불안정성 골반골절의 수술적 치료

이준규,류천환 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

Massive pelvic disruption is an important and aften life threatening injury. The goals of orthopedic management of pelvic bone injuries are mobilization of parient as early as possible by achieving anatomical reduction and secure fixation of fragments. The authers reviewed 26 cases of unstable pelvic bone fracture treated at the orthopedic department of Chung Nam National University Hospital during the period from January 1985 to August 1990. The injury was classified according to the Pennal and Bucholz method and analyzed the causes of injury, methods of treatment. The results were obtained as follows. 1. The highest incidence was in the 3rd decade and sex ratio between male and female was 6:7. 2. The causes of injury were traffic accidents, fall down, motor bicycle accidents, industrial accidents in order of frequency. 3. According to classification of Pennal et al, type II fracture due to lateral compression injury was most common(68%). According to classification of Bucholz, type II fracture was most common(77%). 4. The fracture of tibia or fibular was most commonly associated bone injury and the most common associated soft tissue injury was genitounary tract injury. 5. 10 cases of Bucholz type II were treated with external fixation with internal fixation or internal fixation. 6 cases of Bucholz type III were treated external fixation or external fixation with internal fixation or internal fixation. 6. The result analysed by grading the outcome of pelvic fracture proposed SAID ABDUL MAJEED were excellant, good, fair, poor; 4, 6, 4, 0, in operative cases, 0, 3, 3, 4 in conservative cases. 7. The average weeks of immobilization were 6 in operative cases, 12 in conservative cases. 8. Even unstable pelvic bone fracture, we recommend early anatomical reduction and secure fixation with operative management.

경주지역 여고생의 초경과 체성장간의 관계

김준섭,권오구,박진석,오종수,박정현,박제식,안세한,이용환,서정호,신태섭,최영배,김덕수,이관,박수경 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

본 연구는 경주지역 1개 고등학교 3학년 여고생을 대상으로 초경 시작 전인 초등학교 4학년부터 고등학교 2학년까지의 키, 몸무게, 가슴둘레 수치와 초경 연령을 파악하여 여성의 초경이 빠를수록 체성장 속도의 변화가 있을 것이라는 가설을 기초로 두 요인간의 관련성을 파악하고자 시행되었다. 경주시 1개 여자고등학교 3학년생 총 317명에 대해 ㅊ경 나이, 초경시 심리 상태, 초경이 시작되었을 때의 상담 여부와 상담하였던 사람, 부모 신장과 초경전후의 식사 규칙성, 다이어트 경험, 수면시간, 스트레스, 음주/흡연 여부, 질병력 등에 대한 설문 조사를 시행하였고, 초등학교 4학년부터 고등학교 2학년까지의 키, 몸무게, 가슴둘레에 대한 정보는 건강기록부에서 확보하였다. 상기 대상자 중 건강기록부가 분실된 39명, 초경나이에 대해 응답하지 않았던 29명 및 결석 등으로 조사를 하지 못하였던 42명을 제외한 조사 대상자는 206명으로 선정하였다. 대상자들의 초경연령 평균값(Mean±SD)은 13.0±1.11이었고, 초등학교 4학년부터 고등학교 2학년까지의 초경 이후 신장 성장률은 감소하였으며, 초경연령이 빠른 군이 초등학교 때는 신장에 있어서 우위를 차지하나 고등학교에 오면서 신장은 비슷한 수준이 되었다. 초경후 1-2년 사이에 체중과 흉위의 증가율은 감소하였고, 초경연령이 빠른 군이 초등학교와 고등학교 사이에 체중과 흉위에서 모두 우위를 차지하였다. 본 연구의 결과는, 흔히 이차 성징의 시작 시점 혹은 사춘기의 시작 시점으로 보고있는 초경 연령이 청소년기의 성장과 밀접한 관련성이 있고, 특히 체중과 흉위의 성장 속도와 밀접한 관련성이 있음을 시사한다. To understand the onset of menarche in relation to changes in physical growth that take place during female adolescence, especially the changes in height and weight velocity. The 207 senior in one women high school of Kyongju were investigated in April 3 to 8, 2001. We collected the information, relation in the age at menarche, height & weight of parents, regularity of eating, and obesity diet, duration of sleeping, sickness & stress near age at menarche, by self-recording. The status of height, weight & chest circumference between the 4th grade of primary school and the junior of high school was collected by individual Health Record. The results were followed; The average age at menarche was 12.95±1.11 years old and the most frequent age of menarche is 13 years. After menarche, the velocity of height, weight and chest circumference were decreased. The most rapid group of menarche hold dominant position in height during elementary school. As time passed, they dont hold dominant position in height. The most rapid group of menarche get an advantage in the weight and the girth of chest after elementary school. The height of subjects is directly proportional to the height of their parents. These results suggest that the starting age at menestuation can be closely associated with physical growth and development.

척추 전이성 종양의 수술적 치료 : 삶의 질에 대한 평가를 중심으로 focused in evaluation of life quality

양준영,이준규,홍의표,안성환,이정범 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

목적 : 척추에 발생한 전이성 종양 환자들을 대상으로, 수술적 치료를 시행한 환자에 있어서, 술후 생존 기간과 생존 기간 내 동통, 신경학적 증상, 일상 생활 능력 등의 평가를 통한 수술적 치료의 결과에 대하여 보고하고자 한다 . 연구대상 및 방법 : 1996년부터 1999년까지 본원에서 전이성 종양으로 수술적 치료를 받았던 환자중 추시가 가능했던 13례의 환자를 대상으로 하였으며 술 후 생존 기간 및 술 전 및 술 후 추시 중의 동통 양상 및 신경학적 증상의 호전여부, 일상 생활 수행 능력을 분석하였다 . 결과 : 전례에서 술 전 동통을 호소하였으며, 1례에서만 단독 보행이 가능하였고, 1례에서는 앉는 것만 가능하였으며, 11례에서는 앉지도 못하였다. 술 후 평가에서는 전례에서 동통이 감소하였으며, 술전에 신경학적 증상이 보였던 환자 중 75%에서 신경학적 증상이 호전이 나타났으며, 대상환자 중 92%에서 자가 보행이 가능하거나, 앉는 것이 가능하게 되었다. 사망한 환자의 술후 생존기간은 평균 11.2 개월이었다. 결론 : 수술적 치료를 받은 척추의 전이성 골종양 환자에서 술 후 신경학적 증상의 호전, 동통의 감소 및 보행 능력의 호전을 볼 수가 있었다. 따라서 척추의 전이성 종양 환자에 있어, 수술의 적응증이 된다면 수술적 치료를 적극적으로 시행하는 것이 환자의 삶의 질을 향상시킬 수 있다고 사료된다. To evaluate the clinical results of surgical treatment in metastatic spinal tumor patients. Thirteen patients of spinal metastatic tumor, treated by surgical methods, in this hospital from 1996 to 1999, were included in this study. We analysed pre and post operative pain, neurologic symptom and life quality. Preoperatively, all patients complained of pain and one case do could self walking, one case could do self sitting, and eleven patients were bed-ridden states. Postoperatively, pain was subsided in all cases. Neurologic symptom recovered in 75% of patients who had had preoperative neurologic symptoms. Postoperatively, patients walk or sit without assistance in 92% of cases. Mean postoperative span of survival was 11.2 months. Surgical treatment of spinal metastatic tumor improved the neurologic status and reduced pain. So, we conclude that if indicated, surgical treatment seems to achieve better results than conservative treatment in spinal metastatic tumor patient.

국산 침엽수 철물접합부의 인장하중 특성

심국보,박정환,이준호 한국목재공학회 2003 목재공학 Vol.31 No.5

국산 주요 침엽수재인 소나무, 잣나무, 낙엽송의 철물접합부 인장하중 특성 구명을 위하여 본 연구를 수행하였다. 철물 접합부의 최대 인장하중은 AA형의 경우 소나무가 3,612 kgf로 낙엽송, 잣나무에 비해 각각 1.2배, 1.7배, EA형의 경우 2,704 k9f로 1.1배, 1.5배 우수하였다. 또한 AA형은 EA형에 비해 3 수종 모두 약 1.2배 이상 높은 인장하중을 나타내었다. 철물접합부의 파괴모드는 주로 이의 빠짐, 철물의 인장파괴와 목재의 전단파괴로 이루어지며, 특히 소나무 접합부는 철물의 인장파괴를 나타내었다. 철물접합부재의 인장하중-변위 특성은 Foschi 모형으로 정확하게 추정할 수 있었으며 , 철물접합부의 초기강성은 소나무 접합부재가 높게 나타났다. 국산 침엽수재의 철물접합부에 대한 설계하중은 소나무, 낙엽송, 잣나무의 순으로 높게 나타났으며, AA형의 경우 이당 설계하중이 소나무 25 kgf, 낙엽송 22 kgf, 잣나무 15 kgf이었으며, EA형의 경우 소나무 19 kgf, 낙엽송 17 kgf, 잣나무 13 kgf 이었다. This study was conducted to evaluate the tensile properties of metal plate connector for the domestic major softwoods, such as Korean red pine, Korean white pine, and Japanese larch. The maximum tensile load of Korean red pine was 3,612㎏f in AA type, it was 1.2 and 1.7 times higher load than that of Japanese larch and Korean white pine. In EA type, it was 2,704㎏f, and 1.1 and 1.5 times higher than the loads of Japanese larch and Korean white pine. The failure modes of metal plate connector were metal plate withdrawal, plate tensile failure, and wood shear block failure. The failure mode of Korean red pine connector was tensile failure of plate, that is reason of the high tensile load resistance for metal plate connections in Korean red pine. The mechanical properties of metal plate connector could be predicted by the Foschi model parameter. In the initial stage, the Korean red pine connector was stiffer than the other species. The design values for metal plate connector per tooth was 25, 22, and 15kgf for Korean red pine, Japanese larch, and Korean white pine in AA type and 19, 17, and 13㎏f in EA type.

만성 무릎관절 통증환자에서 내측 반월상연골 손상과 관절 퇴행성 변화의 감별을 위한 ^99mTc-MDP 무릎관절 SPECT의 진단기준

팽진철,정준기,정환정,유재호,강원준,소영,이동수,이명철,성상철,이명철 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.2

목적 : 만성 무릎관절 통증환자에서 관절의 퇴행성 변화로 인하여 ^99mTc-MDP SPECT를 이용한 관절 내 장애의 진단성능이 떨어지게 된다. 이 연구에서는 내측 구획의 섭취 증가가 관찰될 때 이를 내측 반월상연골 손상(MMI)과 퇴행성 변화(DC)로 감별 진단하기 위한 진단기준을 찾고자 하였다. 대상 및 방법 : 3개월 이상의 만성 통증으로 무릎관절 SPECT를 시행하고 이후 관절경 검사를 통해 관절 병소의 확진을 받은 환자 중 SPECT 상 내측 구회에 섭취 증가를 보인 47명, 49예의 영상을 대상으로 하였다. SPECT 영상에서 내측 경골 고원부에 초승달 모양의 섭취가 관찰될 때 MMI로 진단하는 기준(진단기준 Ⅰ), 초승달 모양 섭취 양상에 따라 전측, 중앙측, 후측 및 미만성으로 구분하고 이 중 중앙측, 후측, 미만성만을 MMI로 진단하는 기준(진단기준 Ⅱ), 이에 더해 섭취의 정도를 등급화하여 내측 구획에서 대퇴골 부위보다 경골 고원부의 섭취가 더 높을 때만 MMI로 진단하는 기준(진단기준 Ⅲ)의 세 가지 진단기준을 설정하고 이들의 진단성능을 비교하였다. 결과 : MMI 진단의 예민도와 특이도가 진단기준 Ⅰ에서 각각 93%, 14%, 진단기준 Ⅱ에서 각각 89%, 38%, 진단기준 Ⅲ에서 75%. 67%로 형태학적 기준과 섭취 정도에 의한 기준을 첨가할수록 진단성능이 향상되었다. 결론 : 이 연구에서는 무릎관절 SPECT가 적용되는 실제 임상 적응중에 가까운 만성 무릎관절 통증에서, 퇴행성 변화와 관절 내 장애를 감별하는 향상된 진단기준을 제시하였다. 이를 통하여 선별검사로서 무릎관절 SPECT의 진단적 가치를 더욱 높일 것으로 기대된다. Purpose: In patients with chronic knee pain, the diagnostic performance of ^99mTc-MDP knee SPECT for internal derangement of knee is deteriorated due to degenerative changes. In this study, we tried to establish diagnostic criteria to differentiate medial meniscal injury (MMI) from degenerative change (DC) when the uptake is increased in medial compartment. Materials and Methods: A total of 49 knee SPECT of the patients with chronic (more than 3 months) knee pain, which showed increased ^99mTc-MDP uptake in the medial compartment, were included in this study. The diagnosis was confirmed by arthroscopy. On knee SPECT, 3 diagnosic criteria for MMI were investigated. In Criterion Ⅰ, MMI was diagnosed when crescentic uptake was observed in the medial tibial plateau. In Criterion Ⅱ, crescentic uptake was further classified into anterior, mid, posterior, and diffuse patterns, according to the location of maximal uptake; and only crescentic mid posterior, and diffuse patterns were diagnosed as MMI. In Criterion Ⅲ, MMI was diagnosed when medial tibial plateau showed higher activity then medial femoral condyle. The diagnostic performance of the 3 criteria was compared. Results: The sensitivity and specificity were 93% and 14% in Criterion Ⅰ, 89% and 38% in Criterion Ⅱ, and 75% and 67% in Criterion Ⅲ, respectively. Criterion Ⅲhad significantly improved diagnostic performance, especially, specificity. Conclusion: In this study, we established a practical diagnostic criterion to differentiate MMI from DC on knee SPECT. The result is helpful to improve the diagnostic value of knee SPECT as a screening test for chronic knee pain.

Panoramic Image Stitching Using Feature Extracting and Matching on Embedded System

Lee, June-Hwan The Korean Institute of Electrical and Electronic 2017 Transactions on Electrical and Electronic Material Vol.18 No.5

Recently, one of the areas where research is being actively conducted is the Internet of Things (IoT). The field of using the Internet of Things system is increasing, coupled with a remarkable increase of the use of the camera. However, general cameras used in the Internet of Things have limited viewing angles as compared to those available to the human eye. Also, cameras restrict observation of objects and the performance of observation. Therefore, in this paper, we propose a panoramic image stitching method using feature extraction and matching based on an embedded system. After extracting the feature of the image, the speed of image stitching is improved by reducing the amount of computation using the necessary information so that it can be used in the embedded system. Experimental results show that it is possible to improve the speed of feature matching and panoramic image stitching while generating a smooth image.

Cryogenic measurement of alpha decay in a 4π absorber

Lee, Sang-Jun,Lee, Min Kyu,Jang, Yong Sic,Kim, Il Hwan,Kim, Sun Kee,Lee, June Sur,Lee, Kyoung Beom,Lee, Young Hwa,Kim, Yong-Hamb IOP Pub 2010 Journal of Physics. G, Nuclear and Particle Physic Vol.37 No.5

<P>We established <I>Q</I> spectroscopy, a novel method for the study of alpha decay, by combining 4π detection scheme with a low-temperature microcalorimeter. A 4π metal absorber guarantees absolute measurement of radioactivity without energy loss in the source and absorber. As a clear demonstration of <I>Q</I> spectroscopy, the <SUP>241</SUP>Am alpha source enclosed by a thin gold foil was measured below 100 mK. Its resulting energy spectrum has two dominant peaks with 10 keV FWHM. The more dominant one corresponds to the complete absorption of the <I>Q</I> value, the total decay energy, and the less dominant one to γ-ray escapes. Consequential one-to-one correspondence with high-energy resolution appears between mixed radioisotopes and peaks in <I>Q</I> spectroscopy, which will simplify procedures of nuclear material analysis.</P>

In Vivo radioprotective effect of Panax ginseng C.A. Meyer and identification of active ginsenosides

Lee, Hae June,Kim, Se Ra,Kim, Jong Choon,Kang, Chang Mo,Lee, Yun Sil,Jo, Sung Kee,Kim, Tae Hwan,Jang, Jong Sik,Nah, Seung Yeol,Kim, Sung Ho Heyden & Son 2006 Phytotherapy research Vol.20 No.5

<P>This study evaluated the effect of water extracts of Panax ginseng C.A. Meyer (PG), panaxadiol (PD), panaxatriol (PT), ginsenoside Rb<SUB>1</SUB>, Rb<SUB>2</SUB>, Rc, Rd, Re and Rg<SUB>1</SUB> on jejunal crypt survival, endogenous spleen colony formation and apoptosis in jejunal crypt cells in gamma-irradiated mice. Jejunal crypts were protected by pretreatment with PG, Rc and Rd. Administration of PG, PD, Rd and Re prior to irradiation resulted in an increase in the formation of endogenous spleen colonies. The frequency of radiation-induced apoptosis in intestinal crypt cells was also reduced by pretreatment with PG, PD, Rb<SUB>2</SUB>, Rc, Rd, Re and Rg<SUB>1</SUB>. In experiments on the effects of the individual ginsenosides, the rank order of activity was Rc > Rd > Rg<SUB>1</SUB> > Rb<SUB>2</SUB> > Re > Rb<SUB>1</SUB> on intestinal crypt survival assay, Re > Rb<SUB>2</SUB> > Rd > Rg<SUB>1</SUB> > Rb<SUB>1</SUB> > Rc on the spleen colony formation assay, and Rg<SUB>1</SUB> > Re > Rd > Rc > Rb<SUB>2</SUB> > Rb<SUB>1</SUB> on inhibiting the death of cells caused by apoptosis. The results indicated that Rc, Rd and Re may have a major radioprotective effect in mice irradiated with high and low doses of radiation. When the same experiments were performed using PD and PT, it was observed that most of the inhibitory effects came from PD rather than PT. Copyright © 2006 John Wiley & Sons, Ltd.</P>

Role of protein kinase C delta in X-ray-induced apoptosis of keratinocyte

Lee, Young-Sook,Sohn, Kyung-Cheol,Kim, Ki-Hwan,Cho, Moon-June,Hur, Gang Min,Yoon, Tae-Jin,Kim, Sung Kyu,Lee, Kyungmoon,Lee, Jeung-Hoon,Kim, Chang Deok Blackwell Publishing Ltd 2009 Experimental dermatology Vol.18 No.1

<P>Abstract: </P><P>In this study, we investigated the process of X-ray-induced apoptosis of skin keratinocyte, and the functional role of protein kinase C delta (PKC&dgr;) and downstream signalling cascade. High-dose X-ray irradiation (10 Gy) led to the apoptosis of HaCaT keratinocyte, accompanied by PKC&dgr; cleavage. Treatment with PKC&dgr; inhibitor and adenoviral transduction of dominant-negative PKC&dgr; clearly inhibited the X-ray-induced apoptosis of keratinocyte. In addition, X-ray induced the phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) and inhibition by ERK1/2 inhibitor abrogated the X-ray-induced apoptosis. Interestingly, overexpression of dominant-negative PKC&dgr; markedly blocked the X-ray-induced phosphorylation of ERK1/2, suggesting that ERK1/2 is the functional downstream effector of PKC&dgr;. Next, we investigated the difference between UVB and X-ray response. UVB induced the apoptosis of keratinocyte in a PKC&dgr;-dependent manner, similar to X-ray response. However, UVB irradiation induced the phosphorylation of c-jun N-terminal kinases (JNK) and inhibition of JNK significantly protected the UVB-induced apoptosis. These results demonstrate that PKC&dgr; is a key regulator in X-ray-induced apoptosis of keratinocyte and suggest that there is subtle difference in downstream signalling cascade between UVB and X-ray response of keratinocyte.</P>

Benefits of hypomethylating therapy in IPSS lower-risk myelodysplastic syndrome patients: A retrospective multicenter case series study

Lee, Je-Hwan,Kim, Yoo-Jin,Sohn, Sang Kyun,Yoon, Sung-Soo,Kim, Hawk,Cheong, June-Won,Lee, Won-Sik,Lee, Gyeong-Won,Lim, Sung-Nam,Kim, Min Kyoung,Lee, Ho Sup,Kim, Hyeoung-Joon Elsevier 2017 Leukemia research Vol.60 No.-

<P><B>Abstract</B></P> <P>We retrospectively analyzed the results of hypomethylating therapy in 586 patients (azacitidine in 423 and decitabine in 163) with International Prognostic Scoring System (IPSS) lower-risk myelodysplastic syndrome (MDS). The patients were reclassified with newer scoring systems (revised IPSS [R-IPSS], revised WHO classification-based Prognostic Scoring System [R-WPSS], and Lower Risk Prognostic Scoring System [LR-PSS]), and 21.8–38.4% of patients had high or very high risk features by the newer scoring systems. Median overall survival (OS) was 27.3 months and newer scoring systems well stratified the patients in terms of OS (R-IPSS, <I>P</I> =0.001; R-WPSS, <I>P<</I> 0.001; LR-PSS, <I>P<I> <</I> </I> 0.001). Hematologic improvement (HI) was observed in 279 patients (47.6%). OS differed by the achievement of HI (39.4% vs. 36.2%, <I>P</I> =0.067). The differences were significant only in patients of intermediate or high risk group by LR-PSS (<I>P</I> =0.034) or R-IPSS (<I>P</I> =0.018). In summary, IPSS lower-risk MDS included a broad range of prognosis, and hypomethylating therapy induced HI in approximately half of the patients. Achievement of HI was associated with longer survival, especially in patients with intermediate or high risk features by newer scoring systems. Hypomethylating therapy seems to have potential benefits in IPSS lower-risk MDS.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Some IPSS lower-risk patients had high risk features by newer scoring systems. </LI> <LI> IPSS lower-risk patients were well stratified by newer systems for survivals. </LI> <LI> Hematologic improvement was observed in 48% after hypomethylating therapy. </LI> <LI> Achievement of hematologic improvement was associated with longer survival. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>