본태성 고혈압 환자에서 양측 신혈류의 비교

양광익,양동호,홍세용 대한고혈압학회 1997 대한고혈압학회지 Vol.3 No.1

급성 말초 전정신경병증 소견을 보인 후하부소뇌동맥의 내측 분지 경색 1례

양광익 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

A "pseudolabyrinthine" syndrome caused by acute infarction in the territory of the medial branch of the posterior inferior cerebellar artery (mPICA) has rarely been reported. The infarct also involved the lateral and dorsal medulla when the mPICA supplied all or part of these regions. A 53-year-old man of mPICA infarction developed with vertigo, nausea, vomiting, and imbalance. On examination, they fell to the lesion side on attempts to stand with eyes open. He had not nystagmus, limb ataxia, opthalmoparesis, visual tilting of the environment, and other abnormal neurologic signs. MRI showed a recent infarct involving medial part of inferior cerebellum. Vertgio, nausea, and vomiting resolved within 1-2 days. But, imbalance improved within 1-2 weeks. We report a case of mPICA infarction mimicking clinical sings of APV. So, we suggest that absent nystagmus and longstanding imbalance were point of differential diagnosis from APV.

어지럼증 환자들의 수면 질에 대한 예비 연구

양광익,서일교,최윤임,박종규,정두신 순천향대학교 순천향의학연구소 2010 Journal of Soonchunhyang Medical Science Vol.16 No.2

The sleep disorders and poor sleep quality cause various daytime function impairment like fatigue, attention impairment, irritability,energy reduction, and daytime sleepiness. However, systemically studies on the sleep quality in patient with dizziness still remain,relatively. The objective of this study was to evaluate whether the quality of sleep is related to dizziness. We investigated 138patients who had presented dizziness. Men or woman were from 18 to 60 years old who had no symptoms or signs of major medical,psychiatric, and neurological disorders so that they completed the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), the Fatigue Severity Scale (FSS), the Epworth Sleepiness Scale (ESS), Beck Depression Inventory (BDI). All mean score of scale is high: PSQI, 7.45±4.23; FSS, 39.82±14.17; ISI, 9.02±7.05; BDI, 14.09±10.12; ESS, 9.06±4.75. This study is preliminary study did not analysis comparing control group yet but these findings predict poor quality of sleep, fatigue, daytime sleepiness, and depression in dizziness patient. We anticipate the dizziness patients might have poor sleep quality and underlying sleep disorders that were overlooked so far. The analysis by comparing normal control should be needed in the future.

Prevalence of Self-Perceived Snoring and Apnea and Their Association with Daytime Sleepiness in Korean High School Students

양광익,김지현,황보영,구대림,김대영,황경진,홍승봉 대한신경과학회 2017 Journal of Clinical Neurology Vol.13 No.3

Background and Purpose There has been no nationwide population-based study of the prevalence of self-perceived snoring/apnea in Korean adolescents. The purpose of this study was to estimate prevalence of self-perceived snoring/apnea in Korean high-school students and to evaluate their association with daytime sleepiness. Methods An online survey was used to investigate 12,672 students at 75 high schools across the 15 nationwide districts of South Korea. The variables were obtained using a self-reported questionnaire. The students answered questions about self-perceived snoring/apnea during the past 30 days. Daytime sleepiness was measured using a validated Korean version of the Epworth Sleepiness Scale, which was modified for adolescents. Covariates were the sex, school grade, frequency of self-perceived snoring/apnea, body mass index, sleep duration during a school day, and subjective perception of sleep duration. Results The prevalence of self-perceived snoring/apnea was 22.8% (26.4% for males vs. 18.8% for females, p<0.001) and 9.2% (10.5% for males vs. 7.7% for females, p<0.001). Obesity was significantly associated with self-perceived snoring [odds ratio (OR)=2.18, 95% confidence interval (CI)=1.94–2.46] and apnea (OR=1.57, 95% CI=1.33–1.86). Multivariate analysis showed that any frequency of self-perceived snoring/apnea was significantly associated with excessive daytime sleepiness (EDS). The OR of EDS increased significantly with the frequency of snoring and apnea. Female, sleep duration of <5 hours during a school day, and subjective perceptions of insufficient and considerable sleep durations were also significantly associated with EDS. Conclusions The prevalence of self-perceived snoring/apnea was significantly higher in students who were male and obese. Students with self-perceived snoring/apnea exhibited more significant EDS and an increased risk of EDS as the frequency of snoring and apnea increased.

수면제 장기 복용의 유효성 및 안전성

양광익,황보영 대한수면연구학회 2010 Journal of sleep medicine Vol.7 No.2

Insomnia may present with a variety of complaint and etiology, making the evaluation and management of chronic insomnia demanding on a clinician’s time. Long-term use of hypnotics and sedatives has been discouraged for a number of reasons, including tolerance, abuse liability, and the belief that insomnia is a symptom that remit with treatment of the underlying medical or psychiatric disorder. Moreover, pharmacotherapy produces only moderate improvement during drug administration and returns toward baseline after discontinuation. Although efficacy and safety have been established for benzodiazepine receptor agonists when used for short-duration therapy, there are few data that establish their continued efficacy and safety in long-term use. Benzodiazepine hypnotics have been implicated as a cause of numerous adverse events, including dependency, withdrawal, rebound symptom, daytime sedation, fall, and hip fracture, especially in older people. In order to use hypnotic properly, correct diagnosis of the underlying causes of sleep disturbance is acquired at first and extreme caution of hypnotics use to primary sleep disorders is needed, especially in sleep related breathing disorders. Physicians and patients should be cautioned about the potential adverse effects and using of hy-pnotics. After initial treatment, clinical efficacy and side effect should be observed regularly. Easy accessibility of cognitive behavior therapy for patient can be also a coping with long-term use of hypnotics.

Snoring의 국문 용어에 대한 변경 제안

양광익,정기영 대한수면연구학회 2021 Journal of sleep medicine Vol.18 No.1

Olivopontocerebellar Atrophy 환자의 MRI에서 보인 뇌교 십자모양 징후 1례

양광익,김수아,배원경 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Multiple systemic atrophy (MSA) is a progressive sporadic neurodegenerative disease of undetermined etiology that causes parkinsonism and cerebellar, autonomic, and pyramidal dysfunction in varying combinations. Clinically, the syndrome is difficult to distinguish from other neurodegenerative disorders such as idiopathic Parkinson's disease or other types of cerebellar ataxia. Pontine signal abnormalities on MRI (the cross sign) have been shown to be a typical feature of MSA as compared to controls and idiopathic Parkinson's disease, while their specificity had not yet been clearly established with regard to cerebellar degenerations. A 73-year-old man presented with a gait disturbance, dysarthria and dizziness during 2 years. He complained additional urinary incontinence. His past medical and family history were nonspecific. On neurologic examination, there were cerebellar ataxia, bradykinesia and rigidity. There were no other focal neurologic signs. Routine laboratory parameters were not remarkable. Axial T2-weighted and sagittal T1-weighted MRI showed pontine hyperintesity and cerebellar atrophy. We diagnosed possible OPCA by the criteria of Quinn. We present the pontine cross singn in a case with the clinically diagnosed as possible OPCA.

편측 미각소실을 보인 뇌교경색 1예

양광익,남상원,정두신,방차옥,안무영,박형국 대한신경과학회 2001 대한신경과학회지 Vol.19 No.6

이차 전기영동을 이용한 프로테오믹 접근을 통한 정맥 압박이 혈장 프로테옴에 미치는 영향

양광익,박선아,오형근,정두신,박형국,성기범,안무영,홍세용 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

The human proteomics-based approaches, which examine the expressed proteins of a tissue or cell type, are increasingly being used. Venous occlusion is commonly employed for stimulating tissue-plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-l) release from venous endothelial cells, and this has been regarded as a parameter of the individual fibrinolytic capacity of plasma. The present work involved a detailed investigation of the plasma proteome and fibrinolytic activity in normal subjects, with the aim of determining whether correlations exist between various parameters of the fibhnolytic system before and after venous occlusion. We analyzed fibhnolytic parameters and plasma proteome before and after 15-min periods of venous occlusion in the forearm in 10 healthy 3rd-decade volunteers. Proteome analysis was performed using two-dimensional gels. The tryptic digests of some proteins were confirmed by MALDI-TOF and the MS-Fit algorithm. The fibrinolytic response as measured by the absolute amount of t-PA after venous occlusion was increased by venous occlusion (5.5 vs 9.6 ng/㎗, p<0.05), as was PAI-l (46.8 vs 56.1 ng/㎗, p<0.05). However, two-dimensional electrophoresis finding was virtually nonspecific and inconsistent after venous occlusion in healthy male subjects. Venous occlusion does not influence plasma proteome in healthy males. Although the fibhnolytic response to venous occlusion is attributed to an increase in free tUPA antigen, this change is not correlated with plasma proteome.

폐쇄수면무호흡이 우리에게 주는 것

양광익 대한신경과학회 2013 대한신경과학회지 Vol.31 No.2

Obstructive sleep apnea (OSA) is a common disorder which is characterized by intermittent upper airway collapse occurring during sleep. It is well known that OSA often results in a wide range of comorbid disorders. I introduce here what OSA brings to the patients in neurologic department. Epidemiological studies have shown that OSA is associated with cognitive impairment, headache, metabolic syndrome, various cardiovascular diseases including hypertension,ischemic heart disease, arrhythmia, and stroke. Motor vehicle accident is not seemed to be related to a neurological condition but it can be also related in terms of excessive daytime sleepiness and decreased attention in patients with OSA. Obstructive respiratory events like apnea, hypopnea, and respiratory effort related arousal cause repetitive hypoxia,hypercarpnea, arousal, and decreased intrathoracic pressure. In turn, these can increase blood pressure, sympathetic activity, insulin resistance, and left ventricular wall tension. Consequentially, these processes can be considered as possible mechanism. Although further researches are needed to prove that OSA is independent cause of comorbid conditions, OSA especially in moderate or severe cases can develop and aggravate such conditions as risk factor. So we should know what OSA brings to us and pay attention whether OSA is combined in the patients whom we meet in neurological department.