agency can use the kind of information to determine whether the antimicrobial drug product under study is safe and effective in the treatment of the specific infection studied.

파킨슨씨병 환자에 있어서 자가부신수질 이식술

정상섭,박상근,오성훈,김선호,윤도흠,박정수,양우익,최인준,안영수,김경환,박창일,김진수,이현철 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.6

Recent experimental studies and clinical cases have suggested that grafting tissue from the adrenal medulla into the brain may alleviate the symptoms of Parkinson's disease. Autologous adrenal medullary grafts into the striatum was performed stereotactically in two patients with Parkinson's disease. Both patients were bedridden preoperatively, but 4 months after the surgery both became ambulatory and one was even capable of returning to his job. Even though the number of cases was small⑵ and the follow-up period was short, this study shows that adrenal medullary transplantation into the striatum may have some beneficial effects in patient with Parkinson's disease. Further experimental and clinical trials are necessary to see whether this procedure will be a recommendable surgical treatment for patients suffering from Parkinson's disease.

체육교육분야 컴퓨터 코딩시스템의 적용과 이해

정우영,박성제 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

The purpose of the study was to introduce so that we can use from now on at my a country spot education and an offer about various a future educational research through Sequential Behavior Analysis research theoretical consideration and Case Study to there is one analysis use system observational coding system in sport pedagogy. SBA, as differentiated from more traditional approaches to the analysis of behavior, focuses explicitly on the interactions among multiple behaviors and takes into account the situational or environmental variables within which these many interactions take place. such information will lead to what may be most effective in a generalized sense, and what may be more or less relatively effective with certain student types, in what ecologies, and for what subject matters, Equally important, this type of education practices.

좌심실 이완기 장애 평가에서 Atrioventricular Plane Displacement의 임상적 중요성

정연손,조구영,이태유,김근숙,최창순,류제헌,최민호,박우정,임종윤,이영 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.12

微細血管의 自家靜脈移植, Silicone Tube 揷入, 同種動脈移植의 實驗的 比較觀察

朴承河,丁銓殷,金雨慶 大韓成形外科學會 1985 Archives of Plastic Surgery Vol.12 No.2

In many microvascular surgery, vascular replacement of small artery is often necessary due to arterial defect or tension, and autogenous vein graft has been widely used. But graft has some problems such as aneurysm formation, presence of valve, need much time, difficulites in gain of sufficient length and proper diameter,and stenosis tue to thickening of vessel. The use of vascular prosthesis has been increased, but the complications such as hemorrhage, infection, and thrombosis were reported by many authors. The diameter of vascular prosthesis is smaller, the occlusion rate tue to thrombosis is higher, and clinically the vascular prosthesis has not been used in small arterial defect. In this experimental studies, the arterial defect was made by excision of carotid artery of rat which its average external diameter is 1.2mm, and this was replaced with 4 different methods. 80 rats were divided into 4 groups as following. 1. Autogenous vein graft from femoral vein. 2. Implantation of silicone tube which its internal diameter is 1.0mm 3. Arterial allograft not preserved in alcohol. 4. Arterial allograft preserved in alcohol. The patency rate and histologic changes are observed at postoperative 3 days, 1 week ,2 weeks and 3 weeks, and the results are as followings; 1. The patency rate is the highest in autogenous vein graft group(89%) and the lowest in silicone tube implant group(53%) 2. The aneurysm formation is most frequently noted in autogenous vein graft group(37%) 3. The occlusion due to thrombosis is the most frequent in silicone tube implant group(47%) 4. Arterial allograft preserved in alcohol is more patent, and less foreign body reaction than arterial allograft not preserved in alcohol.

화학 이론의 전통 과학적 연구

박서영,정원우,방경곤,김용수,문장수,이우붕 慶北大學校 師範大學 科學敎育硏究所 2007 科學敎育硏究誌 Vol.31 No.-

According to the system of the oriental traditional science, everything has to be harmony and interact with one another. The fundamental notions of the traditional natural philosophy are "do(doctrine)", "taegeuk(the great absolute)", "yin-yang," "five primary substance", "four events", and "eight signs for divination". Taegeuk, especially, explains the formation and the death of all things in the universe through circulation of yin-yang, and shows the balance of nature and universe. Yin-yang, relative ideas produces four events, and four events also is divided into the eight signs for divination. 'four events', 'eight signs for divination' like 'yin-yang' indicates the cycle of nature. The essential notions of the traditional science are not different from those of modern chemistry. Taegeuk which is the origin of all things in the universe means the situation of harmony and balance through ceaseless circulation and connotes dynamic equilibrium on neutralization that chemical reaction get to. A number of opponent concepts such as acid-base, oxidation-reduction, atomic nucleus-electron are given an explanation by ying-yang(the positive and negative) that reaches Taegeuk through chemical bonding or reaction over simple antagonistic relationship. 'Yin-yang', 'four-events', 'eight signs for divination' do not imply a substance or a phenomenon in itself but the properties of them. That is why it is possible to see into various chemical concepts like a relative strength of acid-base, groups of periodic table with traditional scientific philosophy. We have regretfully neglected studies in traditional science. It is time to perform the concrete work connecting theory of traditional science with that of modern science for advisable appreciating of traditional science. Moreover, It is necessary to do research and development of educational programs or teaching-learning materials using the traditional science properly. 동양 과학 철학이나 자연 철학은 태극,음양오행,사상팔괘를 이용해 우주 만물의 운동과 자연의 순환을 설명하는데 있어 그 학문적 우수성을 부인할 수 없으나 현대의 화학식이나 수식이 현상을 미시적 관점에서 구체적으로 설명할 수 있는 것과는 달리 전통 과학이론은 거시적 관점에서 그 전체적 흐름만을 나타낸다는 한계를 가지고 있다. 그럼에도 불구하고 태극,음양오행 그리고 사상팔괘론을 중심으로 한 전통 과학 이론은 현대인들에게 과학에 대한 새로운 시각을 제공함으로써 무분별하고 비윤리적인 과학 기술 활용으로 인한 전 지구적인 문제들을 해결하는데 있어 핵심적인 역할을 수행함은 물론 오늘날의 한국 과학이 한 걸음더 전진하는데 이바지 할 수 있을 것이다. 그러므로 서구 중심의 기존의 과학문명에만 머무를 것이 아니라 동양의 전통 과학 철학을 연구하여 민족의 과학 체계를 수립하고 과학의 토착화를 이루어야 한다. 이를 성공적으로 수행하기 위해서는 전통 과학과 현대 과학 사이에 다리를 놓는 구체적인 작업이 본격적으로 진행되어야 한다. 기본적인 화학 개념들을 전통 과학적 관점에서 재해석 하는 것은 물론이고 더 나아가 전통 과학의 이론을 이용하여 화학 반응 과정을 구체적으로 설명하려는 시도가 필요할 것이다.

體育專攻學生과 體育特技者學生들의 性格特性 比較

鄭相澤,朴宇奎 慶北大學校 體育科學硏究所 1988 체육과학연구지 Vol.4 No.-

The purpose of this study was to offer athletes data for guidance and performance improvement through comparative analysis of personality traits of sutdents majoring in physical education and athletes majoring in others. The subjects employed were 75 male students in K University, who were devided into 3 groups of 25 athletes majoring in physical education, 25 monathletes majoring in physical education, and 25 athletes majoring in others. The results obrained are sumarized as follows: 1. Athletic gourp majoring in physical education was somewhat higher in superiority and sociality than in other traits. 2. Athletic gourp majoring in physical education was somewhat lower in masculinity, responsibility, superiority, and emotional stability than in other traits. 3. In nonathletic group majoring in physical education, sociality showed the highest rate. Conformity is the next highest rate and then follows superiority. 4. In nonathletic group majoring in physical education, the remaining personality traits with exception of sociality stay the normal range. Therefore, we understanded that could not persist certainly "What does personality trait of sportsman show?"

Murine Sarcoma Virus로 변이시킨 가토신장세포의 지질조성에 대한 연구

정주광,박주홍,김우제,김경진,고광삼 朝鮮大學校 附設 醫學硏究所 1986 The Medical Journal of Chosun University Vol.11 No.1

Differencies of lipid composition of mnrine sarcoma virus 970-17 traiisfomed rabbit kidney cells and their plasma membranes were studied. Free cholesterol was the major neutral lipid extracted from the whole cells and plasma membranes of all these cells. The micromoles of total neutral lipids and phospholipids are elevated in plasma membranes compared to whole cells from monolayer cultures. The distribution of fatty acids in the major lipid classes of plasma membranes and whole cells generally follow the composition of calf serum used in the culture media.

재활용재 혼입 콘크리트 패널의 진동감쇠성 평가실험

정영수,조성호,최우성,박용구 中央大學校 建設環境硏究所 1998 環境科學硏究 Vol.9 No.1

Vibration-controlled concrete has been developed by using various concrete mixtures, such as latex, rubber powders, plastic resins and polystyrene(styrofoam). As part of the recycling research of obsolete aged <tires and plastic> materials, vibration-reducing mixtures are used for 10 concrete panels above 200 ㎏/㎠ in uniaxial compressive strength. Laboratory test and open space test have been carried out for the analysis of the impact wave, of which data have been transferred by the FFT technique to comparatively investigate damping ratios of 10 concrete panels. According to wave propagation analysis on vibration- controlled concrete for this research, it can be concluded that Latex concrete has relatively larger damping ratios than those for noncontrolled normal concrete with similar compressive strength.

일반인과 정신과 환자 보호자들의 정신질환에 대한 인식과 태도에 관한 연구

박정우,곽영숙,백기청 大韓神經精神醫學會 1995 신경정신의학 Vol.34 No.4

This study was conducted to examine the knowledge and attitude toward mental illness in the lay people and the psychiatric patients' caretakers from December 1993 to October 1994. 242 lay people who were the parents of the students in an elementary school and 164 psychiatric patients' caretakers at Seoul National Mental Hospital were asked to answer a questionnaire about mental illness. In addition, parent Bonding Instrument(PBI) was used to determine the parental bonding style in 94 psychiatric patients' caretakers. And the results were as follows : 1) the primitive, supernatural concepts toward mental illness were significantly high in caretakers and in low educational group. 2) The psychological, environmental concepts toward mental illness were significantly high in female and in low educational group. 3) The negative attitudes toward the mentally ill were significantly high in female caretakers and in older age group and how educational group. 4) The caretakers' negative attitude toward the mentally ill were significantly associated with increased number of admissions. 5) The Mothers had more psychological, environmental concepts and more negative attitudes toward mental illness than the siblings in caretakers. 6) The negative attitudes toward the mentally ill were significantly associated with high level of parental overprotection and low level of parental care and the primitive, supernatural concepts toward mental illness were significantly associated with high level of paternal overprotection and low level of paternal care. We suggest that educational programs on the mental illness, especially for the primary caretakers, are necessary for early detection and treatment of illnesses, prevention of relapses- and rehabilitation.