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고정화 및 저장 온도에 따른 Photobacterium phosphoreum의 Bioluminescence 안정성의 변화
김현숙,정계훈,전억한 경희대학교 생명자원과학연구원 1998 硏究論文集 Vol.19 No.-
P phosphoreum의 고정화에 있어 중요한 것은 matrix의 선택이며, matrix로서 soudium alginate만을 사용하여 고정화 하는 것보다는 strontium chloride를 첨가하여 gel의 견고성을 높여주었을 때 세포의 bioluminescence 유지도가 증가하였다. 저장온도에 따른 세포의 bioluminescence 유지도와 활성도와 관련하여 -70℃, -20℃, 20℃에서 저장한 세포의 경우 저장 1일 후에 급격한 bioluminescence의 감소를 보였으며 낮은 세포 활성도를 보인 반면 4℃의 경우 bioluminescence의 유지도가 15일 이상 이어졌으며 높은 활성도를 나타내었다. 따라서 P phosphoreum의 bioluminescence 안정성에 있어 가장 좋은 결과를 나타낸 것은 2.5%(W/W) sodium alginated와 0.3M(W/V) strontium chloride로 고정화하여 4℃에 저장한 세포였다. The objective of this work was to unprove biolummescence stability of Photobacterium phosphoreum when stored at different temperature in view of developing contmuous on-line monitonng system for pollutants m environment. A long-term experiment was performed to determine how immobilization affects the mamtenance and stability of biolummescence from luminescent bacteria at appropnate temperature. The unmobhzed cells of P. phosphoreum were compared with free cells m terms of mamtenance of biolummescence at room temperature. It was found that the biolummescence of cells immobilized on strontium alginate showed higher biolummescence mtensity than both free and mixed cells with only algmate as a matrix. The effect of temperature on the biolummescence stability was investigated with free and immobilized cells stored at 20℃, 4℃, -20℃ and -70℃ for 20 days. Both free and immobilized cells stored at 4℃ emtted a stable biolummescence whde the biolummescence markedly decreased with those stored at 20℃, -20℃ and -70℃.
쪽파[Allium ascalonicum L.] 재배기간 중 Diazinon, Iprodione 및 Chlorfenapyr의 잔류랑 변화
고광용,나은식,김성헌,김상준,장영희,이규승 충남대학교 농업과학연구소 2005 농업과학연구 Vol.32 No.2
In order to know the residual pattern of pesticides and predict to the degradation period until below MRL, we experimented diazinon, iprodinon and chlorfenapyr for shallot. They were the most detected pesticide in shallot by NAQS (National Agricultural product Quality management Service) survey. In this experiment, we sprayed those pesticides 15days before harvest and analyzed 0, 1, 2, 3, 5, 7, 10, 14 day sample to establish logical equation and to calculate DT_(50). During the cultivating period, the residue amount of diazinon was changed from 1.02 mg/kg (0 day) to 0.01 mg/kg (14 day), DT_(50) was 2.19 days, and iprodione was changed from 1.45 mg/kg (0 day) to 0.14 mg/kg (14 day), DT_(50) was 4.15 days, and chlorfenapyr was changed from 1.5 mg/kg (0 day) to 0.01 mg/kg (14 day), DT_(50) was 1.97 days. The DT_(50) of double amount in those pesticides, diazinon was 2.24 days, iprodione was 4.82 days, and chlorfenapyr was 2.24 days, respectively.
Kim, Sung-Hwan,Yun, Sung-Cheol,Park, Jin Joo,Lee, Sang Eun,Jeon, Eun-Seok,Kim, Jae-Joong,Cho, Myeong-Chan,Chae, Shung Chull,Kang, Seok-Min,Choi, Dong-Ju,Yoo, Byung-Su,Kim, Kye Hun,Oh, Byung-Hee,Baek, The Korean Society of Cardiology 2019 Korean Circulation Journal Vol.49 No.3
<P><B>Background and Objectives</B></P><P>Beta-blockers are indicated in patients with heart failure (HF) with reduced ejection fraction. However, their efficacy in patients with HF with preserved ejection fraction (HFpEF) is uncertain. We investigated the hypothesis that beta-blockers are associated with reduced adverse events in patients with HFpEF.</P><P><B>Methods</B></P><P>The Korea Acute Heart Failure (KorAHF) is a prospective observational multicentre cohort study. The 5,625 patients hospitalized for acute HF syndrome in 10 tertiary university hospitals across the country have been consecutively enrolled between March 2011 and February 2014. Of these patients, 2,152 patients with HFpEF (ejection fraction ≥40%) were investigated. The primary outcome was all-cause mortality according to beta-blocker use.</P><P><B>Results</B></P><P>During a median follow-up duration of 807 days, 702 patients died. In Cox proportional hazards model beta-blocker use was associated with a 14% reduced all-cause death (hazard ratio [HR], 0.86; 95% confidence interval [CI], 0.75–0.98), but not with reduce rehospitalization (HR, 1.03; 95% CI, 0.85–1.27). In the propensity-score matched population, beta-blockers were also associated with reduced all-cause death (HR, 0.80; 95% CI, 0.69–0.94) but not with reduced rehospitalization (HR, 1.08; 95% CI, 0.87–1.33).</P><P><B>Conclusions</B></P><P>In Korean patients with HFpEF, use of beta-blockers is associated with reduced all-cause death but not with reduced rehospitalization.</P>
Kim, Seong-Hun,Lee, Kye-Bok,Chung, Kyu-Rhim,Gerald Nelson,Kim, Tae-Woo 대한치과교정학회 2009 대한치과교정학회지 Vol.39 No.1
This paper describes the case of a 50-year-old female with a Class II malocclusion who presented with severe bimaxillary protrusion and generalized alveolar bone loss due to adult periodontitis. The treatment plan consisted of extracting both upper and lower first premolars and periodontal treatment. Anterior segmental osteotomy (ASO) of the mandible and upper anterior segment retraction using compression osteogenesis after peri-segmental corticotomy (Speedy orthodontics) was performed. Correct overbite and overjet, facial balance, and improvement of lip protrusion were obtained. However, a slight root resorption tendency was observed on the lower anterior dentition. The active treatment period was 9 months and the results were stable for 27 months after debonding. This new type of treatment mechanics can be an effective alternative to orthognathic surgery. 본 증례보고는 성인형 치주염으로 인해 전반적인 치조골소실을 보이고 양악 전돌을 동반한 II급 부정교합으로 진단된 50세 10개월 된 여자환자의 치료를 소개하고자 한다. 치주 치료를 진행한 후 양악 전돌을 해소하기 위해 양악 제1소 구치를 발치하고, 상악 전치부는 피질골 절단술 시행 후 악정형적 견인을, 하악 전치부는 6전치의 전방부 분절골 절단술[Anterior segment osteotomy (ASO)]을 국소마취하에 시행하였다. 총 치료기간은 9개월이 소요되었고 안정적인 교합관계와 안모의 개선이 이루어졌다. 하지만 치료 후에 하악 전치부에 약간의 치근 흡수 소견이 관찰되었다. 치료 27개월 후에도 안정적인 치료결과가 유지되었다.
Current Clinical Status of Telehealth in Korea: Categories, Scientific Basis, and Obstacles
Kim, Hun-Sung,Kim, Hyunah,Lee, Suehyun,Lee, Kye Hwa,Kim, Ju Han Korean Society of Medical Informatics 2015 Healthcare Informatics Research Vol.21 No.4
<P><B>Objectives</B></P><P>Through telehealth, medical services have expanded beyond spatial boundaries and are now available in living spaces outside of hospitals. It can also contribute to patient medical knowledge improvement because patients can access their hospital records and data from home. However, concepts of telehealth are rather vague in Korea.</P><P><B>Methods</B></P><P>We refer to several clinical reports to determine the current clinical status of and obstacles to telehealth in Korea.</P><P><B>Results</B></P><P>Patients' health conditions are now reported regularly to doctors remotely, and patients can receive varied assistance. Self-improvement based on minute details that are beyond medical staff's reach is another possible benefit that may be realized with the help of a variety of medical equipment (sensors). The feasibility, clinical effect, and cost-benefit of telehealth have been verified by scientific evidence.</P><P><B>Conclusions</B></P><P>Patients will be able to improve their treatment adherence by receiving help from various professionals, such as doctors, nurses, nutritionists, and sports therapists. This means that the actual treatment time per patient will increase as well. Ultimately, this will increase the quality of patients' self-administration of care to impede disease progression and prevent complications.</P>
Kim, Hyun Kuk,Hong, Young Joon,Jeong, Myung Ho,Kim, Weon,Kim, Sung Soo,Ko, Jum Suk,Lee, Min Goo,Sim, Doo Sun,Park, Keun Ho,Yoon, Nam Sik,Yoon, Hyun Ju,Kim, Kye Hun,Park, Hyung Wook,Kim, Ju Han,Ahn, Yo The Korean Association of Internal Medicine 2011 The Korean Journal of Internal Medicine Vol.26 No.1
<P><B>Background/Aims</B></P><P>Carvedilol is an antioxidant that inhibits smooth muscle cell proliferation and migration. The aim of this study was to investigate the beneficial effects of carvedilol-loaded stents on 2-year clinical outcomes after stent implantation in patients with coronary artery disease.</P><P><B>Methods</B></P><P>We performed a prospective trial with male subjects to compare the safety and effects of carvedilol-loaded BiodivYsio® stents implanted into 20 patients with those of bare-metal BiodivYsio® stents implanted into 21 patients for de novo coronary lesions. The primary end point was the degree of neointimal hyperplasia, which was measured by intravascular ultrasound (IVUS) 6 months after the procedure; the secondary end point was major adverse cardiac events (MACE) at 2 years after implantation. All carvedilol and control stents were deployed successfully.</P><P><B>Results</B></P><P>A 2-year follow-up was completed for 19 patients (95%) in the carvedilol stent group and 20 patients (95%) in the control stent group. IVUS showed a trend toward a larger luminal area (6.86 ± 2.59 vs. 5.47 ± 1.52 mm<SUP>2</SUP>, <I>p</I> = 0.267), smaller neointimal area (1.34 ± 0.70 vs. 2.40 ± 1.73 mm<SUP>2</SUP>, <I>p</I> = 0.18), and reduced net decrease in luminal area (-0.78 ± 0.97 vs. -1.89 ± 1.78 mm<SUP>2</SUP>, <I>p</I> = 0.106) in the carvedilol stent group compared with the control stent group, respectively. There were no significant differences in the incidence of MACE (10.5 vs. 30.0%, respectively, <I>p</I> = 0.132) between the groups at 2 years after stent implantation. Stent thrombosis did not occur in either group after 2 years.</P><P><B>Conclusions</B></P><P>The carvedilol-loaded stents tended to inhibit neointimal hyperplasia without the occurrence of cardiac death, myocardial infarction, or stent thrombosis at 2-year follow-up.</P>