Optical temperature sensing properties of Yb3+/Tm3+ co-doped NaLuF4 crystals

Lili Tong,Xiangping Li,Ruinian Hua,Lihong Cheng,Jiashi Sun,Jinsu Zhang,Sai Xu,Hui Zheng,Yanqiu Zhang,Baojiu Chen 한국물리학회 2017 Current Applied Physics Vol.17 No.7

Yb3þ/Tm3þ and Yb3þ/Er3þ co-doped NaLuF4 crystals were synthesized by a facile hydrothermal method. The optical temperature sensing properties of Tm3þ based upon its two thermally coupled energy levels 3F2, 3 and 3H4 were systematically investigated by means of fluorescence intensity ratio (FIR) technique. The 980 nm laser-induced thermal effect on Tm3þ doped NaLuF4 crystals was studied by using Er3þ doped sample as thermal probe. The temperature sensitivity of Tm3þ in NaLuF4: Yb3þ/Tm3þ crystals shows a nonlinear dependence on temperature, and the maximum value is about 0.00045 K『1 at 600 K. The accuracy and reliability of the optical thermometry based on Tm3þ in NaLuF4: Yb3þ/Tm3þ crystals has been checked by using Yb3þ/Er3þ co-doped sample as temperature sensing unit. The results demonstrate that NaLuF4: Yb3þ/Tm3þ crystals have good sensing stability and may have potential application for the optical thermometry.

Experimental study on hydrogen behavior and possible risk with different injection conditions in local compartment

Liu Hanchen,Tong Lili,Cao Xuewu 한국원자력학회 2020 Nuclear Engineering and Technology Vol.52 No.8

Comparing with the large containment, the gas can not flow freely within the local compartment due to the small volume of the compartment in case of serious accident, which affects the hydrogen flow distribution, and it will determines the location where high concentration occurs in compartment. In this paper, hydrogen distribution and possible hydrogen risk in the vessel under the different conditions are investigated. The results show that when the initial gas momentum is increased, the ability of gas enters into the upper region of the vessel will be strengthened, and the hydrogen volume fraction in the upper region of the vessel is higher. Comparing with horizontal source direction, when source direction is vertically towards upper space, hydrogen is more likely to accumulate in the upper region of the vessel. With the increasing of steam mass flow, the dilution effect of steam on the hydrogen volume fraction will be strengthened, while the pressure in the vessel is also increased. When steam flow is decreased, the hydrogen explosion risk is higher in the vessel. The experiment data can provide technical support for the validation of the CFD software and the mitigation of hydrogen risk in the containment compartment

Preliminary numerical study on hydrogen distribution characteristics in the process that flow regime transits from jet to buoyancy plume in time and space

Di Wang,Lili Tong,Luguo Liu,XUEWU CAO,Zhiqiang Zou,Lingjun Wu,Xiaowei Jiang 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.6

Hydrogen-steam gas mixture may be injected into containment with flow regime varying both spatiallyand transiently due to wall effect and pressure difference between primary loop and containment insevere accidents induced by loss of coolant accident. Preliminary CFD analysis is conducted to gain informationabout the helium flow regime transition process from jet to buoyancy plume for forthcomingexperimental study. Physical models of impinging jet and wall condensation are validated using separatedeffect experimental data, firstly. Then helium transportation is analyzed with the effect of jetmomentum, buoyancy and wall cooling discussed. Result shows that helium distribution is totallydominated by impinging jet in the beginning, high concentration appears near gas source and wallwhere jet momentum is strong. With the jet weakening, stable light gas layer without recirculating eddyis established by buoyancy. Transient reversed helium distribution appears due to natural convectionresulted from wall cooling, which delays the stratification. It is necessary to concern about hydrogenaccumulation in lower space under the containment external cooling strategy. From the perspective ofexperiment design, measurement point should be set at the height of connecting pipe and near the wallfor stratification stability criterion and impinging jet modelling validation.

Condensation oscillation characteristic of steam with non-condensable gas through multi-hole sparger at low mass flux

Zhang Dandi,Tong Lili,Cao Xuewu 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.2

To study oscillation characteristic of steam and non-condensable gas direct contact condensation through multi-hole sparger at low mass flux, a series of experiments of pure steam and mixture gas condensation have been carried out under the conditions of steam mass flux of 20e120kg/m2s, water temperature of 20e95 C and mass fraction of non-condensable gas of 0e5%. The regime map of pure steam condensation through multi-hole sparger is divided into steam chugging, separated bubble, aggregated bubble and escaping aggregated bubble. The bubbles behavior of synchronization in the same hole columns and desynchronized excitation between different hole columns can be found. The coalescence effect of mixture bubbles increases with water temperature and non-condensable gas content increasing. Pressure oscillation intensity of pure steam condensation first increases and then decreases with water temperature increasing, and increases with steam mass flux increasing. Pressure oscillation intensity of mixture gas condensation decreases with water temperature and non-condensable gas content increasing, which is significantly weaker than that of pure steam condensation. The oscillation dominant frequency decreases with the rise of water temperature and non-condensable gas content. The correlations for oscillation intensity and dominant frequency respectively are developed in pure steam and mixture gas condensation at low mass flux.

Investigation of aerosol resuspension model based on random contact with rough surface

He Liwen,Tong Lili,Cao Xuewu 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.3

Under nuclear reactor severe accidents, the resuspension of radioactive aerosol may occur in the containment due to the disturbing airflow generated by hydrogen combustion, hydrogen explosion and containment depressurization resulting in the increase of radioactive source term in the containment. In this paper, for containment conditions, by considering the contact between particle and rough deposition surface, the distribution of the distance between two contact points of particle and deposition surface, rolling and lifting separation mechanism, resuspension model based on random contact with rough surface (RRCR) is established. Subsequently, the detailed torque and force analysis is carried out, which indicates that particles are more easily resuspended by rolling under low disturbing airflow velocity. The simulation result is compared with the experimental result and the prediction of different simulation methods, the RRCR model shows equivalent and better predictive ability, which can be applicable for simulation of aerosol resuspension in containment during severe accident

Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage

Pan Yibin,Yan Lili,Chen Qiaoqiao,Wei Cheng,Dai Yongdong,Tong Xiaomei,Zhu Haiyan,Lu Meifei,Zhang Yanling,Jin Xiaoying,Zhang Tai,Lin Xiaona,Zhou Feng,Zhang Songying 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

In early pregnancy, the placenta anchors the conceptus and supports embryonic development and survival. This study aimed to investigate the underlying functions of Shh signaling in recurrent miscarriage (RM), a serious disorder of pregnancy. In the present study, Shh and Gli2 were mainly observed in cytotrophoblasts (CTBs), Ptch was mainly observed in syncytiotrophoblasts (STBs), and Smo and Gli3 were expressed in both CTBs and STBs. Shh signaling was significantly impaired in human placenta tissue from recurrent miscarriage patients compared to that of gestational age-matched normal controls. VEGF-A and CD31 protein levels were also significantly decreased in recurrent miscarriage patients. Furthermore, inhibition of Shh signaling impaired the motility of JAR cells by regulating the expression of Gli2 and Gli3. Intriguingly, inhibition of Shh signaling also triggered autophagy and autolysosome accumulation. Additionally, knockdown of BECN1 reversed Gant61-induced motility inhibition. In conclusion, our results showed that dysfunction of Shh signaling activated autophagy to inhibit trophoblast motility, which suggests the Shh pathway and autophagy as potential targets for RM therapy.

Application of advanced biomaterials in photothermal therapy for malignant bone tumors

Bo Chao,Jianhang Jiao,Lili Yang,Yang Wang,Weibo Jiang,Tong Yu,Linfeng Wang,He Liu,Han Zhang,Zhonghan Wang,Minfei Wu 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Malignant bone tumors are characterized by severe disability rate, mortality rate, and heavy recurrence rate owing to the complex pathogenesis and insidious disease progression, which seriously affect the terminal quality of patients' lives. Photothermal therapy (PTT) has emerged as an attractive adjunctive treatment offering prominent hyperthermal therapeutic effects to enhance the effectiveness of surgical treatment and avoid recurrence. Simultaneously, various advanced biomaterials with photothermal capacity are currently created to address malignant bone tumors, performing distinctive biological functions, including nanomaterials, bioceramics (BC), polymers, and hydrogels et al. Furthermore, PTT-related combination therapeutic strategies can provide more significant curative benefits by reducing drug toxicity, improving tumor-killing efficiency, stimulating anti-cancer immunity, and improving immune sensitivity relative to monotherapy, even in complex tumor microenvironments (TME). This review summarizes the current advanced biomaterials applicable in PTT and relevant combination therapies on malignant bone tumors for the first time. The multiple choices of advanced biomaterials, treatment methods, and new prospects for future research in treating malignant bone tumors with PTT are generalized to provide guidance.

Knockdown of circ_0006872 alleviates CSE‑induced human bronchial epithelial cells injury in chronic obstructive pulmonary disease

Wang Jieqiong,Li Zegeng,Zheng Lili,Tong Jiabing,Wang Chuanbo 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-

Circular RNAs (circRNAs) have been reported to be related to the initiation and progression of chronic obstructive pulmonary disease (COPD) by affecting the function of human bronchial epithelial cells (HBECs). Here, we aimed to investigate the function and mechanism of circ_0006872 in regulating COPD process using cigarette smoke extract (CSE)-induced 16HBEC in vitro. The results showed that circ_0006872 was increased in smokers without or with COPD, especially in smokers with COPD. Also, its expression was dose-dependently up-regulated by CSE exposure in 16HBECs. Functionally, circ_0006872 knockdown dramatically attenuated CSE-evoked proliferation arrest, apoptosis, inflammatory response and oxidative stress in 16HBECs. Mechanistically, circ_0006872/miR-485-3p/cyclin-dependent kinase inhibitor 1B (CDKN1B) formed a competitive endogenous RNA (ceRNA) network. CDKN1B was increased and miR-485-3p was decreased in COPD patients and CSE-induced 16HBECs. MiR-485-3p overexpression or CDKN1B knockdown protected 16HBEC against CSE-induced 16HBEC injury mentioned above. Moreover, rescue experiments showed that circ_0006872 regulated CSE-induced 16HBEC injury via miR-485-3p/CDKN1B axis. Circ_0006872 silencing protected against CSE-induced bronchial epithelial cell injury via miR-485-3p/CDKN1B axis, suggesting the potential application of circ_0006872 in preventing cigarette smoke-induced COPD.

Neuropeptide Y Promotes the Treatment of Adipose Stem Cells on Type 2 Diabetic Wounds

Lu Tinghuan,Cong Lu,Jiang Tong,Dong Xiao,Song Lili 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.5

BACKGROUND: Type 2 diabetes (T2D) is a common metabolic disorder. Due to insufficient insulin secretion or insulin resistance, increased blood glucose often leads to impaired wound healing in T2D patients. Our previous research showed that adipose-derived stem cells (ASCs) from normal mice and T2D mice improved the cutaneous wound healing of diabetic mice. We also found that the expression of neuropeptide Y (NPY) in T2D ASCs was significantly decreased. METHODS: In order to explore the effects of NPY on ASCs and diabetic wound healing, we investigated the effects of NPY on ASCs proliferation and growth factors expression and secretion, the effects of NPY on skin fibroblasts, and the effects of NPY combined with ASCs on T2D wound healing. RESULTS: The results showed that a certain concentration of NPY could promote the proliferation and the growth factors expression and secretion of ASCs, and promote the proliferation and migration of fibroblasts. At the same time, NPY and ASCs have a synergistic effect, which can promote wound healing and decrease inflammation in T2D wounds. NPY may regulate ASCs through the ERK pathway. These results are conducive to promoting ASCs and NPY in the treatment of diabetic wounds. CONCLUSIONS: NPY can promote the effect of ASCs in the treatment of diabetic wounds.

Use of antibiotics and other treatments in Chinese adults with acute cough: An online survey

Xiao-yang Hu,Ru-yu Xia,Michael Moore,Beth Stuart,Wen Ling-Zi,Bertrand Graz,Lai Lily,Liu Jian-Ping,Yu-tong Fei,Merlin Willcox 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.1

Background: Acute respiratory tract infections are common worldwide and there has been a rapid in- crease in antibiotic consumption. This study aimed to identify use of various treatments and their as- sociation with the use of antibiotics and patient reported clinical recovery in Chinese adults with acute cough. Methods: An online survey recruiting people who had recently experienced cough was conducted. Their sociodemographic, clinical characteristics, treatments received and their perceived changes in symptoms were collected. Factors influencing avoidance of antibiotics and improvement in symptoms were explored. Results: A total of 22,787 adults with recent acute cough completed the questionnaire, covering all 34 province-level administrative units in China. Most respondents were male (68.0%), young (89.4%, aged 18–45), educated to university/degree or postgraduate level (44.6%), with a median cough severity of 6/10 on a numerical rating scale. Nearly half of the participants (46.4%) reported using antibiotics, among which 93.1% were for presumed upper respiratory tract infections (URTIs). Pharmacies (48.8%) were the most common source of antibiotics. Fewer patients took antibiotics after taking CHM (14.9%), compared to those who started with home remedies (18.0%), or allopathic non-antibiotic medication (25.0%). An- tibiotics, allopathic non-antibiotic medications, CHM and home remedies were all perceived beneficial in relieving cough. Conclusions: Chinese adult responders report use of a considerable variety of treatments alone or in combination for acute cough. Patient-reported clinical recovery was similar regardless of treatment. There is likely a high proportion of inappropriate use of antibiotics for treatment of simple acute cough. As the majority of respondents did not use antibiotics as a first-line, and use of CHM was associated with relief of cough symptoms and reduction in the use of antibiotics, this presents an important opportunity for prudent antibiotic stewardship in China.