Design of the Pohang Accelerator Laboratory (PAL) X-ray Free Electron Laser (XFEL) Test Machine

Mun Gyung Kim,Jinhyuk Choi,Tae Yeon Lee,Heung Sik Kang,Chang-Mook Yim,In Soo Ko 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.6

The Pohang Accelerator Laboratory is going to build an X-ray free electron laser (FEL) based on self-amplied spontaneous emission (SASE). This new machine will utilize the existing 2.5-GeV injection linac to the storage ring by upgrading its energy up to 3.7 GeV or more. The target wavelength will be 0.3 - 0.45 nm and its third harmonic 0.1 - 0.15 nm will also be used. The project will proceed in two stages: In the first stage, a visible light SASE machine with an energy of 200 MeV will be constructed and tested for the proof of principle. The full X-ray machine will be constructed in the next stage. This paper describes the updated design status of the first-stage test machine. The Pohang Accelerator Laboratory is going to build an X-ray free electron laser (FEL) based on self-amplied spontaneous emission (SASE). This new machine will utilize the existing 2.5-GeV injection linac to the storage ring by upgrading its energy up to 3.7 GeV or more. The target wavelength will be 0.3 - 0.45 nm and its third harmonic 0.1 - 0.15 nm will also be used. The project will proceed in two stages: In the first stage, a visible light SASE machine with an energy of 200 MeV will be constructed and tested for the proof of principle. The full X-ray machine will be constructed in the next stage. This paper describes the updated design status of the first-stage test machine.

김치 및 김치 유래 유산균의 건강 기능성에 대한 연구 동향 조사

김보경(Kim, Bohkyung),문은경(Mun, Eun-Gyung),김도연(Kim, Doyeon),김영(Kim, Young),박용순(Park, Yongsoon),이해정(Lee, Hae-Jeung),차연수(Cha, Youn-Soo) 한국영양학회 2018 Journal of Nutrition and Health Vol.51 No.1

Purpose: This review article provides an overview of the trends of research papers on the health benefits of kimchi and kimchi lactic acid bacteria published from 1995 to 2017. Methods: All publications from 1995 to 2017 regarding kimchi and kimchi lactic acid bacteria were collected, reviewed, and classified. This review article covers the publications of the health benefits of kimchi and kimchi lactic acid bacteria on experimental, clinical trials, and epidemiology studies. Results: The number of publications on kimchi over the period were 590: 385 publications in Korean and 205 publications in English. The number of publications on the health benefits of kimchi and kimchi lactic acid bacteria were 95 in Korean and 54 in English. The number of publications on kimchi and kimchi lactic acid bacteria were 84 and 38, respectively, in the experimental models. Ten research papers on kimchi in clinical trials and 7 publications in epidemiology were found. Kimchi or kimchi lactic acid bacteria had protective effects against oxidative stress, mutagenicity, toxicity, cancer, dyslipidemia, hypertension, immunity, and inflammation in in vitro, cellular, and in vivo animal models. Moreover, kimchi had effects on the serum lipids, intestinal microbiota, iron status, obesity, and metabolic parameters in human clinical trials. In epidemiology, kimchi had effects on hypertension, asthma, atopic dermatitis, rhinitis, cholesterol levels, and free radicals. Conclusion: This review focused on the publications regarding the health benefits of kimchi and kimchi lactic acid bacteria, suggesting the future directions of studies about kimchi and kimchi lactic acid bacteria by producing a database for an evaluation of the health benefits of kimchi.

숭실 인문학 연구 회고와 과제

김문경 ( Kim Mun-gyung ) 숭실대학교 인문과학연구소 2004 인문학연구 Vol.34 No.-

The institute of humanities was established in March 1966. Since the first collections of thesis was published on October 10. 1967, 33 issues of thesis collections had been published until 2003. The total numbers of the articles reached to 430 volumes. Following Soongsil University's Christian ideology, large proportions of articles were about the study of Christianity. In 1980s, the research activities were conducted more vigorously by many of scholars, and it also helped to broaden the range of research subjects. For example, old Korean’s role and activities in Japan and China was emerged as one of new research subject When Korea established official diplomatic relationship with China in 1992, studying of the new subjects, which was mentioned previously, became a lot easier and more active. Collaborated with Chinese university, the research and exploring historic scene were also conducted around Yien-ben area. In addition to that, international academic conference was held, which ignited more vigorous research activities on the study of the humanities. In 2000s, the term of ‘The Crisis of humanities’ was often mentioned by the intelligentsia. Special issue of 'The study of humanities and intelligent was published in 2002 influenced by the academic tendency. Also, 'How to educate the humanities?' was published on the 33rd issue of thesis collection. Based on the previous retrospect, I would like to propose a couple of subjects for study of Soongsil humanities research. The crisis of the humanities always has been existed with the changes of society and the human history through out the world. However, many scholars in the past overcame the crisis wisely and they even brought the level of the humanities study up one step higher. Regardless of the Eastern and Western, the revival of literacy had been took place when the period of humanism and humanities crisis occurred. Hence, the study of classics cannot be ignored and should be doing an important role in the field of humanities study. Searching for the 'true spirit of human' and bring it back to life is the way to survive the critical era. In addition to that, the study of Southeast Asia, central Asia and Islamic world need to be conducted as well. The misunderstanding between the two worlds caused negligence of the study of global world. (Eastern and Western) Such negligence created antagonism between the two worlds. The study of classics, including human, academic research, ideology and religion, is essential to create new values that fits into the modem society, and we need to take the initiative.

[S10-1] The Characteristics of Fermentation Liquor of Wild Vegetables

Eun-Gyung Mun,Bo-Young Lee,Ju Kim,Kang-Yeol Yu,Tae-Ho Kwon,Jong-Wook Kim 한국식품영양과학회 2010 한국식품영양과학회 학술대회발표집 Vol.2010 No.10

건강 기능성 연구를 중심으로 한 전통발효식품의 연구동향

문은경(Eun-Gyung Mun),김보경(Bohkyung Kim),김은영(Eun-Young Kim),이해정(Hae-Jeung Lee),김영(Young Kim),박용순(Yongsoon Park),차연수(Youn-Soo Cha) 한국식품영양과학회 2018 한국식품영양과학회지 Vol.47 No.4

본 연구는 한식에서 양념으로 이용하는 발효식품 5종류(간장 및 된장, 고추장, 청국장, 젓갈)에 대한 연구 동향을 살펴보았다. 발효식품에 대한 논문은 1995년부터 2017년까지 634편이 출판되었으며, 그중 159편이 건강 기능성을 평가한 논문이었다. 간장이 17편, 된장 60편, 고추장 20편, 청국장 58편, 젓갈이 4편으로 집계되었다. 간장과 젓갈을 대상으로 한 세포 및 동물을 이용한 실험은 7편과 2편에 불과하였으며 인체실험은 이루어지지 않았다. 간장은 면역 활성 및 염증 억제에 대한 연구가 가장 많이 이루어졌다. 된장을 이용한 세포 및 동물실험은 인체실험 3편과 역학조사 4편을 포함하여 31편이 보고되었다. 된장의 건강 기능성 중 항비만/당뇨에 대해 다루는 논문이 세포 및 동물, 인체실험을 모두 포함하여 11편으로 집계되었다. 전통발효식품을 연관한 역학조사는 콩 및 콩 제품, 발효식품군의 섭취가 위암과 심혈관계 질환, 아토피 피부염에 미치는 영향을 보고하였다. 고추장에 대한 건강 기능성 평가는 12편이 세포 및 동물실험을 이용하였고 인체실험은 3편이 보고되었다. 고추장 역시 항비만/당뇨에 대한 건강 기능성 평가가 8편으로 가장 많았다. 그 밖에 암세포를 이용한 항암실험 및 면역 활성 증강, 염증 억제에 대한 연구가 이루어졌다. 청국장에 대한 건강 기능성 평가는 8편의 인체실험을 포함하여 47편의 세포 및 동물실험이 이루어졌다. 그중 21편이 항비만/당뇨에 대한 연구였으며, 5편이 인체실험이 이루어졌다. 그 외에도 청국장은 뼈의 미네랄 증진 및 피부 개선, 면역 활성 증진 등 다양한 분야에서 건강 기능성 검증이 이루어졌으며, 다른 발효식품에 비하여 연구의 범위가 넓었다. 본 총설은 발효식품의 건강 기능성 평가를 위한 데이터베이스 작업이며, 향후 연구를 기획하고자 할 때 방향을 제시할 수 있을 것이다. This study aimed to investigate the trends in five fermented foods used as seasonings in Korean cuisine: ganjang (Korean fermented soy sauce), doenjang (Korean fermented soybean paste), kochujang (Korean fermented red pepper paste), cheonggukjang (Korean fermented soybean product), and jeotgal (Korean salted fish). There were 634 articles on traditional fermented foods published from 1995 to 2017. Among these, 159 papers were on the health function of fermented foods, 17 on ganjang, 60 on doenjang, 20 on kochujang, 58 on cheonggukjang, and four on jeotgal. Regarding ganjang and jeotgal, seven and two articles were published, respectively, based on cell and animal experiments, but no human trials were reported. Most studies on ganjang were related to immunological activity and inhibition of inflammation. In the experiments on doenjang, 31 papers were published, including three human trials, and most were anti-obesity/anti-diabetes studies. Four epidemiological studies have been reported on soybean including soybean products as well as fermented food categories reporting effects on gastric cancer, cardiovascular disease, and atopic dermatitis. For kochujang, 12 studies including cell and animal experiments, as well as three human trials were reported. The most published topics on kochujang were anti-obesity/anti-diabetes. In addition, suppressive effects on cancer cells, increased immune activity, and inhibition of inflammation were observed. Study of cheonggukjang consisted of 47 articles, including eight human trials, and 21 of them were anti-obesity/anti-diabetes experiments. Studies related to bone mineralization, skin improvement, and immune-boosting were conducted using cheonggukjang. This review focuses on the reported health benefits of Korean fermented foods, suggesting directions to be taken while planning a study on fermented foods by generating a database for the evaluation of the health benefits of Korean fermented foods.

기억성 경도인지장애 및 알츠하이머 치매 환자에서 해마, 편도체, 뇌들보, 내후각 피질과 혈중 지질, 호모시스테인, 엽산 농도와의 연관성

이상준,김태형,허량,최승은,이봉주,김경미,이정구,김홍대,문치웅,김영훈,Lee, Sang Jun,Kim, Tae Hyung,Huh, Lyang,Choi, Seung Eun,Lee, Bong Ju,Kim, Gyung Mee,Lee, Jung Goo,Kim, Hong Dae,Mun, Chi Woong,Kim, Young Hoon 대한생물정신의학회 2015 생물정신의학 Vol.22 No.4

Objectives In this study, the authors evaluated the correlation between levels of serum lipid, homocysteine, and folate with volumes of hippocampus, amygdala, corpus callosum, and in patients with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease (AD) type. Methods The study recruited patients who visited the dementia clinic of Haeundae Paik Hospital in Korea between March 2010 and June 2014. Among those, patients who had taken the neurocognitive test, brain magnetic resonance imaing, tests for serum lipid, homocysteine, folate, and apolipoprotein E (APOE) genotyping and diagnosed with aMCI or AD were included for analysis. Bilateral hippocampus, entorhinal cortex, amygdala and corpus callosum were selected for region of interest (ROI). The cross-sectional relationships between serum lipid, homocysteine, folate and ROI were assessed by partial correlation analysis and multiple linear regression analysis. Results In patients with aMCI, old age (> 80) and APOE ${\varepsilon}4$ carrier were associated with AD [odds ration (OR) : 12.80 ; 95% confidence interval (CI) : 2.25-72.98 and OR : 4.48 ; 95% CI : 1.58-12.67, respectively]. In patients with aMCI or AD, volumes and thickness of ROI were inversely correlated with levels of serum lipid and homocysteine. In multiple linear regression analyses, higher total cholesterol level was related to lower left, right hippocampus volume and left amygdala volume ; higher low-density lipoprotein cholesterol was related to lower right entorhinal cortex thickness ; higher homocysteine level was related to lower corpus callosum volume. Conclusions Higher serum lipid and homocysteine levels are associated with decreased volume of hippocampus, amygdala, corpus callosum and entorhinal cortex thickness in patients with aMCI or AD. These findings suggest that serum lipid and homocysteine levels are associated with AD as a modifiable risk factor.

Erratum : The antioxidant activity of steamed ginger and its protective effects on obesity induced by high-fat diet in C57BL/6J mice

Kim, Hee-Jeong,Kim, Bohkyung,Mun, Eun-Gyung,Jeong, Soon-Yeon,Cha, Youn-Soo The Korean Nutrition Society 2019 Nutrition Research and Practice Vol.13 No.3

Management of Pediatric Patients Presenting with Acute Abdomen Accompanying Dilatation of the Common Bile Duct

Kim, Young A,Kim, Gyung Min,Chun, Peter,Hwang, Eun Ha,Mun, Sang Wook,Lee, Yeoun Joo,Park, Jae Hong The Korean Society of Pediatric Gastroenterology 2018 Pediatric gastroenterology, hepatology & nutrition Vol.21 No.3

Purpose: The aim of this study was to describe our treatment experiences with patients who had acute abdomen (AA) with common bile duct (CBD) dilatation. Methods: The treatment outcomes in children with AA and CBD dilatation were retrospectively reviewed. According to the shape of the intrahepatic bile ducts on ultrasonography (US), the origin of the pain was estimated as choledochal cyst (CC) complication or choledocholithiasis in normal CBD. Patients with complicated CC underwent surgery, and patients with choledocholithiasis in a normal appearing CBD underwent symptomatic treatment initially. Results: Of the 34 patients, 30 (88.2%) were female. The mean age of the patients was $6.4{\pm}4.9$ (range, 0.8-17) years. Seventeen (50.0%) patients had CBD stones and 17 (50.0%) did not. Surgical treatment was performed in 20 (58.8%) patients, 2 of whom underwent preoperative stone removal with endoscopic retrograde cholangiopancreatography and an operation. Conservative treatment was applied in 12 (35.3%) patients (8 with and 4 without stones), 1 of whom developed symptom relapse and underwent an operation. Among the 8 patients with CBD stones, 4 (4/17, 23.5%) had complete resolution of the stones and recovery of the CBD diameter after conservative treatment. US findings of patients with stone showed a fusiform or cylindrical shape of the CBD in 14 (82.4%) patients. Conclusion: The presence of stones in the distal CBD and the US features of CBD dilatation may be helpful to diagnose and treat the causes of biliary dilatation. Conservative treatment can be considered as initial therapy in patients with uncomplicated CBD dilatation with stone.

Antihypertensive effect of Ganjang (traditional Korean soy sauce) on Sprague-Dawley Rats

Mun, Eun-Gyung,Sohn, Hee-Sook,Kim, Mi-Sun,Cha, Youn-Soo The Korean Nutrition Society 2017 Nutrition research and practice Vol.11 No.5

BACKGROUND/OBJECTIVES: Although Korean fermented foods contain large amounts of salt, which is known to exacerbate health problems, these foods still have beneficial effects such as anti-hypertension, anti-cancer, and anti-colitis properties. We hypothesized that ganjang may have different effects on blood pressure compared to same concentrations of salt. MATERIALS/METHODS: Sprague-Dawley rats were divided into control (CT), NaCl (NC), and ganjang (GJ) groups and orally administered with 8% NaCl concentration for 9 weeks. The systolic blood pressure (SBP), serum chemistry, $Na^+$ and $K^+$ concentrations and renal gene expressions were measured. RESULTS: The SBP was significantly increased in the NC group compared to the GJ and CT groups. In addition, the $Na^+$ concentration in urine was higher in the GJ and NC groups than the CT group, but the urine volume was increased in the GJ group compared to the other groups. The serum renin levels were decreased in the GJ group compared to the CT group, while the serum aldosterone level was decreased in the GJ group relative to the NC group. The mRNA expression of the renin, angiotensin II type I receptor, and mineralocorticoid receptor were significantly lower in the GJ group compared to other groups. Furthermore, GJ group showed the lowest levels of genes for $Na^+$ transporter in kidney cortex such as $Na^+/K^+$ $ATPase{\alpha}1$ ($NKA{\alpha}1$), $Na^+/H^+$ exchanger 3 (NHE3), $Na^+/HCO_3{^-}$ co-exchanger (NBC), and carbonic anhydrases II (CAII). CONCLUSIONS: The decreased SBP in the GJ could be due to decreased renin and aldosterone levels in serum and increased urinary volume and excretion of $Na^+$ with its transporter gene alteration. Therefore, ganjang may have antihypertensive effect despite its high contents of salt.

유방암에서 술 전 화학요법의 반응 예측지표로서 c-erbB2 과발현과 p53 돌연변이의 유용성

손경모(Gyung Mo Son),곽희숙(Hi Suk Kwak),배영태(Young Tae Bae),심문섭(Mun Sup Sim),김지연(Jee Yeon Kim) 대한외과학회 2003 Annals of Surgical Treatment and Research(ASRT) Vol.65 No.2