비장의 상피양 낭종 : 1예 보고 A Report of A Case

양기화,강창석,심상인,김선무,함흥정 최신의학사 1986 最新醫學 Vol.29 No.12

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

정신분열병 환자에서 정신병적 증상과 위스콘신카드 분류검사와의 관계

엄양기,김철권,조진석,변원탄 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.5

The purpose of this study was to investigate 1) the difference of performance on the Wisconsin Card Sorting Test(WCST) between schizophrenecs and normal controls, 2) and the change of performance while clinically improved. WCSTs were administered in 28 schizophrenics and 32 normal controls. The results were as follows. 1) Schizophrenic patients performed poorly on the WCST compared to normal controls. 2) There was no significant change of performance in WCST as clinical symptoms improved 3) There was no significant correlation between the performance of the Wisconsin Card Sorting Test and age, sex, education level and volcabulary test in both groups. These findings suggest that the WCST mat be an indicator of vulnerability to schizophrenia.

MgCl₂溶液內에서 STS 304 HP Stainless Steel 熔接部의 破壞擧動에 對한 硏究

金永奭,丁太權,朴昌彦,洪錫柱,梁仁榮,金基玉,朴煥奎,李茂錫,曺圭宰,鄭在康 조선대학교 생산기술연구소 1983 生産技術硏究 Vol.1983 No.-

This paper is based on an experiment analysing the stress corrosion cracking behaviour of welding specimens compared to that of non-welding specimens of STS 304 HP stainless steel in corrosion solution. As a corrosion condition, stainless steel has been known to be the most fragile in a solution of 42% MgCl₂heated to the boiling point, therefore the experiment was carried out in this condition. The experiment was carried out with argon gas TIG welding specimens and non-welding ones made of stainless steel plates, thickness 2mm, by tensile force. At this time, the tensile force was taken to be the value of the yield strength of the tensile test specimens divided by the safety factor of 3.0 to 3.5, 4.0, 4.5, and 5.0. In this paper, the relations between Time of Initial Crack, Time of Failure, Time of Final Fracture and Crack Propagation Length were investigated and then plotted. Furthermore, the relations between Stress Intensity Factor K proposed by Irwin and the Time of Initial Crack, the Time of Failure, the Time of Final Fracture were calculated and plotted. At the last, all the relations plotted were expressed to normal equations by computer, and the equations were used to analyse the data obtained in the experiment. The conclusions obtained in this study are as follows: 1. Welding materials, compared with non-welding ones, as the Time of Initial Crack, the Time of Failure, and the Time of Final Fracture were generally very fast, appeared to be a phenomenon of unstable brittleness fracture. 2. Non-welding materials, compared with welding ones, as the safety factor was larger or the working stress was smaller, appeared to be a phenomenon that the longer had had greater durability. Therefor, welding materials must be considered enough to be used in heate affected and stress corrosion atmosphere. 3. The normal equations of the Time of Initial Crack and the variation rate to the same Stress Intensity Factor K are as follows: (A) Non-welding T =259702.4-5451.2 K+28.386 K² T = -5451.2+28.386 K (B) Welding T= -332.693+28.043 K-0.211 K² T' =28.043-0.211 K here, T; Time of Initial Crack, T'; Variation Rate of Time of Initial Crack to Stress Intensity Factor K, K ; Stress Intensity Factor.

마우스 종양발생에서 Nitric Oxide의 역할에 관한 연구 Ⅲ : Helicobacter pylori에 의해 유발된 마우스 위암에서 염증매개인자의 역할 The role of inducible nitric oxide synthase and cyclooxygenase-2 in H. Pylori-associated gastric carcinogenesis

남기택,오상연,조현무,이국경,강진석,제정환,최미나,한상욱,김대용,장동덕,양기화,안병우 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

feficotorfer fyf☞ri(Hp)가 위암파 관련이 있다는 역학적인 증거는 많이 있지만 이에 대한 정확한 기전에 대해선 밝혀져 있지 않고 있으며 실험동물 모델도 적절하지 못한 것으로 알려져있다. 본 실험에서는 위암의 원인으로 알려져 있는 f, fyforf'(Hp)를 이용하여 마우스에서 위암 모델을 확립하고 만성염증과정 중에 생성되는 리0와 COX-2 등의 발현이 위암발생에 미치는 명향을 통하여 예방과 치료를 위한 점근을 시도하고자 하였다. 마우스를 7군으로 나누어서 1, 2, 3, 4군의 등물은 MNU를 증류수에 200ppm 농도로 음수병득 이용하띤 10주간 격주로 투여하였으며 MHU 음술 투여 1주 휴씩 후 배양한 f. fyrofi 를 약 109cru/rfll 로 맞춰 한 마리당 0.1ml 씩 이틀 간격으로 세 번에 걸쳐 하룻방 금식시킨 1, 2, 3, 5, 6, 7군기 마우스의 위장에 투입하떴다. 균 투입을 마친 후 다응 날부터 2군쏙 6군은 iNOS 억제제인 aminoguanidine(AG)을 음수병으로 툰여하였으며 3군과 7군은 COX-2 척제제인 nimesulide(NSD)를 투여하였다. 위의 종양발생양상을 샅최보면 bfNU와 Hp만을 투여한 1 관 ; (hfNU +Hp), 2군 : iNO을 inhibitor 투여군(MNU+HP+AG'1. 3군 ;CO딘-2 Inilibitor 투여군(MNU누Hp누 NSD), 4군 ,MNlf 단독투여군, 5군 ;Hp 단독투여춘, 6군 ; 러p 단독에 AG투여군, 7군 , Hp 단독에 NSD투여군의 종양발샐을은 각각 쁜.Bff(l1/16), 70.6%f12/ti), 했.9ff(7/18), 10%(1/10), Off(O/IS)0%(O/S), 0%(O/5)의 발쟁율을 보여 iNOS 억제제인 AC은 좁양발생을 억계하지 못하였으며, COX-2억제제인 NSD 는 종양발생을 유의적으로 감소시켰다. 콩양발생개수에서는 2.62±0.36, 1.41츠0.14, 0.44 르0.12, 0.10±0.10을 보여 AC와 NSD에서 유의성 있게 발생개수를 줄였다. Hp 단독투여에 의해즌는 종양발생이 나타나지 않았으며 HP+AG, Hp+ IfSD 추여군에콕 시험증료 시점에 약물에 의해 Hp의 제균효과가 있는지의 여부를 확인끓기 위하여 PCR을 이용하여 확인한 결과 모두 양성인 것으로 나타나 Hp의 제균효과에 의한 촐양발생 억제가 일어나지는 않았다. 위의 결과로 볼 때 Hp는 위암발생을 촉진하는 것으로 나타났고 딘p 감염시 매개되는 염증인자를 억제하였을 때 종양발생을 억제하는 것으로 위암 발생에서 염증매개인자는 종양을 촉진하는 것으로 나타났으며 it,705 억제제쓱 COX-』 억제제의 위알 예밭효과fl는 효과적일 것으로 사료된다 In spite of a large volume of epidemiological evidence indicating significant relationship between H. pylori infection and gastric adenocarcinoma, a doubt still exists on an elevated risk of stomach cancer by H. pylori infection due to lack of direct evidence of their exact mechanistic link. It is, therefore, essential to have an appropriate animal model for detailed analysis of the role of H. pylori played in gastric carcinogenesis. There is a wealth of evidence to support that over production of inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2) is involved in the pathogensis of various cancer in both rodents and humans. The aim of this study was to establish a mouse model for H. pylori-associated gastric carcinogenesis and to identify the role of inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2) played during the gastric carcinogenesis in mice. Eighty-three specific pathogen free, six-week-old male C57BL/6 mice were randomly divided into seven groups. Animals of the group 1, 2, 3, 4 were given MNU in their drinking water at the concentration of 200 p.p.m. for total five cycles of one-week regimen with one-week pause. After completion of MNU administration, they were given autoclaved distilled water for one weeks, and groups 1, 2, 3, 5, 6, 7 were inoculated with H. pylori. After completion of H. pylori. inoculation, groups 2 and 6 were given aminoguanidine in their drinking water at concentration of 1000p.p.m. and animals of group 3 and 7 were given the diet containing 200 ppm nimesulide at 12 weeks of age. All animals were killed at 50 weeks of age. The incidences of the glandular stomach tumors in the group 1, 2, 3 and 4 were 87.5%(14/16), 76.4%(13/17), 44.4(8/18), 10.0%(1/10), respectively and the tumor incidence of group 3(MNU→Hp+nimesulide) was significantly lower than those of group 1(MNU→Hp) at the value of P<0.01. The average numbers of tumors of group 2(MNU→Hp+AG : 1.41±0.24) and group 3(MNU→Hp+nimesulide : 0.44±0.12) were significantly lower than those of group 1(MNU→Hp : 2.62±0.36) at the value of P<0.05. Therefore, overproduced iNOS and COX-2 plays an important role in mice gastric carcinogenesis. We concluded iNOS and COX-2 inhibitor have good effects on gastric carcinogenesis.

FEM에 의한 차체구조용 단일모자형 단면부재의 축압궤특성에 관한 연구

차천석,황창숙,백경윤,김기형,양인영 朝鮮大學校 機械技術硏究所 2002 機械技術硏究 Vol.5 No.1

차체전면부 사이드부재는 점용접에 의해서 이루어진 모자형 단면형상을 갖는 강도부재로써, 차량의 전면충돌에 있어서 중요한 역할을 한다. 전면충돌에 있어서 차량의 전면부에서 충분한 에너지를 흡수한다면, 승차자에게 가해지는 충격에너지를 경감시킬 수 있다. 따라서, 이러한 강도부재는 충분한 강성을 가져야 하지만, 적절한 압궤 또한 이루어져야 한다. 본 연구에서는 단일모자형 단면부재에 대하여 플랜지부 점용접 간격을 변화시켜 준정적(0.017m/sec) 및 충격합궤(7.19m.sec, 1034J)하에서 압궤특성을 해석하고자 유한요소 프로그램인 LS-DYNA3D을 이용하여 준정적 및 충격압궤 시뮬레이션을 행하였다. 시뮬레이션은 압궤실험 결과와 비교함으로서 시뮬레이션의 타당성을 학인하였다. The hat shaped section members of vehicles compose the base frame which plays an important role in a front-end collision. It consists of the hat shaped section members with spot welds. In front-end collision, the impact energy for the passengers will be decreased as the front parts of vehicles has sufficiently absorbed energy. And then, this structures have not to be very stiff but collapse progressively to absorb the kinetic energy as expected. In this study. LS-DYNA3D has been used for analyzing collapse characteristics on hat shaped section members with respect to spot weld pitches under quasi-static(0.017m/sec) and impact load(7.19m/sec. 1034J). By comparing the results from simulation and the experimental results. the utilization fo simulation has been certified.

3차 의료기관 응급실로 내원한 안면부 열상 환자에 대한 임상적 고찰

김양원,안성훈,류석용,김홍용,전병민,김기태 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2

Background: Facial laceration is a common clinical problem in the emergency room that is frequently associated with other craniofacial injuries. It elicits an emotional response from the patient because of the underlying concern of permanent scar and secondary facial disfigurement, so they demand prompt and adequate treatment. The aim of this study is to analyze the incidence, etiology, depth, and site of facial lacerations to provide basic data for further understanding. Method: This study reviewed 1,043 facial-laceration patients treated in the emergency room at Pusan Paik Hospital between March 1999 and February 2000. This retrospective study was done by reviewing and analyzing the sex and age distributions, the monthly and daily distributions, the causes of injury, the types of injury, the sites of injury, the lengths of the lacerations, and associated injuries. Results: The sex ratio of men to wemen was 2.4:1, and the 0~10 age group was at the top of the age distribution. The number of patients was the highest on sundays and during March. About 9.2% of the patients visited the emergency room between 10:00 P.M. and 11:00 P.M. Falls(38.1%) were the most common cause of facial laceration, and deep laceration(51.8%) was the most common type of facial laceration. The most common laceration site was the forehead, followed by the chin and the nose. The most common associated craniofacial injury was facial bone fracture(39%), Facial-lacerations were sutured by plastic surgeons(80%), emergency physicians(10%), and oromaxillofacial surgeons(10%). We found statistical significance in the types and lengths of lacerations between men and women, among age groups(p<0.05). Conclusion: Facial laceration is one of the most common craniofacial injuries in the emergency room. By now, most lacerations have been repaired by plastic surgeons, But, the causes of lacerations are diverse and many patients are admitted due to the associated injuries. Therefore, emergency physicians should participate more aggressively in the care of facial-laceration patients to improve the outcome of the patients.

모자형단면 점용접부재의 축압궤특성에 관한 실험적 연구

차천석,김영남,심재기,김기형,양인영 朝鮮大學校 機械技術硏究所 2002 機械技術硏究 Vol.5 No.1

차량 전면충돌시 에너지흡수량이 가장 큰 차량전면부 사이드부재의 기본형상인 점용접된 단일모자형 단면부재에 대하여, 정적(0.00017m/sec), 준정적(0.017m/sec) 축방향 압궤실험을 행하였다. 이를 기초로 자체 제작한 수직식 공기압 충격실험장치를 이용하여 실제 차량이 충돌하는 것을 상정하여 충격속도 7.19m/sec(충격에너지 1034J)하에서 형상의 변화 및 폭비와 플랜지 용접간격의 변화에 따른 압궤특성을 고찰하여, 최적의 에너지 흡수성능을 갖는 구조부재에 대하여 검토하였다. The fundamentally and widely used spot welded sections of automobiles(hat and double hat shaped section members) absorb most of the energy in a front-end collision. The sections were tested on axial static(0.00017m/sec) and -quasi-staic(0.017m/sec) loads. Based on these test results, spcimens with various thicknesses, width ratios and spot weld pitches on the flange have been tested with high impact velocity(7.19m/sec 1034J) which imitate a real life car arash Characteristics of collapse have been reviewed and structures of optimal energy absorbing capacity is suggested.

소결밀도에 따른 분말 소결금속과 탄소강의 이종금속 레이저 용접성 고찰

김용,양현석,박기영,이경돈 한국레이저가공학회 2008 한국레이저가공학회지 Vol.11 No.2

Sintered specimen which used for a blade of diamond tool was manufactured in order to verify CO_(2) laser weldability depend on sintered temperature. Five kind of specimen were prepared and the range of temperature is from 600℃ to 1000℃ at intervals of 100℃. As a result of the sintered density test, the porosity rate appeared in the range of 2.1%∼21.4%. After welding, the most segments had exceeds the minimum fracture stress (600MPa, The Standard Safety of Europe) at the welding strength test except on the sintered at 600℃. In case of the sintered at 700℃, even satisfied the safety allowable stress but cannot get the good quality for bead appearance because of humping defect. In the conclusion, we could know that it showed not only relatively soundness bead but also enough welding strength when the sintered blade of diamond tool is included less than 4% of porosity rate.

여성 외음부에 발생한 선상 편평상피세포암종

김창옥,양기화,강석진,이안희,김병기,김선무 대한병리학회 1991 Journal of Pathology and Translational Medicine Vol.25 No.1