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- 저자 : Libing Liu (검색결과 11 건)
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Ting Deng,Kaijiang Liu,Liang Chen,Xiao-jun Chen,Hua Wen Li,Hongyan Guo,Huijiao Zhang,Libing Xiang,Xin Feng,Xiaoyu Wang,Hextan Y. S. Ngan,Jianguo Zhao,Dongling Zou,Qing Liu,Jihong Liu 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.3
Background: The Lymphadenectomy in Ovarian Neoplasms (LION) study revealed that systemic lymphadenectomy did not bring survival benefit for advanced ovarian cancer patients with clinically normal lymph nodes and was associated with a higher incidence of operative complications. However, there is no consensus on whether lymphadenectomy has survival benefit or not in early epithelial ovarian cancer (EOC). Methods: We designed the LOVE study, a multicenter, randomized controlled, phase III trial to compare the efficacy and safety of comprehensive staging surgery with or without lymphadenectomy in stages IA-IIB EOC and fallopian tube carcinomas (FTC). The hypothesis is that the oncological outcomes provided by comprehensive staging surgery without lymphadenectomy are non-inferior to those of conventional completion staging surgery in early-stage EOC and FTC patients who have indications for post-operative adjuvant chemotherapy. Patients assigned to experimental group will undergo comprehensive staging surgery, but lymphadenectomy. Patients assigned to comparative group will undergo completion staging surgery including systematic pelvic and para-aortic lymphadenectomy. All subjects will receive 3–6 cycles of standard adjuvant chemotherapy. Major inclusion criteria are pathologic confirmed stage IA-IIB EOC or FTC, and patients have indications for adjuvant chemotherapy either confirmed by intraoperative fast frozen section or previous pathology after an incomplete staging surgery. Major exclusion criteria are non-epithelial tumors and low-grade serous carcinoma. Patients with severe rectum involvement which lead to partial rectum resection will be excluded. The sample size is 656 subjects. Primary endpoint is disease-free survival.
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Somatic cell reprogrammed by oocyte: process and barricade
LiBing Ma,XiaoYing He,FengMei Wang,Teng Cheng,XiYu Liu 한국통합생물학회 2014 Animal cells and systems Vol.18 No.3
Somatic cell nuclear transfer (SCNT) is a technology in which a somatic nucleus is transferred into thecytoplasm of a matured oocyte – reconstructed embryos have the capacity to develop to term. Why somaticcells can be reprogrammed by oocytes – the answer for this question must exist in the cytoplasm of maturedoocytes. In this review, totipotent characters of matured oocytes were discussed, which may confer maturedoocytes with the capacity to reprogram somatic nucleus. Moreover, the procedure of SCNT also makes apossibility for somatic nucleus to be reprogrammed by oocytes. Compared with fertilized embryos, embryosderived from SCNT exhibit low developmental ability; the barricades in reprogramming process and theirpossible reasons were also discussed. This review maybe can benefit the mechanism research of SCNTtechnology and can make contribution for improving the efficiency of this technology.
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Calculation of Torque and Loss of Coaxial Magnetic Gear with Halbach Array in 3D Model
Jing Libing,Liu Wei,Tang Weizhao,Rao Yingying,Tan Can,Ben Tong 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.3
In two-dimensional fi eld, the end eff ect exists in the calculation of the electromagnetic characteristics of the magnetic gear, which leads to the inaccurate calculation of the air-gap magnetic fi eld and torque. In order to improve the calculation accuracy of the electromagnetic characteristics of the magnetic gear, a 3D coaxial magnetic gear (CMG) with Halbach arrays distribution is proposed in this paper. Using the unilateral eff ect of the Halbach arrays, the magnetic fi eld on the air gap side is strengthened, and the magnetic fi eld on the iron yoke side is weakened. The topology of CMG with 4 inner and 17 outer poles is established and compared with the 2D model with the same parameters. The results show that the 3D CMG with Halbach array distribution can eff ectively reduce the torque ripple, and the accuracy of torque and loss calculation is improved compared with 2D model. The analysis results can provide a basis for the design and manufacture of magnetic gear.
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Xin Liu,Chuang Gao,Huanqing Wang,Libing Wu,Yonghui Yang 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.8
In this study, an adaptive neural backstepping control scheme is proposed for a class of nonstrict-feedback time-delay systems with input saturation, full-state constraints and unknown disturbances. A structural property of radial basis function neural network is presented to deal with the design from the nonstrict-feedback formation. This method does not require the parameter separation technique and its assumption. With the help of the Lyapunov-Krasovskii functionals and Young’s inequalities, the effects of time delays are compensated, and the unknown disturbances are eliminated in the design process. The barrier Lyapunov function (BLF) is applied to arrest the violation of the full-state constraints. To overcome the problem of input saturation nonlinearity, the smooth nonaffine function of the control input signal is adopted to approach the input saturation function. Moreover, an adaptive backstepping neural control strategy is proposed. The proposed adaptive neural controller ensures that all the closed-loop signals are semi-globally uniformly ultimately bounded (SGUUB). Furthermore, the tracking error can converge to a small neighborhood of the origin. The simulation result shows the effectiveness of this method.
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A High Torque and Low Ripple Magnetic Gear with Embedded Permanent Magnet
Tan Can,Jing Libing,Liu Wei,Rao Yingying,Tang Weizhao 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.3
In order to further improve the output torque and transmission stability of coaxial magnetic gear (CMG), a new topology of embedded permanent magnets (PMs) is proposed in this paper, which has large torque and low ripple. In the structure, the PMs of the inner rotor are embedded into the yoke and radial magnetization is adopted. On the outer rotor, the PMs are magnetized by the Halbach array. At the same time, in this magnetization mode, the PMs with radial magnetization are moved a certain distance towards the outer rotor yoke. At this time, the gap between the PMs and the outer air gap is filled with silicon steel, so that part of the PMs is embedded in the yoke, and the parallel magnetization PMs is still in the original position. Finally, a two-dimensional model is established, and the magnetic field and torque of the model are optimized. Compared with the conventional CMG model, it is found that the improved model increases the average output torque of the inner and outer rotors by 16.08% and 16.87%, respectively, and reduces the ripple by 18.85% and 43.26%, respectively. It is proved that the topology is an effective attempt to improve the operation efficiency of CMG.
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Detection and quantification of phenol in liquid and gas phases using a clay/dye composite
Guocheng Lv,Shiyuan Liu,Meng Liu,Libing Liao,Limei Wu,Lefu Mei,Zhaohui Li,Caofeng Pan 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.62 No.-
In this study, an organic dye lucigenin (BNMA) was successfully intercalated into the interlayer of montmorillonite (MMT) to prevent fluorescence quenching. With its enhanced fluorescent property, the composite was fabricated into solid strips for it fast and sensitive phenol detection in both liquid and gas phases. Under proper optimizations it is anticipated that the composite would show great potential for phenol determination in real world environment such as wastewater treatment industry.
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Xiaoteng Jia,Ce Wang,Danming Chao,Libing He,Hongtao Liu,Tian Zheng,Chengcheng Zhang 한국고분자학회 2011 Macromolecular Research Vol.19 No.11
A novel hyperbranched electroactive azo polyamide containing oligoaniline was synthesized by oxidative coupling polymerization. The detailed characteristics of the obtained polyamide were systematically studied by Fourier transform infrared (FTIR) spectra, nuclear magnetic resonance (^1H NMR) spectroscopy, and gel permeation chromatography (GPC). The thermogravimetric analysis (TGA) revealed a good thermal resistance of the polymer. The photoisomerization process and doping process of the polymer were monitored with ultraviolet-visible spectroscopy. Further, the electrochemical behavior of the polymer was explored by cyclic voltammogram (CV), and the mechanism of electrochemical oxidation process was studied in detail. The polymer in the HCl-doped form possessed much higher dielectric constants compared with that of the similar linear polymer reported before, mainly due to the highly branched three-dimensional molecular architecture and the high content of oligoaniline segments.
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State Feedback Control Promotes Transition Efficiency of Bag Filters
Kun Li,Yukai Li,Rui Cong,Zheng Xu,Lei Zhang,Libing Liu,Song Zhang 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.1
How to improve the efficiency of bag filters has attracted a considerable amount of attention. However, effective control of the transition stage, which plays an important role in reducing the time to reach a new steady state, still lacks research. Here, we utilize a nominal linear system with a time delay to characterize the transition stage. We introduce two state feedback mechanisms, namely linear matrix inequality based state-feedback robust controller and parameter-tuning controller based on nonlinear matrix inequality, into control process. Results of both genetic algorithms simulations and closed-loop control experiments show that these controllers dramatically shorten the transition stage compared to open-loop control. Furthermore, we find that parameter-tuning controller outperforms linear matrix inequality based state-feedback robust controller in terms of both stable time and steady error. These results are robust to different experimental settings. From industrial economic perspective, this technology could help to conserve energy and protect environment.
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Ting-Yan Shi,Sheng Yin,Jianqing Zhu,Ping Zhang,Jihong Liu,Libing Xiang,Yaping Zhu,Sufang Wu,Xiaojun Chen,Xipeng Wang,Yin-Cheng Teng,Tao Zhu,Aijun Yu,Yingli Zhang,Yanling Feng,He Huang,Wei Bao,Yanli Li 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.3
Background: In China, secondary cytoreductive surgery (SCR) has been widely used in ovarian cancer (OC) over the past two decades. Although Gynecologic Oncology Group-0213 trial did not show its overall survival benefit in first relapsed patients, the questions on patient selection and effect of subsequent targeting therapy are still open. The preliminary data from our pre-SOC1 phase II study showed that selected patients with second relapse who never received SCR at recurrence may still benefit from surgery. Moreover, poly(ADP-ribose) polymerase inhibitors (PARPi) maintenance now has been a standard care for platinum sensitive relapsed OC. To our knowledge, no published or ongoing trial is trying to answer the question if patient can benefit from a potentially complete resection combined with PARPi maintenance in OC patients with secondary recurrence. Methods: SOC-3 is a multi-center, open, randomized, controlled, phase II trial of SCR followed by chemotherapy and niraparib maintenance vs chemotherapy and niraparib maintenance in patients with platinum-sensitive second relapsed OC who never received SCR at recurrence. To guarantee surgical quality, if the sites had no experience of participating in any OC-related surgical trials, the number of recurrent lesions evaluated by central-reviewed positron emission tomography–computed tomography image shouldn't be more than 3. Eligible patients are randomly assigned in a 1:1 ratio to receive either SCR followed by 6 cycles of platinum-based chemotherapy and niraparib maintenance or 6 cycles of platinum-based chemotherapy and niraparib maintenance alone. Patients who undergo at least 4 cycles of chemotherapy and must be, in the opinion of the investigator, without disease progression, will be assigned niraparib maintenance. Major inclusion criteria are secondary relapsed OC with a platinum-free interval of no less than 6 months and a possibly complete resection. Major exclusion criteria are borderline tumors and non-epithelial ovarian malignancies, received debulking surgery at recurrence and impossible to complete resection. The sample size is 96 patients. Primary endpoint is 12-month non-progression rate. Trial Registration: ClinicalTrials.gov Identifier: NCT03983226
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