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뇌경색 환자에서 PAI-1 유전자의 다형성에 대한 연구
방차옥,안무영 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
Background : Decreased fibrinolysis due to increased plasminogen activator inhibitior-1 (PAI-1) activity has been associated with hypertension or cerebral infarction. The aims of this study were to observe associations of the genetic polymorphism for PAI-1 with hypertension and cerebral infarction, and to elucidate whether impaired fibrinolytic activity in cerebral infarction was related to atherothrombosis or to risk factors such as hypertension. Methods : Patients with cerebral infarction (n=60), hypertension (n=100), and control subjects (m=100) were enrolled. We genotyped all subjects for 4G/5G polymorphism in the promoter region of the PAI-1 gene. Results : The frequency of 4G/4G genotype of PAI-1 was significantly higher in the patients of cerebral infarction than the control subjects (41.7% versus 21.0%; P=0.005), but not in the hypertensive subjects. There was a significant association between 4G/4G genotypes of PAI-1 and cerebral infarction (adjusted odds ratio=3.11, 95% confidence interval, 1.18-8.15), adjusting for age, sex, total cholesterol, low-density lipoprotein, triglyceride, and body mass index. Conclusion : Our results suggest that the 4G/4G genotype of the PAI-1 gene is significantly associated with an increased risk of cerebral infarction.
허혈성 뇌졸중과 응고인자 XIII Val 34 Leu 다형성과의 무관성
방차옥,최종순,박형국,안무영,홍세용 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2
Background and purpose: Although a common G to T point mutation (FXIII Val34Leu) in exon 2 of the alpha-subunit of the FXIII is protective against myocardial infarction and venous thrombosis, there are few reported the association of FXIII Val34Leu and ischemic stroke. The aim of this study was to investigate the protective role of the FXIII Val34Leu against ischemic stroke and its suggested interaction with the plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism. Methods: We carried out genotype analyses for FXIII Val34Leu using single-stranded conformation polymorphism and 4G/5G polymorphism in the promoter region of the PAI-1 gene in 53 patients with ischemic stroke and in 82 race-matched control subjects. Results: Age, hypertension, diabetes, and low-density lipoprotein were significantly higher in ischemic stroke patients. However, genetic distributions of FXIII A subunit and promoter region of PAI-1 were not different on both groups. Even adjusting for age, sex, hypertension, diabetes, and total cholesterol, there were not significantly associated between FXIII Val34Leu or 4G/4G genotype of PAI-1 and ischemic stroke. Conclusion: FXIII Val34Leu and the 4G/4G genotype of the PAI-1 gene are not significantly associated with an increased or decreased risk of ischemic stroke.