An automated quality assurance system with deep learning for small cube-ball phantom localization in noisy megavoltage images

Park Min-Jae,Lee Gyemin,Kwak Jungwon,Jeong Chiyoung,Goh YoungMoon,Kim Sung-woo,Cho Byungchul,Song Si Yeol,Kim Jong Hoon,Jung Jinhong,Shin Young Seob,Oh Jungsu 한국물리학회 2024 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.84 No.9

To enhance effi ciency and minimize errors, we automated the quality assurance (QA) process in radiation oncology, specifi - cally laser localization. Additionally, we explored the use of a convolutional neural network (CNN) to enhance the detection of small cube-ball phantoms in noisy images. Laser localizations were measured manually on the acquired images. To automate the QA workfl ow, we developed a Linux server equipped with database and web servers. Digital Imaging and Communications in Medicine (DICOM) fi les were retrieved 40 times for 10 linear accelerators (LINACs). The center of the cube-ball phantoms was estimated through Gaussian fi tting. We applied CNN using 6,968 stored results to improve the estimation performance in noisy megavoltage (MV) images. Subsequently, both analysis time and accuracy were compared. Our hospital has been employing the automated QA system since 2018, notably reducing the time for laser localization from 30 min to just 1 min. The average and standard deviation (SD) of inter-observer variability in the X- and Y-axes were 0.06 ± 0.01 mm and 0.05 ± 0.01 mm, respectively. Absolute diff erences between manual assessment and Gaussian fi tting presented average and SD values of 0.40 ± 0.51 mm and 0.23 ± 0.24 mm, respectively. In contrast, absolute diff erences between manual assessment and CNN presented average and SD values of 0.12 ± 0.10 mm and 0.11 ± 0.09 mm, respectively. Overall, the automated QA system signifi cantly hastened procedures in our large hospital and improved the estimation of the cube-ball phantom’s position in noisy images through deep learning.

Ether-free polymeric anion exchange materials with extremely low vanadium ion permeability and outstanding cell performance for vanadium redox flow battery (VRFB) application

Cha, Min Suc,Jo, Sang Woo,Han, Seung Hui,Hong, Soo Hyun,So, Soonyong,Kim, Tae-Ho,Oh, Seong-Geun,Hong, Young Taik,Lee, Jang Yong Elsevier 2019 Journal of Power Sources Vol.413 No.-

<P><B>Abstract</B></P> <P>Ether-free poly(<I>p</I>-phenylene)-based anion exchange membrane materials with outstanding vanadium ion blocking properties are reported. The synthesized ionomers with a rigid backbone structure show small dimensional variations despite the high ion exchange capacities. Among the synthesized membranes, the QPPP-2 membrane with ion exchange capacity of 2.1 meq·g<SUP>−1</SUP> exhibits high anion (OH<SUP>−</SUP>, SO<SUB>4</SUB> <SUP>2−</SUP>, and Cl<SUP>−</SUP>) conductivity. The QPPP-2 membrane shows an extremely low diffusion coefficient (2.12 × 10<SUP>−9</SUP> cm<SUP>2</SUP> min<SUP>−1</SUP>) for VO<SUP>2+</SUP>, which is much lower than that of Nafion 115 (2.88 × 10<SUP>−6</SUP> cm<SUP>2</SUP> min<SUP>−1</SUP>), indicating the vanadium ion blocking property of QPPP-2. Moreover, the chemical and operational stabilities of the membranes are investigated <I>via</I> ex situ soaking tests in 0.1 M VO<SUB>2</SUB> <SUP>+</SUP> solution and in situ operation tests for 100 cycles, respectively. The vanadium redox flow battery single cell assembled with the QPPP-2 membrane exhibits a coulombic efficiency of 99%, voltage efficiency of 87%, and energy efficiency of 86% during 100 cycles at 80 mA cm<SUP>−2</SUP>. The excellent chemical, morphological, and electrochemical properties of the QPPP-2 membrane make it suitable for use in vanadium redox flow battery.</P> <P><B>Highlights</B></P> <P> <UL> <LI> AEMs are fabricated by a Ni(0)-catalyzed cross-coupling reaction. </LI> <LI> The synthesized ionomers indicated excellent dimensional and chemical stability. </LI> <LI> Ether-free polymeric AEMs showed extremely low vanadium ion cross over. </LI> <LI> The performance of developed AEM showed high EE (87%) with high capacity retention. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

The Korean Association of lnternal Medicine : Poster Session ; PS 1357 : Nephrology ; Age is the Strongest Effector for the Relationship between Estimated Glomerular filtration Rate and Coronary Artery Calcifi cation in Apparently Healthy Korean Adults

( Hyun Beom Chae ),( Eun Jung Rhee ),( Hae Jung Park ),( Min Kyung Lee ),( Won Seon Jeon ),( Se Eun Park ),( Cheol Young Park ),( Won Young Lee ),( Ki Won Oh ),( Sung Woo Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Cardiovascular disease (CVD) is a major clinical problem and the most common cause of morbidity and mortality in patients with chronic kidney disease (CKD). Coronary artery calcifi cation (CAC) is a potential mechanism that explains the association between renal function and cardiovascular mortality. We aimed to evaluate the association between renal function and CAC in apparently healthy Korean subjects. Methods: In 23,617 participants in the health screening program in Kangbuk Samsung Hospital health screening program from January 2010 to December 2011, estimated glomerular fi ltration rate (eGFR) was assessed by Cockcroft-Gault equation. Coronary artery calcium score (CACS) was measured by multi-detector computed tomography (MDCT). Subjects were divided into 3 groups according to the CKD Staging system with eGFR grade; stage 1: eGFR = 90 mL/min/1.73 m2, stage 2: eGFR 60-89 mL/ min/1.73 m2, stage 3: eGFR 30-59 mL/min/1.73 m2. Results: Mean age of the participants was 41.4 years, and mean eGFR was 103.6±21.7 mL/min/1.73 m2. Hypertension and diabetes were noted in 43.7% and 5.5% of the participants, respectively. eGFR showed weakly negative but signifi cant association with CACS in bivariate correlation analysis (r=-0.076, p<0.01). Mean CACS signifi cantly increased from CKD stage 1 to 3. The proportion of subjects who had CAC signifi cantly increased from CKD stage 1 to 3. Although odds ratio for CAC signifi cantly increased from stage 1 to 3 after adjustment for confounding factors, this signifi cance was inversed when age was included in the model. Age was the strongest factor that affects CAC. Conclusions: This study performed in young Korean subjects with relatively normal renal function, age was the mostly strongest effector on the association between eGFR and the degree of CAC.

토지이용패턴에 따른 하천수질과 식생분포

오영주,강병화,김병우,김성필,한민수,김진호,나영은 한국환경농학회 2006 한국환경농학회지 Vol.25 No.1

정신분열증 환자와 우울증 환자의 감별진단을 위한 성격평가질문지 타당성 연구

오상우,박민철,이산수 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.1

배경: 성격평가질문지(PAI)의 DEP, SCZ척도 그리고 직업 유무와 결혼상태 등의 변인을 사용하여 정신분열병 환자와 우울장애 환자를 가려낼 수 있는지를 알아보았다. 방법: 정신분열병 환자 85명, 우울장애 환자 85명을 대상으로 PAI의 DEP, SCZ척도 직업유무, 결혼상태를 예언변인으로 하고, 진단을 종속변인으로 하여 이항 로지스틱 회귀 분석을 하였다. 결과: PAI 척도의 DEP척도를 예언변인으로 한 첫 번째 모델을 분석한 결과 정신분열병 환자와 우울장애 환자를 가려낼 수 있는 예언치는 67.1%로 나타났다. 또한 PAI 척도의 DEP, SCZ 척도를 예언변인으로 한 두 번째 모델을 분석한 결과 두 장애를 가진 환자를 구분할 수 있는 예언치는 77.1%로 증가하였다. 마지막으로 PAI의 DEP, SCZ척도와 직업유무, 결혼상태를 예언변인으로 한 세 번째 모델을 분석하였을 때, 두 장애를 가진 환자를 가려낼 수 있는 예언치는 증가하였으나, 직업유무와 결혼상태가 예언변인으로 두 장애를 가진 환자를 가려내는데는 실패하였다. 결론: 정신분열병 환자와 우울장애 환자를 가려낼 수 있는 예언변인은 PAI의 DEP, SCZ 척도인 것으로 나타났다. Background: The present study was examined the validity of the personality assessment inventory for differential diagnosis in patients with schizophrenia and depression. Methods: Subjects were 85 patients with schizophrenia and depression each other. The depression scale and schizophrenia scale of the PAI, job and marital status in demographic variables were used as tools of assessment in the study. Materials were analysed statistically by t-test and binary logistic regression analysis. Results: The results were as follows, 1) One model, probability to be discriminated patients with schizophrenia and depression by using depression scale of the PAI was 67.1%. 2) Two model, probability to be discriminated patients with schizophrenia and depression by using depression scale and schizophrenia sacle of the PAI was 77.1%. 3) Three model, probability to be discriminated patients with schizophrenia and depression by using depression scale and schizophrenia scale of the PAI, job and married states in demographic variables was low. Conclusion: Predictive variables to be discriminated patients with schizophrenia and depression were depression scale and schizophrenia scale of the PAI.

BDI의 요인분석 : 의학계열 대학생 자료를 중심으로

오상우,피상순,박민철 圓光大學校 醫科大學 神經精神科學敎室 1997 圓光精神醫學 Vol.13 No.1

본 연구는 의학계열 대학생 집단의 BDI 자료를 중심으로 BDI의 요인구조를 알아보고자 하였다. 연구대상자는 심리학(혹은 임상심리학)을 수강하는 305명의 대학생(남자: 142명, 여자: 163명)이었다. BDI의 요인구조를 알아본 결과, 의학계열 대학생 집단의 자료에서는 4개 요인이 추출되었다. 4개 요인의 전체 설명변량은 43.8%이었는데, 제1요인(일반 우울 증상), 제2요인(생리적 증상과 정서증상), 제3요인(정서 증상과 인지 증상) 및 제 4요인(생리적 증상)으로 나타났으며, 요인들의 설명 변량은 각각 25.5%, 6.8%, 6.0% 및 5.5%이었다. 끝으로 본 연구의 의의, 제한점 및 시사점이 논의되었다. This study examined the factor analysis of the BDI in a sample of 305 medical college students. who attended introduction to psychology(or clinical psychology). Four factors in medical college students sample were abstracted from the BDI by factor analysis. Variance of the four factors were 43.8%. And variance of factor 1(general depressive symptoms), factor 2(physiological symptoms & affective symptoms), factor 3(affective symptoms & cognitive symptoms) and factor 4(physiological symptoms) were 25.5%, 6.8%, 6.0%, and 5.5% respectively. Finally, significances, limitions and suggestions of this study were also discussed.

정신질환자 수용시설환자의 정신과적 입원치료 경험 유무에 따른 비교연구

박민철,오상우,권혁일,박남진,김종주 圓光大學校 醫科學硏究所 1986 圓光醫科學 Vol.2 No.2

We have visited the asylums in Chollapukdo for two months since March of 1985. We conducted a comparative study between the patients who has been previously hospitalized and who has not been hospitalized for psychiatric problems. We individually interviewed 489 patients using the interview schedule. The results are shown as follows: 1. The group who were young, single and highly educated have been more hospitalized than the groups who were old, married and little educated. However, no significant difference was made by sex and districts. 2. The group who lived alone or were deserted from the family has been rarely hospitalized. 3. The group, who has been entered the asylum by the family or who explained the reason as treatment, has been more hospitalized previously than the group entered by the others or who said that they came due to alcohol. 4. While the group who has been hospitalized showed tendency to accept having their psychiatric disorders, but the group who has not been hospitalized showed tendency to deny having their disorders. 5. The group who named their disorders psychoses or schizophrenia has been more hospitalized than the group who named them alcoholics. 6. The group hospitalized previously has been also treated in other ways besides psychiatric treatment, and chronic patients with the duration of more than three years has been relatively hospitalized previously. 7. While the group who has been previously hospitalized was relatively indicated for hospitalization, but the other group was not relatively indicated.

산채류로부터 혈소판응집 억제물질의 검색

윤민호,임치환,오진환,이종철,최우영 충남대학교 농업과학연구소 1997 농업과학연구 Vol.24 No.2

To select potential inhibitors of platelet aggregation form large numbers of crude plant extracts, the modified thin smear method for the anti-platelet aggregating activity using platelet rich plasma was further modified by direct observation under a light microscope without staining the smear. The activities determined by the method were coincided with those by the electrical impedence method using whole blood, when ADP or collagen was employed as the aggregating agent. Among 130 varieties of edible and herbal plants which collected from markets or experimental farms of agricultural research institutes, those showed the anti-platelet aggregating activities were selected by testing the crude methanol extracts: Aster scaber, Aster tataricus, Ligularia stenocephala, Platycodon glaucum Allium victorials, Allium oderum, Morus bombycis, Portulaca oleracea, Acanthopanax sessiliflorus and Rosa davurica. However, some of them activated the platelet aggregation under the same assay conditions: Pimpinella brachycarpa, Hosta plantaginea. Capsella bursapastoris, Fagopym esculentum, Prunus mume, Rubus coreanus and Limaria japonica. In addition, those revealed the antioxidant activities were selected by measuring the abilities to scavenge superoxide anion radicals: Pteridum aquilinum, Aster scaber, Ligularia fischeri, Chrysanthemum zawadskii, Artemisia capipparis, Cirsium setidens, Commelina communis and Capsella bursapastoris among edible plants.

기분장애 환자의 스트레스와 정서반응 : 우울, 불안, 분노 반응

박민철,오상우,류미경,피상순,고정인 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.2

Objectives : This study was investigated to demonstrate the relationship between stress and emotional responses of depression, anxiety, and anger in patients with mood disorder.Methods : Fifty patients with major depressive disorder diagnosed by DSM-IV were compared to those with bipolar manic disorder. All subjects were evaluated for perceived stress, Beck depression inventory, dysfunctional attitude, state-trait anxiety, state-trait anger and anger expression. The data were analyzed by t-test, correlation, and multiple regression analysis.Results : The results were as follows.1. Depressive group had significantly higher score of perceived stressful life events, depression, state anxiety and trait anxiety than manic group.2. Perceived stress in depressive group was positively correlated with depression, anxiety, state and trait anger, anger expression and sex, however that in manic group was positively correlated with state anger and anger expression.3. In depressive group, trait anxiety, trait anger, age, and dysfunctional attitude predicted 70.6% of variance on depression, perceived stress predicted only 1.2%. Trait anxiety predicted 67.6% for state anxiety, and trait anger and trait anxiety predicted 41.5% for state anger, trait anger and sex predicted 34.0% for anger expression.4. In manic group, education and trait anger predicted 28.7% of variance of depression, and trait anger predicted 38.3% for state anxiety. Trait anger and education predicted 29.4% for state anger, and state anger and sex, state anxiety predicted 36.3% for anger expression.Conclusion : The results suggest that emotional responses to perceived stress in depressive group are related to depression, anxiety, and anger but those in manic group are related to anger.

원광의대 부속 제 2병원 신경정신과 환자에 대한 통계적 고찰

박민철,김종주,박남진,오상우,권혁일,권영숙,박종호 圓光大學校 醫科學硏究所 1986 圓光醫科學 Vol.2 No.2

We examined 1,856 patients who visited Won Kwang Neuropsychiatric hospital since July 11 of 1984(since the hospital opened) until June 11 of 1986. We researched diagnostic and other distributions of inpatients and outpatients. The study revealed as follows : 1. Of total patients males visited this hospital more than females as 52.7%. Most of them(67.1 %) resided in Iri, Iksan and Kimje. In the point of insurance, insured patients and uninsured patients except medicaids were 73 %. Males(60%) were more insured medically than females (55.4%). While insured patients relatively resided in urban area, but uninsured patients except medicaids did in rural area. 2. Of outpatients neurotic disorder was the most as 35.1%, secondly schizophrenic disorder and thirdly affective disorder, but of inpatients schizophrenic disorder was the most as 41.4%, secondly neurotic disorder thirdly affective disorder. 3. Alcohol abuse (98.2 %), paranoid disorder, convulsive disorder and child mental disorder were mostly found in males, but neurotic disorder (59 .6 %), affective disorder and other psychotic disorder were mostly found in females. 4. In unmarried ones schizophrenic disorder ( 43 .6 %), neurotic disorder, other psychotic disorder were common, but in married ones neurotic disorder (55.1 %), schizophrenic disorder, affective disorder were common. 5. On the distribution of age schizophrenic disorder was found the most in the twenties (28.4 %), next in the thirties and in the forties, but neurotic disorder was found the most in the thirties, next in the twenties and in the forties. 6. On the distribution of age at onset schizophrenic disorder develops mostly during the twenties (45.5 %), secondly during the teens and thirdly during the thirties, but neurotic disorder develops mostly during the thirties and the twenties (53.1 %). 7. On the duration of hospitalization 34.4% of the patients was hospitalized during less than 15 days, 22.0% during 60-90 days and 80.4% during less than 3 months. 8. In the result of treatment 41.2% of the patients was improved and 31.7% a little improved. In total 72.9% of the patients got helped therapeutically.