제2형 당뇨병 남성 환자에서 유리 테스토스테론과 성호르몬 결합 글로블린 농도

남기덕,김영설,박철영,오승준,김덕윤,우정택,김성운,양인명,김진우,최영길 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.6

연구배경:인슐린저항성은 제2형 당뇨병과 심혈관질환의 주요한 위험 인자로 성호르몬과 상호 관계가 있다고 알려져 있다. 그러나 여성과는 달리 남성에서는 연령과 인슐린저항성에 따른 유리 테스토스테론과 성호르몬 결합 글로블린 농도의 변화에 대한 연구가 부족한 실정이다. 그러므로, 본 저자등은 제2형 당뇨병 남성 환자에서 정산인과 비교해서 유리 테스토스테론과 성호르몬 결합 글로블린 농도를 측정하고 연령에 따른 변화 정도를 알아보고자 하였다. 방법:대상 환자 모두에서 연령과 체질량지수, 총 콜레스테롤, 중성지방, 공복혈당과 인슐린 농도를 측정하였다. 혈중 유리 테스토스테론 농도는 방사면역측정법(radioimmunoassay)을 이용해서 측정하였고, 혈중 성호르몬 결합글로불린은 면역방사계측측정법(immunoradiometric assay)을 이용해서 측정하였다(Diagnostic System Laoratories, Wbster, TX, USA). 결과:1)제2형 당뇨병 남성 환자에서 정상 대조군 남성에 비해 성호르몬 결합글로불린은 104.1±35.0 vs 25.7±3.5 mole×10??로 의미 있게 높았으나(p<0.001), 유리 테스토스테론은 13.7±9.5 vs 13.6±6.5 ng/dL로 차이가 없었다. 2)연령과 성호르몬 결합 글로블린 사이의 상관 계수는 제2형 당뇨병 남성 환자에서 0.40로 중등고의 양의 상관 관계를 보였고(p<0.001), 정상 대조군 남성에서 0.11로 유의한 상관 관계를 보이지 않았다. 연령과 유리 테스토스테론 사이의 상관 계수는 제2형 당뇨병 남성 환자에서 0.08, 정상 대조군 남성에서-0.17로 모두에서 유의한 상관 관계를 보이지 않았다. 3)연령과 체질량지수를 보정한 후에 제2형 당뇨병 남성 환자와 정상 대조군 남성에서 혈중 인슐린 농도, 유리 테스토스테론과 성호르몬 결합 글로블린 사이에는 상관 관계가 없었다. 결론:제2형 당뇨병 남성 환자에서 정상 남성에 비해 성호르몬 결합 글로블린 농도가 증가되어 있었으며, 유리 테스토스테론은 차이가 없었다. 연령이 증가함에 따라 성호르몬 결합 글로블린이 제2형 당뇨병 남성 환자에서 정상 남성에 비해 증가 폭이 의미있게 컸으며, 유리 테스토스테론은 변화가 없었다. Background: Insulin resistance is a risk factor for cardiovascular disease and type 2 diabetes mellitus. There are many previous studies indicating that insulin lowers serum sex hormone-binding globulin levels, and there is inverse correlation between insulin resistance and serum sex hormone-binding globulin levels in women. However, in men, a limited number of studies are available to explain the effect of sex hormone on age and insulin. Therefore, the present study was undertaken to investigate the relationship among free testosterone, hormone-binding globulin and age in type 2 diabetic men and control subjects. Method: Age, body mass index, total cholesterol, triglyceride, fasting blood sugar, and insulin concentrations were examined on 89 type 2 diabetic men and 47 control subjects. The free testosterone level was measured by commercially available double-antibody system (Radioimmunoassay). The sex hormone-binding globulin level was also measured by commercially available double-antibody system(Immunoradiometric assay). Results: 1) Sex hormone-binding globulin level was significantly increased in patients with type 2 diabetes. However, there was no significantly difference in free testosterone level between the two groups. 2) Sex hormone-binding globulin was positively correlated with age (r=0.4, p <0.001) in patients with type 2 diabetes. Sex hormone-binding globulin and free testosterone were not correlated with age in control sujects. 3) Free testosterone and sex hormone-binding globulin concentrations were not significantly related to serum insulin concentration after adjusting for age and body mass index. Conclusions: We observed increased sex hormone-binding globulin concentration in diabetes man, and was a positively related to age. Further studies are needed to understand the relationships between age, insulin resistance, testosterone, and sex hormone-binding globulin concentrations(J Kor Diabetes Asso 24:699~707,2000).

거대적아구성빈혈의 임상적 고찰

곽승근,천재민,박남숙,박상은,박수진,윤환중,김삼용,조덕연 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Megaloblastic anemias are disorders caused by impaired DNA synthesis and chara-cterized by the presence of megaloblastic cells. Clinical data on these disorders in Korea are limited. The aim of this study was to analyze clinical characteristics of megaloblastic anemias caused by vitamin B12 deficiency. We identified 40 cases who were diagnosed as megaloblastic anemia from January 1993 to December 2002 in a retrospective study on the basis of chart review. We investigated the annual distribution of diagnosed patients, clinical manifestations and response to treatment. 19 cases were complicated with a previous total gastrectomy(gastrectomy group) and 21 cases had no history of surgical operation(non-gastrectomy group). The most common presenting complaint was generalized weakness. The median age at diagnosis was 7(range: 38-79) years in non-gastrectomy group. The mean pos-toperative duration was 7(range: 4-25)years in group of total gastrectomy and mean level of serum vitamin B12 was lower than 100 pg/mL in both group. Peripheral blood revealed thrombocy-topenia, macrocytic anemia and hypersegmented neutrophil in all cases. After treatment of pareliteral vitamin B12, Their clinical symptoms and hematologic findings improved except two patients who had bone marrow with lower cellularity. Cobalamin replacement after total gastrectomy is still missing. Diagnoses are made too late in a population of patients, resulting in irreversible neurological sequale, and we suggest that Pernicious anemia seems not to be very rare in Korea.

벼 생산경영 종합관리 S/W개발

김웅,김창수,김동원,국중덕,송영주,오남기,최영근 한국농업정보과학회 2001 농업정보과학 Vol.3 No.1

This programme consisted of 8 menus, which are basic information, job worksheet, technique information, management analysis, file management, window management, help and conclusion. The major functions of this programme by menus classified as follows : 1. The basic information menu, which consisted of a lots of basic farm management information, can be easily accessible to get general farm status of S/W users and inputted data used as basic data for farm management analysis. 2. In worksheet menu, users can easily access to record and search of farm work planning, contents of work, agricultural materials and selling status. 3. In management achievement menu, lots of indexes which represent one years' management achievements are produced and can be compare this years' achievements with last years' ones. This programme Delphi5 and Object pascal programme were used for tools and languages. Also Paradox4 and BDE were used for DB and DB engine respectively.

大田 3大 河川의 自然河岸과 人工河岸의 植物相과 植物群落의 比較

이정하,조국연,김성덕,이남주 忠南大學校 環境問題硏究所 1998 環境硏究 Vol.16 No.-

The phytosociological investigation was carried out at natural and artificial streamsides over 3 main streams located in Taejeon, by Braun- Blanquet's method for the comparative study of the flora and vegetation from May to October, 1998. On the natural streamside, total number of vascular plant species were 142 species and hydrophyte of them was 27 species, while on the artificial streamside the former species number was 138 species and hydrophyte was 21 ones. The plant communities in the natural streamside were classified into 17 groups, such as Zizania latifolia community, Typha orientalis community, Phragmites communis community, Phragmites japonica community, Miscanthus sacehariflorus-Hemarthria sibirica community, Leersia japonica community, Trapa japonica-Trapa pseudo-incisa community, Marsilea quadrifolia community, Hydrilla verticillata-Myriophyllum verticillatum community, Vallisneria asiatica-Potamogeton malaianus var. latifolius community, Myriophyllum verticillatum community, Spirodela polyrhiza- Lemna paucicostata community, Salix glandulosa-Salix koreensis community, Salix gracilistyla community, Salix koreensis community, Phalaris arundinacea community, Persicaria hydropiper community. On the other hand, the plant community in the artificial streamside was classified into 14 communities, such as Zizania latifolia community, Typha orientalis community, Miscanthus sacchariflorus - Hemarthria sibirica community, Phragmites japonica community, Leersia japonica community, Hydrilla verticillata-Myriophyllum verticillatum community, Vallisneria asiatica- Potamogeton malaianus community, Paspalum distichum community, Phalaris arundinacea community, Persicaria hydropiper community, Zoysia japonica-Digitaria sanguinalis community, Panicum dichotomiflorum-Persicaia lapathifolia community, Echinochloa crusgalli- Setaria viridis community, Artemisia princeps community, Rumex crispus- Rorippa islandica community, Portulaca oleracea community, Potentilla paradoxa community, Panicum dichtomiflorum community. Number of species and plant communities were variously distributed over the various sites in the natural streamside, it is more than in the artificial streamside was distributed. These results mean that the distribution of plant community and number of species in the wild plant were more closely to be related to the human impacts or one's disturbance.

FCL(5-FU, Carboplatin, Leucovorin) 항암 화학요법에서 Gm-CSF의 효과

최지영,김현수,김종숙,박상준,윤환중,조덕연,남상륜,김삼용 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Background: One of the major side effects of cancer chemotherapy is myelosuppression. Neutropenia and/or thrombocytopenia are dose-limiting factors in chemotherapy. Colony-stimulating factor induces proliferation and functional maturation of hematopoietic progenitor cells. GM-CSF is primarily active on progenitor cells of granulocytic and monocytic lineage. Methods: Fifteen patients with histologically proven malignancy diagnosed at Chungnam National University Hospital from January 1993 to August 1995 were included in this study. We could evaluate the clinical efficacy of GM-CSF in 13 patients undergoing FCL(5-FU, Carboplatin and Leucovorin) chemotherapy; the first cycles involved no GM-CSF while the second cycles involved GM-CSF on day 6 through 15 of chemotherapy. Results: 1) The subjects were fifteen patients in all, there were five patients with head and neck cancer, which was the most common types of maligancy. There were four patients with colon cancer, two patients with stomach cancer, and one patient with breast cancer, gallbladder cancer, cervix cancer and cholangiocarcinoma respectively, two patients, who did not complete two cycles of chemotherapy were excluded. 2) Age distribution was from 38 years to 78 years with a median age of 57. 3) In FCL chemotherapy cycles with GM-CSF, the duration of neutropenia(<500/μL) was 0.5±0.3 day, while FCL chemotherapy cycles without GM-CSF, it was 2.9±0.7 day(P=0.008). 3) There was no significant difference in platelet count between the two chemotherapy cycles(P=0.133). 4) Febrile duration without GM-CSF was 4.9±2.1 day, but with GM-CSF the duration was 1.3±0.7 day, which was significantly different(P=0.003). The duration of antibiotics use with GM-CSF was 1.7±1.2 day and without GM-CSF was 6.8±3.2 day, also significantly different(P=0.002). But hospital stay between the two cycles were not significantly different(P=0.064). Conclusion: GM-CSF was effective in preventing or restoring bone marrow depression after FCL chemotherapy.

A Cost-effective 60Hz FHD LCD Using 800Mbps AiPi Technology

Nam, Hyoung-Sik,Oh, Kwan-Young,Kim, Seon-Ki,Kim, Nam-Deog,Kim, Sang-Soo The Korean Infomation Display Society 2009 Journal of information display Vol.10 No.1

AiPi technology incorporates an embedded clock and control scheme with a point-to-point bus topology, thereby having the smallest possible number of interface lines between a timing controller and column drivers. A point-to-point architecture boosts the data rate and reduces the number of interface lines, because impedance matching can be easily achieved. An embedded clock and control scheme is implemented by means of multi-level signalling, which results in a simple clock/data recovery circuitry. A 46" AiPi-based 10-bit FHD prototype requires only 20 interface lines, compared to 38 lines for mini-LVDS. The measured maximum data rate per data pair is more than 800 Mbps.

An Investigation on the Effects of Fixed Charge and Interface States on the Drain Current of a-Si:H TFT's

Nam-Deog Kim,Choong-Ki Kim 대한전기학회 1990 Journal of KIEE Vol.3 No.2

Novel Impulsive Driving Schemes for 120Hz LCD Panels

Nam, Hyoung-Sik,Oh, Jae-Ho,Shin, Byung-Hyuk,Oh, Kwan-Young,Berkeley, Brian H.,Kim, Nam-Deog,Kim, Sang-Soo The Korean Infomation Display Society 2008 Journal of information display Vol.9 No.1

Two new impulsive driving technologies for 120Hz liquid crystal display (LCD) panels are proposed to improve moving picture quality. One technology generates the dark frame using an adder and a shifter simply without using any look up tables (LUTs). It results in a cost effective impulsive scheme with motion picture quality comparable to that of high speed driving. The other is a backlight flashing method designed to avoid ghost images. The issue of ghost images caused by the slow response time of liquid crystal (LC) is solved by means of 120Hz overdriving and 120Hz backlight flashing. Using the perceived blur edge time (PBET) metric, measured moving picture response time (MPRT) values were 10.8ms and 4.4ms, respectively, while that of 120Hz high speed driving was 10.1ms.

오스테나이트계 SS배관의 협개선 TIG 용접부 특성 조사

심덕남(Deog-Nam Shim),정인철(In-Cheol Jung) 대한기계학회 2003 대한기계학회 춘추학술대회 Vol.2003 No.4

Although Gas Tungsten Arc Welding (GTAW or TIG welding) is considered as high quality and precision<br/> welding process, it also has demerit of low melting rate. Narrow-gap TIG welding which has narrow joint width<br/> reduces the groove volume remarkably, so it could be shorten the welding time and decrease the overall shrinkage in<br/> heavy wall pipe welding. Generally Narrow-gap TIG welding is used as orbital welding process, it is important to<br/> select the optimum conditions for the automatic control welding<br/> This paper looks at the application and metallurgical properties on Narrow-gap TIG welding joint of heavy wall<br/> large austenitic stainless steel pipe to determine the deposition efficiency, the resultant shrinkage and fracture toughness.<br/> The fracture toughness depends slightly on the welding heat input.

Evaluation of Runners Produced at High Elevation for Forcing Culture of New Strawberry Cultivars

Jong Nam Lee,Ju Sung Im,Jun Gu Lee,Chun Woo Nam,Ki Deog Kim,Eung Ho Lee,Young Rog Yeoung 한국원예학회 2008 한국원예학회 학술발표요지 Vol.2008 No.5