Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Zheng, Xiao-Nan,Wang, Xiao-Wen,Li, Li-Ya,Xu, Zi-Wei,Huang, Hsin-Yi,Zhao, Jin-Sheng,Zhang, Duo,Yin, Xu,Sheng, Jun,Tang, Jin-Tian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

Background: Chemotherapy is one of the major means for control of malignancies, with cisplatin (CDDP) as one of the main agents, widely used for the treatment of various malignant solid tumors. However, prevention of hepatotoxicity from cisplatin is one of the urgent issues in cancer chemotherapy. In this study, we aimed to investigate the effects of pu-erh tea on hepatotoxicity through body weight and tissue antioxidant parameters like, liver coefficient, serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), malondialdehyde(MDA) and glutathione (GSH) levels, and light microscopic evaluation by histological findings. Materials and Methods: The rats were randomly divided into five groups: Control (n=10), cisplatin (3 mg/kg p.i., n=10), cisplatin+pu-erh (0.32 g/kg/day i.g., n=10), cisplatin+pu-erh (0.8 g/kg/day i.g., n=10) and cisplatin+pu-erh (1.6 g/kg/day i.g., n=10). Pu-erh tea powder was administrated for 31 consecutive days. The rats were sacrificed at the end on the second day after a single dose of cisplatin treatment for measuring indices. Results: Pu-erh tea powder exhibited a protective effect by decreasing MDA and GSH and increasing the SOD and GSH-PX levels and GSH-PX/MDA ratio in camparison with the control group. Besides, pu-erh tea was also able to alleviate the pathological damage to some extent. Conclusion: Pu-erh tea powder is protective against cisplatin-induced liver oxidative damages, especially at the medium dosage (0.8 g/kg/d).

Sensing formic acid with a water-based chitosan lanthanide luminescence film

Xu Zheng,Xi Chen,Xudong Yu,Yifan Yang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.125 No.-

A sensitive and selective formic acid sensor could be useful in detecting this corrosive acid in industrial,medical, and environmental settings. Herein, we present a film for detection of formic acid. We introducedchitosan as a film-forming factor to creatively overcome the problem that chitosan dissolves inacids. A carboxylic acid-carbon dot solution was used to replace the strong acid solution and prepare aluminescent film in which the color changed from green to blue when it was exposed to formic acid. Integrated data analysis of the film was used to distinguish vapor from formic acid/water solutions at differentconcentrations and with a detection limit of 0.01% v/v. The selectivity of the sensor was also investigated. After fumigation with ethanol and other common solvents, there was no response similar to thatfor formic acid. It is believed that films based on lanthanide complexes and chitosan could prevent corrosionand injury from formic acid.

Association Between the Ku70-1310C/G Promoter Polymorphism and Cancer Risk: a Meta-analysis

Xu, Lu,Ju, Xiao-Bing,Li, Pu,Wang, Jue,Shi, Zhu-Mei,Zheng, Ming-Jie,Xue, Dan-Dan,Xu, Yan-Jie,Yin, Yong-Mei,Wang, Shui,You, Yong-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2

Ku70 plays an important role in DNA double-strand break repair. Studies revealing conflicting results on the role of the Ku70-1310C/G promoter polymorphism on cancer risk led us to perform a meta-analysis to investigate this relationship. Ten case-control studies with 2566 cases and 3058 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of associations. The overall results suggested no association between the Ku70-1310C/G promoter polymorphism and total cancer risk. However, on stratified analysis, significantly increased risks were observed among the Asian population (GG vs. CC: OR=1.50, 95%CI=1.10-2.06; GG vs. CC/CG: OR=1.47, 95%CI=1.07-2.01) and population-based case-control studies (GG vs. CC: OR=1.57, 95%CI=1.12-2.22; CG vs. CC: OR=1.35, 95%CI=1.11-1.64; CG/GG vs. CC: OR=1.37, 95%CI=1.14-1.65). Additionally, variant genotypes were associated with a significantly increased breast cancer risk (GG vs. CC: OR=1.80, 95%CI=1.26-2.56; GG vs. CC/CG: OR=1.40, 95%CI=1.01-1.95).

Monitoring and control of wind-induced vibrations of hanger ropes of a suspension bridge

Xu G. Hua,Zheng Q. Chen,Xu Lei,Qin Wen,Hua W. Niu 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.23 No.6

In August 2012, during the passage of the typhoon Haikui (1211), large amplitude vibrations were observed on long hangers of the Xihoumen suspension Bridge, which destroyed a few viscoelastic dampers originally installed to connect a pair of hanger ropes transversely. The purpose of this study is to identify the cause of vibration and to develop countermeasures against vibration. Field measurements have been conducted in order to correlate the wind and vibration characteristics of hangers. Furthermore, a replica aeroelastic model of prototype hangers consisting of four parallel ropes was used to study the aeroelastic behavior of hanger ropes and to examine the effect of the rigid spacers on vibration mitigation. It is shown that the downstream hanger rope experiences the most violent elliptical vibration for certain wind direction, and the vibration is mainly attributed to wake interference of parallel hanger ropes. Based on wind tunnel tests and field validation, it is confirmed that four rigid spacers placed vertically at equal intervals are sufficient to suppress the wake-induced vibrations. Since the deployment of spacers on hangers, server hanger vibrations and clash of hanger ropes are never observed.

Enhanced machining efficiency and surface quality by electrochemical discharge drilling using low concentration electrolyte

Zheng-Yang Xu,Yan Zhang,Dong Zhu 한국생산제조학회 2014 한국생산제조시스템학회 학술발표대회 논문집 Vol.2014 No.9(2)

Colorectal Cancer Incidence and Mortality in China, 2010

Zheng, Zhao-Xu,Zheng, Rong-Shou,Zhang, Si-Wei,Chen, Wan-Qing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: The National Central Cancer Registry of China (NCCR) affiliated to the Bureau of Disease Control, National Health and Family Planning Commission of China is responsible for cancer surveillance in the entire country. Cancer registration data from each local registry located in each province are collected by NCCR annually to be analyzed and published to provide useful information for policy makers and cancer researchers. Materials and Methods: Until 1st June, 2013, 219 population-based cancer registries submitted data of 2010 to the National Central Cancer Registry of China covering about 207,229,403 population, and 145 cancer registries were selected after quality evaluation for this study. Colorectal cancer cases were selected from the database according to ICD-10 coded as "C18-C20". We calculated the crude incidence and mortality rates by sex, age groups and location (urban/rural). The China population in 2000 and Segi's population were used as standardized populations for the calculation of age-standardized rates. The 6th National Population Census data of China was used to combined with the cancer registries' data to estimate the colorectal cancer burden in China in 2010. Results: Colorectal cancer was the sixth most common cancer in China. It was estimated that there were 274,841 new cases diagnosed in 2010 (157,355 in males and 117,486 in females), with the crude incidence rate of 20.1/100,000, highest in males in urban areas. Age-standardized rates by China standard population of 2000 (ASRcn) and World standard population (Segi's population, ASRwld) for incidence were 16.1/100,000 and 15.9/100,000 respectively. There were 132,110 cases estimated to have died from colorectal cancer in China in 2010 (76,646 men and 55,464 women) with the crude mortality rate of 10.1/100,000. The ASRcn and ASRwld for mortality were 7.55/100,000 and 7.44/100,000 respectively, higher in males and urban areas than in females and rural areas. The incidence and mortality rates increased with age, reaching peaksin the 80-84 year old, and oldest age groups, respectively. Conclusions: Colorectal cancer is one of the most common incident cancers and cause of cancer death in China. Primary and secondary prevention, with attention to a health lifestyle, physical activity and screening should be enhanced in the general population.

Assembly of micro/nanomaterials into complex, three-dimensional architectures by compressive buckling

Xu, Sheng,Yan, Zheng,Jang, Kyung-In,Huang, Wen,Fu, Haoran,Kim, Jeonghyun,Wei, Zijun,Flavin, Matthew,McCracken, Joselle,Wang, Renhan,Badea, Adina,Liu, Yuhao,Xiao, Dongqing,Zhou, Guoyan,Lee, Jungwoo,Chu American Association for the Advancement of Scienc 2015 Science Vol.347 No.6218

<P><B>Popping materials and devices from 2D into 3D</B></P><P>Curved, thin, flexible complex three-dimensional (3D) structures can be very hard to manufacture at small length scales. Xu <I>et al.</I> develop an ingenious design strategy for the microfabrication of complex geometric 3D mesostructures that derive from the out-of-plane buckling of an originally planar structural layout (see the Perspective by Ye and Tsukruk). Finite element analysis of the mechanics makes it possible to design the two 2D patterns, which is then attached to a previously strained substrate at a number of points. Relaxing of the substrate causes the patterned material to bend and buckle, leading to its 3D shape.</P><P><I>Science</I>, this issue p. 154; see also p. 130</P><P>Complex three-dimensional (3D) structures in biology (e.g., cytoskeletal webs, neural circuits, and vasculature networks) form naturally to provide essential functions in even the most basic forms of life. Compelling opportunities exist for analogous 3D architectures in human-made devices, but design options are constrained by existing capabilities in materials growth and assembly. We report routes to previously inaccessible classes of 3D constructs in advanced materials, including device-grade silicon. The schemes involve geometric transformation of 2D micro/nanostructures into extended 3D layouts by compressive buckling. Demonstrations include experimental and theoretical studies of more than 40 representative geometries, from single and multiple helices, toroids, and conical spirals to structures that resemble spherical baskets, cuboid cages, starbursts, flowers, scaffolds, fences, and frameworks, each with single- and/or multiple-level configurations.</P>

Refolding Behavior of Urea-Induced Denaturation Collagen

Xu Wei,Yanqiu Zhao,Jingjing Zheng,Qin Cao,Sheng Li,Lang He,Benmei Wei,Juntao Zhang,Chengzhi Xu,Haibo Wang 한국고분자학회 2021 Macromolecular Research Vol.29 No.6

Exploration of the denaturation and refolding of natural collagen is important for the application of collagen and its denatured products. In this study, using urea as a denaturant, we prepared a denatured natural collagen product and analyzed its structural changes. The denaturation treatment severely destroyed the triple helix conformation of collagen, but had no significant effect on the primary structure of its α chains or the covalent cross-linking between α chains. Next, we observed the refolding behavior of the denatured collagen by removing urea through dialysis. We found that the denatured collagen products from different sources (grass carp skin, bovine tendon) all showed a reconstruction of the triple helix conformation up to 60-75% of the value of natural collagen during the refolding process. The telopeptide did not significantly promote triple helix reconstruction. In conclusion, the reconstruction of the α chains did not perfectly occur in a “head-to-head, tail-to-tail” manner in refolded collagen, as each α chain was participating in the reconstruction of multiple triple helix domains. The refolded collagen still had weak self-assembly ability and formed a unique network-like structure containing small interlaced and closely combined fibers, which shows favorable cell compatibility and potential applications.

Corroded pipeline failure analysis using artificial neural network scheme

Xu, Wen-Zheng,Li, Chun Bao,Choung, Joonmo,Lee, Jae-Myung Elsevier Applied Science 2017 Advances in engineering software Vol.112 No.-

<P><B>Abstract</B></P> <P>Corrosion defects occur very often on the internal and external surfaces of pipelines, which may result in a serious threat to the integrity of the pipelines. Numerous studies investigated failure behavior of corroded pipelines with single corrosion defects. However, few studies focus on interacting corrosion defects. Interacting defects are defined as defects with certain proximity that interact to reduce the overall strength of a pipeline. In the present study, the failure behavior of pipelines with interacting corrosion defects was studied using a finite element method, and then a solution was proposed to predict burst pressure using an artificial neural network. The solution was validated by experimental results in previous studies and compared with other existing assessment solutions to prove its applicability and efficiency.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The failure behavior of pipelines with interacting corrosion defects was studied using FE method. </LI> <LI> A series of models were created for the sensitive study of the various parameters. </LI> <LI> A solution was proposed to predict burst pressure using an artificial neural network (ANN). </LI> <LI> The solution was validated by comparing with experimental results and existing codes. </LI> </UL> </P>

Inter‑turn short‑circuit fault detection with high‑frequency signal injection for inverter‑fed PMSM systems

Zheng Xu,Jianzhong Zhang,Zakiud Din,Yongbin Wu,Ming Cheng 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.6

This paper develops an online inter-turn short-circuit fault (ISF) detection method for inverter-fed permanent magnet synchronous machine (PMSM) systems. A high-frequency (HF) mathematical model of a PMSM with an ISF is established. Based on the presented HF model, the HF responses of the PMSM with various severity of ISF under HF voltage injectionare analyzed in detail, where both the short-circuit ratio and the fault resistance are considered to evaluate the fault severity. In the proposed fault diagnosis method, the amplitude of the HF negative-sequence component is used to determine the fault severity, and the initial phase is used to locate the position of the faulty phase. The simulation and experimental results verify the effectiveness of the proposed method.