Clinical Manifestations and Treatment Outcomes of Eosinophilic Gastroenteritis in Children

Jong Sub Choi,Shin Jie Choi,Kyung Jae Lee,Ahlee Kim,Jung Kyung Yoo,양혜란,문진수,장주영,고재성,강경훈 대한소아소화기영양학회 2015 Pediatric gastroenterology, hepatology & nutrition Vol.18 No.4

Purpose: The aim of the present study was to investigate the clinical features and outcome of eosinophilic gastro-enteritis (EGE) in children.Methods: Our study enrolled 24 children who were diagnosed with EGE from 1993 to 2014 at the Department of Pediatrics, Seoul National University Children’s Hospital. The patients’ clinical manifestations, treatments, and out-comes were reviewed from the medical records.Results: The mean age at diagnosis was 5.3 years. Most patients had gastrointestinal symptoms including diarrhea (54.2%) and abdominal pain (45.8%). Peripheral eosinophilia was present in 91.7% of the patients. Thirteen patients (54.2%) showed anemia, and 15 patients (62.5%) had hypoalbuminemia. EGE was classified as mucosal, sub-serosal, or muscular in 75.0%, 20.8%, and 4.2% of cases, respectively. Three patients showed gastroduodenal ulcers upon endoscopic analysis. A history of allergy was reported in 13 patients, including atopic dermatitis, allergic rhinitis, and asthma. Five patients (20.8%) improved with food restrictions. Among the 19 patients treated with steroids, 11 (57.9%) discontinued steroid treatment without subsequent relapse, 4 (21.1%) relapsed after ceasing steroid treat-ment, and 4 (21.1%) showed no response to steroids. Two patients who were resistant to steroids underwent ther-apeutic surgery. The presence of gastroduodenal ulcers was significantly associated with relapse and steroid resistance.Conclusion: A high suspicion of EGE is warranted when children have nonspecific gastrointestinal symptoms and peripheral eosinophilia. Most patients improved with food restrictions or steroid treatment, although one-third of pa-tients showed a relapse or steroid resistance.

Inkjet‐Printable Nanoporous Ag Disk Arrays Enabling Coffee‐Ring Effect‐Driven Analyte Enrichment Towards Practical SERS Applications

Jung-Sub Wi,Jeong Dae Kim,Wonseok Lee,Hyunsik Choi,Minjeong Kwak,Jungkeun Song,Tae Geol Lee,Jong G. Ok 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.2

To make surface enhanced Raman scattering (SERS) sensors more practical, we propose nanoporous Ag disks as SERSactive plasmonic structures that can be readily inkjet-printed just before use to avoid degradation of SERS enhancement. Together with the aid of the enhanced plasmonic fi elds from the nanoporous Ag (confirmed by electromagnetic simulation), we utilize a coffee-ring effect to concentrate target analytes, which is demonstrated by confocal Raman measurements. By using the proposed SERS sensor, Raman signals of TiO 2 nanoparticles with a concentration of ppm to sub-ppb have been successfully measured. TiO 2 in commercial consumables has been also detected by distinguishing its crystalline phase.

Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Yong Soon Kim,Min Won Baek,Jae Hyuck Sung,Hyun Youl Ryu,Jin Sik Kim,Hyun Sun Cho,Byung Gil Choi,Min Sub Song,Moon Yong Song,Eun Ju Baik,Young Kuk Choi,Jong Kyu Kim,Il Je Yu,Kyung Seuk Song 한국독성학회 2009 Toxicological Research Vol.25 No.3

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 ㎎/㎏ body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 ㎎/㎏ body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 ㎎/㎏ body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

Acute and Sub-chronic Oral Toxicity Study of Ammonium Persulfate in Spraque-Dawley Rats

Kim, Yong-Soon,Baek, Min-Won,Sung, Jae-Hyuck,Ryu, Hyun-Youl,Kim, Jin-Sik,Cho, Hyun-Sun,Choi, Byung-Gil,Song, Min-Sub,Song, Moon-Yong,Baik, Eun-Ju,Choi, Young-Kuk,Kim, Jong-Kyu,Yu, Il-Je,Song, Kyung-Se Korean Society of ToxicologyKorea Environmental Mu 2009 Toxicological Research Vol.26 No.3

The toxicity test of ammonium persulfate was conducted to ensure of its potential toxic effects according to the single-dose acute oral toxicity study (OECD Guideline 423) and 90-day repeated dose sub-chronic oral toxicity study guideline (OECD Guideline 408) for establishing national chemical management system, and matching in the Globally Harmonized Classification System (GHS) category. In acute oral toxicity study, pasty stool, perineal contamination and temporary body weight decrease were observed after dosing 1st and 2nd challenge (300 mg/kg body weight). All test animals were dead within 6 hours after dosing at 3rd challenge (2000 mg/kg body weight). Therefore, the GHS class of test substance is considered class 4. In sub-chronic toxicity study, body weight changes, food consumptions, hematological, biochemical and pathological examination did not show any noticeable and significant differences between the administered (5, 20, 80 mg/kg body weight) and control (vehicle only) group animals. Based on these results, the no observed adverse effect level (NOAEL) is considered above 80 mg/kg body weight.

창조영역과 콘텐츠산업의 시너지 효과분석: 세부산업별·지역별 비교를 중심으로

전종섭(Chun, Jong Sub),허식(Heo, Shik) 한국문화산업학회 2021 문화산업연구 Vol.21 No.4

문화산업의 기반이 되는 창조영역의 역할을 이해하는 것은 문화산업의 지속가능한 발전과 나아가 이를 통한 경제 활성화 정책에서 필수적이다. 그럼에도 이에 대한 실증적 연구는 미미하며, 문화산업의 세부적인 장르에 제약되었다는 한계를 가진다. 본 연구에서는 문화산업의 발전과정에서 시너제틱스 이론과 CCD (coupling coordination degree)모형을 기반한 창조영역과 콘텐츠산업의 시너지를 확인함으로써 창조영역의 역할을 제시하고자 한다. 본 연구에서는 통계청 「서비스업 조사」 2007년에서 2019년도 자료를 활용하였으며 문화산업의 지역별 자료를 구축하였다. Throsby의 동심원모형에 기반하여, 예술인력과 문화시설을 ‘창조영역’으로, 영화·인쇄·방송·음반·게임산업을 "콘텐츠산업"으로 구분하였다. 이에 대한 분석 결과는 다음과 같다. 첫째, 창조영역과 콘텐츠산업의 시너지 효과는 낮은 수준으로 나타났으나 점차 상승하는 추세를 보였다. 이는 시너지를 통한 문화산업의 발전이 발생하고 있으나 아직 미약한 단계임을 의미한다. 둘째, 창조영역과 콘텐츠산업의 시너지 효과는 서울·경기에만 높게 나타났다. 이는 문화산업이 대도시 중심의 발전이 이루어지는 현상을 반영하며, 지역 간 격차를 줄이기 위한 노력의 필요성이 제기된다. 셋째, 콘텐츠산업의 세부영역별 시너지 효과는 다르게 나타났다. 영화·게임산업과 창조영역의 시너지는 관찰된 기간에 급격한 시너지의 상승이 나타났으며, 출판산업과 창조영역의 시너지 효과는 다소 완만한 성장이 관찰되었다. 마지막으로, 지역·영역별 시너지 효과는 다르게 관찰되었다. 이는 지역별 문화산업이 다른 방식의 시너지가 발생하고 있음을 의미한다. 결과적으로 우리의 연구는 창조영역과 콘텐츠산업의 시너지를 통해 문화산업이 발전하고 있음을 확인한다. 그러나 지적된 문제들을 해결하기 위하여 지역 간 문화적 교류의 활성화, 지역 기반의 문화산업 특성화, 문화산업 간의 연계강화 등의 노력은 지속되어야 하겠다. Recognizing the role of creative sectors in the cultural industry is essential for the sustainable development of the cultural industry and the effective policy decision of economic revitalization. However, empirical research supporting this proposition is scarce and is limited to a specific genre. Based on the synergetics theory and CCD (coupling coordination degree) model, this study verifies synergy effects between the creative sectors and the content industry. For the analysis, we establish a data set for local cultural industries, using the “Service Industry Survey” data from 2007 to 2019. Under the Throsby’s concentric circle model, while pure artists and cultural institutions are classified into ‘creative areas’, the film industry, printing industry, broadcasting industry, sound industry, and game industry are classified into "content industry". Our results are summarized as follows. First, the synergy effect between the creative sectors and the content industry is low levels, but it shows a gradually increasing trend. This means that the cultural development through synergies is still in a weak stage but is increasing. Second, the synergy effect with the creative sectors is high only in Seoul and Gyeonggi. This reflects the phenomenon that the cultural industry is developing in centered on principal cities, and the government need for efforts to narrow the gap between regions is raising. Third, the synergy effect with the creative sectors seems different from each detailed parts in the content industry. The synergy effect between the film & game industries and the creative sectors shows a sharp increase during the observed period, and the synergy effect between the publishing industry and the creative sectors is observed to grow somewhat slowly. Finally, the regional synergy effects are observed differently by regional areas. Our results suggest that, since the cultural industry is developing through synergies between sub-industries, our efforts are still needed such as promoting cultural exchanges between the capital cities and regions, creating cultural marketing strategies reflecting the intrinsic characteristics of each region, and strengthening links among sub-sectors of the cultural industry.

체육수업의 재미요인이 학생들의 심리적 유인성향에 미치는 영향

이종철(Lee Jong-Chul),조홍식(Cho Hong-Sik),박윤혁(Park Yoon-Hyuk),이상섭(Lee Sang-Sub) 한국체육과학회 2006 한국체육과학회지 Vol.15 No.3

The purpose of this study was to explore ways to at identifying what factors made students felt enjoyment during physical education class and how much those factors influence on psychological of inducement inclination. To this end, Cluster Random Sampling was used to set up the population with boys and girls middle school students in Kyunggi-do and Inchon-si area. The survey tool was questionnaire and Collected data hereof were analyzed by one way ANOVA analysis and Multiple Regression Analysis with SPSS WIN Ver 11.5. The aforementioned method and procedure led this research to the conclusion as follows. Firstly, out of sub-factors of physical education class enyoyment by middle schoolers' individual characteristics(gender, result), boy students showed more than girl students, in which there were statistically significant difference. Meanwhile, statistically significant difference was not found in free time, explanation and modeling. Secondly, out of sub-factors of psychological of inducement inclination by middle schoolers' individual characteristics(gender, result), boy students' response was higher in senses of confidence, enthusiasm, accomplishment and indulgence than girl students' in which all considers appeared. Thirdly, the effect enjoymant factors of physical education class had statistically significant on sub-factors of psychological of inducement inclination senses of confidence, enthusiasm, accomplishment and indulgence, free time that is a sub-factor of enjoymant which did not had statistically significant influenced on sense of accomplishment.

체육수업에 대한 교과 흥미도가 학생들의 기본적 심리욕구에 미치는 영향

이종철(Lee, Jong-Chul),이상섭(Lee, Sang-Sub) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.6

The purpose of this study is to identify effects of subject interest in physical education on basic psychological desires of students. For doing this, the authors established the students in middle and high schools in Gyeonggi Province as the population, selecting 340 students by using convenience sampling. The collected data was conducted of multiple regression analysis by using the PASW Ver 18.0 statistic program, and the results are as follows. First, the subject interest in physical education had statistically significant effects on the basic psychological desires of the students(competence), but among the sub-factors, teacher preference factors did not have significant effects on the basic psychological desires(competence). Second, all the sub-factors of the subject interest in physical education(teacher preference, subject content, values & efforts, and subject competence) had statistically significant effects on the basic psychological desires of the students(relation). Third, the subject interest in physical education had statistically significant effects on the basic psychological desires of the students(autonomy), but among the sub-factors, teacher preference factors did not have significant effects on the basic psychological desires(autonomy).

신이식에서 이식신의 생존분석

오선미,김종학,황평주,구영선,강민규,나기량,김종섭,김성숙,이강욱,신영태,설종구,배진선,손기섭 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

To investigate the prognostic factors for the survival of transplanted kidney in patients with end-stage renal failure, 59 cases of renal transplantation from September 1986 to Feburary 1997 in Chungnam National University Hospital were analyzed retrospectively. The results were as follows: 1)The mean age of recipients was 33.8 years and that of doners was 38.9 years. The male to female ratio of recipients was 2.5:1, and that of donors was 1.03:1 2) Living related donore(LRD) were 79.6% and living non-related donors were 20.3%. The HLA-identical donors(ID) in LRD were 18.7% and HLA-haploidentical donors(HID) were 61.0%. In living non-related donors(LNRD), mean matched HLA-AB antigens were 1.56 and mean matched HLA-DR antigens were 0.56. 3) The average 5-year patient survival fate was 94%, and average 5-year graft survival rate was 70%. The 5-year graft survival fate of HLA-ID was 100%, and those HLA-HID and LNR were 70% and 36% respectively. 4) Total 33 episodes of acute rejection were found in 45.8% of transplanted patients. The number of acute rejection episode did not show significant difference between LRD and LNRD(P > 0.05). There was no significant difference in MLC between two groups(p > 0.05). 5) In comparison between the 18 patients who lost their graft function in 5 years and 17 patients who are maintaining graft function for more than 5 years, MLC was significantly lower in patients with functioning graft than of patients with non-functioning graft (p < 0.05). The number of rejection episode was also lower in patients with functioning graft than that of the patients with non-functioning graft(p < 0.05). However, there were no significant difference in recepient and donor age and history of pre-transplantation donor specific transfusion between two groups. With the results above, we can speculate that adequate donor selection according to good matched HLA typing and low MLC is very important for graft survival in renal transplantation. Prevention and treatment of acute rejection in renal transplantation is also na important factor for graft survival.

사관생도의 체육활동을 통한 사회성발달요인이 신체적 자기효능감에 미치는 영향

민창기(Min, Chang-Gi),이종민(Lee, Jong-Min),박상섭(Park, Sang-Sub),박순희(Park, Sun-Hee),김인기(Kim, In-Ki) 한국체육과학회 2014 한국체육과학회지 Vol.23 No.2

The purpose of this study of cadets social development through physical activity factor out the impact of physical self-efficacy are seeing. To this end, on the basis of previous research and theory, cadets according to the individual characteristics of participants in physical activity factors, social development, and physical effects on self-efficacy was determined empirically. The subjects of this study are based in KAFA cadets to participate in physical activity among the 200 selected patients, 169 were used in the final part were used. By the way, more studies were summarized as follows. First, the social development of the sub-factors of the social factors, governance, stability, no statistically significant differences between men and women in the show, and overall social development factors in men than in women was higher. Physical self-efficacy subscale of physical competence and physical attractiveness in the sense of gender showed statistically significant differences, and about the physical self-efficacy was higher in women than men. Second, the social development of the factors involved in the stability of the sub-factors, depending on stocks showed a statistically significant difference, and the overall social development factors were the highest in the group event. Self-efficacy of physical competence subscale of the body involved in the events showed significant differences according to the tatistical and physical competence, the individual events and the most underestimated, interpersonal and organization in order. In other words, the overall physical self-efficacy and the lowest individual events, personal events, corporate events in order, respectively. Third, social development, physical factors impact on self-efficacy to evaluate the results with social dominance physical competence, physical self-expression, sense of physical attractiveness showed a positive correlation, and perceived physical ability and a negative correlation with has shown. Stability in the perceived physical ability, has shown a positive correlation.

국내 바이오에탄올 혼합연료유 도입을 위한 실증평가연구

임의순(Yim, Eui-Soon),민경일(Min, Kyung-Il),전철환(Jeon, Cheol-Hwan),이돈민(Lee, Don-Min),김종렬(Kim, Jong-Ryeol),김승수(Kim, Seung-Soo),장은정(Jang, Eun-Jung),박천규(Park, Cheon-Kyu),정충섭(Jung, Chung-Sub),김재곤(Kim, Jae-Kon),임 한국신재생에너지학회 2007 한국신재생에너지학회 학술대회논문집 Vol.2007 No.11

국제 원유가의 지속적인 상승에 따라 화석연료 고갈을 대비한 대체에너지 빛 온실가스배출감소를 위하여 바이오연료의 사용 및 상용보급은 전세계적인 추세이다. 우리나라의 경우 바이오디젤은 2002년부터 시범보급사업(Demonstration & dissemination)을 거쳐 2006년 7월부터 전국주유소를 통하여 경유 중에 바이오디젤 0.5%를 혼합한 BDO.5를 수송용 연료로 도입하여 아시아 최초로 상용보급화를 시행하고 있다. 또한 휘발유 중 바이오에탄올 혼합 연료유 도입을 위한 실증평가연구를 2006년 8월부터 2008년 7월까지 수행중이다. 자동차용 휘발유의 옥탄가 향상을 위해 함산소 기재로 사용되는 MTBE(Methyl Tertiary Butyl Ether)를 바이오에탄올로 대체한 바이오에탄올 혼합연료유는 수분 혼입에 의한 상 분리(Phase separation)와 금속에 대한 부식성 문제를 야기 시킬 수 있다. 바이오에탄올을 서브옥탄가솔린(Sub-octane gasoline)에 혼합하여 상 분리 모사실험, 금속류 부식시험, 고무류 침지실험 등 다양한 품질특성평가를 수행하였으며, 이런 결과들을 바탕으로 국내실정에 알맞은 최적의 혼합량(E3, E5)을 도출하였다. 또한 전국에 4개 시범주유소를 운영하여 바이오에탄올 혼합 연료유의 유통 및 보급을 통해 최적의 유통인프라(Distribution infrastructure) 보완 및 구축 방안을 도출 하고자 한다.