A Structural View of Xenophagy, a Battle between Host and Microbes

권도훈,송현규 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.1

The cytoplasm in mammalian cells is a battlefield between the host and invading microbes. Both the living organisms have evolved unique strategies for their survival. The host utilizes a specialized autophagy system, xenophagy, for the clearance of invading pathogens, whereas bacteria secrete proteins to defend and escape from the host xenophagy. Several molecules have been identified and their structural investigation has enabled the comprehension of these mechanisms at the molecular level. In this review, we focus on one example of host autophagy and the other of bacterial defense: the autophagy receptor, NDP52, in conjunction with the sugar receptor, galectin-8, plays a critical role in targeting the autophagy machinery against Sal-monella; and the cysteine protease, RavZ secret-ed by Legionella pneumophila cleaves the LC3-PE on the phagophore membrane. The structure-function relationships of these two examples and the directions of future research will be dis-cussed.

Tianeptine,SSRIs,Moclobemide가 성기능에 미치는 영향

권도훈,강병조 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

In this study, the author prospectively analyzed the effects of SSRIs, RIMA(moclobemide) and SSRE (tianeptine) on sexual function using a questionnaire. Among patients who visited the outpatient department of Kyungpook University Hospital from November 1998 to May 2000, the author included patients who met DSM-IV diagnostic criteria for depressive disorder. Sexual function and satisfaction was evaluated using a series of questions asked of each patient every 2 weeks for 8 weeks. Among 24 patients who completed the full 8 weeks of treatment, 8 received tianeptine(men 3, women 5), 7 received moclobemide(men 3, women 4), and 9 receded SSRIs(men 6, women 3). Of 8 tianeptine group, 7 reported total improvement in sexual function and satisfaction comparable to premorbid condition within 4 weeks of treatment, and another woman who had net experienced substantial improvement till 8 weeks had good tolerance in sexual function and reported some improvement in lubrication. Of 7 moclobemide group, 5 reported no significant differences in their sexual function associated with medication. In SSRI group, all patients complained of delayed ejaculation and anorgasmia associated with medication within 4 weeks of treatment, and among them 2 reported decreased libido and difficulty in erection (lubrication) in addition. But at 8 weeks, except for 1 female patient who couldn't tolerate general sexual dysfunction(especially anorgasmia) and was switched over to another antidepressant, 5 male patients reported no significant differences in their sexual function. The result of this study demonstrated that sexual dysfunction associated with SSRIs might be adapted in most cases when taken continuously and moclobemide had no significant association with sexual dysfunction. Tianeptine, in most depressive patients, recovered general sexual function including libido, erection (lubrication), ejaculation and orgasm to premorbid condition and might be a desirable drug of choice and an altermative in patients who complain of sexual dysfunction.

CRDI 자동차의 인젝터 제어 종류가 이산화탄소와 연비에 미치는 영향에 관한 실험적 연구

권도훈,김철수 한국기계기술학회 2022 한국기계기술학회지 Vol.24 No.1

The fuel efficiency was 16.77km/L on average for D-ENG and 12.97 km/L for B-ENG. The fuel efficiency of D-ENG was 22.66% higher than that of B-ENG. NOX had an average D-ENG of 191.75ppm and B-ENG of 104ppm. NOX of D-ENG occurred 145.76% more than B-ENG. The amount of CO2 generated was 154.25ppm for D-ENG and 199ppm for B-ENG. CO2 of D-ENG occurred 29.01% less than B-ENG. From this, it was found that the higher the fuel efficiency, the higher the emission of nitrogen oxide and the lower the emission of carbon dioxide decreased.

CRDI 디젤 자동차의 인젝터의 종류가 연비와 배기가스에 미치는 영향에 관한 연구

권도훈,김철수 한국기계기술학회 2021 한국기계기술학회지 Vol.23 No.1

In this paper, we compare and analyze the injector defects of P-ENG and S-ENG with normal injectors by measuring current waveforms, voltage waveforms, exhaust gases and driving fuel economy. In the case of FTS failure, the S-ENG reduced the overall injection time by 3.7% and the main injection by 3.5% compared to the normal engines. In the case of AFS failure, the overall injection time increased by 45.7% and the main injection time increased by 24.1% compared to the normal engine. The rest data showed that fuel economy of S-ENG had 25.9% higher than P-ENG, NOX had 162.5% higher than that of P-ENG, and CO2 of S-ENG had 26.7% lower than P-ENG.

UTD-supplemented Mode-matching Method Analysis of High-frequency Wave Coupling into Large Paralled Plate Waveguides

권도훈,선영식,명노훈 대한전자공학회 1993 대한전자공학회 학술대회 Vol.1993 No.10

Psychosis, Intermittent Hyponatremia, and Polydipsia에 의해 혼수에 빠진 만성정신분열병 1례

권도훈,정성훈 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.2

PIP 증후군은 임상에서 흔히 볼 수 있는 심인성 다음증에 SIADH가 서로 상호보완적으로 작용하여 발생하는 질환으로 볼 수 있으나, 다음증과 PIP 증후군이 구분없이 사용될 만큼 아직까지 개념이 명백하지 않는 질환으로 많은 경우에서 내과적 질환으로 생각하고 간과되는 경향이 있다. 향후 다음증과 PIP 증후군에 대한 진단기준, 발생기전, 치료에 대해 체계적인 연구가 필요할 것으로 생각되며 현재로서는 보다 많은 임상의들이 이 질환에 대해 주의를 해서 조기에 발견하여 PIP 증후군의 심각한 합병증들을 방지하도록 노력할 필요가 있다. Molindone, risperidone, clozapine과 같은 항정신병약물과 naloxone은 정신병적 증상호전과 함께 PIP 증후군 증상완화에 도움이 되리라 생각된다. Psychosis, Intermittent hyponatremia, and Polydipsia(PIP syndrome) is a serious problem in many patients with chronic psychiatric illness. It may have lot of complications. These complications, if not recognized, are likely to contribute to worsening of psychosis despite appropriate pharmacological treatment while severly limiting the patient's ability to actively participate in behavioral interventions. A 48 year old chronic schizophrenic patient developed PIP syndrome with coma state induced by two antipsychotics. Potential pathophysiological mechanisms and treatment considerations are discussed.

CRDI 디젤 자동차의 인젝터 공급전력이 연비에 미치는 영향에 관한 연구

권도훈,김철수 한국기계기술학회 2020 한국기계기술학회지 Vol.22 No.6

In this paper, the injectors with normal quantity, over quantity of +10%, under quantities of -10% and –30%, were mounted on S-ENG and P-ENG in order to measure the voltage energy, current energy and power supplied to the injectors and the fuel economy under several speed of rpm conditions. The voltage and current energy of S-ENG was greater than P-ENG, and the power of S-ENG was measured and analyzed 4.8 times higher than that of P-ENG at all injectors, and the tendency of carbon dioxide emissions calculated from fuel efficiency measurement results was not significantly affected by the type of injectors, but P-ENG was measured to be slightly affected by the type of injectors. It is assumed that the model year and mileage of the test vehicle affects this tendency.

Opuntia 속 선인장으로부터 추출분획된 생리활성물질에 관한 연구

권도훈,김해남,윤웅찬,전홍기 한국생명과학회 2004 한국생명과학회 심포지움 Vol.41 No.-

모스정합을 결합한 UTD에 의한 큰 평행도파관의 고주파간섭 해석

권도훈,선영식,명노훈 대한전자공학회 1994 전자공학회논문지-A Vol.31 No.10

The problem of a plane wave impinging upon a semi-infinite paralle-plate waveguide is investigated. The interior fields can be analyzed by converting the initial field into vaveguide modes. Kirchhoff approximation is usually made at the waveguide aperture in the literature. In this paper, a modified approximation is made using the Uniform Gemetrical Theory of Diffraction(UTD). Numerical results show excellent agreement between UTD-supplemented mode-matching solution and UTD solution.

Psychosis, Intermittent Hyponatremia, and Polydipsia에 의해 혼수에 빠진 만성정신분열병 1례

정성훈,권도훈 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.2

PIP 증후군은 임상에서 흔히 볼 수 있는 심인성 다음중에 SIADH가 서로 상호보완적으로 작용하여 발생하는 질환으로 볼 수 있으나, 다음증과 PIP 증후군이 구분없이 사용될 만큼 아직까지 개념이 명백하지 않는 질환으로 많은 경우에서 내과적 질환으로 생각하고 간과되는 경향이 있다. 향후 다음증과 PIP 증후군에 대한 진단기준, 발생기전, 치료에 대해 체계적인 연가 필요할 것으로 생각되며 현재로서는 보다 많은 임상의들이 이 질환에 대해 주의를 해서 조기에 발견하여 PIP 증후군의 심각한 합병증들을 방지하도록 노력할 필요가 있다. Molindone, risperidone, clozapine과 같은 항정신병약물과 naloxone은 정신병적 증상호전과 함께 PIP 증후군 증상완화에 도움이 되리라 생각된다. Psychosis, Intermittent hyponatremia, and Polydipsia(PIP syndrome) is a serious problem in many patients with chronic psychiatric illness. It may have lot of complications. These complications, if not recognized, are likely to contribute to worsening of psychosis despite appropriate pharmacological treatment while severly limiting the patient's ability to actively participate in behavioral interventions. A 48 year old chronic schizophrenic patient developed PIP syndrome with coma state induced by two antipsychotics. Potential pathophysiological mechanisms and treatment considerations are discussed.