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이해정(Hae Jeung Lee),이행신(Haeng Shin Lee),이윤나(Yoon Na Lee),장영애(Young Ai Jang),문재진(Jae Jin Moon),김초일(Cho Il Kim) 대한지역사회영양학회 2007 대한지역사회영양학회지 Vol.12 No.3
This study was performed to delineate the relationship between lifestyle and nutritional risk factors associated with hypertension in representative middle-aged Korean population. Hypertension in this study is defined as hypertensive (SBP≥ 140 mmHg or DBP≥ 90 mmHg) adults without recognition of a disease state before a health exam. With data from the 1998 and 2001 National Health and Nutritional Survey, nutrient intakes of 6,112 adults, 40-64 years of age were calculated using food composition database and matched with health examination records by individual ID. After excluding those with extreme intake values, the number of final subjects included in the analysis was 5,200 (male 2,458, female 2,742). Using logistic regression method, socio-demographic data, lifestyle factors, and nutrient intakes were analyzed. Risky factors for hypertension revealed in this study were age, sex, BMI over 23, waist circumference, alcohol intake of more than 16 g (male) or 8 g (female). Regarding nutrient intakes, the intakes of highest quartile for energy (≥ 2363.0 kcal) and protein (≥ 90.2 g) were significantly associated with higher risk of hypertension after adjusting for age, sex, and other socio-demographic factors (OR = 1.312 (1.046 - 1.711), OR = 1.488(1.194 - 1.854), respectively)). Although high intakes of sodium (≥ 6604.0 mg) and phosphorus seemed to be risk factors of hypertension also before energy adjustment (OR = 1.278(1.034 - 1.581), OR = 1.280(1.024 - 1.600), respectively), only high intakes of energy and protein remained significant after adjustment. This study revealed that modifying risky lifestyles and dietary patterns, especially high energy intake, high protein intake, and high alcohol drinking, in middle-aged Korean adults could result in a prevalence decrease and/or prevention of hypertension. (Korean J Community Nutrition 12(3) : 272~283, 2007)
대도시·중소도시·읍면지역 및 동일한 지역내에서의 소득수준에 따른 노인의 영양소 섭취 현황: 국민건강영양조사 2016-2018년 자료 활용
김상연,홍혜숙,이해정,Kim, Sangyeon,Hong, Hye-Sook,Lee, Hae-Jeung 한국식생활문화학회 2021 韓國食生活文化學會誌 Vol.36 No.1
There is little information on the nutrient intake according to the city size and small town in Korean elderly. This study analyzed the nutritional consumption of older people in metropolitan, middle and small cities, and rural areas according to four income levels. The recent data from the 2016~2018 Korean National Health and Nutrition Survey, Centers for Disease Control and Prevention were used. The final analysis included 4,325 individuals (Male: 1,856, Female: 2,469) over 65 years old. Multivariable regression with a complex sample design was conducted to compare the nutrient intake among the groups. In a comparison within regions, the nutrition status of the elderly in small towns was more vulnerable than metropolitan and middle & small cities. The energy intakes were similar between the groups. The carbohydrate intake of middle & small cities was significantly higher than the other regions. The intake of other nutrients in metropolitan and middle & small cities appeared to be higher than in rural areas. The number of nutrients with statistical significance between low and high-income levels were 19 in metropolitan, 11 in middle & small cities, and 5 in rural areas. Each contribution of carbohydrate, fat, and protein to the total energy intake was lower in the low-income level than the high-income level in metropolitan and middle & small cities. On the other hand, in rural areas, only the contribution of protein to energy intake was lower in the low-income level than the high-income level. Cities with higher levels of urbanization had more severe nutritional inequality in relation to the income level. There was also nutritional inequality present in rural areas but it was to a lesser extent. Moreover, the generally low level of nutrient intake was problematic in rural areas. These findings could be used as fundamental evidence for developing community nutritional policies for the elderly.
피세아테놀과 레스베라트롤의 혈당조절 및 TLR4-NF-κB 경로 조절 작용
이희재(Hee Jae Lee),이해정(Hae-Jeung Lee),양수진(Soo Jin Yang) 한국식품영양과학회 2017 한국식품영양과학회지 Vol.46 No.2
본 연구에서는 팔미틴산을 처리한 지방간질환 간세포 모델과 비만/당뇨 동물 모델인 KK/HlJ 마우스를 이용하여 피세아테놀과 레스베라트롤 투여가 염증조절에 주는 영향을 알아보고자 하였다. 4주간의 피세아테놀과 레스베라트롤 섭취는 공복혈당과 경구당부하 검사 2시간 후 AUC를 감소시켜 혈당 조절 개선 효과를 보였다. 또한, 팔미틴산을 처리한 지방간질환 간세포 모델에 피세아테놀과 레스베라트롤을 처리한 결과 염증조절 경로인자인 TLR4와 NF-κB의 발현을 유의적으로 감소시켰다. 이를 in vivo 비만/당뇨 동물 모델인 KK/HlJ 마우스의 간 조직에서 확인한 결과 피세아테놀 섭취는 NLRP3와 NF-κB의 간 조직에서의 발현을 유의적으로 감소시켰고, IL-1 발현을 감소시키는 경향을 보였다. 하지만 동량의 레스베라트롤 섭취는 이와 같은 항염증 효과를 보이지 않았다. 결론적으로 혈당 조절 개선 효과와 항염증 효과에 있어 피세아테놀이 레스베라트롤보다 우수한 효과를 가지고, 피세아테놀의 항염증 효과는 혈당 조절 개선효과에 부분적으로 기여할 것으로 제안한다. Piceatannol (PIC) is a natural hydroxylated analog of resveratrol (RSV), which is a polyphenol known to extend lifespan by stimulating sirtuins. The aim of this study was to investigate the effects of PIC and RSV on the toll-like receptor 4 (TLR4)-nuclear factor kappa B (NF-κB) pathway in mouse hepatocytes and an obese/diabetic KK/HlJ mouse model. AML12 mouse hepatocytes in the absence or presence of palmitic acids (PA) were treated with PIC (50 μM) or RSV (50 μM). Male KK/HlJ mice at 20 weeks of age were divided into three subgroups as follows: 1) obese and diabetic control (KK), 2) KK_PIC, and 3) KK_RSV. PIC and RSV were administered orally at a dose of 10 mg/kg/d for 4 weeks. Four weeks of PIC and RSV treatment did not affect body weight or food intake in KK mice. Serum fasting blood glucose was significantly reduced in KK_PIC, and 2 h oral glucose tolerance test area under the curve was significantly reduced by PIC and RSV treatment in KK mice. PIC tended to improve homeostasis model assessment of the insulin resistance index (HOMA-IR) and HOMA beta-cells in diabetic KK mice. TLR4 and NF-κB were down-regulated by PIC and RSV treatments in hepatocytes in the absence or presence of PA. Insulin receptor, AMP-activated protein kinase, peroxisome proliferator-activated receptor gamma, nucleotide oligomerization domain-like receptor family pyrin domain-containing 3, interleukin-1, and NF-κB were altered in PIC-treated livers. Collectively, PIC and RSV inhibited the TLR4-NF-κB pathway, and PIC seems to be more effective than RSV in the regulation of analyzed targets, which are involved in insulin signaling and inflammation in vivo.