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이은경(Eun Kyoung Lee),이용주(Yong Joo Lee),이근래(Kuen Lae Lee),김은주(Eun Ju Kim),은백린(Baik Lin Eun) 대한소아신경학회 1995 대한소아신경학회지 Vol.2 No.2
Two cases of acute Ginkgo Biloba intoxication in a nineteen month old girl and two years old girl were presented. The patients were admitted with clinical manifestations of abrupt vomiting, generalized tonic convulsion which were developed after ingestion of significant amounts of Ginkgo. Laboratory works revealed no specific findings. These patients were treated with supportive cares such as parenteral fluid administration and close observation. The were discharged with complete improvements on the second and third day of admission.
Adiponectin Concentrations: A Genome-wide Association Study
Jee, Sun Ha,Sull, Jae Woong,Lee, Jong-Eun,Shin, Chol,Park, Jongkeun,Kimm, Heejin,Cho, Eun-Young,Shin, Eun-Soon,Yun, Ji Eun,Park, Ji Wan,Kim, Sang Yeun,Lee, Sun Ju,Jee, Eun Jung,Baik, Inkyung,Kao, Lind Elsevier 2010 American journal of human genetics Vol.87 No.4
<P>Adiponectin is associated with obesity and insulin resistance. To date, there has been no genome-wide association study (GWAS) of adiponectin levels in Asians. Here we present a GWAS of a cohort of Korean volunteers. A total of 4,001 subjects were genotyped by using a genome-wide marker panel in a two-stage design (979 subjects initially and 3,022 in a second stage). Another 2,304 subjects were used for follow-up replication studies with selected markers. In the discovery phase, the top SNP associated with mean log adiponectin was rs3865188 in <I>CDH13</I> on chromosome 16 (p = 1.69 × 10<SUP>−15</SUP> in the initial sample, p = 6.58 × 10<SUP>−39</SUP> in the second genome-wide sample, and p = 2.12 × 10<SUP>−32</SUP> in the replication sample). The meta-analysis p value for rs3865188 in all 6,305 individuals was 2.82 × 10<SUP>−83</SUP>. The association of rs3865188 with high-molecular-weight adiponectin (p = 7.36 × 10<SUP>−58</SUP>) was even stronger in the third sample. A reporter assay that evaluated the effects of a <I>CDH13</I> promoter SNP in complete linkage disequilibrium with rs3865188 revealed that the major allele increased expression 2.2-fold. This study clearly shows that genetic variants in <I>CDH13</I> influence adiponectin levels in Korean adults.</P>
<i>Terriglobus aquaticus</i> sp. nov., isolated from an artificial reservoir
Baik, Keun Sik,Choi, Jong-Soon,Kwon, Joseph,Park, Seong Chan,Hwang, Yeoung Min,Kim, Mi Sun,Kim, Eun Mi,Seo, Dong-Cheol,Cho, Ju-Sik,Seong, Chi Nam International Union of Microbiological Societies 2013 International journal of systematic and evolutiona Vol.63 No.12
<P>A pink-pigmented, chemo-organotrophic bacterium, designated strain 03SUJ4<SUP>T</SUP>, was isolated from the freshwater of Juam reservoir, Republic of Korea (35° 03′ 43′′ N 127° 14′ 15′′ E). Cells were aerobic, Gram-reaction-negative and non-motile rods. Strain 03SUJ4<SUP>T</SUP> grew at pH 6–7 (optimum, pH 6) and at 15–30 °C (optimum, 25 °C). Phylogenetic analysis based on 16S rRNA gene sequences indicated that the isolate belonged to the genus <I>Terriglobus</I>, showing sequence similarities of 97.09 % and 96.82 % to <I>Terriglobus roseus</I> DSM 18391<SUP>T</SUP> and <I>Terriglobus saanensis</I> SP1PR4<SUP>T</SUP>, respectively. Low <I>rpoB</I> gene sequence similarity with members of the genus <I>Terriglobus</I> and different fingerprints with the repetitive primers BOX, ERIC and REP indicated that the isolate represented a novel species of the genus <I>Terriglobus</I>. The major cellular fatty acids were iso-C<SUB>15 : 0</SUB>, C<SUB>16 : 0</SUB>, C<SUB>20 : 1</SUB>ω9<I>c</I>, C<SUB>14 : 0</SUB> and summed feature 3 (C<SUB>16 : 1</SUB>ω7<I>c</I>/C<SUB>16 : 1</SUB>ω6<I>c</I>). The DNA G+C content of strain 03SUJ4<SUP>T</SUP> was 63.2±0.1 mol% (mean±<SMALL>sd</SMALL> of three determinations). The predominant menaquinone was MK-8. The major polar lipids were phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylglycerol and two unidentified phospholipids. Several phenotypic characteristics served to differentiate the novel isolate from recognized members of the genus <I>Terriglobus</I>. On the basis of the evidence presented in this study, a novel species, <I>Terriglobus aquaticus</I> sp. nov. is proposed for strain 03SUJ4<SUP>T</SUP> ( = KCTC 23332<SUP>T</SUP> = JCM 17517<SUP>T</SUP>).</P>
Mepivacaine attenuates vasodilation induced by ATP-sensitive potassium channels in rat aorta
Baik, Jiseok,Ok, Seong-Ho,Kim, Eun-Jin,Kang, Dawon,Hong, Jeong-Min,Shin, Il-Woo,Lee, Heon Keun,Chung, Young-Kyun,Cho, Youngil,Lee, Soo Hee,Kang, Sebin,Sohn, Ju-Tae Canadian Science Publishing 2016 Canadian journal of physiology and pharmacology Vol.94 No.11
<P> The goal of this in vitro study was to investigate the effect of mepivacaine on vasodilation induced by the ATP-sensitive potassium (KATP) channel opener levcromakalim in isolated endothelium-denuded rat aortas. The effects of mepivacaine and the KATP channel inhibitor glibenclamide, alone or in combination, on levcromakalim-induced vasodilation were assessed in the isolated aortas. The effects of mepivacaine or combined treatment with a protein kinase C (PKC) inhibitor, GF109203X, and mepivacaine on this vasodilation were also investigated. Levcromakalim concentration-response curves were generated for isolated aortas precontracted with phenylephrine or a PKC activator, phorbol 12,13-dibutyrate (PDBu). Further, the effects of mepivacaine and glibenclamide on levcromakalim-induced hyperpolarization were assessed in rat aortic vascular smooth muscle cells. Mepivacaine attenuated levcromakalim-induced vasodilation, whereas it had no effect on this vasodilation in isolated aortas pretreated with glibenclamide. Combined treatment with GF109203X and mepivacaine enhanced levcromakalim-induced vasodilation compared with pretreatment with mepivacaine alone. This vasodilation was attenuated in aortas precontracted with PDBu compared with those precontracted with phenylephrine. Mepivacaine and glibenclamide, alone or in combination, attenuated levcromakalim-induced membrane hyperpolarization. Taken together, these results suggest that mepivacaine attenuates vasodilation induced by KATP channels, which appears to be partly mediated by PKC. </P>
Baik, In-Su,Choi, Ju-Hwan,Jung, Byoung-Sun,Jeon, Sang-Youn,Song, Eun-Kyoung,Lee, Seung-Hee The Korean Institute of Electrical and Electronic 2006 Transactions on Electrical and Electronic Material Vol.7 No.1
We have studied the motion of charged micro-particles that are immersed in a nematic liquid crystal (LC) and controlled by in-plane field. The LC is an anisotropic liquid such that the viscosity of the LC depends on flow direction, phase of the LC, and temperature, which affects the motion of the charged particles under the influence of electric field. This study shows that the motion of charged particles mainly depends on the applied voltage and the LC phase, but does not show any significant influence from the initial alignment of LC, although one may expect directional difference in drag force due to interaction between LC and particle. The viscosity changes due to temperature variations in nematic phase also show no signification influence on particle velocity when compared to the effect from varying in-plane field strength.
Levobupivacaine-induced contraction of isolated rat aorta is calcium dependent
Baik, Ji Seok,Sohn, Ju-Tae,Ok, Seong-Ho,Kim, Jae-Gak,Sung, Hui-Jin,Park, Sang-Seung,Park, Jae-Yong,Hwang, Eun Mi,Chung, Young-Kyun Canadian Science Publishing 2011 Canadian journal of physiology and pharmacology Vol.89 No.7
<P> Levobupivacaine is a long-acting local anesthetic that intrinsically produces vasoconstriction in isolated vessels. The goals of this study were to investigate the calcium-dependent mechanism underlying levobupivacaine-induced contraction of isolated rat aorta in vitro and to elucidate the pathway responsible for the endothelium-dependent attenuation of levobupivacaine-induced contraction. Isolated rat aortic rings were suspended to record isometric tension. Cumulative levobupivacaine concentration-response curves were generated in either the presence or absence of the antagonists verapamil, nifedipine, SKF-96365, 2-aminoethoxydiphenylborate, Gd<SUP>3+</SUP>, N<SUP>W</SUP>-nitro-l-arginine methyl ester (L-NAME), 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ), and methylene blue, either alone or in combination. Verapamil, nifedipine, SKF-96365, 2-aminoethoxydiphenylborate, low calcium concentrations, and calcium-free Krebs solution attenuated levobupivacaine-induced contraction. Gd<SUP>3+</SUP> had no effect on levobupivacaine-induced contraction. Levobupivacaine increased intracellular calcium levels in vascular smooth muscle cells. L-NAME, ODQ, and methylene blue increased levobupivacaine-induced contraction in endothelium-intact aorta. SKF-96365 attenuated calcium-induced contraction in a previously calcium-free isotonic depolarizing solution containing 100 mmol/L KCl. Levobupivacaine-induced contraction of rat aortic smooth muscle is mediated primarily by calcium influx from the extracellular space mainly via voltage-operated calcium channels and, in part, by inositol 1,4,5-trisphosphate receptor-mediated release of calcium from the sarcoplasmic reticulum. The nitric oxide - cyclic guanosine monophosphate pathway is involved in the endothelium-dependent attenuation of levobupivacaine-induced contraction. </P>