Factors associated with the risk of colorectal neoplasia in young adults under age 40

Ilsoo Kim,Han Hee Lee,Young Jae Ko,Ho Eun Chang,Dae Young Cheung,Bo-In Lee,Young-Seok Cho,Jin Il Kim,Myung-Gyu Choi 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.5

Background/Aims: Recent epidemiologic studies have shown a continued increase in colorectal cancer incidence among younger adults. Little is known about the factors that contribute to the development of young-onset colorectal neoplasia (CRN). Methods: A cross-sectional analysis was performed for individuals younger than 40 years who underwent colonoscopy in Seoul St. Mary’s Hospital and its affiliated health screening center. High-risk CRN was defined as adenoma or sessile serrated lesion ≥ 10 mm, with three or more adenomas, villous histology, high grade dysplasia, or carcinoma. Results: Of these 13,621 included participants, 2,023 (14.9%) had one and more CRN. Young patients with CRN tended to be elderly, male, obese, smoker, having a habit of drinking, and having comorbidities such as hypertension, dyslipidemia, diabetes, and chronic kidney disease. In a multivariate analysis adjusted for age, sex, obesity, smoking status, and alcohol intake, old age (odds ratio [OR], 1.086; 95% confidence interval [CI], 1.054 to 1.119), male sex (OR, 1.748; 95% CI, 1.247 to 2.451), obesity (OR, 1.439; 95% CI, 1.133 to 1.828), and smoking (OR, 1.654; 95% CI, 1.287 to 2.127) were independent risk factors for overall CRN. Obesity and smoking as two modifiable factors increased the risk for high-risk CRN even more than for overall CRN (OR, 1.734; 95% CI, 1.168 to 2.575 and OR, 1.797; 95% CI, 1.172 to 2.753, respectively). Conclusions: Obesity and smoking were modifiable risk factors for CRN in young adults. They increased the risk for highrisk CRN even more than for overall CRN. A colonoscopy might be beneficial for young individuals with these factors.

Neuroprotective effects of bovine colostrum on intracerebral hemorrhage-induced apoptotic neuronal cell death in rats

Kim, Sung Eun,Ko, Il Gyu,Shin, Mal Soon,Kim, Chang Ju,Ko, Young Gwan,Cho, Hanjin Medknow PublicationsMedia Pvt Ltd 2012 Neural regeneration research Vol.7 No.22

<P>Brain cell death after intracerebral hemorrhage may be mediated in part by an apoptotic mechanism. Colostrum is the first milk produced by mammals for their young. It plays an important role in protection and development by providing various antibodies, growth factors and nutrients, and has been used for various diseases in many countries. In the present study, we investigated the anti-apoptotic effects of bovine colostrum using organotypic hippocampal slice cultures and an intracerebral hemorrhage animal model. We performed densitometric measurements of propidium iodide uptake, a step-down avoidance task, Nissl staining, and caspase-3 immunohistochemistry. The present results revealed that colostrum treatment significantly suppressed N-methyl-D-aspartic acid-induced neuronal cell death in the rat hippocampus. Moreover, colostrum treatment improved short-term memory by suppressing hemorrhage-induced apoptotic neuronal cell death and decreasing the volume of the lesion induced by intracerebral hemorrhage in the rat hippocampus. These results suggest that colostrum may have a beneficial role in recovering brain function following hemorrhagic stroke by suppressing apoptotic cell death.</P>

공황장애의 임상적 특성

고은정,최영희,박기환,이정흠 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.2

Objectives : To clarify clinical features of panic disorder and to compare the characteristics of cognitive patterns, avoidance behaviors, and coping strategies among patients who have panic disorder with or without agoraphobia. Methods : Family backgrounds, cognitive patterns in the first panic attack, coping strategies, and avoidance behaviors were compared among the three groups classified by panic patients with mild agoraphobia(mild PDA=66), severe agoraphobia(severe PDA=71), and without agoraphobia(PD=21) Results : 1) Severe PDA reported significantly high panic attack frequency and more dysfunctional level than PD. 2) Catastrophic thinking of 'dying' in PD was significantly frequent than the other groups. Other fears of 'going craze or loss of control' in severe PDA were the highest among the three groups, though it was not significant. Specific thinking process or interpretation in the first panic attack was not significantly different among the three groups. 3) As avoidance behaviors became worse, the frequency of avoidance behaviors and the patters of avoidance behaviors increased. Conclusions : The results suggested that as avoidance behaviors became worse, the frequency of panic, maladaptive functioning and the patterns of avoidance behaviors increase. This might be why we need to decrease avoidance behaviors through exposure as the treatment.

서울 시내 6개 대학 여대생의 흡연 실태 조사 및 공중보건학적 고찰

고영태,이은주 德成女子大學校 1996 德成女大論文集 Vol.26 No.-

A survey on smoking state, smoking habit and viewpoint on smoking of 897 female students in 6 universities (3 coeducational universities and 3 women's universities) in Seoul was undertaken. The results are as follows : 1) Among 897 subjects investigated, 18.1% and 81.9% of the subjects were smokers and nonsmokers, respectively. Among smokers, 44.4% were coed and 55.6% were women's university students. Among smokers, 48.1% belonged to the art and athletic departments, 34.0% belonged to the liberal arts departments and 17.9% belonged to the science departments. (2) 50.6% of the smokers smoked almost every day. Daily smoking amount of 43.8% of the smokers was less than several pieces. 80.9% of the smokers started smoking after the entrance of university. 50.6% of the smokers smoked in the university neighboring facilities. 32.7% of the smokers enjoyed the smoking. 79% of the smokers responded to yound women's smoking famorably. 49.4% of the smokers responded to the effect of smoking on health unfavorably. 32.1% of the smokers commented on the smoking in the public place and 30.9% of the smokers commented on the juvenile smoking as the social problem. (3) 33.8% of nonsmokers responded to young women's smoking favorably. 79.2% of the nonsmokers responded to the effect of smoking on health unfavorally.

인터넷 쇼핑 웹 사이트의 디자인 비교연구 : 의류 쇼핑 사이트 사례 중심으로 Case study of the fashion sites

고은주,목보경 창원대학교 생활과학연구소 1999 생활과학연구 Vol.3 No.-

The purpose of this study were 1) to find the present condition of clothing shopping web site. 2) to analyze web design elements, and 3)to propose the problem and improvement, so meaning to prepare basis for effective web site design and analysis method of web site design. Subject for this study were 3 shopping web site(Fashionpia. Hansol CS Club, James Dean). The result of study were as follows. 1. Text form is not convenient of shopping process more than catalog form. 2. Fashionpla and Hansol CS Club sites are lack of pleasure and entertainment elements. 3. Display were not differentiated image and characters of product and brand were not provided well.

쪽파의 callus 배양에 의한 변이체 유기

고영은,고찬훈,임순희,김현정,안장순 全南大學校 農業科學技術硏究所 1998 農業科學技術硏究 Vol.33 No.-

A. wakegi Araki의 배발생 캘러스 유도에는 2,4-D의 단독 첨가가 보다 효과적이었으나 2,4-D의 농도가 높을수록 기형배의 배발생율이 높았다. BA를 혼합첨가하였을 때는 기형배가 보다 많이 발생하였다. 외식편의 부위별로는 경정, 인편, 엽조직 중, 경정이 배형성을 위한 외식편으로 가장 좋았으며 그 다음 인편, 엽조직 순으로 정상적인 배도 가장 많이 발생하였다. Sucrose 7%에서 배발생 callus 유도가 가장 좋았지만 기형 배의 발생율도 가장 높았다. 재분화 식물체의 염색체 변이는 인편유래 callus에서보다 경정유래 callus에서 높았다. Explant source, growth regulators and sugar contents in the culture media suitable for in vitro plant regenerations through somatic embryogenesis in Allium wakegi Araki were examined. Adition of 2,4-D alone was more effective on embryogenic callus induction than its addition in combination with BA. The embryogenic calluses induced on the media containing 2,4-D at high concentration or 2,4-D in combination with BA produced abnormal embryos at high frequency. Stem apex was the best explant source for normal embryo production, followed in order by scale and in vitro leaf segments. sucrose at 7% resulted in the best embryogenic callus induction though the callus produced abnormal embryos at highest frequency. The highest level of chromosomal variation was shown in the regenerants from the shoot apex-derived embryogenic callus.

여대생의 체형과 Diet 식품에 관한 의식구조 조사

고영태,강정화,김태은 德成女子大學校 1999 德成女大論文集 Vol.30 No.-

A survey on the state of dietary habit, degree of obesity, viewpoint about body shape, BMI calculated from subjcts' height and weight, amount of body fat measured by body fat computer and viewponit about diet food and drug for 196 female university students was undertaken. The results are as follows : (1) In response to the question about activity frequency, 38.8% and 27.6% of the subjects answered as "less than once per month" and "1 or 2 times per week" , respectively. In case of activity intensity, 59.2% of the subjects answered as "moderate aerobic activity". Activity time of 32.1% and 29.1% of the subjects was "under 10 minutes" and "10-20 minutes", respectively. Activity level of 54.1% and 43.9% of the subjects was "light" and "moderate", respectively. (2) Distribution of measured body fat showed that 51.0% of the subjects were in the range of "30-35%" and 27.0% of the subjects were in the range of "25-30%". The average value of 196 subjects was 31.03%. In response to the question about body shape, 43.4%, 41.3%, 9.7% and 5.6% of the subjects answered as "plump", "normal", "obese" and "thin", respectively. However, BMI calulated from subjects' height and weight showed that 1.0% of the subjects were "obesity", 0.5% were "overweight", 41.8% were "normal" , and 56.6% were "underweight". (3) The results of fitness obtained from body fat & fitness computer showed that fitness of 68.4% of the subjects were "very poor" and that of 25.0% were "poor". The results of longevity showed that longivity of 69.4% of the subjects were "good" and that of 24.0% were "excellent". (4) 11.7% of the subjects had experience of diet food or drug intake. 43.5% of the taken subjects had effect only during taking period, 34.8% had no effect, and 13.0% had some side effect.

쪽파[Allium ascalonicum L.] 재배기간 중 Diazinon, Iprodione 및 Chlorfenapyr의 잔류랑 변화

고광용,나은식,김성헌,김상준,장영희,이규승 충남대학교 농업과학연구소 2005 농업과학연구 Vol.32 No.2

In order to know the residual pattern of pesticides and predict to the degradation period until below MRL, we experimented diazinon, iprodinon and chlorfenapyr for shallot. They were the most detected pesticide in shallot by NAQS (National Agricultural product Quality management Service) survey. In this experiment, we sprayed those pesticides 15days before harvest and analyzed 0, 1, 2, 3, 5, 7, 10, 14 day sample to establish logical equation and to calculate DT_(50). During the cultivating period, the residue amount of diazinon was changed from 1.02 mg/kg (0 day) to 0.01 mg/kg (14 day), DT_(50) was 2.19 days, and iprodione was changed from 1.45 mg/kg (0 day) to 0.14 mg/kg (14 day), DT_(50) was 4.15 days, and chlorfenapyr was changed from 1.5 mg/kg (0 day) to 0.01 mg/kg (14 day), DT_(50) was 1.97 days. The DT_(50) of double amount in those pesticides, diazinon was 2.24 days, iprodione was 4.82 days, and chlorfenapyr was 2.24 days, respectively.

성남시 지역주민의 정신질환에 대한 태도 연구

고영,신수경,황태연,이충순,박연수,김인숙,황은숙,정원재 용인정신의학연구소 1999 용인정신의학보 Vol.6 No.1

Aerobic Exercise Affects Myostatin Expression in Aged Rat Skeletal Muscles: A Possibility of Antiaging Effects of Aerobic Exercise Related With Pelvic Floor Muscle and Urethral Rhabdosphincter

Ko, Il Gyu,Jeong, Jin Woo,Kim, Young Hoon,Jee, Yong Seok,Kim, Sung Eun,Kim, Sang Hoon,Jin, Jun Jang,Kim, Chang Ju,Chung, Kyung Jin Korean Continence Society 2014 International Neurourology Journal Vol.18 No.2

<P><B>Purpose</B></P><P>Aging-induced loss of muscle mass and subsequent reduction of strength is a fundamental cause of frailty, functional decline, and disability. And this may lead to muscular dysfunction, voiding dysfunction, or urinary incontinence due to pelvic muscle weakness induced by aging. Physical exercise has been recommended for the prevention and the treatment of these age-related frail states. We investigated the effects of treadmill exercise on muscle strength, myostatin mRNA and protein expression, and gastrocnemius myocytes proliferation in aged rats to investigate the possible antiaging effects of aerobic exercise on skeletal muscles such as pelvic floor muscles and urethral rhabdosphincter muscle.</P><P><B>Methods</B></P><P>In this study, 5-month-old male Sprague-Dawley rats were used as the young-age group (n=20) and 24-month-old rats were used as the old-age group (n=20). Each group was randomly divided into two groups (n=10 in each group): the sedentary and the treadmill exercise group. The rats in the exercise groups were forced to run on a motorized treadmill for 30 minutes, once a day, for 6 weeks. For this study, a weight load test, hematoxylin and eosin staining, real-time and reverse transcription polymerase chain reaction for myostatin mRNA, myostatin western blot, and 5-bromo-2'-deoxyuridine immunohistochemistry were performed in the gastrocnemius muscle.</P><P><B>Results</B></P><P>The age-induced reduction of muscle mass and strength was associated with a decrease in myocyte proliferation and an increase in myostatin mRNA and protein expression in the gastrocnemius. However, treadmill exercise improved muscle mass and strength through suppression of myostatin mRNA and protein expression, and myocyte proliferation increase in the gastrocnemius against the aging process.</P><P><B>Conclusions</B></P><P>Aerobic exercise is a useful strategy for enhancing muscle function against aging-induced loss of skeletal muscle mass and functions.</P>