인슐린의존형 당뇨병환자에서 임신중 병발한 당뇨병성 케톤산증 1예

이성근,신영구,이성규,정윤석,이관우,김현만,김행수 아주대학교 1997 아주의학 Vol.2 No.2

저자등은 인슐린의존형 당뇨병환자에서 임신중에 병발한 당뇨병성 케톤산증을 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. IDDM is an autoimmune disease resulted from beta cell destruction and insulin deficiency, and developed mostly in children and puberty. Ketoaddosis remains one of the most senous complications that can occur in the pregnant diabetic. A 26-year-old woman, gravida 1, para 0, was admitted at 32 weeks gestation because of fever lasted for 6 days. She had been treated with insulin pump during the pregnancy. Blood sugar was well controlled before admission, and the etiology of her ketoacidosis was urinary tract infection and no insulin-intake. DKA was treated with fluids and intravenous insulin. Urinary tract infection was treated with antibiotics, based on culture test. Healthy newbom was later delivered by cesarean section due to fetal distress. We experienced a case of DKA in pregnant woman and report it with a review on literature.

제2형 당뇨병 외래 환자의 비만도에 따른 미세혈관합병증

이성규,조남한,김현만,이관우,정윤석,채봉남,김윤정,이미덕,노혜림,홍은경,조현경 대한당뇨병학회 2000 Diabetes and Metabolism Journal Vol.24 No.1

Background: Korean type 2 diabetic patients who are frequently non-obese, may be genetically different from Western type 2 diabetics who are frequently obese. Therefore, the diabetic complications of type 2 diabetes mellitus in Korea may be also different from those of Western countries. Until now, most studies reported in Korea did not analyse the microvascular complications of type 2 diabetes mellitus according to obesity, and also the criteria in the diagnosis of microvascular complications were different in each study. We investigated the microvascular complications and its relationship with obesity, in type 2 diabetic patients visiting an outpatient clinic. Methods: The study subjects were type 2 diabetic patients visiting an outpatient clinic of Ajou University Hospital. We selected patients participating in a 75 g oral glucose tolerance test, retrospectively. Type 2 diabetes was diagnosed according to the WHO/NDDG classification of diabetes. Biochemical studies including lipid profile, plasma insulin and C-peptide levels were done. Anthropometric measurements were performed. Based on BMI (㎏/㎡), the patients were divided into the following groups: the lean group, when the BMI was less than 20 ㎏/㎡ the ideal body weight (IBW) group, if the BMI was between 20 ㎏/㎡ and 25 ㎏/㎡ in women and 20 ㎏/㎡ and 27 ㎏/㎡ in men; and the obese group, when the BMI was $gt;25 ㎏/㎡ in women and $gt;27 ㎏/㎡ in men. Results: 1. Neuropathy (45.2%) was the most frequent among the microvascular complications, and the frequency of retinopathy was 15.1%, and that of nephropathy was 4.9%. Within 5 years of diabetes duration, the frequency of neuropathy, retinopathy, and nephropathy was 43.2%, 11.8%, and 2.9%, respectively. 2. Glycosylated hemoglobin (HbA_(1c)) and fasting blood glucose levels were not different among the three groups. Beta cell function{Δ (insulin 30min - insulin Omin)/Δ(glucose 30min - glucose 0min)} was the highest in the obese group. However, beta cell function(ΔI/ΔG) divided by the basal insulin level, considered insulin resistance, was not different among the three groups. 3. Within 5 years of diabetes duration, retinopathy tended to be the most frequent in the lean group, whereas neuropathy tended to be the most frequent in the obese group, and body mass index influenced the retinopathy and neuropathy, statistically significantly. Conclusion: Diabetic neuropathy was the most frequent among microvascular complications of type 2 diabetes mellitus in our study subjects. At the time of presentation within 5 years of diabetes duration, the lean group of type 2 diabetics had a tendency of the more frequent retinopathy, the obese group had a tendency of the more frequent neuropathy. These results suggest that type 2 diabetes mellitus in Korea is also not a single disease entity, as in Western countries and is a heterogenous group of disorders with a diversity of microvascular complications. However, the more studies about this will be required.

한국 주요정신장애의 유병률 및 관련요인 : 2006 전국정신질환역학조사

조맹제,장성만,함봉진,정인원,배안,이영문,안준호,원승희,손정우,홍진표,배재남,이동우,조성진,박종익,이준영,김진영,전홍진,이해우 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3

Objectives The aims of this study are to estimate the prevalence of the DSM-IV psychiatric disorders in the Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI), and to compare those with previous studies. Methods The Korean Epidemiologic Catchment Area study Replication (KECA-R) was Conducted between August 2006 and April 2007. The sampling of the subjects was carried out across 12 catchment areas. A multistage, cluster sampling design was adopted. The target Population included all eligible residents aged 181o 64 years. Face-to-face interviews were conducted with the Korean version of Composite International Diagnostic Interview (K-CIDI) based on the DSM-IV (N=6,510, response rate=81.7%). Results A total of 6,510 participants completed the interview. The lifetime and 12-month prevalence rates for all types of DSM-IV disorders were 30.0% and 17.3%, respectively. Those of Specific disorders were as follows : 1) alcohol use disorder, 16.2% and 5.6% ; 2) nicotine use disorder, 9.0% and 6.0% ; 3) specific phobia, 3.8% and 3.4% ; 4) major depressive disorder, 5.6% and 2.5% ; and 5) generalized anxiety disorder, 1.6% and 0.8%. Data relating to nicotine and alcohol use disorder revealed a very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among females than males. Conclusion The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in the distribution of psychiatric disorders across the country and times were observed.

신문언어의 텍스트언어학적 연구 (Ⅱ) : 한·독 일간지 기사들의 상호 텍스트적 재작성 관계를 중심으로 Zu intertextuellen Relationen zwischen Reformulierungsausdru¨cken in Tageszeitungen in Korea und Deutschland

이성만 한국독일어문학회 2003 독일어문학 Vol.20 No.-

In dieser Arbeit wird ein Ansatz zur Beschreibung von A¨uβerungsvernetzungen u¨ber Reformulierungen entwickelt. Er baut auf dem Konzept der Textlinguistik und auf Forschungsarbeiten zur Medienwissenschaft auf, um der Komplexita¨t der zu beschreibenden Erscheinung gerecht werden zu ko¨nnen. Es werden ebenso die einschla¨gigen Froschungen zur Redewiedergabe und zu Reformulierungen beru¨cksichtigt wie textanlytische Untersuchungen. So wird vor allem der Reformulierungsansatx diskutiert, angewendet und fu¨r die Bechreibung von Reformulierungen zwischen Texten weiterentwickelt. Die Studie ist integrativ, weil beru¨cksichtigt wird besonders, was durch den vielgestaltigen Charakter des sprachlichen Pha¨nomens 'Reformulierung' erscheint. Basierend auf einem dynamischen Textversta¨ndnis im Sinne von Heinemann und Viehweger(1991), beru¨cksichtigt die Arbeit zwei Perspektiven: (1) Strukturen, Funktionen und afgumentative Einbettungen von Reformulierungen in Texten. (2) Strukturen des o¨ffentlichen Diskurses. Reformulierungen werden als beziehungsstiftende Verfahren zwischen Texten im o¨ffentlichen Diskurs beschrieben. Auf diese Weise erfasst die Untersuchung sprachliche Regularita¨ten im speziellen Bereich der o¨ffentlichen Kommunikation. Die Arbeit besteht aus sechs Kapiteln. Im zweiten Kapitel wird terminologisch die Begriffe wie (Inter-)Text. Intertextualita¨t. Bezugstext, Reformulierungstext usw, festgelegt. Auβerdem wir die Grundidee einer Diskurskonstituion u¨ber ein Gefu¨ge von Bezugstext, Reformulierungstexten und anderne wiedergebenden Texten anhand eines konkreten Falls von A¨uβerungsvernetzung dargestellt. Dann werden strukturelle und funktionelle Eigenschaften von Reformulierungsrelationen zwischen Texten. Es geht darum, die grundlegenden Analysekategorien 'Bezungsausdruck', 'Reformulierungsausdruck' und auch 'Kontextausdruck' zu spezifizieren. In vierten und fu¨nften wird untersucht, inwieweit die reformulierten Entita¨ten dem Original entspricht oder in welcher Art und Weise sich relevante Vera¨derungen ergeben. Anhand von ausgewa¨hlten Beispielen wird der Nachweis versucht: Es sollen Anspielungsstrategien im Titel von Nachrichten, Werbetexten, Feuilletons u.a. zur Illustration ihrer unterschiedlichen formalen Auspra¨gung, der verschiedenee Herkunft und Inhalte der Bezugstexte dienen. Hierbei handelt es sich um Anspielungen auf Teile des Bezugtextes. Hier werden volle und partielle formale Identita¨t unterschieden. Die Wiederholungsverfahren von Elementen des Bezugstextes dominieren in Verbindung mit folgenden Reformulierungstypen: Substitution, Addition und Subtraktion in Isolation oder Kombination. Schlieβlich fasst die Analyseergebnisse zusammen. Es wird weiterhin die Auffassung vertreten und begru¨ndet, dass die Refromulierungseffekte fu¨r o¨ffentliche Kommunikation u¨berhaupt gelten.

텍스트종류 `부음`에서 `모토`의 형태와 기능

이성만 한국독일어문학회 2001 독일어문학 Vol.15 No.-

천마(天麻, Gastrodia elata Blume) 종균배양의 최적화에 대한 연구

이진만,김성호 東國專門大學 2002 金龜論叢 Vol.9 No.1

천마는 뽕나무버섯과 공생관계로 버섯에 의한 영양공급에 의해서만 생육이 가능한 것으로 알려져 있다. 따라서 천마의 다수확재배를 위한 가장 중요한 인자중의 하나로 우수한 품질의 종균배양은 천마의 재배지의 활착율에 큰 영향을 미치므로 생육 및 수확량, 재배기간 등과 직결된다고 생각된다. 한편 5-6년 전부터 경북 칠곡군 관내에서 대량인공 재배되기 시작하여 그 재배방법에 대한 기초연구가 절실한 실정이다. 따라서 천마재배에 대한 기초연구로서 천마의 종균배양의 최적화를 통해 천마의 다수확재배법의 구축을 위한 기초연구를 수행한 결과, 종균배양에 있어서 액체배양시 물에 용해될 때 친수기 부분이 이온으로 해리되지 않는 계면활성제인 Tween80의 첨가량을 0.0066%, 5mm glass bead ball 30개를 첨가하여 배양시 pulpy growth를 유도할 수 있었으며, 균사체의 질과 양적인 면에서 가장 우수하였다. 따라서 상기의 조건에서 배양한 종균을 참나무 톱밥배지에 5%접종하여 45일간 종균 배양후 25℃, 60%의 습도조건에서 참나무 활착도가 가장 우수하였다.

톨루엔 폭로 작업자에서 Aldehyde dehydrogenase2(ALDH2)의 유전자형과 요중 마뇨산

이강숙,노영만,박정일,허성옥 가톨릭대학 산업의학 센타 산업의학연구소 1995 韓國의 産業醫學 Vol.34 No.2

This study was conducted to evaluate the distribution and the effect to urinary hippuric acid excretion according to the polymorphism of aldehyde dehydrogenase2(ALDH2) which is major role in oxidaton of benzaldehyde to benzoic acid. For 39 workers exposed to toluene and 42 white collar workers, we extracted the DNA from venouse blood and confirmed the genotype of aldehyde dehydrogenase2 using the polymerase chain reaction(PCR) and artificial created restriction site method. In workers exposed to toluene, normal (NN) type were 34 (88%) and inactive(ND) type were (12%), but in white collar workers NN type were 27(65%) and ND type were 14(33%), DD type were 1(2%). It showed the significant lower rate of inactive type of ALDH2 in workers exposed to toluene than white collar workers. The results of workplace toluene measurement were below 20ppm. For urinary hippuric acid there was not significant differnce between normal and inactive type of ALDH2. It suggested that further evaluation should be conducted in high concentration of toluene exposure group.

한약재 천마(Gastrodia elata Blume)의 증자조건 모니터링

이진만,김성호 東國專門大學 2002 金龜論叢 Vol.9 No.1

최근 기능성 식품에 대한 인식이 높아지면서 국내에서 재배되고 있는 생약제의 생리 활성에 관한 연구가 이루어지고 있으며, 그중 천마의 약리적인 효능이 인정됨에 따라 가공식품으로의 개발 확대가 더욱 요구되고 있다. 생약은 자연에서 채취한 그대로 이용하는 데에는 생체의 보존에 따른 불편과 독성, 자극성 등의 부작용이 있어 간단한 가공처리를 필요로 한다. 따라서 본 연구에서는 천마를 이용한 가공제품을 개발하기 위하여 반응표면분석법을 이용하여 각 조건별로 증자된 천마의 항산화적 특성을 모니터링하고 최적 증자조건을 예측하였다, 중심합성계획법에 따라 증자온도(80∼120℃), 증자시간(20∼60 min)을 달리하였을 때 총 페놀성 화합물 함량은 증자온도 94.43℃, 증자시간 42.38 min고 전자공여능은 증자온도 101.67℃, 증자시간 41.09 min이었다. 항산화능 및 아질산염소거능에 대한증자은도와 증자시간의 최적 조건은 100.00℃, 40.00 min으로 같게 나타났다. 이상과 같이 각각의 증자조건에 따른 천마의 항산화적 특성을 종합하여 superimposed contour map을 작성하여 최적 조건을 예측한 결과 증자은도 96∼107℃, 증자시간 28∼46 min이었다.

간접흡연이 동맥혈 산소포화도 및 혈압에 미치는 영향

이종삼,윤재만,전중기,고성경 대구대학교 인문과학연구소 2007 人文科學硏究 Vol.30 No.-

We investigated that the effect of passive smoking on percent oxygen saturation (%SaO2) and blood pressure (BP). Total 16 healthy male subjects were recruited, and subjects were allocated into one of two groups: either smoker group (n=8) or non-smoker group (n=8). All subjects were stayed in sealed laboratory room until all the experiment completed. Each subject in smoker group have smoked every one hour, and %SaO2 in arterial blood, BP, heart rate (HR), lung vital capacity (VC), and blood glucose and lactate were measured. BP was increased more rapidly in non-smoker group than smoker group during experimental period. SaO2 was significantly lower in non-smoker group compared to smoker group. There was no significant change in HR, and blood glucose and lactate. It was not also significantly changed in VC. In conclusion, passive smoking can deteriorate in %SaO2 and BP in nonsmoker healthy people, and smoking should be prohibited in any public area as well as room in which multi-persons work together.

산업보건관리자를 위한 소음성 난청 예방지침서의 개발

이원철,유경혜,장성실,이세훈,구정완,김현욱,노영만,이경재,김형아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1996 韓國의 産業醫學 Vol.35 No.1

Occupational hearing loss became the leading occupational disease by constioution 56% of all work-related diseases in Korea. However, the prevalance rates showed wide variations among the specific medical examination providers and were very low(0.8-1.4%) compared with those 8.4% in Japan. The sources of these variations was regarded in the preview study as 1) Employee audometric estings were primarily conducted by nurses and nurse-aids who had no formal training for audiometry; 2) althought audiometric testing equipment used by the spedific medical examination providers, it should be periodically calibrated, a significant number of them were not properly calibrated : 3) Initial audiometric testings were conducted at any available spaces in workplace or at the testing room without considering bachground noise level. One of solutions that can be done for sloving surrent noise related problems is to provide a noise related manual for the occupational health managers including doctors, nurses and hyginests. This study was done to provide such a manual. The main core of the manual was hearing conservation program. And the contents of the manual was the same as the main frame of hearing conservation program such as noise survey, provided of the diagram showing the core contents of each factor of the hearing conservation program. Hopefully, this manual will be the references of the standardized performances of the specific medical examination providers.