Film중감지와 Film의 활용에 따른 화질특성의 고찰

권용재,이상모,김순희,김도형,최태균 한국건강관리협회 2000 건협 Report Vol.3 No.-

폐암세포에 대한 附子 추출물의 독성 효과

권강범,김은경,문형철,송용선,류도곤 한국전통의학연구소 2006 한국전통의학지 Vol.15 No.1

The aim of this study was to investigate the cytotoxic effect and its mechanism on Radix Aconiti(RA) extract in lung cancer cell lines. RA extract treatment decreased the cell viability in a dose-dependent fashions in lung cancer cells including A549, H460, H23 and H157 cells. Many investigators reported that A549 and H460 cells expressed wild-type p53, but H23 and H157 cells preserved mutated p53. After treatment with RA extract in A549 and H460 cells, we measured the expression of p53 protein levels using Western blot, analysis. In both cells treated with RA extracts, p53 protein expressions were increased in a dose-dependent manner. In our experiments, RA extracts also have cytotoxic effects in H23 and H157, which have mutated p53. Treatment with RA extract decreased bcl-2 protein expressions in both cells. These results suggest that RA extracts have cytotoxic effects via p53 expression increase and bcl-2 inhibitable pathways in A549, H460 cells and H23, H157 cells, respectively.

고등급 이형성을 보인 편평톱니샘종

권경주,정성애,심기남,정정화,강석형,송도경,전승정,김혜인 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.1

Until recently, colorectal polyps were classified predominantly as hyperplastic or adenomatous. While adenomatous polyps are well-characterized precursor lesions of adenocarcinomas, hyperplastic polyps have been considered as benign lesion. However, some hyperplastic polyps with serrated morphology of the crypts have been recognized to have distinctive features and these polyps were termed ‘serrated adenomas’. Recent data show that sessile serrated adenomas (SSA) might be the precursors of serrated colonic cancers, underlining the necessity of identifying them. SSA is approximately 3% of all polyps, commonly appears as flat or sessile and yellowish due to mucus production. In the pathogenesis of SSA, progression to high grade dysplasia or early invasive carcinoma may be associated with serrated neoplasia pathway different from adenoma-carcinoma sequence. We report a case with a colon polyp diagnosed as sessile serrated adenoma with high grade dysplasia after endoscopic submucosal dissection.

한국에서 메스암페타민 남용 또는 의존 환자의 인격장애에 관한 연구

김소영,권성민,조성남,권도훈,강병조,김형태 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.2

연구 목적 : 메스암페타민 남용 또는 의존이 없는 군과 있는 군 사이의 인격장애의 유병율을 알아보고, 메스암페타민 남용 또는 의존군에서 동반 인격장애가 그들의 전반적 기능 및 일반적 특성에 어떠한 영향을 미치는지 알아보고자 하였다. 방 법 : 대상은 정상대조군에서 메스암페타민 남용 또는 의존이 없는 50명과 정신병원에 입원한 메스암페타민 남용 또는 의존환자 50명이었다. 메스암페타민 남용과 전반적 기능에 대한 평가는 DSM-Ⅳ에 의거하였고, 인격장애를 평가하기 위해 대상군 모두에서 PDQ-4+를 시행하였다. 결 과 : 정상대조군은 34%에서 적어도 1개 이상의 인격장애를 나타내었으며, 한 사람 당 평균 3.94개였다. 메스암페타민 남용 또는 의존군은 64%에서 적어도 1개 이상의 인격장애를 보였으며, 한 환자 당 평균 4.72개였다. 메스암페타민 남용 또는 의존군에서 동반 인격장애의 유무는 시작 연령, 사용 용량, 그리고 입원 또는 구치 횟수와는 관련성이 없는 것으로 나타났으나, 3개 이상의 동반 인격장애를 가질 경우, 그렇지 않은 군에 비해 전반적 기능이 떨어졌다. 결 론 : 본 연구 결과, 우리나라에서도 일반인에 비해 물질사용장애 환자에서 인격장애를 동반할 가능성이 높으며, 물질사용장애 환자 중에서도 인격장애를 동반한 군이 그렇지 않은 군에 비해 전반적으로 기능이 떨어진다는 결론이 가능하게 되었다. Objectives : The purpose of this study was to examine the prevalence of personality disorders between normal control group and hospitalized methamphetamine abuse or dependent patients and, among the latter, the influence of comorbid personality disorder on their global assesment function and general characteristics. Methods : Subjects were 50 non-methamphetamine abuse or dependent persons in the general population group and 50 methamphetamine abuse or dependent patients admitted to the psychiatric hospital. Methamphetamine abuse or dependence and the global assesment function were diagnosed according to DSM-Ⅳ, and the presence of personality disorder was assessed with the PDQ-4+. Results : In the normal control group, 34% of subjects had at least one personality disorder and the average number of personality disorder was 3.94 per person. In the methamphetamine abuse or dependent group, 64% of the patients had at least one personality disorder and the average number .of personality disorder was 4.72 per patient. The presence of comorbid personality disorder were not associated with onset age, use dosage and the number of admission or arrest among the methamphetamine abuse or dependent group. But, when methamphetamine abuse or dependent patients had more than three personality disorders, the global assessment function was impaired. Conclusion : In our study, substance use disorder patients had the higher possibility of comorbid personality disorder in Korea, and among substance use disorder patients, those with comorbid personality disorders were associated with the greater global impairment.

전기적 노이즈에 의한 누전차단기의 오동작에 관한 실험적 연구

김태만,권용준,기도형 한국산업안전학회 2002 한국안전학회지 Vol.17 No.1

The purpose of this study was to investigate effect of electrical noise on malfunction of the earth leakage circuit breaker. A three-way experiment for studying its malfunction was conducted, in which electrical products such as radio, alternating current arc welder and cellular phone, distance from the earth leakage breaker to electrical products, and whether or not the earth leakage breaker is contained in the steel box were employed as experimental variables. Eleven earth leakage breakers frequently used in real situations were tested in each experimental treatment. The electrical products were used for generating electrical noise that is known to be able to cause malfunction of the earth leakage breaker. The results showed that except a case for one of the 11 earth leakage breakers when the radio made by M company was located 30 cm ahead of the breaker, malfunction did not occur in any other experimental treatment. Consequently, it is suggested that the breaker should be normally used for preventing electricity-related accidents without fear of its malfunction in industrial sites.

자가 골수 기질세포이식을 이용한 대퇴골두의 무혈성 괴사 및 장관골 골낭종의 치료

이승구,권순용,정진화,정도현,이주형,최숭욱 대한정형외과학회 골.연부조직이식학회 2003 대한골.연부 조직이식학회지 Vol.3 No.2

만성 견비통에 대한 동씨침 치료의 무작위 대조군의 임상 연구

김찬영,권나현,신예지,남동우,김건형,김종인,최도영,이윤호,이재동 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-

Objectives : To observe the effect of acupuncture treatment in chronic shoulder pain patients. Methods : 36 voluntary patients were randomly assigned to an acupuncture treatment group(E GrouP, n=18) and a control group(C GrouP, n=18). The E Group patients received acupuncture treatment on LI_(15), TE_(14), GB_(21) and Master Dong's acupuncture points, Shin-gwan and Gyun-joong, twice a week for four weeks. The C Group patients received no treatment. All patients in both groups were instructed to practise self exercise in their daily lives. Evaluations were made at baseline and after four weeks of study. The Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI) and the patient's subjective pain was measured by Visual Analogue Scale(VAS). The obtained data was analyzed. Results '. The E Group showed significant(p<0.05) improvement in CSA, SPADI and VAS after four weeks of treatment. The C Group showed significant(p<0.05) improvement in CSA, but the change of SPADI and VAS was insignificant(P>0.05). CSA and SPADI of E Group significantly(p<0.05) improved compared to the C GrouP, but the difference of VAS change in the two groups was insignificant(p>0.05). Conclusions : Four weeks of acupuncture treatment significantly improved CSA, SPADI and VAS. The improvement of CSA and SPADI was significant(p<0.05) compared to untreated patients.

Diamond-Like Carbon 코팅을 이용한 금속 장식 용구의 칼라링 및 디자인연구

변건호,김형준,최형우,권도현 한국공예학회 2001 조형디자인연구 Vol.4 No.2

The usual methods of coloring metal ornaments include surface anodizing, plating and painting. However, the anodizing method can apply to AL materials only and the plating method has been causing a severe environmental problem because of the toxicity of materials used. For these methods, surface deteriorations such as decoloration, scratch and corrosion also occur after long-time use. Therefore, a better surface treatment method is needed. This study was conducted to improve corrosion resistance and wear resistance of metal ornaments, and increase their added value by means of the DLC(Diamond-Like-Carbon) coating method, and to expand the range of its application. This study examined the characteristics of the DLC for coloring metal ornaments and the ornamental design for practical application. Coating metal ornaments could be considered as one of promising fields for application of DLC DLC film is very suitable as a coating material because it is an amorphous carbon material based on covalent bond and therefore has excellent hardness, wear resistance, lubricative property, chemical stability and light transmittance. DLC coating film was formed by the PECVD method using 13.56MHz rf plasma and CH4 gas as a material gas. At this time RF power, working pressure, transmittance according to kind and amount of auxiliary gas, and changes in optical band gap were observed. It was shown that the higher the RF power and working pressure, the lower the optical bang gap. This could be demonstrated by observing the amount of carbon-hydrogen bond by means of FT-IR. It was shown that addition of hydrogen and nitrogen would the optical band gap because they serves to break the carbon-hydrogen bond at the time of vapor deposition. The direction of design was set up in the manner that the DLC coating film could be effectively deposited on the surface of an ornament. Design was based on geometric figures and minimalism with plane elements accentuated. Accentuated, partial coating or simple, whole coating was induced by combining quadrangles, triangles and circles basically.

정신분열병의 임상적 고위험군의 특징 : '서울청년클리닉'의 자연 추적 관찰 예비연구

유소영,이경진,강도형,이승재,하태현,위휘,이애라,송지연,김성년,권준수 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1

Objectives : The aims of this study were to identify the intake and following process for subjects at high risk of transition to schizophrenia and to examine the neurocognitive, social, and emotional functions of the subjects compared with healthy controls. Methods : Symptomatic individuals judged at high risk for schizophrenia ('clinical high risk') within Youth Clinic were assessed and followed up. They performed a neurocognitive function test, a social function test and an affective function test. Twenty healthy controls were recruited in this study. Results : Among eighty-two subjects contacted through the Youth clinic, sixteen subjects were judged as the clinical high risk group. Fourteen subjects among the clinical high risk group showed deficits in several domains of neurocognitive functions, such as visual recall memory, verbal short term memory and executive function. Social and affective functions are also impaired in the Cli-nical high risk group compared with healthy controls. Two of 15 subjects (13%) developed a psychotic disorder within 6 months. Conclusion : This study illustrates the state of follow-up study for a clinical high risk group. Despite low numbers and short durations, some impairment of several functions in the clinical high risk group suggests possible predictors of psychosis.

폐경기 여성에서 1년간 호르몬 대치 요법이 혈청 지질에 미치는 영향

이해혁,남계현,김승형,이임순,이권해,최승도 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Cardiovascular disease is one of the most common cause of death in postmenopausal women. After the onset of menopause, the risk of cardiovascular disease is increased. Several risk factors of cardiovascular disease are well known to us. Among the risk factors, the changes of lipid profiles are roles for cardiovascular disease. Estrogen appears to protect the development of cardiovascular disease, by several mechanism. Especially the protective effect is believed to be mediated by the changes of lipid profiles. Decreased high-density lipoprotein (HDL)-cholesterol and increased low density lipoprotein (LDL)-cholesterol are important factors for development of cardiovascular disease. The purpose of this study was to evaluate the effect of hormone replacement therapy on the lipid profiles to include total cholesterol (TC), high density lipoprotein(HDL)-cholesterol, low density lipoprotein(LDL)-cholesterol, and triglycerides. We measured lipid profiles in 31 postmenopausal women and gave each conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 5mg, day 1-12) for 12months. The levels of serum TC, LDL-cholesterol, and triglycerides were decreased significantly (p<0.05) and HDL-cholesterol was increased significantly (p<0.05) after 12months of hormone replacement therapy. These data suggest that hormone replacement therapy appears to protect agianst the development of cardiovascular disease by the changes of lipid profiles.