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안운선,이순보,함경희,이광순 成均館大學校 1983 論文集 Vol.33 No.-
The radial distribution function for 2D fluid of Kr adsorbed on graphite surface is calculated using cluster integrals. The interaction energy between a Kr molecule and graphite surface is assumed as a pairwise addition of Lennard-Jones(12, 6) potentials. From this radial distribution function spreading pressure of the adsorbed layer is calculated. The results agree very well with experimental results and boundary conditions. The isosteric heat of adsorption is also calculated using 2D virial equation of state, and found to agree very well with experimental results.
알코올 금단 발작 환자에서 진전 섬망 예방에 대한 Nimodipine과 Chlordiazepoxide의 효과 비교
정두신,양광익,이보람,방차옥,이태경,성기범,안무영,박형국 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1
Background & objectives : An increase of calcium influx during alcohol withdrawal state may contribute to neuronal hyperexitability, which cause delirium tremens(DT). Some investigators have found calcium channel blockers effects in prevention of DT in experimental animals. Therefore we evaluated the preventive effects of calcium channel blocker(nimodipine) and benzodiazepine(chlordiazepoxide) on the development of DT in alcohol withdrawal seizure(AWS) patients. Method : A total 59 patients with AWS were divided into three groups according to the management nimodipine-treated, chlordiazepoxide-treated, and control(no specific medication) groups. We compared the incidence rates of DT in the three groups. Results : Total incidence rate of DT was 30.5%(18 of 59 patients). There were 6 DTs of 18 patients(33.5%) in nimodipine-treated group, 4 of 21 patients(22.5%) in chlordiazpoxide-treated group, and 8 of 20 patients(44.0%) in control. Conclusion : The control group(44.0%) showed the highest incidence rate of DT. And nimodipine-treated(33.5%) and chlordiazepoxide-treated group(22.5%) were followed. However, this result failed to demonstrated statistically significant differences due to small numbers size.
Introduction of Neodryinus typhlocybae and biological control of invasive Metcalfa pruinosa
Bo Yoon Seo,Jum-Rae Cho,Chang-Gyu Park,Jeong Hwan Kim,Gwan-Seok Lee,Kwang-Ho Kim,Jin-Kyo Jung,Sung Jun Hong,Ki-Su Ahn 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10
미국선녀벌레(Metcalfa pruinosa)는 외래 침입해충으로 조사가 시작된 2009년 이후 발생지역과 발생면적이 계속 증가하여 2018년에는 123개 시군구의 21,154ha에서 발생이 보고되고 있다. 미국선녀벌레는 농경지와 그 주변 산림지에서 활동하기 때문에 정부와 지자체간 협업을 통해 농림지 동시방제를 5월하순경(부화약충 대상)과 7월 중순경(성충 대상) 2회 실시하고 있다. 농촌진흥청에서는 미국선녀벌레의 기생천적인 선녀벌레집게벌(Neodryinus typhlocybae)의 안정적인 도입과 미국선녀벌레에 대한 생물적 방제원으로서 국내 정착을 위해 이탈리아 파도바대학과 국제협력사업을 2017년부터 수행하고 있다. 선녀벌레집게벌은 완주에서 월동이 가능하였으며 6월 초에 50%이상 우화를 하였다. 2018년도에 온실(완주)과 야외(수원, 태안)에서 증식하여 1,000여 개체 이상을 확보하였으며 도입천적의 안정적인 국내 정착과 확산 및 활용 방안에 대해 논의하고자 한다.
Case Reports : Primary Malignant Rhabdoid Melanoma
( Bo Young Chung ),( In Su Ahn ),( Soo Ick Cho ),( Hye One Kim ),( Kwang Ho Kim ),( Chun Wook Park ),( Cheol Heon Lee ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.2s
Melanoma with rhabdoid features is an uncommon variant of malignant melanoma. Here, we describe a rare case of primary rhabdoid malignant melanoma. A 54-year-old man presented with a black tumor measuring 3×4 cm on the right forearm. Histologic sections showed a tumor mass with rhabdoid features composed entirely of polygonal neoplastic cells with eccentric nuclei, prominent nucleoli, and large hyaline cytoplasmic inclusions. The tumor cells were immunoreactive with HMB-45, S100, Fontana-Masson silver and vimentin, and negative for smooth muscle actin, CD68, CD34, CD99, synaptophysin, desmin, and PAS. The differential diagnosis for this tumor included malignant peripheral nerve sheath tumor, malignant peripheral neuroectodermal tumor and rhabdomyosarcoma. The patient was treated with a wide excision and a local skin graft. The excised tumor was entirely composed of rhabdoid tumor cells. No recurrence or metastasis was evident 4 months after removal. This article is relevant to rare cases of primary malignant melanomas showing rhabdoid tumor cells over the entire excised lesion. (Ann Dermatol 23(S2) S155~S159, 2011)
Decrease of ceramides with ultra long-chain fatty acids in psoriasis model
( Bo-kyung Kim ),( Hee Seok Seo ),( Jong Cheol Shon ),( Kwang-hyeon Liu ),( Jong-won Lee ),( Sung Ku Ahn ),( Seung Phil Hong ) 한국피부장벽학회 2020 한국피부장벽학회지 Vol.22 No.2
Perturbed skin barrier function is the key features of psoriasis. As ceramides(CERs) with long-chain fatty acids(FAs) in the stratum corneum(SC) is important for the skin barrier functions, robust skin barrier can be expected when the process of fatty acid elongation is properly carried out. Here, we aimed to identify the alteration of FA chain length of CERs and lipid synthetic enzymes including elongases(ELOVLs) on the imiquimod(IMQ)-induced psoriasis murine model, human psoriasis skin and in-vitro cell culture. And we also investigated whether IFN-γ may induce the alteration of various enzymes and transcription factors related in biosynthesis of long-chain CERs. Psoriasis-like murine model were induced in BALB/c mice with topical applications of IMQ for 5 days. Human stratum corneum(SC) were collected from 12 subjects with psoriasis. To examine the alteration of FA lengths of CERs, each species of CERs were quantified in of the control and IMQ-treated mice by using LC-MS. We found that portion of free CERs with C26 FA moieties was significantly decreased in IMQ-treated group. And this was also obvious in human SC with psoriasis. We also found that free CERs with C26 or longer FAs and bound CERs C35 or longer FA were significantly decreased suggesting that profiles of FA lengths of CERs shifted toward shorter chain in IMQ-treated murine model. When, we investigate various enzymes affecting the alteration of FA lengths by using quantitative RT-PCR, the expression of ELOVL1, ELOVL4, CerS3 were downregulated whereas ELOVL3 were upregulated in IMQ-treated group. These enzymatic changes may cause impairment in synthesis of CERs with ultra long-chain FAs. We further investigated the role of IFN-γ, a prominent cytokine in psoriasis on various factors involved in FA elongation of the CERs. After normal human epidermal keratinocytes(NHEKs) were stimulated with IFN-γ, expression of ELOVL1, ELOVL4 and CerS3 were significantly reduced. Also, the expression of PPARs, LXR and SREBPs, important transcriptional regulators of ELOVLs and CerSs, were significantly reduced in IFN-treated NHEKs. Thus, we suggest that the expression of factors critical to epidermal differentiation and lipid synthesis is downregulated by IFN-γ in psoriasis, which may affect ceramide chain length and then barrier function.
박보름 ( Bo Reum Park ),김광상 ( Kwang Sang Kim ),박해련 ( Hae Ryeun Park ),신규옥 ( Kyu Ok Shin ),안경민 ( Kyung Min Ahn ),김기영 ( Ki Young Kim ) 대한미용과학회(구 한국두피모발미용학회) 2010 대한미용학회지 Vol.6 No.3
Lip balm is now one of useful cosmetics and the phenomena of well-being and LOHAS have extended to the area of cosmetics of which quality is assured. In this study, usability of Lithospermum erthrohizon (L. erthrohizon) investigated to natural cosmetic materials. Ethyl alcohol extract from L. erthrohizon was observed cytotoxicity, DPPH scavenging effect and antimicrobial activity. And lip balm made of 10% L. erthrohizon extract from ethyl alcohol and jojoba oil extract, and tested safety, usability and stability. In the result, fifty percent of fibroblast viability and brain cells were shown at the concentration of 128 mg/mL and 106 mg/mL of ethyl alcohol extracts. No extraordinary reaction or phenomena were detected like erythema (-) or allergy (-) when fore arms were patched for 48 hours with 10% lip balm made of ethyl alcohol and oil extracts. With regard to stability, there was little change in color but generation of alien substances and acidification from UV irradiation to 10% lip balm. Extremely positive responses were directed to lip balm in the order of color, feeling after application, applicability, fragrance and color reaction. DPPH scavenging activity was observed at the concentration of 5.0 mg/mL of ethyl alcohol extracts in comparison with the concentration 0.1 mg/mL of BHT as positive control material. Fractions of ethyl acetate and butanol from L. erthrohizon were measured at 12.5 mg/mL same scavenging effect as BHT. And antimicrobial activities revealed formation of clear zone with size of 9.5 mm against to S. aureus and 10 mm clear zone against to S. epidermidis at the concentration of 100 mg/mL. In conclusion, L. erthrohizon turned out to have excellent effects and antimicrobial activities as natural substance. And the lip balm made of L. erthrohizon is expected to suffice the 4 major requirements of cosmetics (safety, stability, effectiveness and usability), it is thought to be usefully employed in developing the products with natural substances that are verified of antioxidant effect and antimicrobial activity in the industry of cosmetics.
Primary Malignant Rhabdoid Melanoma
Chung, Bo Young,Ahn, In Su,Cho, Soo Ick,Kim, Hye One,Kim, Kwang Ho,Park, Chun Wook,Lee, Cheol Heon Korean Dermatological Association; The Korean Soci 2011 Annals of Dermatology Vol.23 No.suppl2
<P>Melanoma with rhabdoid features is an uncommon variant of malignant melanoma. Here, we describe a rare case of primary rhabdoid malignant melanoma. A 54-year-old man presented with a black tumor measuring 3×4 cm on the right forearm. Histologic sections showed a tumor mass with rhabdoid features composed entirely of polygonal neoplastic cells with eccentric nuclei, prominent nucleoli, and large hyaline cytoplasmic inclusions. The tumor cells were immunoreactive with HMB-45, S100, Fontana-Masson silver and vimentin, and negative for smooth muscle actin, CD68, CD34, CD99, synaptophysin, desmin, and PAS. The differential diagnosis for this tumor included malignant peripheral nerve sheath tumor, malignant peripheral neuroectodermal tumor and rhabdomyosarcoma. The patient was treated with a wide excision and a local skin graft. The excised tumor was entirely composed of rhabdoid tumor cells. No recurrence or metastasis was evident 4 months after removal. This article is relevant to rare cases of primary malignant melanomas showing rhabdoid tumor cells over the entire excised lesion.</P>