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- 저자 : Hui-yao Wang (검색결과 66 건)
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Zheng Tan,Wei-hui Zhong,Bao Meng,Shi-chao Duan,Hong-chen Wang3,Xing-You Yao,Yu-hui Zheng 국제구조공학회 2023 Steel and Composite Structures, An International J Vol.47 No.2
The bearing capacities resisted by the two-bay beams of multi-story planar frames with unequal spans under column removal scenarios differ considerably owing to the asymmetric stress on the left and right beams connected to the failed column and cause the potential for beams with larger span-to-depth ratios to be unable to exert effectively, which is disadvantageous for resisting the vertical load in unequal-span frame structures. To address this problem, the structural measure of adding braces to the weak bays of multi-story unequal-span frames was proposed, with the objective of achieving a coordinated stress state in two-bay beams with unequal spans, thereby improving the collapse resistance of unequal-span frame structures. Before conducting the numerical simulation, the modeling methods were verified by previous experimental results of two multi-story planar frames with and without steel braces. Thereafter, the effects of the tensile and compressive braces on the collapse behavior of the frame structures were elucidated. Then, based on the mechanical action laws of the braces throughout the collapse process, a detailed design method for improving the collapse resistance of unequal-span frame structures was proposed. Finally, the proposed design method was verified by using sufficient example models, and the results demonstrated that the design method has good application prospects and high practical value.
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Integrated Analysis Method of Thin-Walled Turbine Blade Precise Machining
Hui Wang,Lijiang Huang,Chao Yao,Meng Kou,Wenyu Wang,Bohao Huang,Weizhen Zheng 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.
Conventional turbine blade machining technology has to face some challenges on production efficiency, quality and environmental impact. So a new machining technical solution for thin-walled turbine blade is presented. Technical problems associated with the precise machining of turbine blade are discussed in detail. On the basis of analysis with existing demerits, we propose a new fixture optimization and precise machining schema for turbine blade. In the proposed technical methodology, geometric locating tolerance analysis and FEM based structural deformation prediction methods are integrated into one framework to improve the machining performance of thin-walled turbine blade. An automatic machining station of turbine blade is also developed. Promising technical capability of this system is demonstrated and validated by real machining experiments.
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Hui Ran,Yao Lu,Qi Zhang,Qiuyue Hu,Junmei Zhao,Kai Wang,Xuemei Tong,Qing Su 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.3
Background: Skeletal muscle is the largest tissue in the human body, and it plays a major role in exerting force and maintaining metabolism homeostasis. The role of muscle transcription factors in the regulation of metabolism is not fully understood. MondoA is a glucose-sensing transcription factor that is highly expressed in skeletal muscle. Previous studies suggest that MondoA can influence systemic metabolism homeostasis. However, the function of MondoA in the skeletal muscle remains unclear. Methods: We generated muscle-specific MondoA knockout (MAKO) mice and analyzed the skeletal muscle morphology and glycogen content. Along with skeletal muscle from MAKO mice, C2C12 myocytes transfected with small interfering RNA against MondoA were also used to investigate the role and potential mechanism of MondoA in the development and glycogen metabolism of skeletal muscle. Results: MAKO caused muscle fiber atrophy, reduced the proportion of type II fibers compared to type I fibers, and increased the muscle glycogen level. MondoA knockdown inhibited myoblast proliferation, migration, and differentiation by inhibiting the phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/Akt pathway. Further mechanistic experiments revealed that the increased muscle glycogen in MAKO mice was caused by thioredoxin-interacting protein (TXNIP) downregulation, which led to upregulation of glucose transporter 4 (GLUT4), potentially increasing glucose uptake. Conclusion: MondoA appears to mediate mouse myofiber development, and MondoA decreases the muscle glycogen level. The findings indicate the potential function of MondoA in skeletal muscle, linking the glucose-related transcription factor to myogenesis and skeletal myofiber glycogen metabolism.
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Susceptibility Loci Associations with Prostate Cancer Risk in Northern Chinese Men
Wang, Na-Na,Xu, Yong,Yang, Kuo,Wei, Dong,Zhang, Yao-Guang,Liu, Ming,Shi, Xiao-Hong,Liang, Si-Ying,Sun, Liang,Zhu, Xiao-Quan,Yang, Yi-Ge,Tang, Lei,Zhao, Cheng-Xiao,Wang, Xin,Chen, Xin,Hui, Juan,Zhang, Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Background: KLK3 gene products, like human prostate-specific antigen (PSA), are important biomarkers in the clinical diagnosis of prostate cancer (PCa). G protein-coupled receptor RFX6, C2orf43 and FOXP4 signaling plays important roles in the development of PCa. However, associations of these genes with PCa in northern Chinese men remain to be detailed. This study aimed to investigate their impact on occurrence and level of malignancy. Methods: All subjects were from Beijing and Tianjin, including 266 cases with prostate cancer and 288 normal individuals as controls. We evaluated associations between clinical covariates (age at diagnosis, prostate specific antigen, Gleason score, tumor stage and aggressive) and 6 candidate PCa risk loci, genotyped by PCR- high resolution melting curve and sequencing methods. Results: Case-control analysis of allelic frequency of PCa associated with PCa showed that one of the 6 candidate risk loci, rs339331 in the RFX6 gene, was associated with reduced risk of prostate cancer (odds ratio (OR) = 0.73, 95% confidence interval (CI) =0.57-0.94, P = 0.013) in northern Chinese men. In addition, subjects with CX (CC+TC) genotypes had a decreased risk for prostrate cancer compared to those carrying the TT homozygote (OR =0.64, 95% CI = 0.45- 0.90, P = 0.008). The TT genotype of 13q22 (rs9600079, T) was associated with tumor stage (P=0.044, OR=2.34, 95% CI=0.94-5.87). Other SNPs were not significantly associated with clinical covariates in prostate cancer (P > 0.05). Conclusions. rs339331 in the RFX6 gene may be associated with prostate cancer as a susceptibility locus in northern Chinese men.
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Reliability Modeling and Analysis on Metallized Film Capacitors for MMC
Yao Ran,Zheng Meimei,Li Hui,Lai Wei,Wang Xiao,Long Haiyang 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
Metallized film capacitor’s (MFC’s) reliability directly affects the stable operation of MMC valve. Conventional reliability assessment method based on data statistics is limited. This paper studies the reliability modeling of MFC considering aging for the application condition of MMC valve. Firstly, the temperature field and electric field model of MFC is established, and the temperature and electric stress distribution are explored. Secondly, the lifetime model of MFC is established based on the electrical-thermal aging of dielectric films. Finally, the aging model of MFC is established from the aspect of equivalent series resistance. Results show that the aging rate of MFC increase with the service time going by, and increase sharply after 21 years. The failure rate of MFC is small at the beginning of operation, and there is a turning point in the 23rd year. Since then, the failure rate of MFC increases sharply. The lifetime of MFC is concentrated.
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Characteristic analysis of new hybrid compensation topology for wireless charging circuits
Wang, Huanmin,Chen, Yao,Zhang, Hui,Zhang, Shangzhou The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.9
Wireless power transfer (WPT) has the advantages of flexibility, safety, and high reliability. Thus, it is widely used in portable electronic equipment, electric vehicles (EV), medical equipment, and other fields. The resonance compensation method of wireless charging directly affects the gain characteristics of the output current and voltage. As a result, this is one of the main research focuses of wireless power transmission technology. A new hybrid compensation topology circuit is proposed in this paper, which is based on the EV constant-current (CC) and constant-voltage (CV) charging mode. In this hybrid topology circuit, an equivalent loosely coupled transformer T model is established for the primary and secondary coils. Through an analysis of the circuit principle, it is concluded that the wireless power transmission circuit can realize CC and CV outputs under a dynamic load change. The output power efficiency characteristics of the serial/parallel (S/P) compensation and serial/serial (S/S) compensation circuits are analyzed. In addition, the mutual inductance parameters are optimized by an efficiency power product method to achieve the overall optimal parameter design in terms of the circuit output power and efficiency. A simulation model and an experimental prototype of the wireless power transmission circuit are established. The design process of the circuit parameters under a given target current and voltage is also presented. The simulation verifies the correctness of the constant current and constant voltage output of the S/P-S/S hybrid compensation circuit. The experimental platform verifies the CC output under the S/P compensation topology, and the CV output under the serial/serial (S/S) compensation topology.
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Wang, Chong-Zhi,Hou, Lifei,Wan, Jin-Yi,Yao, Haiqiang,Yuan, Jinbin,Zeng, Jinxiang,Park, Chan Woong,Kim, Su Hwan,Seo, Dae Bang,Shin, Kwang-Soon,Zhang, Chun-Feng,Chen, Lina,Zhang, Qi-Hui,Liu, Zhi,Sava-Se The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.2
Background: Ginseng is a commonly used herbal medicine in treating various medical conditions. Chronic gut inflammation is a recognized factor for the development of colorectal cancer (CRC). In this project, Asian ginseng berry polysaccharide preparations were used to assess their effects on CRC and related immune regulation mechanisms. Methods: Ginseng berry polysaccharide extract (GBPE) and purified ginseng berry polysaccharide portion (GBPP) were used to evaluate their activities on human HCT-116 and HT-29 CRC cell proliferation. Interleukin-8 secretion analysis was performed on HT-29 cells. Naive CD4 cell isolation and T-helper cell differentiation were performed and determined using flow cytometry for Th1 and Treg in addition to cell cycle and apoptotic investigation. Results: GBPE and GBPP significantly inhibited interleukin-8 secretion and cancer cell proliferation, inhibited CD4<sup>+</sup>IFN-γ<sup>+</sup> cell (Th1) differentiation, and decreased CD4<sup>+</sup>FoxP3<sup>+</sup> cell (Treg) differentiation. Compared to the GBPE, GBPP showed more potent antiinflammatory activities on the malignant cells. This is consistent with the observation that GBPP can also inhibit Th1-cell differentiation better, suggesting that it has an important role in antiinflammation, whereas Treg cells hinder the body's immune response against malignancies. Supported by cell cycle and apoptosis data, GBPE and GBPP, at various degrees, remarkably enhanced the anticancer activities of 5-fluorouracil. Conclusion: Data from this project suggested that Asian ginseng berry potentially has clinical utility in managing enteric inflammation and suppressing CRC through immunomodulation mechanisms.
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Genetic homogeneity between populations of cotton bollworm from Xinjiang, China
Dongmei Wang,Xianming Yang,Haiqiang Li,Akedan Wuwaishi,Ruifeng Ding,Haobin Li,Hongsheng Pan,Jian Liu,Yao Xu,Yan-Hui Lu 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.1
We studied the population structure of cotton bollworm (CBW), Helicoverpa armigera (Hübner) (Lepidoptera:Noctuidae), in Xinjiang, the largest cotton-growing region in China, using a fragment of cytochrome c oxidasesubunit I (COI) gene. Alignments of all 192 COI sequences revealed 28 haplotypes including 23 in southernXinjiang, 5 in eastern Xinjiang and 13 in northern Xinjiang. Negative and significant values of neutrality tests forthe Tajima's D and Fu's FS parameters, combined with the high values of haplotype diversity (Hd), low values ofnucleotide diversity (π) and a high number of low frequency haplotypes indicated a recent demographic expansionof Xinjiang CBW populations. Analysis of molecular variation (AMOVA) indicated low and non-significantgenetic structure, regardless of geographical scale or crop, with most of genetic variation occurringwithin local CBW populations. Pairwise FST analyses also indicated low genetic differentiation. This demographicevent and high gene flow could be responsible for the low genetic structure currently found. CBW populations inXinjiang need to be considered as one panmictic unit in its management, especially for the design of refuges todelay the development of resistance by this migratory pest to transgenic Bt (Bacillus thuringiensis) cotton.
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