痲疹篇 저자와 저술 시기에 대한 고찰

유철호(Chul-Ho Yoo),김남일(Nam-Il Kim) 한국의사학회 2012 한국의사학회지 Vol.25 No.2

A thesis insisting that Sugjong’s medical doctor Yoo Itae(劉以泰) and the author of Marjinpyeon Yoo Itae(劉爾泰) are not a same person and his activities were in Heonjong(현종) period, and his writing Marjinpyeon is in 1846, is published. In this study, I’d like to reveal that Yoo Itae(劉爾泰), the Marjinpyeon’s author and Yoo Itae(劉以泰), Sugjong’s medical doctor are a same person through analysis of Geochang Yoo’s genealogy, articles, The True Record of the Joseon Dynasty, Seungjeonilgi, Taeweonseonsaengan, Sancheong-gun’s paper, Sancheong Hyanggyo’s paper, Sancheong-gun’s paper, The geographic paper, Dongyuhagan, Sawoo Munjib, and analysis of folk story, the wrote year of his Marjinpyeon and Inseomunkyunrok and his birth year. According to my analysis, Yoo Itae(劉爾泰) the Maninpyeon’s author and Yoo Itae(劉以泰), Sugjong’s medical doctor are a same person. And Marjinpyeon is written in 1696, the year of Byongja, and other his books, InseoMungyonlok at 1709, the year of Gichug. In conclusion, Yoo Itae(劉以泰劉爾泰) was a famous medical doctor at Sancheong, born in 1652 (HyoJong the 3rd year) and passed in 1715 (SugJong the 41th year), left books of Marjinpyeon, Silheomdanbang, and Inseomunkyunrok.

정상인에서 베타3-아드레날린 수용체 유전자의 변이가 복부 비만도 및 지질대사에 미치는 영향

김영선,윤석기,김철희,서교일,김학선,김극배,변동원,유명희 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

The β₃-adrenergic receptor is expressed in visceral adipose tissue in humans and is thought to contribute to the regulation of the resting metabolic rate and lipolysis. We studied the influence of a mutation in the β₃ -adrenergic receptor gene(Trp64Arg) on body fat distribution, central obesity, lipid metabolism in 65 healthy young male adults. One out of 65 subjects were homozygous (Arg/Arg) for the trp64Arg mutation, 17 subjects were heterozygous (Trp/Arg), and 47 lacked the mutation(Trp/Trp). The body weight, height, body mass index, waist-to-hip ratio were similar between the subjects with- and without the mutation. Total body fat, abdominal fat amount, body fat distribution, serum total- and HDL-cholesterol, triglyceride, glucose, and insulin concentrations were also not different according to the presence or absence of the mutation. These results suggested that Trp64Arg mutation in β₃-adrenergic receptor gene is not a major contributing factor for central obesity or change in lipid metabolism in Korean young adults.

나라꽃 무궁화 품종중 가로수용, 분화용 및지피용으로 조경적 활용도가 높은 품종 선정

강호철 ( Ho Chul Kang ),김동엽 ( Dong Yeob Kim ),하유미 ( Yoo Mi Ha ) 한국전통조경학회(구 한국정원학회) 2016 한국전통조경학회지 Vol.34 No.2

본 연구는 조경수용 무궁화 우수품종 보급을 위한 유전자원 수집과 특성을 평가하기 위해 최근 국내외에서 육성된 127품종의 1년생접목묘를 이용하여 2014년부터 2015년까지 2년 동안 생육 및 형태적 특성조사를 실시하였다. 수집된 품종 중 키가 큰 가로수 및 독립수용품종, 왜성형 분화 및 지피용 품종 등을 선정하여 무궁화를 조경수로 활용도를 높이는데 기여하고자 하였으며 얻어진 결과는 다음과 같다. 최근 국내외에서 육성된 나라꽃 무궁화 품종들의 생육특성을 조사하기 위해 먼저 접목 1년생 수고를 조사한 결과 20~120cm까지다양하게 나타났다. 무궁화 ``주몽``과 ``홍가로수``, 종간교잡종 Hibiscus hybrid ``Daewangchun``, ``Daeil``, ``Lohengrin``, ``Jina``, ``Yeonam`` 등이 키가 100cm 이상으로 가장 큰 품종으로 조사되었다. 최근 국내외에서 육성된 무궁화 127품종 중 조경적 활용가치가 높은 교목성 가로수로이용할 수 있는 품종은 무궁화 ``주몽``과 ``홍가로수``, 종간교잡종 Hibiscus hybrid ``Daewangchun``, Hibiscus hybrid ``Daeil``, Hibiscus hybrid ``Lohengrin``, Hibiscus hybrid ``Jina``, Hibiscus hybrid ``Yeonam`` 등이 있었다. 분화 및 분재용으로 이용할 수 있는 왜성형 품종으로는 ``Red Heart``, ``백령도``, 종간교잡종 ``진선``, ``꼬마``, ``여천``, ``야음`` 등이 있었으며, 키가 30cm 미만의 아주 작은 품종으로는 ``안동``, ``청조``, ``Lil Kim`` 등이 포함되었다. 수고가 작은 왜성형으로 가지의 생장이 아래로 향하는 ``탐라``, ``Melrose``, ``비단``, ``하이리``, ``별이``, ``병화``, ``미백``, ``한양``, ``청암``, ``Lil Kim Violet``, ``종무``, ``은하수``, 종간교잡종 Hibiscus hybrid ``Saehanseo``와 Hibiscus hybrid ``Yousoon``은 화단 및 지피용소재로 이용가치가 높았다. This study was carried out to characterize 127 recently developed cultivars of Rose of Sharon (Hibiscus spp.) in Korea and foreign Countries for landscape uses. The examined factors were growth characteristics such as tree height of a 1-year grafted plant(cm), plant type, growth habit, leaf characteristics such as shape and size, flower characteristics such as color, shape, size, and red eye during 2014 and 2015 for landscape uses. The results are obtained as follows; Hibiscus hybrid ``Daewangchun``, ``Daeil``, ``Lohengrin``, ``Yeonam``, ``Joomong``, ``Jina``, and H. syriacus ``Honggarosu`` had vigorous shoot growth and tall tree size of 100cm. New Hibiscus cultivars, Hibiscus hybrid ``Daewangchun`` and ``Daeil``, having vigorous growth, uniform plant habit, upright, and compact branches were developed through interspecific crosses between H. syriacus ``Samchully`` (♀) and H. sinosyriacus ``Seobong`` (♂). This newly developed cultivar ``Daewangchun``, ``Daeil``, ``Lohengrin``, ``Yeonam``, ``Joomong``, ``Jina``, and H. syriacus ``Honggarosu`` having tall vigorous growth d unique flower with long red eye can be used as street tree or specimen plant in landscape. Otherwise, H. syriacus ``Tamla``, ``Melrose``, ``Bidan``, ``Hi Lea``, ``Byeollee``, ``Byunghwa``, ``Mibak``, ``Hanyang``, ``Chungam``, ``Lil Kim Violet``, ``Jongmoo``, ``Eunhasu``, Hibiscus hybrid ``Saehanseo``, and Hibiscus hybrid ``Yousoon`` were selected as small tree of 30~39cm. They had dwarf form in tree seemed to be suitable for pot or flower bed planting on both indoor and outdoor conditions. H. syriacus ``Antong``, ``Chungjo``, and ``Lil Kim`` were less than 30 cm of tree size. H. syriacus ``Antong``, ``Chungjo``, and ``Lil Kim``, characterized by its compact, upright and outwardly spreading plant habit; freely branching habit; dark green-colored leaves; good garden performance. Therefore, the new cultivars with tall and small tree size were a promising cultivar as a ground covers or pot planting as woody landscape plant.

항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

사망진단서(사체검안서) 상의 선행사인으로부터 사망통계의 원사인이 선정되는 비율 : 3개 대학병원에서 교부된 사망진단서를 중심으로

박우성,박석건,정철원,김우철,탁우택,김부연,서순원,김광환,서진숙,부유경 한국의료QA학회 2004 한국의료질향상학회지 Vol.11 No.1

Background : To exatnine the problems intolved in writing practice of death certificates, we cotnpated the determination of underlying cause of death for wital statistics using recorded underlying cause of death in issued death statistics. Methods : We collected 688 rnortality certificates issue in year of 2,000 from 3 university hospitals. And we also collected vital statistics from ministry of statistics. The causes of death were coded by experienced medical record wpecialists. And causes of death determined at ministry of statistics for national vita statistics were mapped to causes of death recorded at each death certificates. The rate that underlying causes of death for vital statistics were derived from underlying causes of death recorded at issued death certificaties sere analysed. Results : 64.5% of underlying cause of death for could be derived from underlying cause of death recorded at issued death certificates, 8.6% derived from intermediate cause of death, and 3.9% derived from direct cause of death. In 23% of cases, underlying cause of death could not be derived using issued death certificates. The rate that underlying cause of death for vital statistics could be derived from underlying cause of death recorded at death certificates was different between 3 university hospitals. Ane the rate was also different between death certificates and postmortem certificates. We classified the causes of death using 21 major categories. The rate was different between diseases or conditions tha caused death too. Conclusion : When we examined the correctness of death certificate writing practice using abpve methods, cortectness of writing could not be told as satisfactory. There was difference in correctness of writing between hospotals, between death certificates and postmortem certificates, and between diseases and conditions that caused death. With this results, we suggested some strategy to improve the correctness of death certificate writing practice.

이질균 세포 단백의 분석에 있어서의 은 염색의 이용

김재석,이유철,조동택 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.3

To study the mechanism of virulence of Shigella, sodium dodecyl sulfate-polyacrylamide gel electro-phresis was conducted on membrane fractions from 2 strains of HeLa cell invasive Shigella flexneri. After electrophresis gel slab was stained first with Coomasie brilliant blue R-250 staining then followed by silver staining, more than tenfold increase in sensitivity was achieved over Coomasie brilliant blue R-250 stain. The total membrane fraction from Shigella flexneri 85DH38 stained with silver showed 12 protein bands; 180 kilodalton(K), 127K, 100K, 78K, 64K, 55K, 47K, 45K, 43K, 39K, 38K and 12.8K, but stained with Coomassie brilliant blue R-250 showed only 5 bands. The sodium lauryl sarcosinate (SLS) soluble membrane fraction showed prominent 100K band and less prominent 5 bands; 180K, 78K, 64K, 55K and 45K. The SLS insoluble membrane fraction showed prominent 47k, 39K, and 38K bands of porin proteins and less prominent 43K and 12.8K band. The total membrane fraction from Shigella flexneri 78B-1 showed 7 protein bands which also appeared in the fractions from Shigella flexneri 85DH38. There were 5 bands of low molecular weight proteins (10K to 20K) in gel run at 20 ㎃ but not appeared at 35 ㎃.

婦人科領域에서 應用된 鍼灸治療에 關한 文獻的 考察

金哲源,柳深根,朴炳烈 圓光大學校 韓醫學硏究所 1991 원광한의학 Vol.1 No.1

Bibliographic study on the acupuncture and moxibustion treatment applied to gynecological diseases divided into 9 Parts. And the results are as follows. 1. Total numbers of meridian-point used in the JO-KYUNG Part(調經門) were 54. Kidney-Meridian, Liver-Meridian, Conception Vessel-Meridian were used with high frequency and Joong-Kuk (CV_3), Sam-Um-Kyo(SP_6), Ki-Hai(CV_6) were frequently used. Also Yin-Meridian was chiefly used. 2. Total numbers of meridian-point used in the BUNG-ROO Part(崩漏門) were 36. Liver-Meridian, Kidney-Meridian, Bladder-Meridian were used with high frequency and Tai-choong(LIV_3), Hyul Hae(SP_10) Um-Gok(K_10) were frequently used. Also Yin-Meridian was chiefly used. 3. Total numbers of meridian-point used in the DE-HA Part(帶下門) were 46. Bladder-Meridian, Conception Vessel-Meridian, Kidney-Meridian were used with high frequency and God-Gol(CV_2), Jook-Kuk(CV_3), Di-Hai(CV_6) were frequently used. Also Yin and Yang-Meridian showed same frequency. 4. Total numbers of meridian-point used in the JING-HA Part(징하문) were 51. Spleen-Meridian, Kidney-Meridian, Conception Vessel-Meridian were used with high frequency and Sa-Man(K_14), Suk-Kwan(K_18), Kok-Chun(LIV_8) were frequently used. Also Yin-Meridian was chiefly used. 5. Total number of meridian-point used in the KOO-SA Part(求嗣門) were 38. Kidney-Meridian, Conception Vessel-Meridian, Bladder-Meridian were used with high frequency and Kwan-Won(CV_4), Joong-Kuk(CV_3), Yeun-Gok(K_2) were used with high frequently used. Also Yin-Meridian was chiefly used. 6. Total numbers of meridian-point used in the IM-SIN Part(姙娠門) were 58. Conception Vessel-Meridian, Spleen-Meridian, Kidney-Meridian were used with high frequency and Sam-Um-Kyo(SP_6), Kwan-Won(CV_4), Kyum Jung(G_21) were frequently used. Also Yin-Meridian was chiefly used. 7. Total numbers of meridian-point used in the SAN-HOO Part(産後門) were 43. Conception Vessel-Meridian, Spleen-Meridian, Liver-Meridian were used with high frequency and Ki-Hai(CV_6), Sam-Um-Kyo(SP_6), Kwan-Won(CV_4) were frequently used. Also Yin-Meridian was chiefly used. 8. Total numbers of meridian-point used in the YOU-BYONG Part(乳病門) were 47. Kidney-Meridian, Stomach-Meridian, Conception Vssel-Meridian were used with high frequency and Jok-Sam-Lee(S_36), Ha-Lyum(S_39), Jun-Jung(CV_17) were frequently used. Also Yin and Yang-Meridian showed same frequency. 9. Total numbers of meridian-point used in the JUN-UM Part(前陰門) were 35. Liver-Meridian, Heart-Meridian, Kidney-Meridian were used with high frequency and Kok-Chun(LIV_8), Sho-Boo(H_8), Dai-Don(LIV_1) were frequently used. Also Yin-Meridian was chiefly used.

전기로 분진에서 납의 휘발반응에 대한 속도론적 연구

김병수,유재민,이재천,남철우,윤정모 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.4

"he removal of lead from electric arc furnace (EAF) dust is important in the process for recovering zinc by a reduction-volatilization method. In this study, experiments on kinetics of the volatilization reaction of lead by chlorine components as NaCl and KCl contained in the EAF dust were carried out in the temperature range of 973 to 1223 K under an air atmosphere using a weight-loss technique. As a result, the volatilization ratio of lead was about 99.0% at the temperature of 1223 K and the reaction time of 180 min. Jander equation was found to fit well the volatilization reaction rate over the entire temperature range. The volatilization reaction of lead is rate controlled by solid-solid diffusion. An activation energy of 175 kJ/mol(41.8 kcal/mol) was obtained. (Received January 8, 2004)

cis-platin에 의한 급성구토예방의 Dexamethasone의 4가지 정주량의 비교

김원,강지은,서영선,이동민,서정균,신병철,정기영,박유환,정춘해 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

B5-hydroxytryptamine _3수용체(5-HT_3) 길항제와 dexamethasone의 동시투여가 cis-platin에 의한 급성 구토를 막는데 가장 효과적이다. 그러나 현재까지 가장 적절한 정주dexamethasone의 용량이 알려져 있지 않았다. 이에 dexamethasone의 4가지 다른 용량을 투여하여 그 효과를 비교하였다. 환자는 임의 추출되어 cis-platin 투여 45분전에 15분 동안 정주로 각각 dexamethasone 5, 10, 15, 20 mg을 투여 받았다. cis-platin 투여 30분전에는 ondansetron 8 mg이 부가하여 정주 되었다. 1999년 3월부터 2000년 2월까지 54명의 환자가 연구에 등록되어졌고 53명의 환자가 연구 대상으로 실험에 4군 (dexamethasone 5 mg 13명, 10 mg 14명, 15 mg 13명, 20 mg 13명)으로 나뉘어 평가 되어졌다. 급성구토와 구역질의 완전한 예방은 dexamethasone 5 mg을 투여 받은 환자에서 각각 69.2%, 60.9%, dexamethasone 10 mg을 투여 환자에서 69.1%, 61%, dexamethasone 15 mg 투여 환자에서 78.5%, 66.9%, dexamethasone 20 mg을 투여 환자에서 83.2%, 71.0%로 나타났다. 구토로부터 완전한 예방은 dexamethasone 20 mg을 투여 환자에서 5, 10 mg을 투여 환자와 비교하여 높았고, dexamethasone 15 mg을 투여 군에 비교하여서는 약간 우수한 효과만 있었다. 구역질으로부터의 완전한 예방도 월등한 것은 아닐지라도 20 mg을 받은 환자에서 높았다. 항 구토 치료는 특별한 불편 없이 조절되었고, 부작용의 발생에서 4가지그룹간에는 커다란 차이가 발견되지 않았다. Dexamethasone의 20 mg 정주양이 cis-platin으로 인한 급성구토를 예방하는데 가장 효과적인 예방량으로 사료되어진다. Background and objective: A 5-hydroxytryptamine _3(5-HT_3) receptor antagonist plus dexamethasone is the most efficacious antiemetic prophylactic treatment for the prevention of cis-platin induced acute emesis, but the optimal intraveous (Ⅳ) dose of dexamethasone is unknown. This prompted us to perform a randomized, double-blind, dose-finding study that compared four different doses of dexamethasone. Materials and Methods: Patients were randomized to receive dexamethasone, either 5, 10, 15, 20 mg, administered by 15-minute Ⅳ infusion 45 minutes before cis-platin. Ondansetron 8 mg was added to dexamethasone and was administered Ⅳ 30 minutes before cis-platin. From March 1999 to February 2000, 54 patients were enrolled onto the study and 53 were assessable according to the intention-to-treat principle (13 patients received 5 mg; 14 patients, 10 mg; 13 patients, 15 mg and 13 patients, 20 mg of dexamethasone). Results: Complete protection from acute vomiting and nausea was achieved by 69.2% and 60.9% of patients, respectively, who received 5 mg of dexamethasone, by 69.1% and 61.0% of those who received 10 mg, by 78.5% and 66.9% of those who received 15 mg, and by 83.2% and 71.0% of those who received 20 mg of dexamethasone. Complete protection from vomiting was significantly superior in patients who received 20 mg compared with those who received 5 and 10 mg of dexamethasone (P<05) and was superior, but not significantly, compared with those who received 15mg. Complete protection from nausea was superior, but not significantly, in patients who received 20 mg of dekamethasone. Multifactorial analysis confirmed these results. Antiemetic treatment was well tolerated, and no significant difference was found among the four groups in the incidence of adverse events. Conclusion: A 20mg single Ⅳ dose of dexamethasone should be considered the most efficacious prophylactic dose for the prevention of ois-platin induced acute amesis in treatment of cancer.

月經痛에 應用되는 淸熱調血湯의 效能에 對한 實驗的 硏究

金哲源,柳深根,朴炳烈 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

To elucidate the effects of Chungyeoljohyeoltang(淸熱調血湯) being applied to dysmenorrhea, after oral administration Chungyeoljohyeoltang water extract in mice and rats, acute toxicity, analgesic, sedative, hypothermic, estrogenec actions, action on isolated uterine muscle and serum estradiol concentration were measured. The results obtained were as follows ; 1. The yield of water extract of Chungyeoljohyeoltang was 21.8%, minimum lethal dose was 4,000mg/kg, which rarely had the acute toxicity in mice and rats. 2. The analgesic effects of Chungyeoljohyeoltang by acetic acid induced writhing syndrome in mice were not remarkably observed. 3. The relaxant action of Chungyeoljohyeoltang by acetic acid induced uterine muscle in estrogenized rats were not remarkably observed. 4. The hypothermic effects of Chungyeoljohyeoltang in rat's rectus were remarked. 5. The sedative effects of Chungyeoljohyeoltnag by hexobarbital sodium induced sleeping time in mice were remarked. 6. Administration of Chungyeoljohyeoltnag increased serum estradiol consentration in rats but without significance. 7. Administration of Chungyeoljohyeoltnag caused remarkably increase in weight of rat's uterus.