고량강의 항염증 작용에 대한 연구

박히준,이제현,김수영,심범상,구헌종,강전모,최일환,이재동,김남재,이지숙,임사비나 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objective : The use of herbal therapy is becoming an increasingly attractive approach for the treatment of various inflammatory disorders. The Alpiniae officinari Rhizoma is popular in Aisa as a traditional herbal medicine. Alpiniae officinari Rhizoma is a species of the ginger family(Zingiberacease). Method : This study was performed to investigate the anti-inflammatory effect of Alpiniae officinari Rhizoma extract by the methods of "carrageenan induced paw edema" and "Lipopolysaccharide-induced inflammatory mediators in mouse macrophage RAW 264.7 cells". Result : We suggest that Alpiniae officinari Rhizoma extract decreased paw volume induced by plantar injection of carrageenan. Also Alpiniae officinari Rhizoma extract inhibited nitric oxide, prostaglandin E₂production and induced nitric oxide synthase, cyclooxygenase-2 protein expression in Mouse macrophage RAW 264.7 cells stimulated with lipopolysaccharide. Conclusion : This study shows that Alpiniae officinari Rhizoma extract seems to have anti-inflammatory effect by inhibition of nitric oxide, prostaglandin E_(2) production and nitric oxide synthase, cyclooxygenase-2 protein expression.

복합레진 색상의 측정 기기에 따른 차이

박수정,노은영,조현구,황윤찬,오원만,황인남 大韓齒科保存學會 2009 Restorative Dentistry & Endodontics Vol.34 No.3

본 연구에서는 동일한 수광 방식을 사용하는 2종의 이동형과 고정형 spectrophotometer인 MiniScan XE plus (Model 4000S, Hunter Lab, USA)와 CM-3500d (Minolta, Japan), 그리고 다른 수광 방식을 사용하는 miniature VIS reflection spectrometer인 Specbos 2100(JETI Technische Instrumente GmbH, Germany)를 이용하여 직경 15 mm, 두께 4 mm의 디스크로 제작한 광중합 복합레진의 색상을 측정하였다. Spcebos 2100은 분광 특성을 측정하는 기기이지만 주문에 의해 제조사에서 측색이 가능한 형태로 제공하였다. 3종의 측색 기기를 사용한 측색 결과를 분석한 결과, 동일한 수광 방식, 광원 및 관찰자 각도를 적용한 2종의 기기 간에도 동일 색상에서 2.4-7.8까지의 색차(ΔE^(*))를 보였으나, L^(*),a^(*), b^(*) 값은 기기 간에 높은 상관관계를 보였다. 서로 다른 수광 방식을 사용하는 기기 간에는 약 20정도의 큰 색차(ΔE^(*))를 보이며, 측정된 각 값 간에도 낮은 상관관계를 보였다. 이상의 결과는 반투명의 치과용 수복 재료나 치아의 측색 시 측색 기기간에도 색차가 나타날 수 있음을 시사하며, 이는 기기에 대해 측정된 색상을 절대적인 색상으로 적용하기 보다는 상대적인 측정치로 이용하는 것이 바람직하리라 사료된다. The objective of this study was to evaluate the effect of color measuring instrument by measuring the color of dental composite resins. Nine shade light cured composite resin disks were prepared (diameter : 15 mm, thickness : 4 mm). CIE L^(*)a^(*)b^(*) color scale of each disk was measured with 3 different types of spectrophotometer 〔MiniScan XE plus (Model 4000S, Hunter Lab, USA), CM-3500d (Minolta, Japan) and Specbos 2100 Miniature VIS Reflection spectrometer (Serial No: 319416, JETI Technishe VIS Instrumentic GmbH, Germany)〕. Miniscan XE Plus and CM-3500d using identical measuiing geometry with different size of viewing aperture. But Specbos 2100 using different measuring geometry. Within the limitation of this study, there were color difference (ΔE^*) from 2.4 to 7.8 between Miniscan XE Plus and CM-3500d, but L^(*), a^(*), b^(*) values showed the high correlation. However, there were great color difference(ΔE^*) in the extent of about 20 between instruments with the different measuring geometry. Therefore, color scale measured by color measuhng instrument should be used as a relative value rather than an absolute value in the field of dentistry.

Java 병행프로그래밍 도구의 개발

박양수,김현규,문남두,이명준 울산대학교 1999 공학연구논문집 Vol.30 No.2

분산응용시스템은 서비스의 효율향상을 위해 일반적으로 병행성을 지원하는 것이 바람직하다. 그러나 병행성을 지원하기 위한 프로그래밍 기법은 난이도가 높은 구현 기법이며, 대부분의 프로그래밍 언어에서 이를 직접적으로 지원하지 않으므로, 분산응용시스템을 위한 개발자의 부담을 가중시키고 있다. 본 논문에서는 현재 분산응용시스템의 작성에 널리 쓰이고 있는 Java에서 병행성을 체계적으로 지원하기 위한 기반으로서, 세미포어나 조건변수와 같은 고수준 동기화 도구의 개발에 대해 소개하였다. 이러한 Java고수준 동기화 도구는 순수한 Java로 개발되어 이식성을 지니고 있으며, 개발자가 쉽게 기술할 수 있는 인터페이스를 제공하고 있다. 또한 Java가 지닌 대중성으로 인해 대부분의 분산응용시스템의 구축에 널리 사용될 수 있을 것으로 기대된다. In a development of distributed applications, it is desirable for a server to support concurrency in order to provide effective services. However, the programming mechanism for concurrency is difficult to implement correctly, so most programming languages do not support this facility directly. Therefore, the fact imposes extra burdens to the developers for distributed applications. The high-level synchronization tools such as Semaphores and Condition Variables in Java are suggested as a basis for systematically supporting concurrency control. The suggested high-level synchronization tools also have a good portability since it has developed in pure Java. In addition, due to the popularity of Java, these tools will ho a long way with developers in building distributed systems.

WWW 기반의 원격교육시스템 설계 및 구현

박남숙,장기화,곽난희,이수현,우용태 國立 昌原大學校 精報通信硏究所 1998 精報通信論文集 Vol.2 No.-

The purpose of this paper is to develope a distance education that would be a courseware for a specific object, which can be available for student to learn the necessary knowledge or function, with no restriction of time or place, using WWW and Oracle DBMS. The distance education was designed in this paper consists of bulletin board, subject information, lecturing schedule, online instructions, questions and answers, submit and confirmation of reports, evaluation of lecturing, reference sites, chatting and discussion room, and data bank. The distance education coupled by WWW and database will change the educational form from one-direction to bi-direction between a teacher and the students. This can also provide a multimedia information to the students through WWW environment with convenient user interface. Those benefits made it possible to offer animated audio-visual materials and search for the information concerned through a hypertext technique. Besides, various kinds of informations were stored at database to increase an effectiveness in managing data. Since both teacher and students, are easy to add new information using the process of instruction to the database, the amount of the stored information in the distance education can be expanded effectively.

계지의 항염 효과에 관한 연구

박히준,이지숙,이재동,김남재,표지희,강전모,최일환,김수영,심범상,이제헌,임사비나 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objectives : Cinnamomi Ramulus (CR), the young twing of Cinnamomi loureirii nees, has been used for treating symptoms related to pain. rheumatic arthritis and inflammation in Korean herb medicine. This study was carried out to investigate the anti-inflammatory effect of CR in vivo and in vitro. Methods : Extracts of CR were prepared and the chemical components of the extracts were examined by gas chromatography-mass spectrometry (GC-MS). The extracts were administrated to the rat paw edema model induced by carrageenan to evaluate the anti-inflammatory effect of CR. The expressions of nitric oxide (NO). prostaglandin E2(PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 were also quantified in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages to survey the effect of CR in vitro. The main components were cinnamaldechyde and coumarin. Results : We examined the anti-inflammatory activity of the 80% ethanol extract of Cinnamomi Ramulus in vivo by using carrageenan-induced rat paw edema model. Maximum inhibition of 54.9% was noted at the dose of 1000㎎/㎏ after 2 hours of drug administration in carrageenan-induced rat paw edema and this showed a potent anti-inflammatory effect. Conclusions : The results showed that Cinnamomi Ramulus suppressed dose-dependently LPS-induced NO production in RAW 264.7 macrophages and also decreased iNOS protein expression. Cinnamomi Ramulus also showed a significant inhibitory effect in LPS-induced PGE2 production and COX-2 expression.

동일한 국제예후지표(International Prognostic Index)를 나타내는 미만성 대형 B-세포 림프종에서 Bcl-2와 p16의 임상적 중요성

박상은,박수진,곽승근,박남숙,천재민,윤환중,조덕연,김삼용,김진만 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

In Korea, malignant lymphoma is a common cancer, comprising about 2.7% of all malignant neoplasm. Diffuse large B cell lymphoma is the most common lymphoma, representing about 50% of all Non-Hodgkin's lymphoma. Diffuse large B-cell lymphoma is usually considered as heterogeneous group of neoplasms rather than a single clinicopathological entity. Clinical prognostic systems, including the International Prognostic Index (IPI), although useful to assess overall prognosis, embrace patients with heterogeneous prognoses. But International Prognostic Index scoring system is not sufficiently predict the prognosis. It is likely that the prognostic assessment of patients with diffuse large B-cell lymphomamight be improved by using biological features. Bcl-2 protein and p16 protein expression is recognized as useful biologic markers predicting the prognosis of patients with diffuse large B-cell lymphoma. To determine the clinical significance and prognostic value of bcl-2 and p16 proteins expression patterns, we studied 18 patients with de novo DLBL, whose archival pathology specimen were available for immunohistochemistry studies, atChungnam National University Hospital from September 1992 to December 2000. Archival specimens from each patient were immunostained with respective antibodies for bcl-2, p16. The results are as follows; 1) The median age was 54(rage : 37-69). There were 12 male patients(66.7%) and 6 female patients(33.3%) The 'B' symptom was abscentin all patients. The stages were as follows : Ⅰ, 2 patient(11.1%), Ⅱ, 10 patient(55.6%), Ⅲ, 4patient(22.2%) and Ⅳ, 2patient(11.1%). 3 patients(16.8%) had the elevated LDH level, 14 patients(77.8%) had the normal LDH level and 1 patients(5.6%) was not identified the LDH level. 2 patients(11.1%) had the bulky disease and 16 patients(88.7%) had no bulky diease. The distribution of ECOG status were O, 2 patients(11.1%c), 1, 14patients(77.8%) and 2, 2patients(11.1%). 2) Theimmunohistochemistry results are as follows bcl-2:+,10 patients(55.6%), bcl-2:-, 8patinets(44.4%), p16:+,3 patients(16.7%), p16:-, 15patients(83.3%) 3) After a median follow UP durations of 67 months, the median survival time was 57 months with a rage of 7-100+ months. 5-years overall survival rates was 44% by Kaplan-Meier method. 4) Reduced overall survival was demonstrated in the patients who expressed bcl-2 protein(P=0.0174). 5-year overall survivial rate was 12%(bcl-2 expression) versus 88%(no bcl-2 expression) 5) Among diffuse large B-cell lymphoma patients with IPI score 0-1, reduced overall survival was demonstrated with bcl-2 expression(P=0.023). 5-year overall survival rate was 18%(bcl-2 expression group) versus 100%(no bcl-2 expressiongroup) 6) Median survival durtation of diffuse large B-cell lymphoma patients negative for p16 expression was 57 months whereas p16 postive patients' median survival duration was not reached(P=0.4478). In diffuse large B-cell lymphoma patients with identical IPI scores, bcl-2 expression had additional prognostic value.

상수도 배수방식의 비교방법

박남식,홍성훈,김한수,황병은 동아대학교 건설기술연구소 2003 硏究報告 Vol.27 No.1

In this study quantitative and systematic methods are proposed to compare alternative water supply pipe networks. The design code gives general guidelines on hydraulics and power requirements. However, the design code lacks detailed approaches. In this study aspects regarding hydraulics, water quality, and power requirements are considered. Various quantitative indices are derived.

신생아 고 17α-Hydroxyprogesterone치의 추이

박은영,조진형,이수진,양승,김광남,신재훈,오필수 대한소아내분비학회 2003 Annals of Pediatirc Endocrinology & Metabolism Vol.8 No.2

부산지역에서 산재보상을 신청한 과로사에 관한 연구

남연,오차재,박정래,이동준,조병만,이수일 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.1

목 적 : 부산지역의 근로복지공단에서 1991년부터 1999년까지 과로사 관련 보상심사가 이뤄진 총 219례를 대상으로 과로사의 발생양상과 그 인정여부에 영향을 밀치는 요인을 밝힘으로써 향후 과로사 관련 연구의 기초적 자료를 제공하고자 하였다. 방 법 : 부산지역의 3개 근로복지공단 지사에 소장된 과로사 심사기록을 대상으로 재해자의 인구통계학적 변수와 소속사업장과 근무환경에 대한 변수, 사망원인질환과 기존질병력, 업무상 과중부하의 성격과 분류, 직무수행성과 직무기인성 여부에 대해 조사하였다. 그리고 행정기관의 과로사 인정에 영향을 미치는 요인들을 평가하였다. 결 과 : 1. 전체 219례 중 135례(61.6 %)가 과로사로 인정을 받았으며, 96년 이후 매년 50례 이상의 보상신청이 이뤄져 왔다. 전체의 30.6 %가 50인 미만의 영세사업장 소속이었고, 직업운전사와 경비 직종이 34.7 %로 높았다. 연령층은 50대 이상이 48.8 % 였고, 하루 12시간 이상의 근무자가 29.6 % 였다. 근무형태에서는 교대근무와 심야근무 등의 불규칙 근무형태가 37.5 %였으며, 새로운업무에 배치된 지 6개월 이내에 발생한 경우가 21.5 %였다. 2. 사망원인으로는 뇌출혈 등의 뇌혈관계 질환이 전체의 49.8 %로 심장질환보다 많았고, 현행법령상의 인정범위에 속하는 경우가 85.4 %였다. 또한 선행질병력이 48.9 %에서 나타났는데, 대다수가 고혈압 등의 순환기 질환으로 확인되어 이들 병력자들의 보건관리에 중점을 둘 필요를 보였다. 3. 운전과 감시·정밀작업, 위험작업, 잦은 장기 출장 등의 위험요인에 노출된 경우가 전체의 53.9 %였고, 재해에 선행된 돌발사건이 전체의 17.8 %에서 관찰되었다. 업무상 과중부하에서 업무량증가와 업무시간연장이 전체의 64.7 % 였고, 6개월 이상의 장기적인 육체적, 정신적 과중부하가 있었던 경우가 42.5 %였다. 이 결과로 볼때 현행 법령상의 장기적인 과로에 대한 인정범위가 보다 확대되어야 할 필요를 보여준다. 4. 과중부하가 발생에 기여한 것으로 평가된 예가 전체의 76.3 %로 실제 인정율보다 높았다. 이중 충분요인으로 작용한 경우가 43.6 %, 부분요인인 경우가 10.4 %, 변경·촉진요인인 경우가 22.3 %였다. 5. 과로사 인정여부와 각 변수간의 로지스틱 회귀분석에서는 해당 업무의 근무경력이 6개월미만인 경우가 교차비 6.76(p=0.016), 사망질환이 법규상의 뇌심혈관계질환에 포함되는 경우가 교차비 3.00(p=0.034)을로 유의하게 높았다. 업무상 과중부하의 증가가 있는 경우는 교차비가 2.02로 높았으나 통계적 유의성은 다소 낮았다(p=0.081). 반면 50대 이상의 고령층과 기존 병력자의 경우는 상대적으로 불인정되는 경향을 보여 현행 행정기관의 인정기준이 과로에 민감한 대상층을 포괄하지 못하고 있음을 보여주었다. 결 론 : 부산지역에서의 과로사는 주로 50인 미만의 영세사업장 중 운전업, 경비업 등에 종사하는 40대 이상의 중·고령층 근로자에서 많았다. 재해자중 다수에서 뇌·심혈관계질환 병력이 확인되었고, 행정기관의 과로사 인정에는 법규상 인정범위의 뇌·심혈관계질환으로 사망한 경우와 재해자의 근무경력이 6개월 미만인 경우에서 인정되는 경우가 의미있게 높았다. 반면 기존 질병력이 있거나 50대 이상의 고령층의 경우 과로사로 인정되지 못하는 경우가 보다 많게 나타났다. 그러나 본 연구에서는 장기적인 과로와 과중부하를 유발하는 고위험직업에서의 과로사 빈도가 높아 현행 법규상의 과로인정기간의 범위를 넓혀야 할 것이고 직업에 대한 고려를 포함하는 인정기준의 검토와 개선이 요구된다. 그리고 과로사를 예방하기 위하여 업무시간 및 업무량의 개선과 관리가 필요할 것으로 판단된다. Onjectives : Karoshi is a word meaning death from work-overload. Work-related diseases due to continuous overwork are primarily cerebro- and cardio-vascular in nature. In korea, despite an increase in the incidence of Karoshi, it is not easy to recognise by workmen's compensation in Korea. This study intended to establish basic information concerning the incidence of Karoshi. Methods : 219 cases were collected based on workers' compensation records of three Busan Regional Centers of Labor Welfare Corporation from 1991 to 1999. The size of workplace, occupation, daily working time, type of working schedule, job tenures, characters of work-overload and duration of work-overload were investigated according of subgroups of general characterictics. Both univariate and multiple logistic regression analyses were userd to estimate the relationship between risk factors and a recognition of Karoshi. Results :1. 61.6 % of total cases were recognized as Karoshi. 30.6 % occurred in a small workplace of less than 50 workers, 34,7 % were drivers or guardss, and 48,8 % were more than 50 years old. Additionally, 29.6 % worked more than 12 hours, 37.5 % were irregular hours and shift workers and 21.5 % of the total had been on the job less than 6 months. 2. Of the causes of death, 49,8 % was cerebro-vascular diseases and it was more than cardio-vascular ones. And 80.4 % of total cases was belonged to the recognition-category of the Labour Ministry's Law. The previous desease history was found on 49.8 % of all cases. Of them, hypertension was most common as 21.9 %. 3. 53.9 % of patients were exposed to job hazards such as driving, monitoring, guarding, risky jobs and frequent long-term official trips. 64.7 % recorded a increased work-overload of job contents and working hours. Of the several types of work-overload, 42.5 % displayed long-term physical and psychotic work-overload and 22.2 % exhibited job characteristic work-overload. 4. In this study, work-overload was associated with the incidence of Karoshi in 76.3 % of cases. This rate was higher than the recognition of Workmen's compensation recorded by the Korea Labor Welfate Corporation. Of these, 43.6 % belonged to sufficient factors, 10.4 % partial factors, and 22.3 % were due to aggravating factors. 5. Logistic regression demonstrated that death due to cerebro- and cardio-vascular disease, short-tenure within 6 month was significantly associated with a recognition of Karoshi (p=0.034, OR=3.00, CI=1.09~8.30/p=0.016, OR=6.76, CI=1.43~32.07 respectively) and that an increase of work-overload was also associated, but its statistical significance was slightly lower(p=0.081, OR=2.02, CI=0.91~4.46). However, no association was found between this recognition and overtime work, hazardous job, irregular work schedule, low-income, injury-onset place, or small size of workplace. The elderly group(>50years old) and those with a previous disease history were negatively associated with recognition although the statistical associaltion was low. Conclusions : Karoshi in Busan occurred frequently in a small workplace of less than 50 workers, especially drivers or guards. Additionally, these cases worked more than 12 hours, were irregular hours and shift workers. The death due to cerebro- and cardio-vascular disease, short-tenure within 6 month was significantly associated with a recognition of Karoshi. However Karoshi in this study occurred frequently in overtime work and high risk groups of work-overload. Therefore, for prevention of Karoshi, work-overload and overtime work need improved and controled.

우리나라 창작동화에 나타난 장애 관련 내용 분석

박남수,권정순 한국초등특수교육학회 2005 초등특수교육연구 Vol.7 No.1