강박장애 환자에서의 안와전두피질 용적의 2년 추적 연구

김성년,강도형,유소영,노규식,장준환,최정석,하태현,권준수,Kim, Sung-Nyun,Kang, Do-Hyung,Yoo, So-Young,Roh, Kyu-Sik,Chang, Joon-Hwan,Choi, Jung-Seok,Ha, Tae-Hyon,Kwon, Jun-Soo 대한불안의학회 2006 대한불안의학회지 Vol.2 No.2

Objective : This study was designed to examine the volumetric abnormality of orbitofrontal cortex (OFC) and its change after 2 years of pharmacotherapy in obsessive compulsive disorder (OCD) patients. Method : Volumetric magnetic resonance imaging studies were conducted in 15 OCD patients and 13 normal volunteers. For 2 years, all patients took at least one serotonin reuptake inhibitor and atypical antipsychotics were used as an augmentation therapy in most patients. The follow-up MRI studies were conducted after the pharmacotherapy and OFC volumes were measured by the manual region of interest method. Results : Bilateral OFC volumes of 15 OCD patients were significantly greater than those of the normal volunteers before the treatment. After 2 years of the treatment, significant decrease was observed in bilateral OFC volumes of OCD patients to the extent that left OFC volume of OCD patients was not different from that of the normal volunteers. Conclusion : This finding suggests that OFC is directly related to the pathophysiology of obsessive compulsive disorder.

성상신경절차단(星狀神經節遮斷)효과

김성년 가톨릭대학 (가톨릭신학대학) 대학원 1994 가톨릭大學醫學部 論文集 Vol.47 No.2

부록 : 연수강좌 ; 마취중 저산소증의 원인과 영향

김성년 대한마취과학회 1981 연수강좌 Vol.- No.-

월성원자로의 초임계 및 노물시험식

김성년 한국원자력학회 1983 Nuclear Engineering and Technology Vol.15 No.1

Ziprasidone의 안전성과 유효성에 관한 국내 시판 후 조사 연구

김성년,김의태,황재연,권준수 대한정신약물학회 2011 대한정신약물학회지 Vol.22 No.2

Objective The aim of this study was to observe the safety and efficacy of ziprasidone in the usual care setting in patients with schizophrenia or acute manic or mixed episodes associated with bipolar disorder. Methods A total of 3,391 patients who were treated with ziprasidone were enrolled from 108 centers in Korea. Differences in the clinical global impression of severity and clinical global impression of improvement (CGI-I) were measured after 8±1 weeks administration of ziprasidone. Adverse events were observed in all subjects who were administered ziprasidone at least once. In 330 patients, the change of weight was evaluated. Results Ziprasidone was effective for most of schizophrenia and acute manic or mixed episodes associated with bipolar disorder patients. CGI-I score was improved in 84.8% of PP subjects. Of the subjects who did not complete the study, sixty-four (1.9%) subjects discontinued treatment due to adverse events. The most common adverse events were akathisia, somnolence,extrapyramidal symptoms and insomnia. In total, 6 serious adverse events were reported in 2 subjects, including psychotic disorder and suicidal attempt. Mean 0.9 kg of weight loss was observed. Conclusion ziprasidone was effective, safe and generally well tolerated for schizophrenia or acute manic or mixed episodes associated with bipolar disorder patients in Korea. 본 연구는 3,391명의 환자에서 ziprasidone의 시판 후 조사를 통해 실제 임상 상황에서의 정신분열병, 양극성 장애와 관련된 급성 조증 혹은 혼재 삽화 치료에 대한 유효성과 안전성을 관찰하였다. 한 번 이상 연구 약물을 복용한 모든 환자에서 82.2%의 임상적 호전이 관찰되었다. 평균 75.8일의 복용기간 동안 평균 0.9 kg의 유의한 체중 감소가 나타났으며, 이 외 가장 흔한 유해사례는 정좌불능, 졸림, 추체외로 증상과 불면증이었다. 중대한 유해사례는 2명의 환자에서 발생하였는데, 그 중 1명에서 정신증적 증상과 자살 시도가 있었다. 결론적으로 국내에서 ziprasidone은 실제의 일반적인 임상 상황에서 정신분열병, 양극성 장애와 관련된 급성 조증 혹은 혼재 삽화 치료에 안전하고 효과적으로 사용될 수 있다고 판단된다.

심인성 다음증의 임상적 특징과 치료

김성년 한국정신병리-진단분류학회 2023 精神病理學 Vol.27 No.1

Psychogenic polydipsia is a clinical condition characterized by an excessive fluid intake and excretion of urine exceeding 40-50 ml/kg body weight, excluding reasons for secondary polydipsia. It occurs commonly in psychiatric patients and is most likely to be seen in schizophrenia. The underlying pathophysiology of this syndrome remains unclear and complex factors have been reported to be associated including medication, hypothalamic defect. It can progress to life threatening state of water intoxication, which symptoms are confusion, lethargy, psychosis, seizure or death. Evaluation of psychogenic polydipsia includes a comprehensive search for other medical reasons of polydipsia, polyuria, hyponatremia, and SIADH. Treatment modalities lack reports of replicated efficacy, but may include water restriction, behavioral approach and medications including clozapine. Recent human neuroimaging studies are revealing complex mechanisms of controlling thirst and drinking. Further studies in needed to provide better understanding of the pathophysiology and treatment guidelines for psychogenic polydipsia.

급식경영 전산화를 통한 업무의 효율화

김성년 대한영양사회 1994 國民營養 Vol.163 No.-

우리나라 RI/방사선이용분야의 바람직한 발전방향과 전망

김성년,Kim, Seong-Nyeon 한국동위원소협회 2000 동위원소회보 Vol.15 No.4

脚筋力과 體力要因과의 相關 : 男子 高等學生을 對象으로

金性年,李永雄 慶尙大學校 1985 論文集 Vol.24 No.2

The purpose of this study is to give a help to an efficient guiding principles of the class for physical education and in profesional physical fitness, comparing and analyzing the correlation bet ween leg strength and the factors of high-school students. The factors of the measured physical fitness were leg strength test, 50m sprint, 100m sprint, 1,000m distance run, sit-ups, dynamic balance and static balance. The height, weight, chest girth, sitting height of the boys as a physical factors were measured. The results of measurement and analysis were as the following: 1. There were high correlation between leg strength and 50m, 100m sprint. 2. There was high correlation between leg strength and 1,000m distance run. 3. There was high .correlation between leg strength and sit-ups, 4. There was low correlation between leg strength and dynamic balance. 5. There was very low .correlation between leg strength and static balance. 6. There was high correlation between leg strength and each item of the factors of physiques.

생쥐에서 수정 직후 아산화질소 노출이 배아의 성장에 미치는 영향

김성년,김장흡,이혜진,조원선 대한마취과학회 1997 Korean Journal of Anesthesiology Vol.32 No.5

Background: Nitrous oxide exposure for long periods during gestation causes the increased fetal wastage, growth retardation, morphological abnormalities in rodents. Most studies have explained deleterious effects of nitrous oxide on postimplantation embryo development. The aim of this study was to evaluate the effects of nitrous oxide on embryo after the fertilization in superovulated BALB/c mice. Methods: Pregnant mice were exposed to 70% nitrous oxide in oxygen for 6, 12 and 24 hours on the day of gestation, and 2-cell stage embryos were cultured to blastocyst. Reproductive data were determined at cesarean section on 16th day of gestation based on embryonic developmental failure in vitro by 24 hours nitrous oxide. The protective effects of folinic acid or methionine against inhibition of 2-cell embryo development were also evaluated. Results: Blastocyst development was significantly lower in 12 and 24 hours nitrous oxide group than in the control and 6 hours nitrous oxide group. The pregnancy rate and the mean number of implantations were significantly lower in 24 hours nitrous oxide group than in the control. No significant differences in percentage of the living fetus, the dead fetus, the resorption per implantation, the mean fetal weight and the crown-rump length were observed between nitrous oxide group and control group. There was no significant difference between the nitrous oxide group and the nitrous exposed group receiving methionine and folinic acid. Conclusions: The exposure to high concentration of nitrous oxide for a long time after the fertilization in mice may be possibility of the early abortion of embryos, whereas there is not any influence on fetus after the implantation. (Korean J Anesthesiol 1997; 32: 701∼709)