The impact of lymph node dissection on survival in patients with clinical early-stage ovarian cancer

Ting Deng,Qidan Huang,Ting Wan,Xiaoling Luo,Yanling Feng,He Huang,Jihong Liu 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.3

Objective: To estimate the impact of lymph node dissection on survival in patients withapparent early-stage epithelial ovarian cancer (EOC). Methods: We conducted a retrospective review of patients with clinical stage I–II EOC. Allpatients underwent primary surgery at Sun Yat-sen University Cancer Center between January2003 and December 2015. Demographic features and clinicopathological information as wellas perioperative adverse events were investigated, and survival analyses were performed. Results: A total of 400 ovarian cancer patients were enrolled, and patients were divided into2 groups: 81 patients did not undergo lymph node resection (group A), and 319 patientsunderwent lymph node dissection (group B). In group B, the median number of removednodes per patient was 25 (21 pelvic and 4 para-aortic nodes). In groups A and B, respectively,the 5-year progression-free survival (PFS) rates were 83.3% and 82.1% (p=0.305), and the5-year overall survival (OS) rates were 93.1% and 90.9% (p=0.645). The recurrence rate inthe retroperitoneal lymph nodes was not associated with lymph node dissection (p=0.121). The median operating time was markedly longer in group B than in group A (220 minutesvs. 155 minutes, p<0.001), and group B had a significantly higher incidence of lymph cysts atdischarge (32.9% vs. 0.0%, p<0.001). Conclusion: In patients with early-stage ovarian cancer, lymph node dissection was notassociated with a gain in OS or PFS and was associated with an increased incidence ofperioperative adverse events.

Low initial human papillomavirus viral load may indicate worse prognosis in patients with cervical carcinoma treated with surgery

Ting Deng,Yanling Feng,Junsheng Zheng,Qidan Huang,Jihong Liu 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.2

Objective: To evaluate the prognostic implication of human papillomavirus (HPV) viral load in cervical cancer patients whounderwent radical hysterectomy. Methods: We conducted a retrospective review of patients with stage IA2 through stage IIIA cervical carcinoma who underwentradical hysterectomy at Sun Yat-sen University Cancer Center between January 2005 and December 2009. Patients who hadundergone preoperative hybrid capture 2 testing to detect HPV DNA were included. A total of 346 patients positive for HPVDNA were enrolled and stratified into two groups according to the median HPV viral load. Results: HPV viral load was significantly correlated with lymphovascular space invasion (p=0.026) and deep stromal invasion(p=0.024). However, other factors, such as age, stage, histologic grade, histologic type, lymph node metastasis, and tumor size,were not significantly associated with viral load. Low HPV viral load was correlated with poor disease-free survival in univariateanalysis (p=0.037) and multivariate analysis (p=0.027). There was no significant difference in overall survival with regard to initialHPV viral load. Conclusion: Low initial HPV viral load may be a poor prognostic factor for cervical cancer patients who have undergone radicalhysterectomy.

Aerodynamic measurements of across-wind loads and responses of tapered super high-rise buildings

Deng, Ting,Yu, Xianfeng,Xie, Zhuangning Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.21 No.3

A series of wind tunnel tests were conducted on tapered super high-rise buildings with a square cross section by applying synchronous pressure measurement technology. The effects of global strategy of chamfered modification on aerodynamic loads and wind-induced responses were investigated. Moreover, local aerodynamic strategies of opening a ventilation slot in the corner of equipment and refuge floors were carried out. Results show that the global strategy of tapered elevation increased the vortex shedding frequency, but reduced vortex shedding energy, leading to reduction of across-wind aerodynamic loads and responses. Chamfered modification suppressed the across-wind vortex shedding effect on tapered buildings. Opening the ventilation slot further suppressed the strength of vortex shedding and reduced the residual energy related to vortex shedding in aerodynamic loads of chamfered buildings. Finally, the optimized locations of local aerodynamic strategies were suggested.

Wetting Ability of DLC Thin Films Coated PTFE

Deng Ting Koay,Tae Gyu Kim,Sae Bom Park,Dong Qi,Seock-Sam Kim 한국트라이볼로지학회 2017 한국트라이볼로지학회 학술대회 Vol.2017 No.10

A prospective randomized multicenter trial for lymphadenectomy in early- stage ovarian cancer: LOVE study

Ting Deng,Kaijiang Liu,Liang Chen,Xiao-jun Chen,Hua Wen Li,Hongyan Guo,Huijiao Zhang,Libing Xiang,Xin Feng,Xiaoyu Wang,Hextan Y. S. Ngan,Jianguo Zhao,Dongling Zou,Qing Liu,Jihong Liu 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.3

Background: The Lymphadenectomy in Ovarian Neoplasms (LION) study revealed that systemic lymphadenectomy did not bring survival benefit for advanced ovarian cancer patients with clinically normal lymph nodes and was associated with a higher incidence of operative complications. However, there is no consensus on whether lymphadenectomy has survival benefit or not in early epithelial ovarian cancer (EOC). Methods: We designed the LOVE study, a multicenter, randomized controlled, phase III trial to compare the efficacy and safety of comprehensive staging surgery with or without lymphadenectomy in stages IA-IIB EOC and fallopian tube carcinomas (FTC). The hypothesis is that the oncological outcomes provided by comprehensive staging surgery without lymphadenectomy are non-inferior to those of conventional completion staging surgery in early-stage EOC and FTC patients who have indications for post-operative adjuvant chemotherapy. Patients assigned to experimental group will undergo comprehensive staging surgery, but lymphadenectomy. Patients assigned to comparative group will undergo completion staging surgery including systematic pelvic and para-aortic lymphadenectomy. All subjects will receive 3–6 cycles of standard adjuvant chemotherapy. Major inclusion criteria are pathologic confirmed stage IA-IIB EOC or FTC, and patients have indications for adjuvant chemotherapy either confirmed by intraoperative fast frozen section or previous pathology after an incomplete staging surgery. Major exclusion criteria are non-epithelial tumors and low-grade serous carcinoma. Patients with severe rectum involvement which lead to partial rectum resection will be excluded. The sample size is 656 subjects. Primary endpoint is disease-free survival.

Aerodynamic measurements of across-wind loads and responses of tapered super high-rise buildings

Ting Deng,Xianfeng Yu,Zhuangning Xie 한국풍공학회 2015 Wind and Structures, An International Journal (WAS Vol.21 No.3

A series of wind tunnel tests were conducted on tapered super high-rise buildings with a square cross section by applying synchronous pressure measurement technology. The effects of global strategy of chamfered modification on aerodynamic loads and wind-induced responses were investigated. Moreover, local aerodynamic strategies of opening a ventilation slot in the corner of equipment and refuge floors were carried out. Results show that the global strategy of tapered elevation increased the vortex shedding frequency, but reduced vortex shedding energy, leading to reduction of across-wind aerodynamic loads and responses. Chamfered modification suppressed the across-wind vortex shedding effect on tapered buildings. Opening the ventilation slot further suppressed the strength of vortex shedding and reduced the residual energy related to vortex shedding in aerodynamic loads of chamfered buildings. Finally, the optimized locations of local aerodynamic strategies were suggested.

Experimental investigation of masonry walls supported by steel plate-masonry composite beams

Deng-Hu Jing,Jian-Fei Chen,Giuseppina Amato,Ting Wu,Shuang-Yin Cao 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.28 No.6

Masonry walls are sometimes removed in buildings to either make new passages or increase the usable space. This may change the loading paths in the structure, and require new beams to transfer the loads which are carried by the masonry walls that are to be removed. One possible method of creating such new beams is to attach steel plates onto part of the existing walls to form a steel plate-masonry composite (SPMC) beam, leading to a new structure with part of the masonry wall supported by a new SPMC beam. This paper presents an experimental investigation into the interaction between the SPMC beam and the masonry wall above. Five SPMC beams supporting a masonry wall were tested to study the influence of parameters including the height-to-span ratio of the masonry wall, height of the beam and thickness of the steel plates. The test results, including failure mode, load-carrying capacity, load-deflection curves and strain distribution, are presented and discussed. It is found that for developing better arching effect in the masonry wall the ratio of the in-plane flexural stiffness of the masonry wall to the flexural stiffness of the SPMC beam must be between 2.8 and 7.1.

THE LONG-TERM HEMISPHERIC VARIATION OF POLAR FACULAE

Deng, Lin-Hua,Qu, Zhong-Quan,Liu, Ting,Huang, Wen-Juan The Korean Astronomical Society 2011 Journal of The Korean Astronomical Society Vol.44 No.6

In this paper, the long-term hemispheric variation of the polar faculae is investigated. It is found that, (1) both the N-S asymmetry and N-S asynchrony of the polar faculae exhibit a long-term persistence, which suggests that they should not be regarded as a stochastic phenomenon; (2) both the N-S asynchrony and N-S asymmetry of the polar faculae are functions of the latitude, implying that the N-S asynchrony of the polar faculae is related to the N-S asymmetry of the polar faculae; (3) from a long-term view, the dominant hemisphere of the polar faculae seems to have close connection with the phase-leading hemisphere of the polar faculae.

Microstructure Evolution and Modeling of 2024 Aluminum Alloy Sheets During Hot Deformation Under Different Stress States

Lei Deng,Peng Zhou,Xinyun Wang,Junsong Jin,Ting Zhao 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.1

In this work, specimens of the 2024 aluminum alloy sheet were compressed and stretched along the original rollingdirection at elevated temperatures. The microstructure evolution was investigated by characterizing the metallographicstructures via electron backscattered diffraction technology before and after deformation. It was foundthat while recrystallization occurred in the compressed specimens, it was not observed to the same extent in thestretched specimens. This difference in the grain morphology has been attributed to the different movement behaviorsof the grain boundaries, i.e., their significant migration in the compression deformation and the transformationfrom low-angle to high-angle boundaries observed mainly during tension deformation. The empirical model,which can describe the grain size evolution during compression, is not suitable in the case of tension, and therefore,a new model which ignores the detailed recrystallization process has been proposed. This model provides adescription of the grain size change during hot deformation and can be used to predict the grain size in the plasticdeformation process.

Optimization Design of the Multi-stage Inventory Management for Supply Chain

Hongxing Deng,Ting Yuan,Chunli Yan 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.10

Aiming at the problem of multi echelon inventory management logistics network based on the concept, the automobile spare parts warehousing logistics as the breakthrough point, the supply chain inventory total profit as the objective function, the automobile spare parts supply chain inventory model is optimized, the multi echelon inventory management strategy, the strategy makes the enterprise inventory cost is reduced, the production efficiency is increased.