비혈연간 조혈모세포이식 후 재발한 만성골수성백혈병에서 Gleevec에 의한 완전관해 및 공여자 조혈 재건 1예

박사라,김우건,이제환,최성준,형철호,손희정,강혜진,지형석,이정신,이규형 대한조혈모세포이식학회 2002 대한조혈모세포이식학회지 Vol.7 No.2

저자들은 만성골수성백혈병으로 동종 골수이식 후 림프구성급성전환으로 재발한 환자에서, Gleevec 투약 후 DLI (donor lymphocyte infusion) 없이 공여자 조혈(donor hematopoiesis)의 재건이 이루어지고, 세포유전학적, 분자생물학적 기준에서 모두 완전관해에 이르고, 12개월째 관해를 유지하고 있는 환자를 경험하였기에 이를 보고하는 바이다. 본례의 환자에서 Gleevec은 동종 골수이식 후 급성전환기로 재발한 환자에서도 매우 효과적인 것으로 나타났다. Gleevec은 동종 골수이식 후 재발한 만성골수성백혈병에서 Interferon-α, DLI, 2차골수이식 등 기존의 치료의 문제점을 보완할 수 있는 유용한 치료방법으로 사용될 수 있을 것으로 생각되며, 이의 장기적 치료효과의 평가와 기존치료와의 병합요법의 유용성 등에 대한 향후 연구가 필요할 것으로 생각된다. We report a 32-year old woman with chronic myelongenous leukemia (CML) in lymphoid blast crisis, who underwent allogenic bone marrow transplantation (BMT) from HLA phenotype full mached unrelated donor. Her disease relapsed into full-blown blast crisis. Upon treatment with gleevec, she achieved immediate remission of leukemia as well as the donor type hematopoiesis without donor lymphocyte infusion (DLI). Our case suggests the high effectiveness of gleevec in CML relapsed after allogeneic BMT. Further studies are needed to define the role of gleevec (with or without DLI) in the management of CML relapsed after allogeneic BMT.

專門大學 體育舞踊科 敎育課程의 開發硏究

李鐵煥,金泰亨,李任仙,姜信和 진주여자전문대학 1986 論文集 Vol.8 No.-

부산지역 모 공단 및 인근지역 사업체의 산업보건 실태에 관한 조사연구

이동영,손혜숙,이채언,박형종,김대환,엄상화,최성용,유병철 인제대학교 1993 仁濟醫學 Vol.14 No.4

부산지역 공단 및 인근지역 사업체의 산업보건실태를 파악하기 위하여 205개 사업체의 보건담당자를 대상으로 1990년도의 보건실태에 관한 설문조사를 하였다. 조사내용을 일반사항, 보건관리실태에 관한 사항, 작업장 유해환경 및 보호구 지급사항, 건강관련 사항 및 근무조건에 관한 사항 등으로 대별하여 분석ㆍ관찰하였다. In order to obtain the fundamental data for developing more effective and acceptable programs of public health manegement in an industrial complex, 205 health manager in the plants answered the questionaire of the status of industrial health during 1990. The questionaire consisted of general charateristics, health care status, environmental problems, health problems, and others. 72.4% of 205 plants had less than 100 workers. Fabricated metal manufacture was 32.4%. Although Footwear manufacture was 6.4%, the percentage of workers was 33.1% of total workers. The percentage(56.2) of retired women was higher than that(38.2) of men. 51.9% of total plants has recieving group health care services. 85.4% of plants was exposed to noise, 66.5% was exposed to dust. Ear plug and mask were given to prevent noise and dust in 69.2% and 68.6%, respectively. Among 22,299 workers, 618(2.8%) were diagnosed as suspected non-occupatinal disease. 85.9% of them worked on continuously and had their disease treated. The cases suspected for occupational disease was 100 workers. 82.5% of them changed their post. 45% had the compensation for their occuaptional disease. The rate of working: accidents was 2.3%.

당밀의 첨가가 갈근탕박 사일리지의 품질과 산양의 기호성에 미치는 영향

김성복,문계봉,이봉덕,오홍록,배형철,이수기 충남대학교 농업과학연구소 2006 농업과학연구 Vol.33 No.1

Two experiments were conducted to investigate the effects of molasses supplementation to silage materials in ensiling Galgeuntang (herbal medicine) meal on the quality of silage, and its palatability in Korean native goats. In experiment Ⅰ, molasses was added at the levels of 0, 0.5, and 1.0% to Galgeuntang meal with three replicates per treatment. In experiment Ⅱ, three 1.5-yr-old Korean native goats were used to measure palatability. In experiment Ⅰ, lactic acid contents in molasses treatments were significantly(p<0.05) higher, and pH and butyric acid contents were lower than those of non-molasses treatment. In addition, molasses treatment increased total microbial cell counts in MRS medium for lactobacillus, but decreased total microbial cell counts in PDA medium for fungi. Molasses supplementation to silage materials increased in vitro dry matter disappearance. Molasses supplementation tended to increase silage intake in Korean native goat (experiment Ⅱ), but the difference was not significant(p>0.05). It is concluded that molasses supplementation to silage materials in ensiling herbal medicine meal could improve its preservability and palatability, the higher the better.

상용 실시간 운영체제에서 EDF스케줄링 알고리즘 및 스택자원정책의 구현

이형철,김용석 강원대학교 정보통신연구소 2001 정보통신논문지 Vol.5 No.-

We implemented the EDF scheduling algorithm and the Stack Resource Policy to overcome the upper bound of processor utilization and to solve the priority inversion problem, respectively. The target for the implementation is a VME board based on MPC 860 which is family of PowerPC processor. RTEMS(Real-Time Executive for Multiprocessor Systems) which is a real-time OS developed OAR, is the basis of the implementation of EDF algorithm. The original RTEMS is based on fixed priority scheduling. Implementation shows better processor utilization than the rate monotonic scheduling algorithm. The implementation of stack resource policy is shown to solve the priority inversion problem by applying the well known PathFinder example.

납착 방법이 치과용 금속의 성상에 미치는 영향에 관한 연구

김철형,송영균,이종혁 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.1

연구 목적: 본 연구는 치과영역에서 많이 사용되는 비귀금속 합금인 니켈-크롬 합금을 산소-아세틸렌 불꽃 납착법과 적외선 용접법을 이용해 용접하고 용접부 및 그 주변을 광학 현미경과 EPMA (Electron Probe Micro Analyzer, 전자미세현미분석기)를 통해 관찰하여 용접방법이 금속의 성상(性狀)에 미치는 영향을 조사하였다. 연구 재료 및 방법:니켈-크롬 합금을 이용하여 3.0 mm 직경, 30 mm 길이의 시편을 제작하였다. 시편은 산소-아세틸렌 불꽃 납착법, 적외선 용접법의 두 개의 그룹으로 분류하였다(n = 4). 시편을 low-speed disc로 자른 후 각각을 산소-아세틸렌 토치와 적외선 용접기를 이용해 용접하였다. 용접과 마무리 후에 시편을 광학현미경으로 용접부, 5 mm 떨어진 지점, 10 mm 떨어진 지점의 3개 부위에서 관찰하고EPMA를 이용하여 분석하였다. 결과: 광학 현미경 관찰 결과 용접부에서는 두 방법 모두 다수의 파절선이 관찰되었고, 10.0 mm 떨어진 거리에서는 두 방법 모두 시편의 표면에서 파절선이 발견되지 않았으나 5.0 mm 떨어진 거리에서는 적외선 용접법에서는 시편의 표면이 다소 거칠기는 했으나 파절선은 발견되지 않았고 산소-아세틸렌 불꽃 납착 표면에서는 다수의 파절선이 관찰되었다. EPMA분석에서 적외선 용접법에 의한 방법에서는 용접부위, 5.0 mm 떨어진 부위, 10.0 mm 떨어진 부위 모두에서 시편 금속의 구성성분 비율이 제조사의 구성성분 비율과 10.0%이내의 오차를 나타내었고, 산소-아세틸렌 불꽃 납착법에서는 5.0, 10.0 mm에서는 시편금속의 구성성분이 10.0%이내의 오차를 나타내었으나, 납착 부위에서는 Ni만이 검출되어 적외선 용접법과는 차이를 나타내었다. 이와 같은 분석결과를 살펴 볼 때 적외선 용접을 시행한 시편의 구성 성분이 모금속의 성분과 유사한 것을 알 수 있었다. 결론: 이상의 결과로 산소-아세틸렌 불꽃 납착법보다 적외선 용접법을 이용할 때, 금속의 결함 및 성분의 변화가 적어서 좀 더 우수한 금속 보철물의 제작이 가능할 것으로 사료된다. PURPOSE. The purpose of this study was to compare Ni-Cr alloy property of gas-oxygen torch soldering and infrared welding using optical microscope and Electron Probe Micro Analyzer (EPMA). MATERIALS AND METHODS. Ni-Cr alloys were casted for specimens. Specimens had 3.0 mm diameter, 30.0 mm length and were divided into two groups. Each group had 4 specimens. One group was for gas-oxygen torch soldering and the other was infrared welding. Specimens were cut with low-speed disc and soldered each other with gas-oxygen torch and infrared machine. After soldering and polishing, specimens were observed at 3 points (soldering point, 5 mm distance point, 10 mm distance point) with optical microscope and analyzed 3 points (soldering point, 5 mm distance point, 10 mm distance point with EPMA. RESULTS. The results of this study were as follows: 1. The observation of gas-oxygen torch soldering at 10 mm distance point under the optical microscope was not founded any specific surface properties, but some crack lines were observed at 5 mm distance and soldering point. 2. There were no crack lines were founded at the observation of infrared welding at 10 mm distance and 5 mm distance points under the optical microscope. However, at the 5 mm distance, the surface was not smooth enough compared with at 10 mm distance point. Some crack lines were observed at the welding point as well. 3. In the EPMA analysis of the gas-oxygen torch soldering, the component of Ni was increased by 4.5%, Cr was increased by 7.5% than that of the Ni-Cr alloy at the 10.0 mm distance. At the 5 mm distance, the component of Ni was decreased by 6.1%, Mo was increased by 9.0% than that of the Ni-Cr alloy but Cr was equally shown at the 5.0 mm distance. Only Ni was shown at the soldering point. 4. In the EPMA analysis of the infrared welding, the component of Ni was increased by 9.1%, Cr was increased by 0.4% than that of the Ni-Cr alloy but Al was equal at the 10.0 mm distance. At the 5 mm distance, the component of Ni was increased by 4.7%, Cr was increased by 4.7% and Al was increased by 0.1% than that of the Ni-Cr alloy. At the welding point, the component of Ni was increased by 8.8%, Cr was increased by 8.2% than that of the Ni-Cr alloy. CONCLUSION.From these results, at the 5 mm distance from the soldering point, the surface of the infrared welding was more smoother than that of the gas-oxygen torch soldering. On the EPMA analysis, the component of the specimens with infrared welding was more similar than that of the gas-oxygen torch soldering compared with the component of the Ni-Cr alloy.

肝蛭(Fasciola hepatica)의 脂質에 關한 硏究

李純炯,宋哲鏞 중앙대학교 의과대학 의과학연구소 1979 中央醫大誌 Vol.4 No.1

The present study was undertaken to observe the quality and quantity of lipids in the adult worms of sheep liverfluke, Fasciola hepatica. Lipid extract was done by the methods of Folch et al. (1957) and Kenny (1952), and the the extracted lipid fractions of the worms were separated by thin layer chromatography. Those fractions were also subjected to perform the quantitative analyses of glycerides, cholesterols and phospholipids. The results obtained were summarized as follows. 1. Total amount of glyceride was 45.29㎎ per gram wet weight of worm tissue: the amount of monoglyceride was 4.46㎎; diglyceride, 13.59㎎; and triglyceride, 25.63㎎ per gm wet weight of worm tissue. 2. Total amount of cholesterol was 8.10㎎ per gm wet weight of worm tissue, and the amount of esterified cholesterol(5.21㎎/gm) was much more than that of free cholesterol (2.15㎎/gm). 3. The following 10 phospholipids were detected in the worm tissue of F. hepatica, i.e., lysophosphatidylcholine, phosphatidylinositol, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, phosphatidylserine, phosphatidylethanolamine and three species of unknown phospholipides.

엄지발가락에 발생한 건초 섬유종 1예

이경호,조유경,한예원,김진아,김형민,박철종 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.4

인체의 수동적 전기특성 계측법 개발

이현철,윤재현,박형준 원광대학교 공업기술개발연구소 2003 工業技術開發硏究誌 Vol.23 No.-

In this study, a system for the method measuring of passive electrical properties in the human body was developed. The system was composed of the stimulating part for input with voltage(about 2[㎷]) and of the measuring part for measurement of electrical properties in human body. As a result of this experiment, the frequency characteristic of each subject represent that the electrical properties goes up in spite of a constant stimulate-voltage according to frequency (l[㎐]-50[㎑]) increment. Namely, the amplitude of stimulate-signal was not reflected but frequency was reflected on the measured results. This result be estimated that the proposed system is able to measure the passive electrical properties of human body. Also, it would be estimated neural signal propagation directions by using the method developed in this study was measured passive electrical properties in each part of body.

Peripheral, soft tissue odontoma에 관한 증례보고

이종갑,최병재,최형준,이광출 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.1

1. Peripheral odontoma는 매우 드문 질환으로 확진을 위해서는 생검이 필수적이다. 2. Peripheral odontoma는 치은의 종창을 동반하며 서서히 성장하는 임상적 특징을 가진다. 3. 골내 치아종과 마찬가지로 Peripheral odontoma의 치료로는 완전한 외과적 절제가 추천되고 예후 또한 양호하다. Odontomas, hamartomas of odontogenic origin, are composed of all the structures that make up teeth. The WHO distinguishes odontoma into two types. The complex odontoma is defined as "a malformation in which all the dental tissues are represented, individual tissues being mainly well-formed but occurring in a more or less disorderly pattern." The compound odontoma is defined as "a malformation in which all the dental tissues are represented in a more orderly pattern than in the complex odontoma, so, that the lesion consists of many toothlike structures. Most of these structures do not resemble morphologically the teeth of normal dentition, but in each one enamel, dentine, cementum, and pulp are arranged as in the normal tooth." Almost all odontomas are located intraosseously, but they have occasionally been reported in extrabony location. Peripheral or soft tissue odontomas, those arising outside of the alveolar bone, are very rare. Peripheral or soft tissue odontoma are defined as tumors that demonstrate the histologic characteristics of their intraosseous counterparts but occur solely in the soft tissue covering the toothbearing portion of the mandible and maxilla, When they mature, they appear as a radiopaque mass without the peripheral halo. The final diagnosis should be confirmed by biopsy. The origin of peripheral odontoma is probably related to remnants of the dental lamina in the gingiva. The treatment of choice is complete surgical excision, similarly to intraosseous odontoma and it does not tend to recur. This report presents a case of 5-year-old boy with swelling on labial gingiva of primary central incisor. And it was diagnosed as peripheral odontoma by excisional biopsy.