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- 검색키워드
- 저자 : Li Ting-Jing (검색결과 54 건)
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Li, Jing-Ping,Cao, Nai-Xia,Jiang, Ri-Ting,He, Shao-Jian,Huang, Tian-Ming,Wu, Bo,Chen, De-Feng,Ma, Ping,Chen, Li,Zhou, Su-Fang,Xie, Xiao-Xun,Luo, Guo-Rong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Background: GC-binding factor 2 (GCF2) is a transcriptional regulator that represses transcriptional activity of the epidermal growth factor receptor (EGFR) by binding to a specific GC-rich sequence in the EGFR gene promoter. In addition to this function, GCF2 has also been identified as a tumor-associated antigen and regarded as a potentially valuable serum biomarker for early human hepatocellular carcinoma (HCC) diagnosis. GCF2 is high expressed in most HCC tissues and cell lines including HepG2. This study focused on the influence of GCF2 on cell proliferation and apoptosis in HepG2 cells. Materials and Methods: GCF2 expression at both mRNA and protein levels in HepG2 cells was detected with reverse transcription (RT) PCR and Western blotting, respectively. RNA interference (RNAi) technology was used to knock down GCF2 mRNA and protein expression. Afterwards, cell viability was analyzed with a Cell Counting Kit-8 (CCK-8), and cell apoptosis and caspase 3 activity by flow cytometry and with a Caspase 3 Activity Kit, respectively. Results: Specific down-regulation of GCF2 expression caused cell growth inhibition, and increased apoptosis and caspase 3 activity in HepG2 cells. Conclusions: These primary results suggest that GCF2 may influence cell proliferation and apoptosis in HepG2 cells, and also provides a molecular basis for further investigation into the possible mechanism at proliferation and apoptosis in HCC.
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Li Li,Fenglin Hua,Hui Xi,Jing Yang,Ting Xiao,Rui Zuo,Xueqing Xu,Zhiwang Yang,Ziqiang Lei 한국고분자학회 2022 Macromolecular Research Vol.30 No.12
A new type of phosphorus-containing intrinsic flame retardant was prepared with L-tryptophan (L-Trp) and 9,10-dihydro-9-oxa-10-phosphorbenzophenanthrene- 10-oxide (DOPO) as the main components. The Schiff base from the reaction of 1,4-terephthalaldehyde and L-tryptophan provides active sites, and then the phosphorous compound, DOPO, is successfully introduced into the Schiff base to synthesize L-Trp-DOPO flame retardant. The intrinsic flame retardant property of LTrp- DOPO comes from the reaction of carbonyl groups and the epoxy groups in epoxy resin (EP) matrix. The prepared L-Trp-DOPO flame retardant can efficiently improve the flame retardancy and smoke suppression of the base material of EP. Cone calorimetric test (CCT) of EP/L-Trp-DOPO composite material was carried out. The data showed that the peak heat release rate (pk-HRR) value was reduced by 50.8% (from 1459 kW/m2 to 717 kW/m2), the THR value reduced by 78.3%, and the limiting oxygen index (LOI) value was increased by 24%. The addition of new flame retardant greatly reduced the release of toxic CO gas. The flame retardant mechanism was explored, and it can be found that after thermal decomposition of L-Trp- DOPO a dense carbon layer can be produced to isolate the fire source. In addition, during the combustion process, L-Trp-DOPO will produce phosphorus-containing free radicals which will quench the active free radicals in the gas phase and dilute the combustible gas. The prepared L-Trp-DOPO flame retardant has a flame retardant effect in both the condensed phase and the gas phase during the combustion process.
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Ting Wang,Ling-li Jiang,Lu-lu Huang,Li-guang Wu,Chun-juan Li,Jing Cai 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.89 No.-
To enhance the performance of ultrafiltration membranes, a polyvinylidenefluoride (PVDF) blendingmembrane with photo-induced antifouling performance was fabricated. La3+- and Yb3+-doped titaniumdioxide-reduced graphene oxide (TiO2-RGO) composites were initially prepared by adsorption-phasesynthesis coupled with solvothermal reduction. The doped TiO2-RGO composites were then blendedwith the PVDF materials. The results showed that adding well-distributed, doped, and hydrophilic TiO2-RGO improved the pore structures and surface polarity of the blending membranes, thus improving theirpermeation and antifouling performance. After addition of doped TiO2-RGO with photocatalytic activity,the antifouling performance of the resulting blending membranes increased under weak visible-lightirradiation. The agglomerated doped TiO2-RGO in the polymeric matrix reduced the hydrophilicity andporosity of the resulting membranes, thereby decreasing their water permeability and antifoulingperformance. Solvothermal reduction through ethylene glycol also improved the photocatalytic activityof Yb-doped TiO2-RGO and enhanced the affinity between doped TiO2-RGO and PVDF. These two effectssimultaneously increased the water permeability and photo-induced antifouling performance of theblending membranes. Theflux recovery rate of the blending membranes containing Yb-doped TiO2-RGOtreated by ethylene glycol exceeded 69% after illumination. In particular, theflux recovery rate ofmembranes reached about 96% after illumination coupling with washing.
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Yang Li,Lin-Quan Tang,Li-Ting Liu,Shan-Shan Guo,Yu-Jing Liang,Xue-Song Sun,Qing-Nan Tang,Jin-Xin Bei,Jing Tan,Shuai Chen,Jun Ma,Chong Zhao,Qiu-Yan Chen,Hai-Qiang Mai 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4
Purpose The purpose of this study was to evaluate the long-term clinical outcome and toxicity of induction chemotherapy (IC) followed by concomitant chemoradiotherapy (CCRT) compared with CCRT alone for the treatment of children and adolescent locoregionally advanced nasopharyngeal carcinoma (LACANPC). Materials and Methods A total of 194 locoregionally advanced nasopharyngeal carcinoma patients younger than 21 years who received CCRT with or without IC before were included in the study population. Overall survival (OS) rate, progression-free survival (PFS) rate, locoregional recurrence-free survival (LRFS) rate, and distant metastasis-free survival (DMFS) rate were assessed by the Kaplan-Meier method and a log-rank test. Treatment toxicities were clarified and compared between two groups. Results One hundred and thiry of 194 patients received IC+CCRT. Patients who were younger and with more advanced TNM stage were more likely to receive IC+CCRT and intensive modulated radiotherapy. The addition of IC before CCRT failed to improve survival significantly. The matched analysis identified 43 well-balanced patients in both two groups. With a median follow-up of 51.5 months, no differences were found between the IC+CCRT group and the CCRT group in 5-year OS (83.7% vs. 74.6%, p=0.153), PFS (79.2% vs. 73.4%, p=0.355), LRFS (97.7% vs. 88.2%, p=0.083), and DMFS (81.6% vs. 81.6%, p=0.860). N3 was an independent prognostic factor predicting poorer OS, PFS, and DMFS. The addition of IC was associated with increased rates of grade 3 to 4 neutropenia. Conclusion This study failed to demonstrate that adding IC before CCRT could provide a significant additional survival benefit for LACANPC patients. Further investigations are warranted.
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Jun-Li Liu,Jing-Ting Sun,Hui-Lin Hu,Hao-Yuan Wang,Yun-Xi Kang,Tian-Qi Chen,Zhu-Hong Chen,Yu-Xuan Shang,Yu-Ting Li,Bo Hu,Rui Liu 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.1
A growing number of neuroimaging studies have revealed abnormal brain structural and functional alterations in subjects with internet addiction (IA), however, with conflicting conclusions. We plan to conduct a systematic review and meta-analysis on the studies of voxelbased morphometry (VBM) and resting-state functional connectivity (rsFC), to reach a consolidated conclusion and point out the future direction in this field. A comprehensive search of rsFC and VBM studies of IA will be conducted in the PubMed, Cochrane Library, and Web of Science databases to retrieve studies published from the inception dates to August 2021. If the extracted data are feasible, activation likelihood estimation and seed-based d mapping methods will be used to meta-analyze the brain structural and functional changes in IA patients. This study will hopefully reach a consolidated conclusion on the impact of IA on human brain or point out the future direction in this field.
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Zhenyun Li,Jing Han,Ting Li,Qina Zhu,Aimin Wang,Ting Liu 한국간호과학회 2017 Asian Nursing Research Vol.11 No.3
Purpose: Self-management is critical to improve health outcomes of elderly patients with coronary heart disease (CHD). Sense of coherence (SOC) is found to be linked with self-management behaviors. However, their deeper relationship is not clear. The purposes of this study were to investigate the association between SOC and self-management behaviors among elderly CHD patients in China, and whether confrontation mediates this association. Methods: A cross-sectional design was used. A total of 275 elderly patients with CHD recruited from the cardiology department in a general hospital in North China were surveyed from October 2015 to April 2016. SOC, confrontation, and self-management behaviors were measured using the Chinese version of the SOC scale, subscale of Medical Coping Modes QuestionnairedConfrontation, and the CHD selfmanagement scale, respectively. Correlation analysis and path analysis were conducted to analyze the data. Results: The mean (±standard deviation) scores of SOC, confrontation, and self-management behaviors were 62.20 (±9.61), 19.55 (±3.15), and 76.17 (±10.63), respectively. Correlation analysis showed that SOC, confrontation, and self-management behaviors were significantly correlated with each other. Path analysis indicated that SOC exerted a direct effect on self-management behaviors, whereas could affect self-management indirectly via confrontation. Bootstrap test result showed that confrontation played a mediating role (b = .20, p < .001) in the relationship between SOC and self-management behaviors. Conclusion: SOC was related to self-management behaviors, whereas confrontation mediated the effect of SOC on self-management behaviors. In practice, the role of confrontation coping should be valued when developing strategies to strengthen SOC and to improve self-management practice among elderly CHD patients.
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The Gender-Sensitive Social Risk Factors for Internet Addiction in College Undergraduate Students
Xia Lin,Jing-yan Gu,Wan-jun Guo,Ya-jing Meng,Hui-yao Wang,Xiao-jing Li,Wei Deng,Lian-sheng Zhao,Xiao-hong Ma,Ming-li Li,Ting Chen,S,K,Cheng,Tao Li 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.7
Objective The current study aims to explore precipitating and social risk factors for internet addiction (IA) in university undergraduate students, and to provide evidence for interventions and the early prevention of IA in different genders. Methods Four thousand eight hundred and fifty-eight college sophomores completed an online survey on their internet use-related behaviours and social risk factors. Results We found that more male (8.3%) than female students (5.4%) had moderate and severe IA. The main online activity in the moderate and severe IA groups was online gaming in males and online streaming in females. Roommates engaging in similar internetbased entertainment was a risk factor of IA only for males, while not being in a romantic relationship was a risk factor of IA for females only. Infatuation with the internet before college and adjustment problems for college life were shared risk factors for both genders in the mild and moderate IA groups. Conclusion IA was a common phenomenon in college students with shared and unique precipitating and social risk factors in males and females. The gender-sensitive risk factors for IA warranted earlier and individualized intervention and prevention strategies for IA in this population.
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Occurrence of biogenic amines in sufu obtained from Chinese market
Da-Wei Li,Jing-Jing Liang,Rui-Qin Shi,Jie Wang,Yan-Li Ma,Xiu-ting Li 한국식품과학회 2019 Food Science and Biotechnology Vol.28 No.2
This study aims at examining the level of biogenicamines (BAs) in different kinds of sufu commonlyconsumed in China. The correlation between different BAsand physical and chemical index in sufu samples was alsoinvestigated. The results proved that different processingtechnologies altered the distribution of BAs in commercialsufu. Total BA level was significantly correlated with saltcontent and pH. Some of the sufu samples in this surveycontained higher levels of BAs, of which 26.6% of thesamples might induce histamine poisoning, 15.6% mightinduce headache in virtue of phenylethylamine, and 23.4%might cause migraine and headache in virtue of tyramine. Moreover, 6.3% of the sufu samples with total BA contentover 1000 mg/kg may be harmful to human health. Fromthe food safety perspective, some sufu should not beexcessively consumed daily and should be processed understrict sanitary conditions to decrease the BA level.
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Zhang, Ya-Li,Sun, Feng-Ting,Zhang, Ze,Chen, Xiao-Xu,Liu, Ai-Xiang,Pan, Jing-Jing,Peng, Fei,Zhou, Shuai,Sun, Li-Jun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Forkhead-box (FOX) transcription factors comprise a large gene family that contains more than 50 members in man. Extensive studies have revealed that they not only have functions in control of growth and development, but also play important roles in different diseases, especially in cancer. However, biological functions for most of the members in the FOX family remain unknown. In the present study, the expression of 39 FOX genes in 48 kinds of cancer was mined from the Gene Expression Atlas database of European Bioinformatics Institute. The analysis results showed that some FOX genes demonstrate overlapping expression in various cancers, which suggests particular biological functions. The pleiotropic features of the FOX genes make them excellent candidates in efforts aimed to give medical treatment for cancers at the genetic level. The results also indicated that different FOX genes may have the synergy or antagonistics effects in the same cancers. The study provides clues for further functional analysis of FOX genes, especially for the pleiotropic biological functions and crosstalk of FOX genes in human cancers.
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